Three-dimensional understanding of the morphological complexity of the human uterine endometrium

Summary: The fundamental morphology of the endometrial glands is not sufficiently understood by 2D observation because these glands have complicated winding and branching patterns. To construct a large picture of the endometrial gland structure, we performed tissue-clearing-based 3D imaging of human...
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Autor*in:	Manako Yamaguchi [verfasserIn] Kosuke Yoshihara [verfasserIn] Kazuaki Suda [verfasserIn] Hirofumi Nakaoka [verfasserIn] Nozomi Yachida [verfasserIn] Haruka Ueda [verfasserIn] Kentaro Sugino [verfasserIn] Yutaro Mori [verfasserIn] Kaoru Yamawaki [verfasserIn] Ryo Tamura [verfasserIn] Tatsuya Ishiguro [verfasserIn] Teiichi Motoyama [verfasserIn] Yu Watanabe [verfasserIn] Shujiro Okuda [verfasserIn] Kazuki Tainaka [verfasserIn] Takayuki Enomoto [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Human Physiology Imaging Anatomy

Übergeordnetes Werk:	In: iScience - Elsevier, 2019, 24(2021), 4, Seite 102258-
Übergeordnetes Werk:	volume:24 ; year:2021 ; number:4 ; pages:102258-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.isci.2021.102258

Katalog-ID:	DOAJ070797994

Internformat


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520			\|a Summary: The fundamental morphology of the endometrial glands is not sufficiently understood by 2D observation because these glands have complicated winding and branching patterns. To construct a large picture of the endometrial gland structure, we performed tissue-clearing-based 3D imaging of human uterine endometrial tissue. Our 3D immunohistochemistry and layer analyses revealed that the endometrial glands form a plexus network in the stratum basalis and expand horizontally along the muscular layer, similar to the rhizome of grass. We then extended our method to assess the 3D morphology of tissue affected by adenomyosis, a representative “endometrium-related disease,” and observed its 3D morphological features, including the direct invasion of endometrial glands into the myometrium and an ant colony-like network of ectopic endometrial glands within the myometrium. Thus, further understanding of the morphology of the human endometrium based on 3D analysis will lead to the identification of the pathogenesis of endometrium-related diseases.
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spelling	10.1016/j.isci.2021.102258 doi (DE-627)DOAJ070797994 (DE-599)DOAJ7a0f167e5ba6481493be0bab6e8baf10 DE-627 ger DE-627 rakwb eng Manako Yamaguchi verfasserin aut Three-dimensional understanding of the morphological complexity of the human uterine endometrium 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: The fundamental morphology of the endometrial glands is not sufficiently understood by 2D observation because these glands have complicated winding and branching patterns. To construct a large picture of the endometrial gland structure, we performed tissue-clearing-based 3D imaging of human uterine endometrial tissue. Our 3D immunohistochemistry and layer analyses revealed that the endometrial glands form a plexus network in the stratum basalis and expand horizontally along the muscular layer, similar to the rhizome of grass. We then extended our method to assess the 3D morphology of tissue affected by adenomyosis, a representative “endometrium-related disease,” and observed its 3D morphological features, including the direct invasion of endometrial glands into the myometrium and an ant colony-like network of ectopic endometrial glands within the myometrium. Thus, further understanding of the morphology of the human endometrium based on 3D analysis will lead to the identification of the pathogenesis of endometrium-related diseases. Human Physiology Imaging Anatomy Science Q Kosuke Yoshihara verfasserin aut Kazuaki Suda verfasserin aut Hirofumi Nakaoka verfasserin aut Nozomi Yachida verfasserin aut Haruka Ueda verfasserin aut Kentaro Sugino verfasserin aut Yutaro Mori verfasserin aut Kaoru Yamawaki verfasserin aut Ryo Tamura verfasserin aut Tatsuya Ishiguro verfasserin aut Teiichi Motoyama verfasserin aut Yu Watanabe verfasserin aut Shujiro Okuda verfasserin aut Kazuki Tainaka verfasserin aut Takayuki Enomoto verfasserin aut In iScience Elsevier, 2019 24(2021), 4, Seite 102258- (DE-627)1019532106 25890042 nnns volume:24 year:2021 number:4 pages:102258- https://doi.org/10.1016/j.isci.2021.102258 kostenfrei https://doaj.org/article/7a0f167e5ba6481493be0bab6e8baf10 kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004221002261 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 24 2021 4 102258-
allfields_unstemmed	10.1016/j.isci.2021.102258 doi (DE-627)DOAJ070797994 (DE-599)DOAJ7a0f167e5ba6481493be0bab6e8baf10 DE-627 ger DE-627 rakwb eng Manako Yamaguchi verfasserin aut Three-dimensional understanding of the morphological complexity of the human uterine endometrium 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: The fundamental morphology of the endometrial glands is not sufficiently understood by 2D observation because these glands have complicated winding and branching patterns. To construct a large picture of the endometrial gland structure, we performed tissue-clearing-based 3D imaging of human uterine endometrial tissue. Our 3D immunohistochemistry and layer analyses revealed that the endometrial glands form a plexus network in the stratum basalis and expand horizontally along the muscular layer, similar to the rhizome of grass. We then extended our method to assess the 3D morphology of tissue affected by adenomyosis, a representative “endometrium-related disease,” and observed its 3D morphological features, including the direct invasion of endometrial glands into the myometrium and an ant colony-like network of ectopic endometrial glands within the myometrium. Thus, further understanding of the morphology of the human endometrium based on 3D analysis will lead to the identification of the pathogenesis of endometrium-related diseases. Human Physiology Imaging Anatomy Science Q Kosuke Yoshihara verfasserin aut Kazuaki Suda verfasserin aut Hirofumi Nakaoka verfasserin aut Nozomi Yachida verfasserin aut Haruka Ueda verfasserin aut Kentaro Sugino verfasserin aut Yutaro Mori verfasserin aut Kaoru Yamawaki verfasserin aut Ryo Tamura verfasserin aut Tatsuya Ishiguro verfasserin aut Teiichi Motoyama verfasserin aut Yu Watanabe verfasserin aut Shujiro Okuda verfasserin aut Kazuki Tainaka verfasserin aut Takayuki Enomoto verfasserin aut In iScience Elsevier, 2019 24(2021), 4, Seite 102258- (DE-627)1019532106 25890042 nnns volume:24 year:2021 number:4 pages:102258- https://doi.org/10.1016/j.isci.2021.102258 kostenfrei https://doaj.org/article/7a0f167e5ba6481493be0bab6e8baf10 kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004221002261 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 24 2021 4 102258-
allfieldsGer	10.1016/j.isci.2021.102258 doi (DE-627)DOAJ070797994 (DE-599)DOAJ7a0f167e5ba6481493be0bab6e8baf10 DE-627 ger DE-627 rakwb eng Manako Yamaguchi verfasserin aut Three-dimensional understanding of the morphological complexity of the human uterine endometrium 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: The fundamental morphology of the endometrial glands is not sufficiently understood by 2D observation because these glands have complicated winding and branching patterns. To construct a large picture of the endometrial gland structure, we performed tissue-clearing-based 3D imaging of human uterine endometrial tissue. Our 3D immunohistochemistry and layer analyses revealed that the endometrial glands form a plexus network in the stratum basalis and expand horizontally along the muscular layer, similar to the rhizome of grass. We then extended our method to assess the 3D morphology of tissue affected by adenomyosis, a representative “endometrium-related disease,” and observed its 3D morphological features, including the direct invasion of endometrial glands into the myometrium and an ant colony-like network of ectopic endometrial glands within the myometrium. Thus, further understanding of the morphology of the human endometrium based on 3D analysis will lead to the identification of the pathogenesis of endometrium-related diseases. Human Physiology Imaging Anatomy Science Q Kosuke Yoshihara verfasserin aut Kazuaki Suda verfasserin aut Hirofumi Nakaoka verfasserin aut Nozomi Yachida verfasserin aut Haruka Ueda verfasserin aut Kentaro Sugino verfasserin aut Yutaro Mori verfasserin aut Kaoru Yamawaki verfasserin aut Ryo Tamura verfasserin aut Tatsuya Ishiguro verfasserin aut Teiichi Motoyama verfasserin aut Yu Watanabe verfasserin aut Shujiro Okuda verfasserin aut Kazuki Tainaka verfasserin aut Takayuki Enomoto verfasserin aut In iScience Elsevier, 2019 24(2021), 4, Seite 102258- (DE-627)1019532106 25890042 nnns volume:24 year:2021 number:4 pages:102258- https://doi.org/10.1016/j.isci.2021.102258 kostenfrei https://doaj.org/article/7a0f167e5ba6481493be0bab6e8baf10 kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004221002261 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 24 2021 4 102258-
allfieldsSound	10.1016/j.isci.2021.102258 doi (DE-627)DOAJ070797994 (DE-599)DOAJ7a0f167e5ba6481493be0bab6e8baf10 DE-627 ger DE-627 rakwb eng Manako Yamaguchi verfasserin aut Three-dimensional understanding of the morphological complexity of the human uterine endometrium 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: The fundamental morphology of the endometrial glands is not sufficiently understood by 2D observation because these glands have complicated winding and branching patterns. To construct a large picture of the endometrial gland structure, we performed tissue-clearing-based 3D imaging of human uterine endometrial tissue. Our 3D immunohistochemistry and layer analyses revealed that the endometrial glands form a plexus network in the stratum basalis and expand horizontally along the muscular layer, similar to the rhizome of grass. We then extended our method to assess the 3D morphology of tissue affected by adenomyosis, a representative “endometrium-related disease,” and observed its 3D morphological features, including the direct invasion of endometrial glands into the myometrium and an ant colony-like network of ectopic endometrial glands within the myometrium. Thus, further understanding of the morphology of the human endometrium based on 3D analysis will lead to the identification of the pathogenesis of endometrium-related diseases. Human Physiology Imaging Anatomy Science Q Kosuke Yoshihara verfasserin aut Kazuaki Suda verfasserin aut Hirofumi Nakaoka verfasserin aut Nozomi Yachida verfasserin aut Haruka Ueda verfasserin aut Kentaro Sugino verfasserin aut Yutaro Mori verfasserin aut Kaoru Yamawaki verfasserin aut Ryo Tamura verfasserin aut Tatsuya Ishiguro verfasserin aut Teiichi Motoyama verfasserin aut Yu Watanabe verfasserin aut Shujiro Okuda verfasserin aut Kazuki Tainaka verfasserin aut Takayuki Enomoto verfasserin aut In iScience Elsevier, 2019 24(2021), 4, Seite 102258- (DE-627)1019532106 25890042 nnns volume:24 year:2021 number:4 pages:102258- https://doi.org/10.1016/j.isci.2021.102258 kostenfrei https://doaj.org/article/7a0f167e5ba6481493be0bab6e8baf10 kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004221002261 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 24 2021 4 102258-
language	English
source	In iScience 24(2021), 4, Seite 102258- volume:24 year:2021 number:4 pages:102258-
sourceStr	In iScience 24(2021), 4, Seite 102258- volume:24 year:2021 number:4 pages:102258-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Human Physiology Imaging Anatomy Science Q
isfreeaccess_bool	true
container_title	iScience
authorswithroles_txt_mv	Manako Yamaguchi @@aut@@ Kosuke Yoshihara @@aut@@ Kazuaki Suda @@aut@@ Hirofumi Nakaoka @@aut@@ Nozomi Yachida @@aut@@ Haruka Ueda @@aut@@ Kentaro Sugino @@aut@@ Yutaro Mori @@aut@@ Kaoru Yamawaki @@aut@@ Ryo Tamura @@aut@@ Tatsuya Ishiguro @@aut@@ Teiichi Motoyama @@aut@@ Yu Watanabe @@aut@@ Shujiro Okuda @@aut@@ Kazuki Tainaka @@aut@@ Takayuki Enomoto @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	1019532106
id	DOAJ070797994
language_de	englisch
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author	Manako Yamaguchi
spellingShingle	Manako Yamaguchi misc Human Physiology misc Imaging Anatomy misc Science misc Q Three-dimensional understanding of the morphological complexity of the human uterine endometrium
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topic_title	Three-dimensional understanding of the morphological complexity of the human uterine endometrium Human Physiology Imaging Anatomy
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title	Three-dimensional understanding of the morphological complexity of the human uterine endometrium
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title_full	Three-dimensional understanding of the morphological complexity of the human uterine endometrium
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author_browse	Manako Yamaguchi Kosuke Yoshihara Kazuaki Suda Hirofumi Nakaoka Nozomi Yachida Haruka Ueda Kentaro Sugino Yutaro Mori Kaoru Yamawaki Ryo Tamura Tatsuya Ishiguro Teiichi Motoyama Yu Watanabe Shujiro Okuda Kazuki Tainaka Takayuki Enomoto
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author-letter	Manako Yamaguchi
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title_sort	three-dimensional understanding of the morphological complexity of the human uterine endometrium
title_auth	Three-dimensional understanding of the morphological complexity of the human uterine endometrium
abstract	Summary: The fundamental morphology of the endometrial glands is not sufficiently understood by 2D observation because these glands have complicated winding and branching patterns. To construct a large picture of the endometrial gland structure, we performed tissue-clearing-based 3D imaging of human uterine endometrial tissue. Our 3D immunohistochemistry and layer analyses revealed that the endometrial glands form a plexus network in the stratum basalis and expand horizontally along the muscular layer, similar to the rhizome of grass. We then extended our method to assess the 3D morphology of tissue affected by adenomyosis, a representative “endometrium-related disease,” and observed its 3D morphological features, including the direct invasion of endometrial glands into the myometrium and an ant colony-like network of ectopic endometrial glands within the myometrium. Thus, further understanding of the morphology of the human endometrium based on 3D analysis will lead to the identification of the pathogenesis of endometrium-related diseases.
abstractGer	Summary: The fundamental morphology of the endometrial glands is not sufficiently understood by 2D observation because these glands have complicated winding and branching patterns. To construct a large picture of the endometrial gland structure, we performed tissue-clearing-based 3D imaging of human uterine endometrial tissue. Our 3D immunohistochemistry and layer analyses revealed that the endometrial glands form a plexus network in the stratum basalis and expand horizontally along the muscular layer, similar to the rhizome of grass. We then extended our method to assess the 3D morphology of tissue affected by adenomyosis, a representative “endometrium-related disease,” and observed its 3D morphological features, including the direct invasion of endometrial glands into the myometrium and an ant colony-like network of ectopic endometrial glands within the myometrium. Thus, further understanding of the morphology of the human endometrium based on 3D analysis will lead to the identification of the pathogenesis of endometrium-related diseases.
abstract_unstemmed	Summary: The fundamental morphology of the endometrial glands is not sufficiently understood by 2D observation because these glands have complicated winding and branching patterns. To construct a large picture of the endometrial gland structure, we performed tissue-clearing-based 3D imaging of human uterine endometrial tissue. Our 3D immunohistochemistry and layer analyses revealed that the endometrial glands form a plexus network in the stratum basalis and expand horizontally along the muscular layer, similar to the rhizome of grass. We then extended our method to assess the 3D morphology of tissue affected by adenomyosis, a representative “endometrium-related disease,” and observed its 3D morphological features, including the direct invasion of endometrial glands into the myometrium and an ant colony-like network of ectopic endometrial glands within the myometrium. Thus, further understanding of the morphology of the human endometrium based on 3D analysis will lead to the identification of the pathogenesis of endometrium-related diseases.
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title_short	Three-dimensional understanding of the morphological complexity of the human uterine endometrium
url	https://doi.org/10.1016/j.isci.2021.102258 https://doaj.org/article/7a0f167e5ba6481493be0bab6e8baf10 http://www.sciencedirect.com/science/article/pii/S2589004221002261 https://doaj.org/toc/2589-0042
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Three-dimensional understanding of the morphological complexity of the human uterine endometrium

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