A selection-based next generation sequencing approach to develop robust, genotype-specific mutation profiles in <i<Saccharomyces cerevisiae</i<

AbstractDistinct mutation signatures arise from environmental exposures and/or from defects in metabolic pathways that promote genome stability. The presence of a particular mutation signature can therefore predict the underlying mechanism of mutagenesis. These insults to the genome often alter dNTP...
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Autor*in:	Natalie A Lamb [verfasserIn] Jonathan E Bard [verfasserIn] Michael J Buck [verfasserIn] Jennifer A Surtees [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Übergeordnetes Werk:	In: G3: Genes, Genomes, Genetics - Oxford University Press, 2012, 11(2021), 6
Übergeordnetes Werk:	volume:11 ; year:2021 ; number:6

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1093/g3journal/jkab099

Katalog-ID:	DOAJ070749698

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callnumber-first	Q - Science
author	Natalie A Lamb
spellingShingle	Natalie A Lamb misc QH426-470 misc Genetics A selection-based next generation sequencing approach to develop robust, genotype-specific mutation profiles in <i<Saccharomyces cerevisiae</i<
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topic_title	QH426-470 A selection-based next generation sequencing approach to develop robust, genotype-specific mutation profiles in <i<Saccharomyces cerevisiae</i<
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title	A selection-based next generation sequencing approach to develop robust, genotype-specific mutation profiles in <i<Saccharomyces cerevisiae</i<
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title_full	A selection-based next generation sequencing approach to develop robust, genotype-specific mutation profiles in <i<Saccharomyces cerevisiae</i<
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title_sort	selection-based next generation sequencing approach to develop robust, genotype-specific mutation profiles in <i<saccharomyces cerevisiae</i<
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title_auth	A selection-based next generation sequencing approach to develop robust, genotype-specific mutation profiles in <i<Saccharomyces cerevisiae</i<
abstract	AbstractDistinct mutation signatures arise from environmental exposures and/or from defects in metabolic pathways that promote genome stability. The presence of a particular mutation signature can therefore predict the underlying mechanism of mutagenesis. These insults to the genome often alter dNTP pools, which itself impacts replication fidelity. Therefore, the impact of altered dNTP pools should be considered when making mechanistic predictions based on mutation signatures. We developed a targeted deep-sequencing approach on the CAN1Saccharomyces cerevisiaernr1rnr1rnr1Y285Frnr1Y285Arnr1
abstractGer	AbstractDistinct mutation signatures arise from environmental exposures and/or from defects in metabolic pathways that promote genome stability. The presence of a particular mutation signature can therefore predict the underlying mechanism of mutagenesis. These insults to the genome often alter dNTP pools, which itself impacts replication fidelity. Therefore, the impact of altered dNTP pools should be considered when making mechanistic predictions based on mutation signatures. We developed a targeted deep-sequencing approach on the CAN1Saccharomyces cerevisiaernr1rnr1rnr1Y285Frnr1Y285Arnr1
abstract_unstemmed	AbstractDistinct mutation signatures arise from environmental exposures and/or from defects in metabolic pathways that promote genome stability. The presence of a particular mutation signature can therefore predict the underlying mechanism of mutagenesis. These insults to the genome often alter dNTP pools, which itself impacts replication fidelity. Therefore, the impact of altered dNTP pools should be considered when making mechanistic predictions based on mutation signatures. We developed a targeted deep-sequencing approach on the CAN1Saccharomyces cerevisiaernr1rnr1rnr1Y285Frnr1Y285Arnr1
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title_short	A selection-based next generation sequencing approach to develop robust, genotype-specific mutation profiles in <i<Saccharomyces cerevisiae</i<
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up_date	2024-07-03T16:30:06.933Z
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