An association between apo-A4 gene polymorphism (Thr347Ser and Gln360His) and coronary artery disease in northern India

Background: Coronary artery disease (CAD) is emerging as a major health problem in India. It is predicted that by 2020, India will be at the verge of CAD epidemic. A low level of high-density lipoproteins (HDL) is prevalent in Asian Indians and is the major lipid risk factor for CAD. HDL contains Apo A, E, C and antioxidant enzymes. The genetic variants of these proteins appear to influence the occurrence and frequency of CAD. In this context APO A4 have drawn much attention. The polymorphisms at Thr347Ser and Gln360His of the apo A4 gene are under investigation in different parts of the world in relation to dyslipidemias, diabetes and CAD. Since data are conflicting and no conclusive data is available from India. Objective: We aimed at studying the relationship between apoA4 gene polymorphisms (Thr347Ser and Gln360His) and coronary artery disease in northern Indian participants. Method: We recruited 200 control (Group-I) and 200 patients (Group-II) and used PCR-RFLP to study the gene polymorphisms. Enzymatic Kits were used to estimate the lipids and lipoproteins. Result: We observed not any significant association for ApoA4 Thr347Ser polymorphism as well as lipid profile [total cholesterol (TC), triglyceride (TG), HDL, low-density lipoproteins (LDL) and HDL/LDL] levels among AA, AT and TT Individuals in controls and patients. However, after adjusting for age and sex, among control AA genotype had significantly lower levels of oxidised LDL (OXLDL) as compared to AT genotype and in patients, levels of OXLDL in AT genotype was lower than with AA genotype and for ApoA4 Gln360His polymorphism, after adjusting for age and sex, and no significant difference was observed in TC, TG, HDL, LDL and HDL/LDL, OXLDL and LDL / OXLDL levels among 1–1, and 1–2. Individuals in controls and patients. Conclusion: To accomplish, this preliminary study brought the information on the ApoA4 polymorphism in the Asian Indians residing in Delhi and adjacent areas. The minor alleles of the Ser347 and His360 showed significant association with lipid risk factors like high levels of OXLDL, TC, and low HDL levels. However neither of these polymorphisms showed an association with CAD. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Pramod Kumar [verfasserIn] Arbind Kumar Choudhary [verfasserIn] Nibhriti Das [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	CAD APO A4 Thr347Ser Gln360His LDL HDL

Übergeordnetes Werk:	In: Egyptian Journal of Medical Human Genetics - SpringerOpen, 2016, 19(2018), 1, Seite 23-29
Übergeordnetes Werk:	volume:19 ; year:2018 ; number:1 ; pages:23-29

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.ejmhg.2017.07.001

Katalog-ID:	DOAJ070792771

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allfields	10.1016/j.ejmhg.2017.07.001 doi (DE-627)DOAJ070792771 (DE-599)DOAJ06cc70a206a24803813cfdb9fac93e3c DE-627 ger DE-627 rakwb eng R5-920 QH426-470 Pramod Kumar verfasserin aut An association between apo-A4 gene polymorphism (Thr347Ser and Gln360His) and coronary artery disease in northern India 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Coronary artery disease (CAD) is emerging as a major health problem in India. It is predicted that by 2020, India will be at the verge of CAD epidemic. A low level of high-density lipoproteins (HDL) is prevalent in Asian Indians and is the major lipid risk factor for CAD. HDL contains Apo A, E, C and antioxidant enzymes. The genetic variants of these proteins appear to influence the occurrence and frequency of CAD. In this context APO A4 have drawn much attention. The polymorphisms at Thr347Ser and Gln360His of the apo A4 gene are under investigation in different parts of the world in relation to dyslipidemias, diabetes and CAD. Since data are conflicting and no conclusive data is available from India. Objective: We aimed at studying the relationship between apoA4 gene polymorphisms (Thr347Ser and Gln360His) and coronary artery disease in northern Indian participants. Method: We recruited 200 control (Group-I) and 200 patients (Group-II) and used PCR-RFLP to study the gene polymorphisms. Enzymatic Kits were used to estimate the lipids and lipoproteins. Result: We observed not any significant association for ApoA4 Thr347Ser polymorphism as well as lipid profile [total cholesterol (TC), triglyceride (TG), HDL, low-density lipoproteins (LDL) and HDL/LDL] levels among AA, AT and TT Individuals in controls and patients. However, after adjusting for age and sex, among control AA genotype had significantly lower levels of oxidised LDL (OXLDL) as compared to AT genotype and in patients, levels of OXLDL in AT genotype was lower than with AA genotype and for ApoA4 Gln360His polymorphism, after adjusting for age and sex, and no significant difference was observed in TC, TG, HDL, LDL and HDL/LDL, OXLDL and LDL / OXLDL levels among 1–1, and 1–2. Individuals in controls and patients. Conclusion: To accomplish, this preliminary study brought the information on the ApoA4 polymorphism in the Asian Indians residing in Delhi and adjacent areas. The minor alleles of the Ser347 and His360 showed significant association with lipid risk factors like high levels of OXLDL, TC, and low HDL levels. However neither of these polymorphisms showed an association with CAD. CAD APO A4 Thr347Ser Gln360His LDL HDL Medicine (General) Genetics Arbind Kumar Choudhary verfasserin aut Nibhriti Das verfasserin aut In Egyptian Journal of Medical Human Genetics SpringerOpen, 2016 19(2018), 1, Seite 23-29 (DE-627)609402625 (DE-600)2515357-2 20902441 nnns volume:19 year:2018 number:1 pages:23-29 https://doi.org/10.1016/j.ejmhg.2017.07.001 kostenfrei https://doaj.org/article/06cc70a206a24803813cfdb9fac93e3c kostenfrei http://www.sciencedirect.com/science/article/pii/S1110863017300666 kostenfrei https://doaj.org/toc/1110-8630 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2018 1 23-29
spelling	10.1016/j.ejmhg.2017.07.001 doi (DE-627)DOAJ070792771 (DE-599)DOAJ06cc70a206a24803813cfdb9fac93e3c DE-627 ger DE-627 rakwb eng R5-920 QH426-470 Pramod Kumar verfasserin aut An association between apo-A4 gene polymorphism (Thr347Ser and Gln360His) and coronary artery disease in northern India 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Coronary artery disease (CAD) is emerging as a major health problem in India. It is predicted that by 2020, India will be at the verge of CAD epidemic. A low level of high-density lipoproteins (HDL) is prevalent in Asian Indians and is the major lipid risk factor for CAD. HDL contains Apo A, E, C and antioxidant enzymes. The genetic variants of these proteins appear to influence the occurrence and frequency of CAD. In this context APO A4 have drawn much attention. The polymorphisms at Thr347Ser and Gln360His of the apo A4 gene are under investigation in different parts of the world in relation to dyslipidemias, diabetes and CAD. Since data are conflicting and no conclusive data is available from India. Objective: We aimed at studying the relationship between apoA4 gene polymorphisms (Thr347Ser and Gln360His) and coronary artery disease in northern Indian participants. Method: We recruited 200 control (Group-I) and 200 patients (Group-II) and used PCR-RFLP to study the gene polymorphisms. Enzymatic Kits were used to estimate the lipids and lipoproteins. Result: We observed not any significant association for ApoA4 Thr347Ser polymorphism as well as lipid profile [total cholesterol (TC), triglyceride (TG), HDL, low-density lipoproteins (LDL) and HDL/LDL] levels among AA, AT and TT Individuals in controls and patients. However, after adjusting for age and sex, among control AA genotype had significantly lower levels of oxidised LDL (OXLDL) as compared to AT genotype and in patients, levels of OXLDL in AT genotype was lower than with AA genotype and for ApoA4 Gln360His polymorphism, after adjusting for age and sex, and no significant difference was observed in TC, TG, HDL, LDL and HDL/LDL, OXLDL and LDL / OXLDL levels among 1–1, and 1–2. Individuals in controls and patients. Conclusion: To accomplish, this preliminary study brought the information on the ApoA4 polymorphism in the Asian Indians residing in Delhi and adjacent areas. The minor alleles of the Ser347 and His360 showed significant association with lipid risk factors like high levels of OXLDL, TC, and low HDL levels. However neither of these polymorphisms showed an association with CAD. CAD APO A4 Thr347Ser Gln360His LDL HDL Medicine (General) Genetics Arbind Kumar Choudhary verfasserin aut Nibhriti Das verfasserin aut In Egyptian Journal of Medical Human Genetics SpringerOpen, 2016 19(2018), 1, Seite 23-29 (DE-627)609402625 (DE-600)2515357-2 20902441 nnns volume:19 year:2018 number:1 pages:23-29 https://doi.org/10.1016/j.ejmhg.2017.07.001 kostenfrei https://doaj.org/article/06cc70a206a24803813cfdb9fac93e3c kostenfrei http://www.sciencedirect.com/science/article/pii/S1110863017300666 kostenfrei https://doaj.org/toc/1110-8630 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2018 1 23-29
allfields_unstemmed	10.1016/j.ejmhg.2017.07.001 doi (DE-627)DOAJ070792771 (DE-599)DOAJ06cc70a206a24803813cfdb9fac93e3c DE-627 ger DE-627 rakwb eng R5-920 QH426-470 Pramod Kumar verfasserin aut An association between apo-A4 gene polymorphism (Thr347Ser and Gln360His) and coronary artery disease in northern India 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Coronary artery disease (CAD) is emerging as a major health problem in India. It is predicted that by 2020, India will be at the verge of CAD epidemic. A low level of high-density lipoproteins (HDL) is prevalent in Asian Indians and is the major lipid risk factor for CAD. HDL contains Apo A, E, C and antioxidant enzymes. The genetic variants of these proteins appear to influence the occurrence and frequency of CAD. In this context APO A4 have drawn much attention. The polymorphisms at Thr347Ser and Gln360His of the apo A4 gene are under investigation in different parts of the world in relation to dyslipidemias, diabetes and CAD. Since data are conflicting and no conclusive data is available from India. Objective: We aimed at studying the relationship between apoA4 gene polymorphisms (Thr347Ser and Gln360His) and coronary artery disease in northern Indian participants. Method: We recruited 200 control (Group-I) and 200 patients (Group-II) and used PCR-RFLP to study the gene polymorphisms. Enzymatic Kits were used to estimate the lipids and lipoproteins. Result: We observed not any significant association for ApoA4 Thr347Ser polymorphism as well as lipid profile [total cholesterol (TC), triglyceride (TG), HDL, low-density lipoproteins (LDL) and HDL/LDL] levels among AA, AT and TT Individuals in controls and patients. However, after adjusting for age and sex, among control AA genotype had significantly lower levels of oxidised LDL (OXLDL) as compared to AT genotype and in patients, levels of OXLDL in AT genotype was lower than with AA genotype and for ApoA4 Gln360His polymorphism, after adjusting for age and sex, and no significant difference was observed in TC, TG, HDL, LDL and HDL/LDL, OXLDL and LDL / OXLDL levels among 1–1, and 1–2. Individuals in controls and patients. Conclusion: To accomplish, this preliminary study brought the information on the ApoA4 polymorphism in the Asian Indians residing in Delhi and adjacent areas. The minor alleles of the Ser347 and His360 showed significant association with lipid risk factors like high levels of OXLDL, TC, and low HDL levels. However neither of these polymorphisms showed an association with CAD. CAD APO A4 Thr347Ser Gln360His LDL HDL Medicine (General) Genetics Arbind Kumar Choudhary verfasserin aut Nibhriti Das verfasserin aut In Egyptian Journal of Medical Human Genetics SpringerOpen, 2016 19(2018), 1, Seite 23-29 (DE-627)609402625 (DE-600)2515357-2 20902441 nnns volume:19 year:2018 number:1 pages:23-29 https://doi.org/10.1016/j.ejmhg.2017.07.001 kostenfrei https://doaj.org/article/06cc70a206a24803813cfdb9fac93e3c kostenfrei http://www.sciencedirect.com/science/article/pii/S1110863017300666 kostenfrei https://doaj.org/toc/1110-8630 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2018 1 23-29
allfieldsGer	10.1016/j.ejmhg.2017.07.001 doi (DE-627)DOAJ070792771 (DE-599)DOAJ06cc70a206a24803813cfdb9fac93e3c DE-627 ger DE-627 rakwb eng R5-920 QH426-470 Pramod Kumar verfasserin aut An association between apo-A4 gene polymorphism (Thr347Ser and Gln360His) and coronary artery disease in northern India 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Coronary artery disease (CAD) is emerging as a major health problem in India. It is predicted that by 2020, India will be at the verge of CAD epidemic. A low level of high-density lipoproteins (HDL) is prevalent in Asian Indians and is the major lipid risk factor for CAD. HDL contains Apo A, E, C and antioxidant enzymes. The genetic variants of these proteins appear to influence the occurrence and frequency of CAD. In this context APO A4 have drawn much attention. The polymorphisms at Thr347Ser and Gln360His of the apo A4 gene are under investigation in different parts of the world in relation to dyslipidemias, diabetes and CAD. Since data are conflicting and no conclusive data is available from India. Objective: We aimed at studying the relationship between apoA4 gene polymorphisms (Thr347Ser and Gln360His) and coronary artery disease in northern Indian participants. Method: We recruited 200 control (Group-I) and 200 patients (Group-II) and used PCR-RFLP to study the gene polymorphisms. Enzymatic Kits were used to estimate the lipids and lipoproteins. Result: We observed not any significant association for ApoA4 Thr347Ser polymorphism as well as lipid profile [total cholesterol (TC), triglyceride (TG), HDL, low-density lipoproteins (LDL) and HDL/LDL] levels among AA, AT and TT Individuals in controls and patients. However, after adjusting for age and sex, among control AA genotype had significantly lower levels of oxidised LDL (OXLDL) as compared to AT genotype and in patients, levels of OXLDL in AT genotype was lower than with AA genotype and for ApoA4 Gln360His polymorphism, after adjusting for age and sex, and no significant difference was observed in TC, TG, HDL, LDL and HDL/LDL, OXLDL and LDL / OXLDL levels among 1–1, and 1–2. Individuals in controls and patients. Conclusion: To accomplish, this preliminary study brought the information on the ApoA4 polymorphism in the Asian Indians residing in Delhi and adjacent areas. The minor alleles of the Ser347 and His360 showed significant association with lipid risk factors like high levels of OXLDL, TC, and low HDL levels. However neither of these polymorphisms showed an association with CAD. CAD APO A4 Thr347Ser Gln360His LDL HDL Medicine (General) Genetics Arbind Kumar Choudhary verfasserin aut Nibhriti Das verfasserin aut In Egyptian Journal of Medical Human Genetics SpringerOpen, 2016 19(2018), 1, Seite 23-29 (DE-627)609402625 (DE-600)2515357-2 20902441 nnns volume:19 year:2018 number:1 pages:23-29 https://doi.org/10.1016/j.ejmhg.2017.07.001 kostenfrei https://doaj.org/article/06cc70a206a24803813cfdb9fac93e3c kostenfrei http://www.sciencedirect.com/science/article/pii/S1110863017300666 kostenfrei https://doaj.org/toc/1110-8630 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2018 1 23-29
allfieldsSound	10.1016/j.ejmhg.2017.07.001 doi (DE-627)DOAJ070792771 (DE-599)DOAJ06cc70a206a24803813cfdb9fac93e3c DE-627 ger DE-627 rakwb eng R5-920 QH426-470 Pramod Kumar verfasserin aut An association between apo-A4 gene polymorphism (Thr347Ser and Gln360His) and coronary artery disease in northern India 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Coronary artery disease (CAD) is emerging as a major health problem in India. It is predicted that by 2020, India will be at the verge of CAD epidemic. A low level of high-density lipoproteins (HDL) is prevalent in Asian Indians and is the major lipid risk factor for CAD. HDL contains Apo A, E, C and antioxidant enzymes. The genetic variants of these proteins appear to influence the occurrence and frequency of CAD. In this context APO A4 have drawn much attention. The polymorphisms at Thr347Ser and Gln360His of the apo A4 gene are under investigation in different parts of the world in relation to dyslipidemias, diabetes and CAD. Since data are conflicting and no conclusive data is available from India. Objective: We aimed at studying the relationship between apoA4 gene polymorphisms (Thr347Ser and Gln360His) and coronary artery disease in northern Indian participants. Method: We recruited 200 control (Group-I) and 200 patients (Group-II) and used PCR-RFLP to study the gene polymorphisms. Enzymatic Kits were used to estimate the lipids and lipoproteins. Result: We observed not any significant association for ApoA4 Thr347Ser polymorphism as well as lipid profile [total cholesterol (TC), triglyceride (TG), HDL, low-density lipoproteins (LDL) and HDL/LDL] levels among AA, AT and TT Individuals in controls and patients. However, after adjusting for age and sex, among control AA genotype had significantly lower levels of oxidised LDL (OXLDL) as compared to AT genotype and in patients, levels of OXLDL in AT genotype was lower than with AA genotype and for ApoA4 Gln360His polymorphism, after adjusting for age and sex, and no significant difference was observed in TC, TG, HDL, LDL and HDL/LDL, OXLDL and LDL / OXLDL levels among 1–1, and 1–2. Individuals in controls and patients. Conclusion: To accomplish, this preliminary study brought the information on the ApoA4 polymorphism in the Asian Indians residing in Delhi and adjacent areas. The minor alleles of the Ser347 and His360 showed significant association with lipid risk factors like high levels of OXLDL, TC, and low HDL levels. However neither of these polymorphisms showed an association with CAD. CAD APO A4 Thr347Ser Gln360His LDL HDL Medicine (General) Genetics Arbind Kumar Choudhary verfasserin aut Nibhriti Das verfasserin aut In Egyptian Journal of Medical Human Genetics SpringerOpen, 2016 19(2018), 1, Seite 23-29 (DE-627)609402625 (DE-600)2515357-2 20902441 nnns volume:19 year:2018 number:1 pages:23-29 https://doi.org/10.1016/j.ejmhg.2017.07.001 kostenfrei https://doaj.org/article/06cc70a206a24803813cfdb9fac93e3c kostenfrei http://www.sciencedirect.com/science/article/pii/S1110863017300666 kostenfrei https://doaj.org/toc/1110-8630 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2018 1 23-29
language	English
source	In Egyptian Journal of Medical Human Genetics 19(2018), 1, Seite 23-29 volume:19 year:2018 number:1 pages:23-29
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topic_facet	CAD APO A4 Thr347Ser Gln360His LDL HDL Medicine (General) Genetics
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authorswithroles_txt_mv	Pramod Kumar @@aut@@ Arbind Kumar Choudhary @@aut@@ Nibhriti Das @@aut@@
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spellingShingle	Pramod Kumar misc R5-920 misc QH426-470 misc CAD misc APO A4 misc Thr347Ser misc Gln360His misc LDL misc HDL misc Medicine (General) misc Genetics An association between apo-A4 gene polymorphism (Thr347Ser and Gln360His) and coronary artery disease in northern India
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topic_title	R5-920 QH426-470 An association between apo-A4 gene polymorphism (Thr347Ser and Gln360His) and coronary artery disease in northern India CAD APO A4 Thr347Ser Gln360His LDL HDL
topic	misc R5-920 misc QH426-470 misc CAD misc APO A4 misc Thr347Ser misc Gln360His misc LDL misc HDL misc Medicine (General) misc Genetics
topic_unstemmed	misc R5-920 misc QH426-470 misc CAD misc APO A4 misc Thr347Ser misc Gln360His misc LDL misc HDL misc Medicine (General) misc Genetics
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title	An association between apo-A4 gene polymorphism (Thr347Ser and Gln360His) and coronary artery disease in northern India
ctrlnum	(DE-627)DOAJ070792771 (DE-599)DOAJ06cc70a206a24803813cfdb9fac93e3c
title_full	An association between apo-A4 gene polymorphism (Thr347Ser and Gln360His) and coronary artery disease in northern India
author_sort	Pramod Kumar
journal	Egyptian Journal of Medical Human Genetics
journalStr	Egyptian Journal of Medical Human Genetics
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author_browse	Pramod Kumar Arbind Kumar Choudhary Nibhriti Das
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class	R5-920 QH426-470
format_se	Elektronische Aufsätze
author-letter	Pramod Kumar
doi_str_mv	10.1016/j.ejmhg.2017.07.001
author2-role	verfasserin
title_sort	association between apo-a4 gene polymorphism (thr347ser and gln360his) and coronary artery disease in northern india
callnumber	R5-920
title_auth	An association between apo-A4 gene polymorphism (Thr347Ser and Gln360His) and coronary artery disease in northern India
abstract	Background: Coronary artery disease (CAD) is emerging as a major health problem in India. It is predicted that by 2020, India will be at the verge of CAD epidemic. A low level of high-density lipoproteins (HDL) is prevalent in Asian Indians and is the major lipid risk factor for CAD. HDL contains Apo A, E, C and antioxidant enzymes. The genetic variants of these proteins appear to influence the occurrence and frequency of CAD. In this context APO A4 have drawn much attention. The polymorphisms at Thr347Ser and Gln360His of the apo A4 gene are under investigation in different parts of the world in relation to dyslipidemias, diabetes and CAD. Since data are conflicting and no conclusive data is available from India. Objective: We aimed at studying the relationship between apoA4 gene polymorphisms (Thr347Ser and Gln360His) and coronary artery disease in northern Indian participants. Method: We recruited 200 control (Group-I) and 200 patients (Group-II) and used PCR-RFLP to study the gene polymorphisms. Enzymatic Kits were used to estimate the lipids and lipoproteins. Result: We observed not any significant association for ApoA4 Thr347Ser polymorphism as well as lipid profile [total cholesterol (TC), triglyceride (TG), HDL, low-density lipoproteins (LDL) and HDL/LDL] levels among AA, AT and TT Individuals in controls and patients. However, after adjusting for age and sex, among control AA genotype had significantly lower levels of oxidised LDL (OXLDL) as compared to AT genotype and in patients, levels of OXLDL in AT genotype was lower than with AA genotype and for ApoA4 Gln360His polymorphism, after adjusting for age and sex, and no significant difference was observed in TC, TG, HDL, LDL and HDL/LDL, OXLDL and LDL / OXLDL levels among 1–1, and 1–2. Individuals in controls and patients. Conclusion: To accomplish, this preliminary study brought the information on the ApoA4 polymorphism in the Asian Indians residing in Delhi and adjacent areas. The minor alleles of the Ser347 and His360 showed significant association with lipid risk factors like high levels of OXLDL, TC, and low HDL levels. However neither of these polymorphisms showed an association with CAD.
abstractGer	Background: Coronary artery disease (CAD) is emerging as a major health problem in India. It is predicted that by 2020, India will be at the verge of CAD epidemic. A low level of high-density lipoproteins (HDL) is prevalent in Asian Indians and is the major lipid risk factor for CAD. HDL contains Apo A, E, C and antioxidant enzymes. The genetic variants of these proteins appear to influence the occurrence and frequency of CAD. In this context APO A4 have drawn much attention. The polymorphisms at Thr347Ser and Gln360His of the apo A4 gene are under investigation in different parts of the world in relation to dyslipidemias, diabetes and CAD. Since data are conflicting and no conclusive data is available from India. Objective: We aimed at studying the relationship between apoA4 gene polymorphisms (Thr347Ser and Gln360His) and coronary artery disease in northern Indian participants. Method: We recruited 200 control (Group-I) and 200 patients (Group-II) and used PCR-RFLP to study the gene polymorphisms. Enzymatic Kits were used to estimate the lipids and lipoproteins. Result: We observed not any significant association for ApoA4 Thr347Ser polymorphism as well as lipid profile [total cholesterol (TC), triglyceride (TG), HDL, low-density lipoproteins (LDL) and HDL/LDL] levels among AA, AT and TT Individuals in controls and patients. However, after adjusting for age and sex, among control AA genotype had significantly lower levels of oxidised LDL (OXLDL) as compared to AT genotype and in patients, levels of OXLDL in AT genotype was lower than with AA genotype and for ApoA4 Gln360His polymorphism, after adjusting for age and sex, and no significant difference was observed in TC, TG, HDL, LDL and HDL/LDL, OXLDL and LDL / OXLDL levels among 1–1, and 1–2. Individuals in controls and patients. Conclusion: To accomplish, this preliminary study brought the information on the ApoA4 polymorphism in the Asian Indians residing in Delhi and adjacent areas. The minor alleles of the Ser347 and His360 showed significant association with lipid risk factors like high levels of OXLDL, TC, and low HDL levels. However neither of these polymorphisms showed an association with CAD.
abstract_unstemmed	Background: Coronary artery disease (CAD) is emerging as a major health problem in India. It is predicted that by 2020, India will be at the verge of CAD epidemic. A low level of high-density lipoproteins (HDL) is prevalent in Asian Indians and is the major lipid risk factor for CAD. HDL contains Apo A, E, C and antioxidant enzymes. The genetic variants of these proteins appear to influence the occurrence and frequency of CAD. In this context APO A4 have drawn much attention. The polymorphisms at Thr347Ser and Gln360His of the apo A4 gene are under investigation in different parts of the world in relation to dyslipidemias, diabetes and CAD. Since data are conflicting and no conclusive data is available from India. Objective: We aimed at studying the relationship between apoA4 gene polymorphisms (Thr347Ser and Gln360His) and coronary artery disease in northern Indian participants. Method: We recruited 200 control (Group-I) and 200 patients (Group-II) and used PCR-RFLP to study the gene polymorphisms. Enzymatic Kits were used to estimate the lipids and lipoproteins. Result: We observed not any significant association for ApoA4 Thr347Ser polymorphism as well as lipid profile [total cholesterol (TC), triglyceride (TG), HDL, low-density lipoproteins (LDL) and HDL/LDL] levels among AA, AT and TT Individuals in controls and patients. However, after adjusting for age and sex, among control AA genotype had significantly lower levels of oxidised LDL (OXLDL) as compared to AT genotype and in patients, levels of OXLDL in AT genotype was lower than with AA genotype and for ApoA4 Gln360His polymorphism, after adjusting for age and sex, and no significant difference was observed in TC, TG, HDL, LDL and HDL/LDL, OXLDL and LDL / OXLDL levels among 1–1, and 1–2. Individuals in controls and patients. Conclusion: To accomplish, this preliminary study brought the information on the ApoA4 polymorphism in the Asian Indians residing in Delhi and adjacent areas. The minor alleles of the Ser347 and His360 showed significant association with lipid risk factors like high levels of OXLDL, TC, and low HDL levels. However neither of these polymorphisms showed an association with CAD.
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title_short	An association between apo-A4 gene polymorphism (Thr347Ser and Gln360His) and coronary artery disease in northern India
url	https://doi.org/10.1016/j.ejmhg.2017.07.001 https://doaj.org/article/06cc70a206a24803813cfdb9fac93e3c http://www.sciencedirect.com/science/article/pii/S1110863017300666 https://doaj.org/toc/1110-8630
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An association between apo-A4 gene polymorphism (Thr347Ser and Gln360His) and coronary artery disease in northern India

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