The Effect of ICOS Polymorphism Interactions with HBV Mutations on HBV Subtype Infection Outcomes

Introduction and aim. Hepatitis B virus (HBV) infection remains a public health problem worldwide. In addition, HBV infection results are influenced by various virological, immunological, and genetic factors. Inducible T-cell costimulator (ICOS) polymorphisms involving chronic HBV infection have bee...
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Autor*in:	Xiao-Mei Song [verfasserIn] Qing-Ling Li [verfasserIn] Feng Guo [verfasserIn] Hong Peng [verfasserIn] Jin-Jun Guo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Hepatitis B virus(HBV) Single nucleotide polymorphisms (SNPs) Inducible T-cell costimulator (ICOS) Enhancer II/ basal core promoter/pre-core region (EnhII/BCP/PC region)

Übergeordnetes Werk:	In: Annals of Hepatology - Elsevier, 2021, 17(2018), 6, Seite 940-947
Übergeordnetes Werk:	volume:17 ; year:2018 ; number:6 ; pages:940-947

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.5604/01.3001.0012.7194

Katalog-ID:	DOAJ070807221

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520			\|a Introduction and aim. Hepatitis B virus (HBV) infection remains a public health problem worldwide. In addition, HBV infection results are influenced by various virological, immunological, and genetic factors. Inducible T-cell costimulator (ICOS) polymorphisms involving chronic HBV infection have been confirmed in previous studies. This study was to explore the effects of ICOS single nucleotide polymorphisms in HBV subtypes and their interactions with viral mutations on HBV infection outcomes.Material and methods. A total of 1,636 Han Chinese individuals were recruited, including 47 asymptomatic HBV carriers (ASC), 353 chronic hepatitis B (CHB) patients, 327 HBV-related liver cirrhosis (LC) patients, 193 HBV-related hepatocellular carcinoma (HCC) patients, 464 patients with spontaneous recovery from HBV infection (SR), and 252 healthy controls (HC). DNA samples from these subjects were genotyped for four ICOS SNPs (rs11883722, rs10932029, rs1559931, and rs4675379). Direct sequencing was used to determine the HBV mutations in the enhancer II, basal core promoter, and pre-core regions.Results. We found that the genotype “TC” of ICOS rs10932029 SNP was associated with decreased HBV-related LC risk in the genotype C group. Additionally, the A1762T, G1764A and A1762T/G1764A mutations were associated with an increased risk of LC in the genotype C group. Further study indicated that interactions between ICOS rs10932029 genotype “TC” and A1762T or A1762T/G1764A mutations significantly decreased the LC risk in the genotype C group.Conclusion. The rs10932029 genotype “TC” might be an LC-protective factor for HBV genotype C infection. The interactions between the rs10932029 genotype “TC” and A1762T or A1762T/G1764A mutations could decrease the risk of LC.
650		4	\|a Hepatitis B virus(HBV)
650		4	\|a Single nucleotide polymorphisms (SNPs)
650		4	\|a Inducible T-cell costimulator (ICOS)
650		4	\|a Enhancer II/ basal core promoter/pre-core region (EnhII/BCP/PC region)
653		0	\|a Specialties of internal medicine
700	0		\|a Qing-Ling Li \|e verfasserin \|4 aut
700	0		\|a Feng Guo \|e verfasserin \|4 aut
700	0		\|a Hong Peng \|e verfasserin \|4 aut
700	0		\|a Jin-Jun Guo \|e verfasserin \|4 aut
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912			\|a GBV_USEFLAG_A
912			\|a SYSFLAG_A
912			\|a GBV_DOAJ
912			\|a GBV_ILN_2002
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allfields	10.5604/01.3001.0012.7194 doi (DE-627)DOAJ070807221 (DE-599)DOAJd0c47efb225a452ca583ff07a84aff53 DE-627 ger DE-627 rakwb eng RC581-951 Xiao-Mei Song verfasserin aut The Effect of ICOS Polymorphism Interactions with HBV Mutations on HBV Subtype Infection Outcomes 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction and aim. Hepatitis B virus (HBV) infection remains a public health problem worldwide. In addition, HBV infection results are influenced by various virological, immunological, and genetic factors. Inducible T-cell costimulator (ICOS) polymorphisms involving chronic HBV infection have been confirmed in previous studies. This study was to explore the effects of ICOS single nucleotide polymorphisms in HBV subtypes and their interactions with viral mutations on HBV infection outcomes.Material and methods. A total of 1,636 Han Chinese individuals were recruited, including 47 asymptomatic HBV carriers (ASC), 353 chronic hepatitis B (CHB) patients, 327 HBV-related liver cirrhosis (LC) patients, 193 HBV-related hepatocellular carcinoma (HCC) patients, 464 patients with spontaneous recovery from HBV infection (SR), and 252 healthy controls (HC). DNA samples from these subjects were genotyped for four ICOS SNPs (rs11883722, rs10932029, rs1559931, and rs4675379). Direct sequencing was used to determine the HBV mutations in the enhancer II, basal core promoter, and pre-core regions.Results. We found that the genotype “TC” of ICOS rs10932029 SNP was associated with decreased HBV-related LC risk in the genotype C group. Additionally, the A1762T, G1764A and A1762T/G1764A mutations were associated with an increased risk of LC in the genotype C group. Further study indicated that interactions between ICOS rs10932029 genotype “TC” and A1762T or A1762T/G1764A mutations significantly decreased the LC risk in the genotype C group.Conclusion. The rs10932029 genotype “TC” might be an LC-protective factor for HBV genotype C infection. The interactions between the rs10932029 genotype “TC” and A1762T or A1762T/G1764A mutations could decrease the risk of LC. Hepatitis B virus(HBV) Single nucleotide polymorphisms (SNPs) Inducible T-cell costimulator (ICOS) Enhancer II/ basal core promoter/pre-core region (EnhII/BCP/PC region) Specialties of internal medicine Qing-Ling Li verfasserin aut Feng Guo verfasserin aut Hong Peng verfasserin aut Jin-Jun Guo verfasserin aut In Annals of Hepatology Elsevier, 2021 17(2018), 6, Seite 940-947 (DE-627)DOAJ078617936 26595982 nnns volume:17 year:2018 number:6 pages:940-947 https://doi.org/10.5604/01.3001.0012.7194 kostenfrei https://doaj.org/article/d0c47efb225a452ca583ff07a84aff53 kostenfrei http://www.sciencedirect.com/science/article/pii/S1665268119310567 kostenfrei https://doaj.org/toc/1665-2681 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_2002 AR 17 2018 6 940-947
spelling	10.5604/01.3001.0012.7194 doi (DE-627)DOAJ070807221 (DE-599)DOAJd0c47efb225a452ca583ff07a84aff53 DE-627 ger DE-627 rakwb eng RC581-951 Xiao-Mei Song verfasserin aut The Effect of ICOS Polymorphism Interactions with HBV Mutations on HBV Subtype Infection Outcomes 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction and aim. Hepatitis B virus (HBV) infection remains a public health problem worldwide. In addition, HBV infection results are influenced by various virological, immunological, and genetic factors. Inducible T-cell costimulator (ICOS) polymorphisms involving chronic HBV infection have been confirmed in previous studies. This study was to explore the effects of ICOS single nucleotide polymorphisms in HBV subtypes and their interactions with viral mutations on HBV infection outcomes.Material and methods. A total of 1,636 Han Chinese individuals were recruited, including 47 asymptomatic HBV carriers (ASC), 353 chronic hepatitis B (CHB) patients, 327 HBV-related liver cirrhosis (LC) patients, 193 HBV-related hepatocellular carcinoma (HCC) patients, 464 patients with spontaneous recovery from HBV infection (SR), and 252 healthy controls (HC). DNA samples from these subjects were genotyped for four ICOS SNPs (rs11883722, rs10932029, rs1559931, and rs4675379). Direct sequencing was used to determine the HBV mutations in the enhancer II, basal core promoter, and pre-core regions.Results. We found that the genotype “TC” of ICOS rs10932029 SNP was associated with decreased HBV-related LC risk in the genotype C group. Additionally, the A1762T, G1764A and A1762T/G1764A mutations were associated with an increased risk of LC in the genotype C group. Further study indicated that interactions between ICOS rs10932029 genotype “TC” and A1762T or A1762T/G1764A mutations significantly decreased the LC risk in the genotype C group.Conclusion. The rs10932029 genotype “TC” might be an LC-protective factor for HBV genotype C infection. The interactions between the rs10932029 genotype “TC” and A1762T or A1762T/G1764A mutations could decrease the risk of LC. Hepatitis B virus(HBV) Single nucleotide polymorphisms (SNPs) Inducible T-cell costimulator (ICOS) Enhancer II/ basal core promoter/pre-core region (EnhII/BCP/PC region) Specialties of internal medicine Qing-Ling Li verfasserin aut Feng Guo verfasserin aut Hong Peng verfasserin aut Jin-Jun Guo verfasserin aut In Annals of Hepatology Elsevier, 2021 17(2018), 6, Seite 940-947 (DE-627)DOAJ078617936 26595982 nnns volume:17 year:2018 number:6 pages:940-947 https://doi.org/10.5604/01.3001.0012.7194 kostenfrei https://doaj.org/article/d0c47efb225a452ca583ff07a84aff53 kostenfrei http://www.sciencedirect.com/science/article/pii/S1665268119310567 kostenfrei https://doaj.org/toc/1665-2681 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_2002 AR 17 2018 6 940-947
allfields_unstemmed	10.5604/01.3001.0012.7194 doi (DE-627)DOAJ070807221 (DE-599)DOAJd0c47efb225a452ca583ff07a84aff53 DE-627 ger DE-627 rakwb eng RC581-951 Xiao-Mei Song verfasserin aut The Effect of ICOS Polymorphism Interactions with HBV Mutations on HBV Subtype Infection Outcomes 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction and aim. Hepatitis B virus (HBV) infection remains a public health problem worldwide. In addition, HBV infection results are influenced by various virological, immunological, and genetic factors. Inducible T-cell costimulator (ICOS) polymorphisms involving chronic HBV infection have been confirmed in previous studies. This study was to explore the effects of ICOS single nucleotide polymorphisms in HBV subtypes and their interactions with viral mutations on HBV infection outcomes.Material and methods. A total of 1,636 Han Chinese individuals were recruited, including 47 asymptomatic HBV carriers (ASC), 353 chronic hepatitis B (CHB) patients, 327 HBV-related liver cirrhosis (LC) patients, 193 HBV-related hepatocellular carcinoma (HCC) patients, 464 patients with spontaneous recovery from HBV infection (SR), and 252 healthy controls (HC). DNA samples from these subjects were genotyped for four ICOS SNPs (rs11883722, rs10932029, rs1559931, and rs4675379). Direct sequencing was used to determine the HBV mutations in the enhancer II, basal core promoter, and pre-core regions.Results. We found that the genotype “TC” of ICOS rs10932029 SNP was associated with decreased HBV-related LC risk in the genotype C group. Additionally, the A1762T, G1764A and A1762T/G1764A mutations were associated with an increased risk of LC in the genotype C group. Further study indicated that interactions between ICOS rs10932029 genotype “TC” and A1762T or A1762T/G1764A mutations significantly decreased the LC risk in the genotype C group.Conclusion. The rs10932029 genotype “TC” might be an LC-protective factor for HBV genotype C infection. The interactions between the rs10932029 genotype “TC” and A1762T or A1762T/G1764A mutations could decrease the risk of LC. Hepatitis B virus(HBV) Single nucleotide polymorphisms (SNPs) Inducible T-cell costimulator (ICOS) Enhancer II/ basal core promoter/pre-core region (EnhII/BCP/PC region) Specialties of internal medicine Qing-Ling Li verfasserin aut Feng Guo verfasserin aut Hong Peng verfasserin aut Jin-Jun Guo verfasserin aut In Annals of Hepatology Elsevier, 2021 17(2018), 6, Seite 940-947 (DE-627)DOAJ078617936 26595982 nnns volume:17 year:2018 number:6 pages:940-947 https://doi.org/10.5604/01.3001.0012.7194 kostenfrei https://doaj.org/article/d0c47efb225a452ca583ff07a84aff53 kostenfrei http://www.sciencedirect.com/science/article/pii/S1665268119310567 kostenfrei https://doaj.org/toc/1665-2681 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_2002 AR 17 2018 6 940-947
allfieldsGer	10.5604/01.3001.0012.7194 doi (DE-627)DOAJ070807221 (DE-599)DOAJd0c47efb225a452ca583ff07a84aff53 DE-627 ger DE-627 rakwb eng RC581-951 Xiao-Mei Song verfasserin aut The Effect of ICOS Polymorphism Interactions with HBV Mutations on HBV Subtype Infection Outcomes 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction and aim. Hepatitis B virus (HBV) infection remains a public health problem worldwide. In addition, HBV infection results are influenced by various virological, immunological, and genetic factors. Inducible T-cell costimulator (ICOS) polymorphisms involving chronic HBV infection have been confirmed in previous studies. This study was to explore the effects of ICOS single nucleotide polymorphisms in HBV subtypes and their interactions with viral mutations on HBV infection outcomes.Material and methods. A total of 1,636 Han Chinese individuals were recruited, including 47 asymptomatic HBV carriers (ASC), 353 chronic hepatitis B (CHB) patients, 327 HBV-related liver cirrhosis (LC) patients, 193 HBV-related hepatocellular carcinoma (HCC) patients, 464 patients with spontaneous recovery from HBV infection (SR), and 252 healthy controls (HC). DNA samples from these subjects were genotyped for four ICOS SNPs (rs11883722, rs10932029, rs1559931, and rs4675379). Direct sequencing was used to determine the HBV mutations in the enhancer II, basal core promoter, and pre-core regions.Results. We found that the genotype “TC” of ICOS rs10932029 SNP was associated with decreased HBV-related LC risk in the genotype C group. Additionally, the A1762T, G1764A and A1762T/G1764A mutations were associated with an increased risk of LC in the genotype C group. Further study indicated that interactions between ICOS rs10932029 genotype “TC” and A1762T or A1762T/G1764A mutations significantly decreased the LC risk in the genotype C group.Conclusion. The rs10932029 genotype “TC” might be an LC-protective factor for HBV genotype C infection. The interactions between the rs10932029 genotype “TC” and A1762T or A1762T/G1764A mutations could decrease the risk of LC. Hepatitis B virus(HBV) Single nucleotide polymorphisms (SNPs) Inducible T-cell costimulator (ICOS) Enhancer II/ basal core promoter/pre-core region (EnhII/BCP/PC region) Specialties of internal medicine Qing-Ling Li verfasserin aut Feng Guo verfasserin aut Hong Peng verfasserin aut Jin-Jun Guo verfasserin aut In Annals of Hepatology Elsevier, 2021 17(2018), 6, Seite 940-947 (DE-627)DOAJ078617936 26595982 nnns volume:17 year:2018 number:6 pages:940-947 https://doi.org/10.5604/01.3001.0012.7194 kostenfrei https://doaj.org/article/d0c47efb225a452ca583ff07a84aff53 kostenfrei http://www.sciencedirect.com/science/article/pii/S1665268119310567 kostenfrei https://doaj.org/toc/1665-2681 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_2002 AR 17 2018 6 940-947
allfieldsSound	10.5604/01.3001.0012.7194 doi (DE-627)DOAJ070807221 (DE-599)DOAJd0c47efb225a452ca583ff07a84aff53 DE-627 ger DE-627 rakwb eng RC581-951 Xiao-Mei Song verfasserin aut The Effect of ICOS Polymorphism Interactions with HBV Mutations on HBV Subtype Infection Outcomes 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction and aim. Hepatitis B virus (HBV) infection remains a public health problem worldwide. In addition, HBV infection results are influenced by various virological, immunological, and genetic factors. Inducible T-cell costimulator (ICOS) polymorphisms involving chronic HBV infection have been confirmed in previous studies. This study was to explore the effects of ICOS single nucleotide polymorphisms in HBV subtypes and their interactions with viral mutations on HBV infection outcomes.Material and methods. A total of 1,636 Han Chinese individuals were recruited, including 47 asymptomatic HBV carriers (ASC), 353 chronic hepatitis B (CHB) patients, 327 HBV-related liver cirrhosis (LC) patients, 193 HBV-related hepatocellular carcinoma (HCC) patients, 464 patients with spontaneous recovery from HBV infection (SR), and 252 healthy controls (HC). DNA samples from these subjects were genotyped for four ICOS SNPs (rs11883722, rs10932029, rs1559931, and rs4675379). Direct sequencing was used to determine the HBV mutations in the enhancer II, basal core promoter, and pre-core regions.Results. We found that the genotype “TC” of ICOS rs10932029 SNP was associated with decreased HBV-related LC risk in the genotype C group. Additionally, the A1762T, G1764A and A1762T/G1764A mutations were associated with an increased risk of LC in the genotype C group. Further study indicated that interactions between ICOS rs10932029 genotype “TC” and A1762T or A1762T/G1764A mutations significantly decreased the LC risk in the genotype C group.Conclusion. The rs10932029 genotype “TC” might be an LC-protective factor for HBV genotype C infection. The interactions between the rs10932029 genotype “TC” and A1762T or A1762T/G1764A mutations could decrease the risk of LC. Hepatitis B virus(HBV) Single nucleotide polymorphisms (SNPs) Inducible T-cell costimulator (ICOS) Enhancer II/ basal core promoter/pre-core region (EnhII/BCP/PC region) Specialties of internal medicine Qing-Ling Li verfasserin aut Feng Guo verfasserin aut Hong Peng verfasserin aut Jin-Jun Guo verfasserin aut In Annals of Hepatology Elsevier, 2021 17(2018), 6, Seite 940-947 (DE-627)DOAJ078617936 26595982 nnns volume:17 year:2018 number:6 pages:940-947 https://doi.org/10.5604/01.3001.0012.7194 kostenfrei https://doaj.org/article/d0c47efb225a452ca583ff07a84aff53 kostenfrei http://www.sciencedirect.com/science/article/pii/S1665268119310567 kostenfrei https://doaj.org/toc/1665-2681 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_2002 AR 17 2018 6 940-947
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source	In Annals of Hepatology 17(2018), 6, Seite 940-947 volume:17 year:2018 number:6 pages:940-947
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topic_facet	Hepatitis B virus(HBV) Single nucleotide polymorphisms (SNPs) Inducible T-cell costimulator (ICOS) Enhancer II/ basal core promoter/pre-core region (EnhII/BCP/PC region) Specialties of internal medicine
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Hepatitis B virus (HBV) infection remains a public health problem worldwide. In addition, HBV infection results are influenced by various virological, immunological, and genetic factors. Inducible T-cell costimulator (ICOS) polymorphisms involving chronic HBV infection have been confirmed in previous studies. This study was to explore the effects of ICOS single nucleotide polymorphisms in HBV subtypes and their interactions with viral mutations on HBV infection outcomes.Material and methods. A total of 1,636 Han Chinese individuals were recruited, including 47 asymptomatic HBV carriers (ASC), 353 chronic hepatitis B (CHB) patients, 327 HBV-related liver cirrhosis (LC) patients, 193 HBV-related hepatocellular carcinoma (HCC) patients, 464 patients with spontaneous recovery from HBV infection (SR), and 252 healthy controls (HC). DNA samples from these subjects were genotyped for four ICOS SNPs (rs11883722, rs10932029, rs1559931, and rs4675379). Direct sequencing was used to determine the HBV mutations in the enhancer II, basal core promoter, and pre-core regions.Results. We found that the genotype “TC” of ICOS rs10932029 SNP was associated with decreased HBV-related LC risk in the genotype C group. Additionally, the A1762T, G1764A and A1762T/G1764A mutations were associated with an increased risk of LC in the genotype C group. Further study indicated that interactions between ICOS rs10932029 genotype “TC” and A1762T or A1762T/G1764A mutations significantly decreased the LC risk in the genotype C group.Conclusion. The rs10932029 genotype “TC” might be an LC-protective factor for HBV genotype C infection. 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callnumber-first	R - Medicine
author	Xiao-Mei Song
spellingShingle	Xiao-Mei Song misc RC581-951 misc Hepatitis B virus(HBV) misc Single nucleotide polymorphisms (SNPs) misc Inducible T-cell costimulator (ICOS) misc Enhancer II/ basal core promoter/pre-core region (EnhII/BCP/PC region) misc Specialties of internal medicine The Effect of ICOS Polymorphism Interactions with HBV Mutations on HBV Subtype Infection Outcomes
authorStr	Xiao-Mei Song
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topic_title	RC581-951 The Effect of ICOS Polymorphism Interactions with HBV Mutations on HBV Subtype Infection Outcomes Hepatitis B virus(HBV) Single nucleotide polymorphisms (SNPs) Inducible T-cell costimulator (ICOS) Enhancer II/ basal core promoter/pre-core region (EnhII/BCP/PC region)
topic	misc RC581-951 misc Hepatitis B virus(HBV) misc Single nucleotide polymorphisms (SNPs) misc Inducible T-cell costimulator (ICOS) misc Enhancer II/ basal core promoter/pre-core region (EnhII/BCP/PC region) misc Specialties of internal medicine
topic_unstemmed	misc RC581-951 misc Hepatitis B virus(HBV) misc Single nucleotide polymorphisms (SNPs) misc Inducible T-cell costimulator (ICOS) misc Enhancer II/ basal core promoter/pre-core region (EnhII/BCP/PC region) misc Specialties of internal medicine
topic_browse	misc RC581-951 misc Hepatitis B virus(HBV) misc Single nucleotide polymorphisms (SNPs) misc Inducible T-cell costimulator (ICOS) misc Enhancer II/ basal core promoter/pre-core region (EnhII/BCP/PC region) misc Specialties of internal medicine
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title	The Effect of ICOS Polymorphism Interactions with HBV Mutations on HBV Subtype Infection Outcomes
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title_full	The Effect of ICOS Polymorphism Interactions with HBV Mutations on HBV Subtype Infection Outcomes
author_sort	Xiao-Mei Song
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author_browse	Xiao-Mei Song Qing-Ling Li Feng Guo Hong Peng Jin-Jun Guo
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author-letter	Xiao-Mei Song
doi_str_mv	10.5604/01.3001.0012.7194
author2-role	verfasserin
title_sort	effect of icos polymorphism interactions with hbv mutations on hbv subtype infection outcomes
callnumber	RC581-951
title_auth	The Effect of ICOS Polymorphism Interactions with HBV Mutations on HBV Subtype Infection Outcomes
abstract	Introduction and aim. Hepatitis B virus (HBV) infection remains a public health problem worldwide. In addition, HBV infection results are influenced by various virological, immunological, and genetic factors. Inducible T-cell costimulator (ICOS) polymorphisms involving chronic HBV infection have been confirmed in previous studies. This study was to explore the effects of ICOS single nucleotide polymorphisms in HBV subtypes and their interactions with viral mutations on HBV infection outcomes.Material and methods. A total of 1,636 Han Chinese individuals were recruited, including 47 asymptomatic HBV carriers (ASC), 353 chronic hepatitis B (CHB) patients, 327 HBV-related liver cirrhosis (LC) patients, 193 HBV-related hepatocellular carcinoma (HCC) patients, 464 patients with spontaneous recovery from HBV infection (SR), and 252 healthy controls (HC). DNA samples from these subjects were genotyped for four ICOS SNPs (rs11883722, rs10932029, rs1559931, and rs4675379). Direct sequencing was used to determine the HBV mutations in the enhancer II, basal core promoter, and pre-core regions.Results. We found that the genotype “TC” of ICOS rs10932029 SNP was associated with decreased HBV-related LC risk in the genotype C group. Additionally, the A1762T, G1764A and A1762T/G1764A mutations were associated with an increased risk of LC in the genotype C group. Further study indicated that interactions between ICOS rs10932029 genotype “TC” and A1762T or A1762T/G1764A mutations significantly decreased the LC risk in the genotype C group.Conclusion. The rs10932029 genotype “TC” might be an LC-protective factor for HBV genotype C infection. The interactions between the rs10932029 genotype “TC” and A1762T or A1762T/G1764A mutations could decrease the risk of LC.
abstractGer	Introduction and aim. Hepatitis B virus (HBV) infection remains a public health problem worldwide. In addition, HBV infection results are influenced by various virological, immunological, and genetic factors. Inducible T-cell costimulator (ICOS) polymorphisms involving chronic HBV infection have been confirmed in previous studies. This study was to explore the effects of ICOS single nucleotide polymorphisms in HBV subtypes and their interactions with viral mutations on HBV infection outcomes.Material and methods. A total of 1,636 Han Chinese individuals were recruited, including 47 asymptomatic HBV carriers (ASC), 353 chronic hepatitis B (CHB) patients, 327 HBV-related liver cirrhosis (LC) patients, 193 HBV-related hepatocellular carcinoma (HCC) patients, 464 patients with spontaneous recovery from HBV infection (SR), and 252 healthy controls (HC). DNA samples from these subjects were genotyped for four ICOS SNPs (rs11883722, rs10932029, rs1559931, and rs4675379). Direct sequencing was used to determine the HBV mutations in the enhancer II, basal core promoter, and pre-core regions.Results. We found that the genotype “TC” of ICOS rs10932029 SNP was associated with decreased HBV-related LC risk in the genotype C group. Additionally, the A1762T, G1764A and A1762T/G1764A mutations were associated with an increased risk of LC in the genotype C group. Further study indicated that interactions between ICOS rs10932029 genotype “TC” and A1762T or A1762T/G1764A mutations significantly decreased the LC risk in the genotype C group.Conclusion. The rs10932029 genotype “TC” might be an LC-protective factor for HBV genotype C infection. The interactions between the rs10932029 genotype “TC” and A1762T or A1762T/G1764A mutations could decrease the risk of LC.
abstract_unstemmed	Introduction and aim. Hepatitis B virus (HBV) infection remains a public health problem worldwide. In addition, HBV infection results are influenced by various virological, immunological, and genetic factors. Inducible T-cell costimulator (ICOS) polymorphisms involving chronic HBV infection have been confirmed in previous studies. This study was to explore the effects of ICOS single nucleotide polymorphisms in HBV subtypes and their interactions with viral mutations on HBV infection outcomes.Material and methods. A total of 1,636 Han Chinese individuals were recruited, including 47 asymptomatic HBV carriers (ASC), 353 chronic hepatitis B (CHB) patients, 327 HBV-related liver cirrhosis (LC) patients, 193 HBV-related hepatocellular carcinoma (HCC) patients, 464 patients with spontaneous recovery from HBV infection (SR), and 252 healthy controls (HC). DNA samples from these subjects were genotyped for four ICOS SNPs (rs11883722, rs10932029, rs1559931, and rs4675379). Direct sequencing was used to determine the HBV mutations in the enhancer II, basal core promoter, and pre-core regions.Results. We found that the genotype “TC” of ICOS rs10932029 SNP was associated with decreased HBV-related LC risk in the genotype C group. Additionally, the A1762T, G1764A and A1762T/G1764A mutations were associated with an increased risk of LC in the genotype C group. Further study indicated that interactions between ICOS rs10932029 genotype “TC” and A1762T or A1762T/G1764A mutations significantly decreased the LC risk in the genotype C group.Conclusion. The rs10932029 genotype “TC” might be an LC-protective factor for HBV genotype C infection. The interactions between the rs10932029 genotype “TC” and A1762T or A1762T/G1764A mutations could decrease the risk of LC.
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_2002
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title_short	The Effect of ICOS Polymorphism Interactions with HBV Mutations on HBV Subtype Infection Outcomes
url	https://doi.org/10.5604/01.3001.0012.7194 https://doaj.org/article/d0c47efb225a452ca583ff07a84aff53 http://www.sciencedirect.com/science/article/pii/S1665268119310567 https://doaj.org/toc/1665-2681
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author2	Qing-Ling Li Feng Guo Hong Peng Jin-Jun Guo
author2Str	Qing-Ling Li Feng Guo Hong Peng Jin-Jun Guo
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up_date	2024-07-03T16:49:13.639Z
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