Fatal Spontaneous Tumor Lysis Syndrome in a Patient with Metastatic Colon Cancer: A Clinical Case of Rare Oncological Emergency

Tumor lysis syndrome (TLS) is a potentially life-threatening complication of chemotherapy. It usually occurs in rapidly proliferating hematological malignancies. TLS is deemed spontaneous (STLS) when it occurs prior to any cytotoxic or definite treatment. STLS is extremely rare in solid tumors. Here...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Inna Shaforostova [verfasserIn] Robert Fiedler [verfasserIn] Martina Zander [verfasserIn] Johannes Pflumm [verfasserIn] Wolfgang Josef März [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	tumor lysis syndrome colon cancer spontaneous tumor lysis syndrome

Übergeordnetes Werk:	In: Case Reports in Gastroenterology - Karger Publishers, 2009, 14(2020), 2, Seite 255-260
Übergeordnetes Werk:	volume:14 ; year:2020 ; number:2 ; pages:255-260

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1159/000507648

Katalog-ID:	DOAJ070652481

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520			\|a Tumor lysis syndrome (TLS) is a potentially life-threatening complication of chemotherapy. It usually occurs in rapidly proliferating hematological malignancies. TLS is deemed spontaneous (STLS) when it occurs prior to any cytotoxic or definite treatment. STLS is extremely rare in solid tumors. Here, we report a rare case of fatal STLS in a 47-year-old woman diagnosed with metastatic colon cancer. The patient developed acute renal failure with anuria, electrolyte disturbances, and metabolic acidosis before initiating chemotherapy. Despite appropriate management of TLS, including renal replacement therapy, she died within a few days from multiorgan failure. Only few other case reports of STLS associated with colon cancer have been reported in the literature.
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topic_facet	tumor lysis syndrome colon cancer spontaneous tumor lysis syndrome Diseases of the digestive system. Gastroenterology
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authorswithroles_txt_mv	Inna Shaforostova @@aut@@ Robert Fiedler @@aut@@ Martina Zander @@aut@@ Johannes Pflumm @@aut@@ Wolfgang Josef März @@aut@@
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callnumber-first	R - Medicine
author	Inna Shaforostova
spellingShingle	Inna Shaforostova misc RC799-869 misc tumor lysis syndrome misc colon cancer misc spontaneous tumor lysis syndrome misc Diseases of the digestive system. Gastroenterology Fatal Spontaneous Tumor Lysis Syndrome in a Patient with Metastatic Colon Cancer: A Clinical Case of Rare Oncological Emergency
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topic_title	RC799-869 Fatal Spontaneous Tumor Lysis Syndrome in a Patient with Metastatic Colon Cancer: A Clinical Case of Rare Oncological Emergency tumor lysis syndrome colon cancer spontaneous tumor lysis syndrome
topic	misc RC799-869 misc tumor lysis syndrome misc colon cancer misc spontaneous tumor lysis syndrome misc Diseases of the digestive system. Gastroenterology
topic_unstemmed	misc RC799-869 misc tumor lysis syndrome misc colon cancer misc spontaneous tumor lysis syndrome misc Diseases of the digestive system. Gastroenterology
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title	Fatal Spontaneous Tumor Lysis Syndrome in a Patient with Metastatic Colon Cancer: A Clinical Case of Rare Oncological Emergency
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title_sort	fatal spontaneous tumor lysis syndrome in a patient with metastatic colon cancer: a clinical case of rare oncological emergency
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title_auth	Fatal Spontaneous Tumor Lysis Syndrome in a Patient with Metastatic Colon Cancer: A Clinical Case of Rare Oncological Emergency
abstract	Tumor lysis syndrome (TLS) is a potentially life-threatening complication of chemotherapy. It usually occurs in rapidly proliferating hematological malignancies. TLS is deemed spontaneous (STLS) when it occurs prior to any cytotoxic or definite treatment. STLS is extremely rare in solid tumors. Here, we report a rare case of fatal STLS in a 47-year-old woman diagnosed with metastatic colon cancer. The patient developed acute renal failure with anuria, electrolyte disturbances, and metabolic acidosis before initiating chemotherapy. Despite appropriate management of TLS, including renal replacement therapy, she died within a few days from multiorgan failure. Only few other case reports of STLS associated with colon cancer have been reported in the literature.
abstractGer	Tumor lysis syndrome (TLS) is a potentially life-threatening complication of chemotherapy. It usually occurs in rapidly proliferating hematological malignancies. TLS is deemed spontaneous (STLS) when it occurs prior to any cytotoxic or definite treatment. STLS is extremely rare in solid tumors. Here, we report a rare case of fatal STLS in a 47-year-old woman diagnosed with metastatic colon cancer. The patient developed acute renal failure with anuria, electrolyte disturbances, and metabolic acidosis before initiating chemotherapy. Despite appropriate management of TLS, including renal replacement therapy, she died within a few days from multiorgan failure. Only few other case reports of STLS associated with colon cancer have been reported in the literature.
abstract_unstemmed	Tumor lysis syndrome (TLS) is a potentially life-threatening complication of chemotherapy. It usually occurs in rapidly proliferating hematological malignancies. TLS is deemed spontaneous (STLS) when it occurs prior to any cytotoxic or definite treatment. STLS is extremely rare in solid tumors. Here, we report a rare case of fatal STLS in a 47-year-old woman diagnosed with metastatic colon cancer. The patient developed acute renal failure with anuria, electrolyte disturbances, and metabolic acidosis before initiating chemotherapy. Despite appropriate management of TLS, including renal replacement therapy, she died within a few days from multiorgan failure. Only few other case reports of STLS associated with colon cancer have been reported in the literature.
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title_short	Fatal Spontaneous Tumor Lysis Syndrome in a Patient with Metastatic Colon Cancer: A Clinical Case of Rare Oncological Emergency
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