Candidemia epidemiology and susceptibility profile in the largest Brazilian teaching hospital complex
INTRODUCTION: Although the spectrum of fungi causing bloodstream fungal infections continues to expand, Candida spp. remains responsible for the majority of these cases. OBJECTIVE: The purpose of this study was to characterize the candidemia epidemiology, species distribution and antifungal suscepti...
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Gespeichert in:
| Autor*in: |
Adriana Lopes Motta [verfasserIn] Gisele Madeira Duboc de Almeida [verfasserIn] João Nóbrega de Almeida Júnior [verfasserIn] Marcelo Nascimento Burattini [verfasserIn] Flávia Rossi [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Brazilian Journal of Infectious Diseases - Elsevier, 2004 |
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| Links: |
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| DOI / URN: |
10.1590/S1413-86702010000500004 |
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| Katalog-ID: |
DOAJ070606102 |
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| 520 | |a INTRODUCTION: Although the spectrum of fungi causing bloodstream fungal infections continues to expand, Candida spp. remains responsible for the majority of these cases. OBJECTIVE: The purpose of this study was to characterize the candidemia epidemiology, species distribution and antifungal susceptibility patterns at a Brazilian tertiary teaching public hospital with 2,500 beds. METHODS: Records from the microbiology laboratory were used to identify patients with positive blood cultures during 2006. The in vitro activity of amphotericin B, caspofungin, itraconazole, fluconazole, voricanozole, and posaconazole were determined using the Etest method. RESULTS: One hundred and thirty-six cases of candidemia were identified and 100 strains were available for antifungal susceptibility testing. The overall incidence of candidemia was 1.87 cases/1.000 admissions and 0.27 cases/1.000 patient-days. Among the patients, 58.1% were male, and the median age was 40 years old. C. albicans was the most common species (52.2%), followed by C. parapsilosis (22.1%), C. tropicalis (14.8%), and C. glabrata (6.6%). All strains were susceptible to amphotericin B with a MIC90 of 0.5 µg/mL. Overall susceptibility for voriconozole, fluconazole, and caspofungin was < 97% with a MIC90 of 0.064, 4.0 and 1.0 µg/mL, respectively. For itraconazole the susceptibility rate was 81% with a MIC90 of 0.5 µg/mL. Posaconazole also demonstrated good in vitro activity with a MIC90 of 0.25 µg/mL. CONCLUSION: This is the first antifungal susceptibility report in our institution | ||
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10.1590/S1413-86702010000500004 doi (DE-627)DOAJ070606102 (DE-599)DOAJ1fd5e8205b374df0b4da704239794979 DE-627 ger DE-627 rakwb eng RC109-216 QR1-502 Adriana Lopes Motta verfasserin aut Candidemia epidemiology and susceptibility profile in the largest Brazilian teaching hospital complex Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier INTRODUCTION: Although the spectrum of fungi causing bloodstream fungal infections continues to expand, Candida spp. remains responsible for the majority of these cases. OBJECTIVE: The purpose of this study was to characterize the candidemia epidemiology, species distribution and antifungal susceptibility patterns at a Brazilian tertiary teaching public hospital with 2,500 beds. METHODS: Records from the microbiology laboratory were used to identify patients with positive blood cultures during 2006. The in vitro activity of amphotericin B, caspofungin, itraconazole, fluconazole, voricanozole, and posaconazole were determined using the Etest method. RESULTS: One hundred and thirty-six cases of candidemia were identified and 100 strains were available for antifungal susceptibility testing. The overall incidence of candidemia was 1.87 cases/1.000 admissions and 0.27 cases/1.000 patient-days. Among the patients, 58.1% were male, and the median age was 40 years old. C. albicans was the most common species (52.2%), followed by C. parapsilosis (22.1%), C. tropicalis (14.8%), and C. glabrata (6.6%). All strains were susceptible to amphotericin B with a MIC90 of 0.5 µg/mL. Overall susceptibility for voriconozole, fluconazole, and caspofungin was < 97% with a MIC90 of 0.064, 4.0 and 1.0 µg/mL, respectively. For itraconazole the susceptibility rate was 81% with a MIC90 of 0.5 µg/mL. Posaconazole also demonstrated good in vitro activity with a MIC90 of 0.25 µg/mL. CONCLUSION: This is the first antifungal susceptibility report in our institution candidemia Candida spp susceptibility testing Candida epidemiology Candida Etest antifungal susceptibility profile Candida antifungal agents azoles Infectious and parasitic diseases Microbiology Gisele Madeira Duboc de Almeida verfasserin aut João Nóbrega de Almeida Júnior verfasserin aut Marcelo Nascimento Burattini verfasserin aut Flávia Rossi verfasserin aut In Brazilian Journal of Infectious Diseases Elsevier, 2004 (DE-627)332927148 (DE-600)2055442-4 16784391 nnns https://doi.org/10.1590/S1413-86702010000500004 kostenfrei https://doaj.org/article/1fd5e8205b374df0b4da704239794979 kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000500004&lng=en&tlng=en kostenfrei https://doaj.org/toc/1678-4391 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR |
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10.1590/S1413-86702010000500004 doi (DE-627)DOAJ070606102 (DE-599)DOAJ1fd5e8205b374df0b4da704239794979 DE-627 ger DE-627 rakwb eng RC109-216 QR1-502 Adriana Lopes Motta verfasserin aut Candidemia epidemiology and susceptibility profile in the largest Brazilian teaching hospital complex Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier INTRODUCTION: Although the spectrum of fungi causing bloodstream fungal infections continues to expand, Candida spp. remains responsible for the majority of these cases. OBJECTIVE: The purpose of this study was to characterize the candidemia epidemiology, species distribution and antifungal susceptibility patterns at a Brazilian tertiary teaching public hospital with 2,500 beds. METHODS: Records from the microbiology laboratory were used to identify patients with positive blood cultures during 2006. The in vitro activity of amphotericin B, caspofungin, itraconazole, fluconazole, voricanozole, and posaconazole were determined using the Etest method. RESULTS: One hundred and thirty-six cases of candidemia were identified and 100 strains were available for antifungal susceptibility testing. The overall incidence of candidemia was 1.87 cases/1.000 admissions and 0.27 cases/1.000 patient-days. Among the patients, 58.1% were male, and the median age was 40 years old. C. albicans was the most common species (52.2%), followed by C. parapsilosis (22.1%), C. tropicalis (14.8%), and C. glabrata (6.6%). All strains were susceptible to amphotericin B with a MIC90 of 0.5 µg/mL. Overall susceptibility for voriconozole, fluconazole, and caspofungin was < 97% with a MIC90 of 0.064, 4.0 and 1.0 µg/mL, respectively. For itraconazole the susceptibility rate was 81% with a MIC90 of 0.5 µg/mL. Posaconazole also demonstrated good in vitro activity with a MIC90 of 0.25 µg/mL. CONCLUSION: This is the first antifungal susceptibility report in our institution candidemia Candida spp susceptibility testing Candida epidemiology Candida Etest antifungal susceptibility profile Candida antifungal agents azoles Infectious and parasitic diseases Microbiology Gisele Madeira Duboc de Almeida verfasserin aut João Nóbrega de Almeida Júnior verfasserin aut Marcelo Nascimento Burattini verfasserin aut Flávia Rossi verfasserin aut In Brazilian Journal of Infectious Diseases Elsevier, 2004 (DE-627)332927148 (DE-600)2055442-4 16784391 nnns https://doi.org/10.1590/S1413-86702010000500004 kostenfrei https://doaj.org/article/1fd5e8205b374df0b4da704239794979 kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000500004&lng=en&tlng=en kostenfrei https://doaj.org/toc/1678-4391 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR |
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10.1590/S1413-86702010000500004 doi (DE-627)DOAJ070606102 (DE-599)DOAJ1fd5e8205b374df0b4da704239794979 DE-627 ger DE-627 rakwb eng RC109-216 QR1-502 Adriana Lopes Motta verfasserin aut Candidemia epidemiology and susceptibility profile in the largest Brazilian teaching hospital complex Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier INTRODUCTION: Although the spectrum of fungi causing bloodstream fungal infections continues to expand, Candida spp. remains responsible for the majority of these cases. OBJECTIVE: The purpose of this study was to characterize the candidemia epidemiology, species distribution and antifungal susceptibility patterns at a Brazilian tertiary teaching public hospital with 2,500 beds. METHODS: Records from the microbiology laboratory were used to identify patients with positive blood cultures during 2006. The in vitro activity of amphotericin B, caspofungin, itraconazole, fluconazole, voricanozole, and posaconazole were determined using the Etest method. RESULTS: One hundred and thirty-six cases of candidemia were identified and 100 strains were available for antifungal susceptibility testing. The overall incidence of candidemia was 1.87 cases/1.000 admissions and 0.27 cases/1.000 patient-days. Among the patients, 58.1% were male, and the median age was 40 years old. C. albicans was the most common species (52.2%), followed by C. parapsilosis (22.1%), C. tropicalis (14.8%), and C. glabrata (6.6%). All strains were susceptible to amphotericin B with a MIC90 of 0.5 µg/mL. Overall susceptibility for voriconozole, fluconazole, and caspofungin was < 97% with a MIC90 of 0.064, 4.0 and 1.0 µg/mL, respectively. For itraconazole the susceptibility rate was 81% with a MIC90 of 0.5 µg/mL. Posaconazole also demonstrated good in vitro activity with a MIC90 of 0.25 µg/mL. CONCLUSION: This is the first antifungal susceptibility report in our institution candidemia Candida spp susceptibility testing Candida epidemiology Candida Etest antifungal susceptibility profile Candida antifungal agents azoles Infectious and parasitic diseases Microbiology Gisele Madeira Duboc de Almeida verfasserin aut João Nóbrega de Almeida Júnior verfasserin aut Marcelo Nascimento Burattini verfasserin aut Flávia Rossi verfasserin aut In Brazilian Journal of Infectious Diseases Elsevier, 2004 (DE-627)332927148 (DE-600)2055442-4 16784391 nnns https://doi.org/10.1590/S1413-86702010000500004 kostenfrei https://doaj.org/article/1fd5e8205b374df0b4da704239794979 kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000500004&lng=en&tlng=en kostenfrei https://doaj.org/toc/1678-4391 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR |
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10.1590/S1413-86702010000500004 doi (DE-627)DOAJ070606102 (DE-599)DOAJ1fd5e8205b374df0b4da704239794979 DE-627 ger DE-627 rakwb eng RC109-216 QR1-502 Adriana Lopes Motta verfasserin aut Candidemia epidemiology and susceptibility profile in the largest Brazilian teaching hospital complex Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier INTRODUCTION: Although the spectrum of fungi causing bloodstream fungal infections continues to expand, Candida spp. remains responsible for the majority of these cases. OBJECTIVE: The purpose of this study was to characterize the candidemia epidemiology, species distribution and antifungal susceptibility patterns at a Brazilian tertiary teaching public hospital with 2,500 beds. METHODS: Records from the microbiology laboratory were used to identify patients with positive blood cultures during 2006. The in vitro activity of amphotericin B, caspofungin, itraconazole, fluconazole, voricanozole, and posaconazole were determined using the Etest method. RESULTS: One hundred and thirty-six cases of candidemia were identified and 100 strains were available for antifungal susceptibility testing. The overall incidence of candidemia was 1.87 cases/1.000 admissions and 0.27 cases/1.000 patient-days. Among the patients, 58.1% were male, and the median age was 40 years old. C. albicans was the most common species (52.2%), followed by C. parapsilosis (22.1%), C. tropicalis (14.8%), and C. glabrata (6.6%). All strains were susceptible to amphotericin B with a MIC90 of 0.5 µg/mL. Overall susceptibility for voriconozole, fluconazole, and caspofungin was < 97% with a MIC90 of 0.064, 4.0 and 1.0 µg/mL, respectively. For itraconazole the susceptibility rate was 81% with a MIC90 of 0.5 µg/mL. Posaconazole also demonstrated good in vitro activity with a MIC90 of 0.25 µg/mL. CONCLUSION: This is the first antifungal susceptibility report in our institution candidemia Candida spp susceptibility testing Candida epidemiology Candida Etest antifungal susceptibility profile Candida antifungal agents azoles Infectious and parasitic diseases Microbiology Gisele Madeira Duboc de Almeida verfasserin aut João Nóbrega de Almeida Júnior verfasserin aut Marcelo Nascimento Burattini verfasserin aut Flávia Rossi verfasserin aut In Brazilian Journal of Infectious Diseases Elsevier, 2004 (DE-627)332927148 (DE-600)2055442-4 16784391 nnns https://doi.org/10.1590/S1413-86702010000500004 kostenfrei https://doaj.org/article/1fd5e8205b374df0b4da704239794979 kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000500004&lng=en&tlng=en kostenfrei https://doaj.org/toc/1678-4391 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR |
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R - Medicine |
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Adriana Lopes Motta |
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Adriana Lopes Motta misc RC109-216 misc QR1-502 misc candidemia misc Candida spp misc susceptibility testing misc Candida epidemiology misc Candida Etest misc antifungal susceptibility profile misc Candida antifungal agents misc azoles misc Infectious and parasitic diseases misc Microbiology Candidemia epidemiology and susceptibility profile in the largest Brazilian teaching hospital complex |
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Candidemia epidemiology and susceptibility profile in the largest Brazilian teaching hospital complex |
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Candidemia epidemiology and susceptibility profile in the largest Brazilian teaching hospital complex |
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Adriana Lopes Motta |
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Adriana Lopes Motta Gisele Madeira Duboc de Almeida João Nóbrega de Almeida Júnior Marcelo Nascimento Burattini Flávia Rossi |
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Adriana Lopes Motta |
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candidemia epidemiology and susceptibility profile in the largest brazilian teaching hospital complex |
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RC109-216 |
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Candidemia epidemiology and susceptibility profile in the largest Brazilian teaching hospital complex |
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INTRODUCTION: Although the spectrum of fungi causing bloodstream fungal infections continues to expand, Candida spp. remains responsible for the majority of these cases. OBJECTIVE: The purpose of this study was to characterize the candidemia epidemiology, species distribution and antifungal susceptibility patterns at a Brazilian tertiary teaching public hospital with 2,500 beds. METHODS: Records from the microbiology laboratory were used to identify patients with positive blood cultures during 2006. The in vitro activity of amphotericin B, caspofungin, itraconazole, fluconazole, voricanozole, and posaconazole were determined using the Etest method. RESULTS: One hundred and thirty-six cases of candidemia were identified and 100 strains were available for antifungal susceptibility testing. The overall incidence of candidemia was 1.87 cases/1.000 admissions and 0.27 cases/1.000 patient-days. Among the patients, 58.1% were male, and the median age was 40 years old. C. albicans was the most common species (52.2%), followed by C. parapsilosis (22.1%), C. tropicalis (14.8%), and C. glabrata (6.6%). All strains were susceptible to amphotericin B with a MIC90 of 0.5 µg/mL. Overall susceptibility for voriconozole, fluconazole, and caspofungin was < 97% with a MIC90 of 0.064, 4.0 and 1.0 µg/mL, respectively. For itraconazole the susceptibility rate was 81% with a MIC90 of 0.5 µg/mL. Posaconazole also demonstrated good in vitro activity with a MIC90 of 0.25 µg/mL. CONCLUSION: This is the first antifungal susceptibility report in our institution |
| abstractGer |
INTRODUCTION: Although the spectrum of fungi causing bloodstream fungal infections continues to expand, Candida spp. remains responsible for the majority of these cases. OBJECTIVE: The purpose of this study was to characterize the candidemia epidemiology, species distribution and antifungal susceptibility patterns at a Brazilian tertiary teaching public hospital with 2,500 beds. METHODS: Records from the microbiology laboratory were used to identify patients with positive blood cultures during 2006. The in vitro activity of amphotericin B, caspofungin, itraconazole, fluconazole, voricanozole, and posaconazole were determined using the Etest method. RESULTS: One hundred and thirty-six cases of candidemia were identified and 100 strains were available for antifungal susceptibility testing. The overall incidence of candidemia was 1.87 cases/1.000 admissions and 0.27 cases/1.000 patient-days. Among the patients, 58.1% were male, and the median age was 40 years old. C. albicans was the most common species (52.2%), followed by C. parapsilosis (22.1%), C. tropicalis (14.8%), and C. glabrata (6.6%). All strains were susceptible to amphotericin B with a MIC90 of 0.5 µg/mL. Overall susceptibility for voriconozole, fluconazole, and caspofungin was < 97% with a MIC90 of 0.064, 4.0 and 1.0 µg/mL, respectively. For itraconazole the susceptibility rate was 81% with a MIC90 of 0.5 µg/mL. Posaconazole also demonstrated good in vitro activity with a MIC90 of 0.25 µg/mL. CONCLUSION: This is the first antifungal susceptibility report in our institution |
| abstract_unstemmed |
INTRODUCTION: Although the spectrum of fungi causing bloodstream fungal infections continues to expand, Candida spp. remains responsible for the majority of these cases. OBJECTIVE: The purpose of this study was to characterize the candidemia epidemiology, species distribution and antifungal susceptibility patterns at a Brazilian tertiary teaching public hospital with 2,500 beds. METHODS: Records from the microbiology laboratory were used to identify patients with positive blood cultures during 2006. The in vitro activity of amphotericin B, caspofungin, itraconazole, fluconazole, voricanozole, and posaconazole were determined using the Etest method. RESULTS: One hundred and thirty-six cases of candidemia were identified and 100 strains were available for antifungal susceptibility testing. The overall incidence of candidemia was 1.87 cases/1.000 admissions and 0.27 cases/1.000 patient-days. Among the patients, 58.1% were male, and the median age was 40 years old. C. albicans was the most common species (52.2%), followed by C. parapsilosis (22.1%), C. tropicalis (14.8%), and C. glabrata (6.6%). All strains were susceptible to amphotericin B with a MIC90 of 0.5 µg/mL. Overall susceptibility for voriconozole, fluconazole, and caspofungin was < 97% with a MIC90 of 0.064, 4.0 and 1.0 µg/mL, respectively. For itraconazole the susceptibility rate was 81% with a MIC90 of 0.5 µg/mL. Posaconazole also demonstrated good in vitro activity with a MIC90 of 0.25 µg/mL. CONCLUSION: This is the first antifungal susceptibility report in our institution |
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Candidemia epidemiology and susceptibility profile in the largest Brazilian teaching hospital complex |
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https://doi.org/10.1590/S1413-86702010000500004 https://doaj.org/article/1fd5e8205b374df0b4da704239794979 http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000500004&lng=en&tlng=en https://doaj.org/toc/1678-4391 |
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Gisele Madeira Duboc de Almeida João Nóbrega de Almeida Júnior Marcelo Nascimento Burattini Flávia Rossi |
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