Basophils and Mast Cells in COVID-19 Pathogenesis

Basophils and mast cells are among the principal inducers of Th2 responses and have a crucial role in allergic and anti-parasitic protective immunity. Basophils can function as antigen-presenting cells that bind antigens on their surface and boost humoral immune responses, inducing Th2 cell differen...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Giuseppe Murdaca [verfasserIn] Mario Di Gioacchino [verfasserIn] Monica Greco [verfasserIn] Matteo Borro [verfasserIn] Francesca Paladin [verfasserIn] Claudia Petrarca [verfasserIn] Sebastiano Gangemi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	basophils mast cells COVID-19 innate immune response adaptive immune response

Übergeordnetes Werk:	In: Cells - MDPI AG, 2012, 10(2021), 10, p 2754
Übergeordnetes Werk:	volume:10 ; year:2021 ; number:10, p 2754

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cells10102754

Katalog-ID:	DOAJ070763631

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allfields	10.3390/cells10102754 doi (DE-627)DOAJ070763631 (DE-599)DOAJf55de35ea94949a4a96f1d4f0a99efe3 DE-627 ger DE-627 rakwb eng QH573-671 Giuseppe Murdaca verfasserin aut Basophils and Mast Cells in COVID-19 Pathogenesis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Basophils and mast cells are among the principal inducers of Th2 responses and have a crucial role in allergic and anti-parasitic protective immunity. Basophils can function as antigen-presenting cells that bind antigens on their surface and boost humoral immune responses, inducing Th2 cell differentiation. Their depletion results in lower humoral memory activation and greater infection susceptibility. Basophils seem to have an active role upon immune response to SARS-CoV-2. In fact, a coordinate adaptive immune response to SARS-CoV-2 is magnified by basophils. It has been observed that basophil amount is lower during acute disease with respect to the recovery phase and that the grade of this depletion is an important determinant of the antibody response to the virus. Moreover, mast cells, present in a great quantity in the nasal epithelial and lung cells, participate in the first immune response to SARS-CoV-2. Their activation results in a hyperinflammatory syndrome through the release of inflammatory molecules, participating to the “cytokine storm” and, in a longer period, inducing pulmonary fibrosis. The literature data suggest that basophil counts may be a useful prognostic tool for COVID-19, since their reduction is associated with a worse prognosis. Mast cells, on the other hand, represent a possible therapeutic target for reducing the airway inflammation characteristic of the hyperacute phase of the disease. basophils mast cells COVID-19 innate immune response adaptive immune response Cytology Mario Di Gioacchino verfasserin aut Monica Greco verfasserin aut Matteo Borro verfasserin aut Francesca Paladin verfasserin aut Claudia Petrarca verfasserin aut Sebastiano Gangemi verfasserin aut In Cells MDPI AG, 2012 10(2021), 10, p 2754 (DE-627)718622081 (DE-600)2661518-6 20734409 nnns volume:10 year:2021 number:10, p 2754 https://doi.org/10.3390/cells10102754 kostenfrei https://doaj.org/article/f55de35ea94949a4a96f1d4f0a99efe3 kostenfrei https://www.mdpi.com/2073-4409/10/10/2754 kostenfrei https://doaj.org/toc/2073-4409 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 10, p 2754
spelling	10.3390/cells10102754 doi (DE-627)DOAJ070763631 (DE-599)DOAJf55de35ea94949a4a96f1d4f0a99efe3 DE-627 ger DE-627 rakwb eng QH573-671 Giuseppe Murdaca verfasserin aut Basophils and Mast Cells in COVID-19 Pathogenesis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Basophils and mast cells are among the principal inducers of Th2 responses and have a crucial role in allergic and anti-parasitic protective immunity. Basophils can function as antigen-presenting cells that bind antigens on their surface and boost humoral immune responses, inducing Th2 cell differentiation. Their depletion results in lower humoral memory activation and greater infection susceptibility. Basophils seem to have an active role upon immune response to SARS-CoV-2. In fact, a coordinate adaptive immune response to SARS-CoV-2 is magnified by basophils. It has been observed that basophil amount is lower during acute disease with respect to the recovery phase and that the grade of this depletion is an important determinant of the antibody response to the virus. Moreover, mast cells, present in a great quantity in the nasal epithelial and lung cells, participate in the first immune response to SARS-CoV-2. Their activation results in a hyperinflammatory syndrome through the release of inflammatory molecules, participating to the “cytokine storm” and, in a longer period, inducing pulmonary fibrosis. The literature data suggest that basophil counts may be a useful prognostic tool for COVID-19, since their reduction is associated with a worse prognosis. Mast cells, on the other hand, represent a possible therapeutic target for reducing the airway inflammation characteristic of the hyperacute phase of the disease. basophils mast cells COVID-19 innate immune response adaptive immune response Cytology Mario Di Gioacchino verfasserin aut Monica Greco verfasserin aut Matteo Borro verfasserin aut Francesca Paladin verfasserin aut Claudia Petrarca verfasserin aut Sebastiano Gangemi verfasserin aut In Cells MDPI AG, 2012 10(2021), 10, p 2754 (DE-627)718622081 (DE-600)2661518-6 20734409 nnns volume:10 year:2021 number:10, p 2754 https://doi.org/10.3390/cells10102754 kostenfrei https://doaj.org/article/f55de35ea94949a4a96f1d4f0a99efe3 kostenfrei https://www.mdpi.com/2073-4409/10/10/2754 kostenfrei https://doaj.org/toc/2073-4409 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 10, p 2754
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allfieldsSound	10.3390/cells10102754 doi (DE-627)DOAJ070763631 (DE-599)DOAJf55de35ea94949a4a96f1d4f0a99efe3 DE-627 ger DE-627 rakwb eng QH573-671 Giuseppe Murdaca verfasserin aut Basophils and Mast Cells in COVID-19 Pathogenesis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Basophils and mast cells are among the principal inducers of Th2 responses and have a crucial role in allergic and anti-parasitic protective immunity. Basophils can function as antigen-presenting cells that bind antigens on their surface and boost humoral immune responses, inducing Th2 cell differentiation. Their depletion results in lower humoral memory activation and greater infection susceptibility. Basophils seem to have an active role upon immune response to SARS-CoV-2. In fact, a coordinate adaptive immune response to SARS-CoV-2 is magnified by basophils. It has been observed that basophil amount is lower during acute disease with respect to the recovery phase and that the grade of this depletion is an important determinant of the antibody response to the virus. Moreover, mast cells, present in a great quantity in the nasal epithelial and lung cells, participate in the first immune response to SARS-CoV-2. Their activation results in a hyperinflammatory syndrome through the release of inflammatory molecules, participating to the “cytokine storm” and, in a longer period, inducing pulmonary fibrosis. The literature data suggest that basophil counts may be a useful prognostic tool for COVID-19, since their reduction is associated with a worse prognosis. Mast cells, on the other hand, represent a possible therapeutic target for reducing the airway inflammation characteristic of the hyperacute phase of the disease. basophils mast cells COVID-19 innate immune response adaptive immune response Cytology Mario Di Gioacchino verfasserin aut Monica Greco verfasserin aut Matteo Borro verfasserin aut Francesca Paladin verfasserin aut Claudia Petrarca verfasserin aut Sebastiano Gangemi verfasserin aut In Cells MDPI AG, 2012 10(2021), 10, p 2754 (DE-627)718622081 (DE-600)2661518-6 20734409 nnns volume:10 year:2021 number:10, p 2754 https://doi.org/10.3390/cells10102754 kostenfrei https://doaj.org/article/f55de35ea94949a4a96f1d4f0a99efe3 kostenfrei https://www.mdpi.com/2073-4409/10/10/2754 kostenfrei https://doaj.org/toc/2073-4409 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 10, p 2754
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authorswithroles_txt_mv	Giuseppe Murdaca @@aut@@ Mario Di Gioacchino @@aut@@ Monica Greco @@aut@@ Matteo Borro @@aut@@ Francesca Paladin @@aut@@ Claudia Petrarca @@aut@@ Sebastiano Gangemi @@aut@@
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author	Giuseppe Murdaca
spellingShingle	Giuseppe Murdaca misc QH573-671 misc basophils misc mast cells misc COVID-19 misc innate immune response misc adaptive immune response misc Cytology Basophils and Mast Cells in COVID-19 Pathogenesis
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topic_title	QH573-671 Basophils and Mast Cells in COVID-19 Pathogenesis basophils mast cells COVID-19 innate immune response adaptive immune response
topic	misc QH573-671 misc basophils misc mast cells misc COVID-19 misc innate immune response misc adaptive immune response misc Cytology
topic_unstemmed	misc QH573-671 misc basophils misc mast cells misc COVID-19 misc innate immune response misc adaptive immune response misc Cytology
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title	Basophils and Mast Cells in COVID-19 Pathogenesis
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title_full	Basophils and Mast Cells in COVID-19 Pathogenesis
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title_sort	basophils and mast cells in covid-19 pathogenesis
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title_auth	Basophils and Mast Cells in COVID-19 Pathogenesis
abstract	Basophils and mast cells are among the principal inducers of Th2 responses and have a crucial role in allergic and anti-parasitic protective immunity. Basophils can function as antigen-presenting cells that bind antigens on their surface and boost humoral immune responses, inducing Th2 cell differentiation. Their depletion results in lower humoral memory activation and greater infection susceptibility. Basophils seem to have an active role upon immune response to SARS-CoV-2. In fact, a coordinate adaptive immune response to SARS-CoV-2 is magnified by basophils. It has been observed that basophil amount is lower during acute disease with respect to the recovery phase and that the grade of this depletion is an important determinant of the antibody response to the virus. Moreover, mast cells, present in a great quantity in the nasal epithelial and lung cells, participate in the first immune response to SARS-CoV-2. Their activation results in a hyperinflammatory syndrome through the release of inflammatory molecules, participating to the “cytokine storm” and, in a longer period, inducing pulmonary fibrosis. The literature data suggest that basophil counts may be a useful prognostic tool for COVID-19, since their reduction is associated with a worse prognosis. Mast cells, on the other hand, represent a possible therapeutic target for reducing the airway inflammation characteristic of the hyperacute phase of the disease.
abstractGer	Basophils and mast cells are among the principal inducers of Th2 responses and have a crucial role in allergic and anti-parasitic protective immunity. Basophils can function as antigen-presenting cells that bind antigens on their surface and boost humoral immune responses, inducing Th2 cell differentiation. Their depletion results in lower humoral memory activation and greater infection susceptibility. Basophils seem to have an active role upon immune response to SARS-CoV-2. In fact, a coordinate adaptive immune response to SARS-CoV-2 is magnified by basophils. It has been observed that basophil amount is lower during acute disease with respect to the recovery phase and that the grade of this depletion is an important determinant of the antibody response to the virus. Moreover, mast cells, present in a great quantity in the nasal epithelial and lung cells, participate in the first immune response to SARS-CoV-2. Their activation results in a hyperinflammatory syndrome through the release of inflammatory molecules, participating to the “cytokine storm” and, in a longer period, inducing pulmonary fibrosis. The literature data suggest that basophil counts may be a useful prognostic tool for COVID-19, since their reduction is associated with a worse prognosis. Mast cells, on the other hand, represent a possible therapeutic target for reducing the airway inflammation characteristic of the hyperacute phase of the disease.
abstract_unstemmed	Basophils and mast cells are among the principal inducers of Th2 responses and have a crucial role in allergic and anti-parasitic protective immunity. Basophils can function as antigen-presenting cells that bind antigens on their surface and boost humoral immune responses, inducing Th2 cell differentiation. Their depletion results in lower humoral memory activation and greater infection susceptibility. Basophils seem to have an active role upon immune response to SARS-CoV-2. In fact, a coordinate adaptive immune response to SARS-CoV-2 is magnified by basophils. It has been observed that basophil amount is lower during acute disease with respect to the recovery phase and that the grade of this depletion is an important determinant of the antibody response to the virus. Moreover, mast cells, present in a great quantity in the nasal epithelial and lung cells, participate in the first immune response to SARS-CoV-2. Their activation results in a hyperinflammatory syndrome through the release of inflammatory molecules, participating to the “cytokine storm” and, in a longer period, inducing pulmonary fibrosis. The literature data suggest that basophil counts may be a useful prognostic tool for COVID-19, since their reduction is associated with a worse prognosis. Mast cells, on the other hand, represent a possible therapeutic target for reducing the airway inflammation characteristic of the hyperacute phase of the disease.
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title_short	Basophils and Mast Cells in COVID-19 Pathogenesis
url	https://doi.org/10.3390/cells10102754 https://doaj.org/article/f55de35ea94949a4a96f1d4f0a99efe3 https://www.mdpi.com/2073-4409/10/10/2754 https://doaj.org/toc/2073-4409
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Basophils and Mast Cells in COVID-19 Pathogenesis

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