Selective and independent associations of phospholipid transfer protein and hepatic lipase with the LDL subfraction distribution

Phospholipid transfer protein (PLTP), hepatic lipase (HL), and lipoprotein lipase (LPL) have all been reported to be intricately involved in HDL metabolism but the effect of PLTP on the apolipoprotein B-containing lipoproteins relative to that of HL and LPL has not been established. Due to our previ...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Susan J. Murdoch [verfasserIn] Molly C. Carr [verfasserIn] Hal Kennedy [verfasserIn] John D. Brunzell [verfasserIn] John J. Albers [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2002

Schlagwörter:	lipoprotein lipase low density lipoprotein lipoprotein distribution high density lipoprotein HDL

Übergeordnetes Werk:	In: Journal of Lipid Research - Elsevier, 2021, 43(2002), 8, Seite 1256-1263
Übergeordnetes Werk:	volume:43 ; year:2002 ; number:8 ; pages:1256-1263

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1194/jlr.M100373-JLR200

Katalog-ID:	DOAJ070780803

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520			\|a Phospholipid transfer protein (PLTP), hepatic lipase (HL), and lipoprotein lipase (LPL) have all been reported to be intricately involved in HDL metabolism but the effect of PLTP on the apolipoprotein B-containing lipoproteins relative to that of HL and LPL has not been established. Due to our previous observation of a positive correlation of PLTP activity with plasma apoB and LDL cholesterol, the relationship of PLTP with the LDL subfractions was investigated and compared with that of HL and LPL. Plasma lipoproteins from 50 premenopausal women were fractionated by density gradient ultracentrifugation. Correlations were calculated between the cholesterol concentration of each fraction and plasma PLTP, HL, and LPL activity. Plasma PLTP activity was highly, positively, and selectively correlated with the cholesterol concentration of the buoyant LDL/dense IDL fractions, yet demonstrated a complete absence of an association with the dense LDL fractions. In contrast, HL was positively correlated with the dense LDL fractions but showed no association with buoyant LDL. LPL was also positively correlated with several buoyant LDL fractions; however, the correlations were weaker than those of PLTP. PLTP and LPL were positively correlated and HL was negatively correlated with HDL fractions.The results suggest that PLTP and HL may be important and independent determinants of the LDL subpopulation density distributions.
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topic_facet	lipoprotein lipase low density lipoprotein lipoprotein distribution high density lipoprotein HDL Biochemistry
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callnumber-first	Q - Science
author	Susan J. Murdoch
spellingShingle	Susan J. Murdoch misc QD415-436 misc lipoprotein lipase misc low density lipoprotein misc lipoprotein distribution misc high density lipoprotein misc HDL misc Biochemistry Selective and independent associations of phospholipid transfer protein and hepatic lipase with the LDL subfraction distribution
authorStr	Susan J. Murdoch
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topic_title	QD415-436 Selective and independent associations of phospholipid transfer protein and hepatic lipase with the LDL subfraction distribution lipoprotein lipase low density lipoprotein lipoprotein distribution high density lipoprotein HDL
topic	misc QD415-436 misc lipoprotein lipase misc low density lipoprotein misc lipoprotein distribution misc high density lipoprotein misc HDL misc Biochemistry
topic_unstemmed	misc QD415-436 misc lipoprotein lipase misc low density lipoprotein misc lipoprotein distribution misc high density lipoprotein misc HDL misc Biochemistry
topic_browse	misc QD415-436 misc lipoprotein lipase misc low density lipoprotein misc lipoprotein distribution misc high density lipoprotein misc HDL misc Biochemistry
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title	Selective and independent associations of phospholipid transfer protein and hepatic lipase with the LDL subfraction distribution
ctrlnum	(DE-627)DOAJ070780803 (DE-599)DOAJd7a89397f2c043a3a78f1cc721d2c012
title_full	Selective and independent associations of phospholipid transfer protein and hepatic lipase with the LDL subfraction distribution
author_sort	Susan J. Murdoch
journal	Journal of Lipid Research
journalStr	Journal of Lipid Research
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author_browse	Susan J. Murdoch Molly C. Carr Hal Kennedy John D. Brunzell John J. Albers
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class	QD415-436
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author-letter	Susan J. Murdoch
doi_str_mv	10.1194/jlr.M100373-JLR200
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title_sort	selective and independent associations of phospholipid transfer protein and hepatic lipase with the ldl subfraction distribution
callnumber	QD415-436
title_auth	Selective and independent associations of phospholipid transfer protein and hepatic lipase with the LDL subfraction distribution
abstract	Phospholipid transfer protein (PLTP), hepatic lipase (HL), and lipoprotein lipase (LPL) have all been reported to be intricately involved in HDL metabolism but the effect of PLTP on the apolipoprotein B-containing lipoproteins relative to that of HL and LPL has not been established. Due to our previous observation of a positive correlation of PLTP activity with plasma apoB and LDL cholesterol, the relationship of PLTP with the LDL subfractions was investigated and compared with that of HL and LPL. Plasma lipoproteins from 50 premenopausal women were fractionated by density gradient ultracentrifugation. Correlations were calculated between the cholesterol concentration of each fraction and plasma PLTP, HL, and LPL activity. Plasma PLTP activity was highly, positively, and selectively correlated with the cholesterol concentration of the buoyant LDL/dense IDL fractions, yet demonstrated a complete absence of an association with the dense LDL fractions. In contrast, HL was positively correlated with the dense LDL fractions but showed no association with buoyant LDL. LPL was also positively correlated with several buoyant LDL fractions; however, the correlations were weaker than those of PLTP. PLTP and LPL were positively correlated and HL was negatively correlated with HDL fractions.The results suggest that PLTP and HL may be important and independent determinants of the LDL subpopulation density distributions.
abstractGer	Phospholipid transfer protein (PLTP), hepatic lipase (HL), and lipoprotein lipase (LPL) have all been reported to be intricately involved in HDL metabolism but the effect of PLTP on the apolipoprotein B-containing lipoproteins relative to that of HL and LPL has not been established. Due to our previous observation of a positive correlation of PLTP activity with plasma apoB and LDL cholesterol, the relationship of PLTP with the LDL subfractions was investigated and compared with that of HL and LPL. Plasma lipoproteins from 50 premenopausal women were fractionated by density gradient ultracentrifugation. Correlations were calculated between the cholesterol concentration of each fraction and plasma PLTP, HL, and LPL activity. Plasma PLTP activity was highly, positively, and selectively correlated with the cholesterol concentration of the buoyant LDL/dense IDL fractions, yet demonstrated a complete absence of an association with the dense LDL fractions. In contrast, HL was positively correlated with the dense LDL fractions but showed no association with buoyant LDL. LPL was also positively correlated with several buoyant LDL fractions; however, the correlations were weaker than those of PLTP. PLTP and LPL were positively correlated and HL was negatively correlated with HDL fractions.The results suggest that PLTP and HL may be important and independent determinants of the LDL subpopulation density distributions.
abstract_unstemmed	Phospholipid transfer protein (PLTP), hepatic lipase (HL), and lipoprotein lipase (LPL) have all been reported to be intricately involved in HDL metabolism but the effect of PLTP on the apolipoprotein B-containing lipoproteins relative to that of HL and LPL has not been established. Due to our previous observation of a positive correlation of PLTP activity with plasma apoB and LDL cholesterol, the relationship of PLTP with the LDL subfractions was investigated and compared with that of HL and LPL. Plasma lipoproteins from 50 premenopausal women were fractionated by density gradient ultracentrifugation. Correlations were calculated between the cholesterol concentration of each fraction and plasma PLTP, HL, and LPL activity. Plasma PLTP activity was highly, positively, and selectively correlated with the cholesterol concentration of the buoyant LDL/dense IDL fractions, yet demonstrated a complete absence of an association with the dense LDL fractions. In contrast, HL was positively correlated with the dense LDL fractions but showed no association with buoyant LDL. LPL was also positively correlated with several buoyant LDL fractions; however, the correlations were weaker than those of PLTP. PLTP and LPL were positively correlated and HL was negatively correlated with HDL fractions.The results suggest that PLTP and HL may be important and independent determinants of the LDL subpopulation density distributions.
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700
container_issue	8
title_short	Selective and independent associations of phospholipid transfer protein and hepatic lipase with the LDL subfraction distribution
url	https://doi.org/10.1194/jlr.M100373-JLR200 https://doaj.org/article/d7a89397f2c043a3a78f1cc721d2c012 http://www.sciencedirect.com/science/article/pii/S0022227520300572 https://doaj.org/toc/0022-2275
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author2	Molly C. Carr Hal Kennedy John D. Brunzell John J. Albers
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doi_str	10.1194/jlr.M100373-JLR200
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up_date	2024-07-03T16:39:55.286Z
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Selective and independent associations of phospholipid transfer protein and hepatic lipase with the LDL subfraction distribution

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