Rapid design and fielding of four diagnostic technologies in Sierra Leone, Thailand, Peru, and Australia: Successes and challenges faced introducing these biosensors
Febrile illnesses are among the most common reasons for visits to hospitals and clinics worldwide. Since fevers can arise from a wide range of diseases, identifying the causative pathogen is essential not only for effective personal treatment but also for early detection of outbreaks. The Defense Th...
Ausführliche Beschreibung
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E-Artikel |
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Englisch |
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2018 |
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Übergeordnetes Werk: |
In: Sensing and Bio-Sensing Research - Elsevier, 2016, 20(2018), Seite 22-33 |
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Übergeordnetes Werk: |
volume:20 ; year:2018 ; pages:22-33 |
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DOI / URN: |
10.1016/j.sbsr.2018.06.003 |
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DOAJ070933383 |
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520 | |a Febrile illnesses are among the most common reasons for visits to hospitals and clinics worldwide. Since fevers can arise from a wide range of diseases, identifying the causative pathogen is essential not only for effective personal treatment but also for early detection of outbreaks. The Defense Threat Reduction Agency (DTRA) tasked a coalition of commercial, academic, and government researchers with moving diagnostic technology concepts from ideation to field use as rapidly as possible using scientifically sound evaluations. DTRA's 24 Month Challenge program examined <30 technologies before fielding four technologies on four continents. <10,000 in field test results were recorded. Here we discuss our tiered evaluation system to assess candidate technologies developed by commercial partners and the process of field testing those technologies at various front-line clinics in Sierra Leone, Thailand, Peru, and Australia. We discuss successes and challenges for introducing two multiplexed lateral flow immunoassay (LFI) tests that detect malaria, dengue fever, melioidosis, and the plague. Additionally we discuss the use of a LFI reader that assisted the interpretation of the assay, communicated results to a data cloud, and greatly facilitated reach-back support. Lastly, we discuss the concurrent field testing of a multiplexed PCR assay on the FilmArray platform, which had an assay pouch specially designed for the 24 Month Challenge. Either standard-of-care or gold-standard testing were run alongside our fielded technologies to benchmark their performance. Keywords: Diagnostic device, Lateral flow immunoassay, Nested PCR, Field testing, Malaria, Dengue fever | ||
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10.1016/j.sbsr.2018.06.003 doi (DE-627)DOAJ070933383 (DE-599)DOAJ605f4a559eb742698527fcf3cbfe043a DE-627 ger DE-627 rakwb eng TA1-2040 Shawn P. Mulvaney verfasserin aut Rapid design and fielding of four diagnostic technologies in Sierra Leone, Thailand, Peru, and Australia: Successes and challenges faced introducing these biosensors 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Febrile illnesses are among the most common reasons for visits to hospitals and clinics worldwide. Since fevers can arise from a wide range of diseases, identifying the causative pathogen is essential not only for effective personal treatment but also for early detection of outbreaks. The Defense Threat Reduction Agency (DTRA) tasked a coalition of commercial, academic, and government researchers with moving diagnostic technology concepts from ideation to field use as rapidly as possible using scientifically sound evaluations. DTRA's 24 Month Challenge program examined <30 technologies before fielding four technologies on four continents. <10,000 in field test results were recorded. Here we discuss our tiered evaluation system to assess candidate technologies developed by commercial partners and the process of field testing those technologies at various front-line clinics in Sierra Leone, Thailand, Peru, and Australia. We discuss successes and challenges for introducing two multiplexed lateral flow immunoassay (LFI) tests that detect malaria, dengue fever, melioidosis, and the plague. Additionally we discuss the use of a LFI reader that assisted the interpretation of the assay, communicated results to a data cloud, and greatly facilitated reach-back support. Lastly, we discuss the concurrent field testing of a multiplexed PCR assay on the FilmArray platform, which had an assay pouch specially designed for the 24 Month Challenge. Either standard-of-care or gold-standard testing were run alongside our fielded technologies to benchmark their performance. Keywords: Diagnostic device, Lateral flow immunoassay, Nested PCR, Field testing, Malaria, Dengue fever Engineering (General). Civil engineering (General) Lisa A. Fitzgerald verfasserin aut Leila J. Hamdan verfasserin aut Bradley R. Ringeisen verfasserin aut Emily R. Petersen verfasserin aut Jaimee R. Compton verfasserin aut Nina L. McAuliff verfasserin aut Tomasz A. Leski verfasserin aut Chris R. Taitt verfasserin aut David A. Stenger verfasserin aut Christopher A. Myers verfasserin aut Erin Hansen verfasserin aut Michelle Ricketts verfasserin aut Chelsea Hoegberg verfasserin aut Kamonthip Homdayjanakul verfasserin aut Rashid Ansumana verfasserin aut Joseph M. Lamin verfasserin aut Umaru Bangura verfasserin aut Joseph Lahai verfasserin aut Victoria Baio verfasserin aut Direk Limmathurotsakul verfasserin aut Gumphol Wongsuvan verfasserin aut Viriya Hantrakun verfasserin aut Supaporn Wacharapluesadee verfasserin aut Anek Mungaomklang verfasserin aut Opass Putcharoen verfasserin aut Pratoomtong Yatoom verfasserin aut Kriengsak Kruthakool verfasserin aut Robert D. Hontz verfasserin aut Christopher Mores verfasserin aut Crystyan Siles verfasserin aut Amy Morrison verfasserin aut Mark Mayo verfasserin aut Bart J. Currie verfasserin aut Kathryn H. Jacobsen verfasserin aut Kathleen Quinn verfasserin aut Jerold Blutman verfasserin aut Flavia Amariei verfasserin aut John Hannan verfasserin aut In Sensing and Bio-Sensing Research Elsevier, 2016 20(2018), Seite 22-33 (DE-627)826105408 (DE-600)2821969-7 22141804 nnns volume:20 year:2018 pages:22-33 https://doi.org/10.1016/j.sbsr.2018.06.003 kostenfrei https://doaj.org/article/605f4a559eb742698527fcf3cbfe043a kostenfrei http://www.sciencedirect.com/science/article/pii/S2214180418300412 kostenfrei https://doaj.org/toc/2214-1804 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 20 2018 22-33 |
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10.1016/j.sbsr.2018.06.003 doi (DE-627)DOAJ070933383 (DE-599)DOAJ605f4a559eb742698527fcf3cbfe043a DE-627 ger DE-627 rakwb eng TA1-2040 Shawn P. Mulvaney verfasserin aut Rapid design and fielding of four diagnostic technologies in Sierra Leone, Thailand, Peru, and Australia: Successes and challenges faced introducing these biosensors 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Febrile illnesses are among the most common reasons for visits to hospitals and clinics worldwide. Since fevers can arise from a wide range of diseases, identifying the causative pathogen is essential not only for effective personal treatment but also for early detection of outbreaks. The Defense Threat Reduction Agency (DTRA) tasked a coalition of commercial, academic, and government researchers with moving diagnostic technology concepts from ideation to field use as rapidly as possible using scientifically sound evaluations. DTRA's 24 Month Challenge program examined <30 technologies before fielding four technologies on four continents. <10,000 in field test results were recorded. Here we discuss our tiered evaluation system to assess candidate technologies developed by commercial partners and the process of field testing those technologies at various front-line clinics in Sierra Leone, Thailand, Peru, and Australia. We discuss successes and challenges for introducing two multiplexed lateral flow immunoassay (LFI) tests that detect malaria, dengue fever, melioidosis, and the plague. Additionally we discuss the use of a LFI reader that assisted the interpretation of the assay, communicated results to a data cloud, and greatly facilitated reach-back support. Lastly, we discuss the concurrent field testing of a multiplexed PCR assay on the FilmArray platform, which had an assay pouch specially designed for the 24 Month Challenge. Either standard-of-care or gold-standard testing were run alongside our fielded technologies to benchmark their performance. Keywords: Diagnostic device, Lateral flow immunoassay, Nested PCR, Field testing, Malaria, Dengue fever Engineering (General). Civil engineering (General) Lisa A. Fitzgerald verfasserin aut Leila J. Hamdan verfasserin aut Bradley R. Ringeisen verfasserin aut Emily R. Petersen verfasserin aut Jaimee R. Compton verfasserin aut Nina L. McAuliff verfasserin aut Tomasz A. Leski verfasserin aut Chris R. Taitt verfasserin aut David A. Stenger verfasserin aut Christopher A. Myers verfasserin aut Erin Hansen verfasserin aut Michelle Ricketts verfasserin aut Chelsea Hoegberg verfasserin aut Kamonthip Homdayjanakul verfasserin aut Rashid Ansumana verfasserin aut Joseph M. Lamin verfasserin aut Umaru Bangura verfasserin aut Joseph Lahai verfasserin aut Victoria Baio verfasserin aut Direk Limmathurotsakul verfasserin aut Gumphol Wongsuvan verfasserin aut Viriya Hantrakun verfasserin aut Supaporn Wacharapluesadee verfasserin aut Anek Mungaomklang verfasserin aut Opass Putcharoen verfasserin aut Pratoomtong Yatoom verfasserin aut Kriengsak Kruthakool verfasserin aut Robert D. Hontz verfasserin aut Christopher Mores verfasserin aut Crystyan Siles verfasserin aut Amy Morrison verfasserin aut Mark Mayo verfasserin aut Bart J. Currie verfasserin aut Kathryn H. 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allfields_unstemmed |
10.1016/j.sbsr.2018.06.003 doi (DE-627)DOAJ070933383 (DE-599)DOAJ605f4a559eb742698527fcf3cbfe043a DE-627 ger DE-627 rakwb eng TA1-2040 Shawn P. Mulvaney verfasserin aut Rapid design and fielding of four diagnostic technologies in Sierra Leone, Thailand, Peru, and Australia: Successes and challenges faced introducing these biosensors 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Febrile illnesses are among the most common reasons for visits to hospitals and clinics worldwide. Since fevers can arise from a wide range of diseases, identifying the causative pathogen is essential not only for effective personal treatment but also for early detection of outbreaks. The Defense Threat Reduction Agency (DTRA) tasked a coalition of commercial, academic, and government researchers with moving diagnostic technology concepts from ideation to field use as rapidly as possible using scientifically sound evaluations. DTRA's 24 Month Challenge program examined <30 technologies before fielding four technologies on four continents. <10,000 in field test results were recorded. Here we discuss our tiered evaluation system to assess candidate technologies developed by commercial partners and the process of field testing those technologies at various front-line clinics in Sierra Leone, Thailand, Peru, and Australia. We discuss successes and challenges for introducing two multiplexed lateral flow immunoassay (LFI) tests that detect malaria, dengue fever, melioidosis, and the plague. Additionally we discuss the use of a LFI reader that assisted the interpretation of the assay, communicated results to a data cloud, and greatly facilitated reach-back support. Lastly, we discuss the concurrent field testing of a multiplexed PCR assay on the FilmArray platform, which had an assay pouch specially designed for the 24 Month Challenge. Either standard-of-care or gold-standard testing were run alongside our fielded technologies to benchmark their performance. Keywords: Diagnostic device, Lateral flow immunoassay, Nested PCR, Field testing, Malaria, Dengue fever Engineering (General). Civil engineering (General) Lisa A. Fitzgerald verfasserin aut Leila J. Hamdan verfasserin aut Bradley R. Ringeisen verfasserin aut Emily R. Petersen verfasserin aut Jaimee R. Compton verfasserin aut Nina L. McAuliff verfasserin aut Tomasz A. Leski verfasserin aut Chris R. Taitt verfasserin aut David A. Stenger verfasserin aut Christopher A. Myers verfasserin aut Erin Hansen verfasserin aut Michelle Ricketts verfasserin aut Chelsea Hoegberg verfasserin aut Kamonthip Homdayjanakul verfasserin aut Rashid Ansumana verfasserin aut Joseph M. Lamin verfasserin aut Umaru Bangura verfasserin aut Joseph Lahai verfasserin aut Victoria Baio verfasserin aut Direk Limmathurotsakul verfasserin aut Gumphol Wongsuvan verfasserin aut Viriya Hantrakun verfasserin aut Supaporn Wacharapluesadee verfasserin aut Anek Mungaomklang verfasserin aut Opass Putcharoen verfasserin aut Pratoomtong Yatoom verfasserin aut Kriengsak Kruthakool verfasserin aut Robert D. Hontz verfasserin aut Christopher Mores verfasserin aut Crystyan Siles verfasserin aut Amy Morrison verfasserin aut Mark Mayo verfasserin aut Bart J. Currie verfasserin aut Kathryn H. Jacobsen verfasserin aut Kathleen Quinn verfasserin aut Jerold Blutman verfasserin aut Flavia Amariei verfasserin aut John Hannan verfasserin aut In Sensing and Bio-Sensing Research Elsevier, 2016 20(2018), Seite 22-33 (DE-627)826105408 (DE-600)2821969-7 22141804 nnns volume:20 year:2018 pages:22-33 https://doi.org/10.1016/j.sbsr.2018.06.003 kostenfrei https://doaj.org/article/605f4a559eb742698527fcf3cbfe043a kostenfrei http://www.sciencedirect.com/science/article/pii/S2214180418300412 kostenfrei https://doaj.org/toc/2214-1804 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 20 2018 22-33 |
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10.1016/j.sbsr.2018.06.003 doi (DE-627)DOAJ070933383 (DE-599)DOAJ605f4a559eb742698527fcf3cbfe043a DE-627 ger DE-627 rakwb eng TA1-2040 Shawn P. Mulvaney verfasserin aut Rapid design and fielding of four diagnostic technologies in Sierra Leone, Thailand, Peru, and Australia: Successes and challenges faced introducing these biosensors 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Febrile illnesses are among the most common reasons for visits to hospitals and clinics worldwide. Since fevers can arise from a wide range of diseases, identifying the causative pathogen is essential not only for effective personal treatment but also for early detection of outbreaks. The Defense Threat Reduction Agency (DTRA) tasked a coalition of commercial, academic, and government researchers with moving diagnostic technology concepts from ideation to field use as rapidly as possible using scientifically sound evaluations. DTRA's 24 Month Challenge program examined <30 technologies before fielding four technologies on four continents. <10,000 in field test results were recorded. Here we discuss our tiered evaluation system to assess candidate technologies developed by commercial partners and the process of field testing those technologies at various front-line clinics in Sierra Leone, Thailand, Peru, and Australia. We discuss successes and challenges for introducing two multiplexed lateral flow immunoassay (LFI) tests that detect malaria, dengue fever, melioidosis, and the plague. Additionally we discuss the use of a LFI reader that assisted the interpretation of the assay, communicated results to a data cloud, and greatly facilitated reach-back support. Lastly, we discuss the concurrent field testing of a multiplexed PCR assay on the FilmArray platform, which had an assay pouch specially designed for the 24 Month Challenge. Either standard-of-care or gold-standard testing were run alongside our fielded technologies to benchmark their performance. Keywords: Diagnostic device, Lateral flow immunoassay, Nested PCR, Field testing, Malaria, Dengue fever Engineering (General). Civil engineering (General) Lisa A. Fitzgerald verfasserin aut Leila J. Hamdan verfasserin aut Bradley R. Ringeisen verfasserin aut Emily R. Petersen verfasserin aut Jaimee R. Compton verfasserin aut Nina L. McAuliff verfasserin aut Tomasz A. Leski verfasserin aut Chris R. Taitt verfasserin aut David A. Stenger verfasserin aut Christopher A. Myers verfasserin aut Erin Hansen verfasserin aut Michelle Ricketts verfasserin aut Chelsea Hoegberg verfasserin aut Kamonthip Homdayjanakul verfasserin aut Rashid Ansumana verfasserin aut Joseph M. Lamin verfasserin aut Umaru Bangura verfasserin aut Joseph Lahai verfasserin aut Victoria Baio verfasserin aut Direk Limmathurotsakul verfasserin aut Gumphol Wongsuvan verfasserin aut Viriya Hantrakun verfasserin aut Supaporn Wacharapluesadee verfasserin aut Anek Mungaomklang verfasserin aut Opass Putcharoen verfasserin aut Pratoomtong Yatoom verfasserin aut Kriengsak Kruthakool verfasserin aut Robert D. Hontz verfasserin aut Christopher Mores verfasserin aut Crystyan Siles verfasserin aut Amy Morrison verfasserin aut Mark Mayo verfasserin aut Bart J. Currie verfasserin aut Kathryn H. Jacobsen verfasserin aut Kathleen Quinn verfasserin aut Jerold Blutman verfasserin aut Flavia Amariei verfasserin aut John Hannan verfasserin aut In Sensing and Bio-Sensing Research Elsevier, 2016 20(2018), Seite 22-33 (DE-627)826105408 (DE-600)2821969-7 22141804 nnns volume:20 year:2018 pages:22-33 https://doi.org/10.1016/j.sbsr.2018.06.003 kostenfrei https://doaj.org/article/605f4a559eb742698527fcf3cbfe043a kostenfrei http://www.sciencedirect.com/science/article/pii/S2214180418300412 kostenfrei https://doaj.org/toc/2214-1804 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 20 2018 22-33 |
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10.1016/j.sbsr.2018.06.003 doi (DE-627)DOAJ070933383 (DE-599)DOAJ605f4a559eb742698527fcf3cbfe043a DE-627 ger DE-627 rakwb eng TA1-2040 Shawn P. Mulvaney verfasserin aut Rapid design and fielding of four diagnostic technologies in Sierra Leone, Thailand, Peru, and Australia: Successes and challenges faced introducing these biosensors 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Febrile illnesses are among the most common reasons for visits to hospitals and clinics worldwide. Since fevers can arise from a wide range of diseases, identifying the causative pathogen is essential not only for effective personal treatment but also for early detection of outbreaks. The Defense Threat Reduction Agency (DTRA) tasked a coalition of commercial, academic, and government researchers with moving diagnostic technology concepts from ideation to field use as rapidly as possible using scientifically sound evaluations. DTRA's 24 Month Challenge program examined <30 technologies before fielding four technologies on four continents. <10,000 in field test results were recorded. Here we discuss our tiered evaluation system to assess candidate technologies developed by commercial partners and the process of field testing those technologies at various front-line clinics in Sierra Leone, Thailand, Peru, and Australia. We discuss successes and challenges for introducing two multiplexed lateral flow immunoassay (LFI) tests that detect malaria, dengue fever, melioidosis, and the plague. Additionally we discuss the use of a LFI reader that assisted the interpretation of the assay, communicated results to a data cloud, and greatly facilitated reach-back support. Lastly, we discuss the concurrent field testing of a multiplexed PCR assay on the FilmArray platform, which had an assay pouch specially designed for the 24 Month Challenge. Either standard-of-care or gold-standard testing were run alongside our fielded technologies to benchmark their performance. Keywords: Diagnostic device, Lateral flow immunoassay, Nested PCR, Field testing, Malaria, Dengue fever Engineering (General). Civil engineering (General) Lisa A. Fitzgerald verfasserin aut Leila J. Hamdan verfasserin aut Bradley R. Ringeisen verfasserin aut Emily R. Petersen verfasserin aut Jaimee R. Compton verfasserin aut Nina L. McAuliff verfasserin aut Tomasz A. Leski verfasserin aut Chris R. Taitt verfasserin aut David A. Stenger verfasserin aut Christopher A. Myers verfasserin aut Erin Hansen verfasserin aut Michelle Ricketts verfasserin aut Chelsea Hoegberg verfasserin aut Kamonthip Homdayjanakul verfasserin aut Rashid Ansumana verfasserin aut Joseph M. Lamin verfasserin aut Umaru Bangura verfasserin aut Joseph Lahai verfasserin aut Victoria Baio verfasserin aut Direk Limmathurotsakul verfasserin aut Gumphol Wongsuvan verfasserin aut Viriya Hantrakun verfasserin aut Supaporn Wacharapluesadee verfasserin aut Anek Mungaomklang verfasserin aut Opass Putcharoen verfasserin aut Pratoomtong Yatoom verfasserin aut Kriengsak Kruthakool verfasserin aut Robert D. Hontz verfasserin aut Christopher Mores verfasserin aut Crystyan Siles verfasserin aut Amy Morrison verfasserin aut Mark Mayo verfasserin aut Bart J. Currie verfasserin aut Kathryn H. Jacobsen verfasserin aut Kathleen Quinn verfasserin aut Jerold Blutman verfasserin aut Flavia Amariei verfasserin aut John Hannan verfasserin aut In Sensing and Bio-Sensing Research Elsevier, 2016 20(2018), Seite 22-33 (DE-627)826105408 (DE-600)2821969-7 22141804 nnns volume:20 year:2018 pages:22-33 https://doi.org/10.1016/j.sbsr.2018.06.003 kostenfrei https://doaj.org/article/605f4a559eb742698527fcf3cbfe043a kostenfrei http://www.sciencedirect.com/science/article/pii/S2214180418300412 kostenfrei https://doaj.org/toc/2214-1804 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 20 2018 22-33 |
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Shawn P. Mulvaney @@aut@@ Lisa A. Fitzgerald @@aut@@ Leila J. Hamdan @@aut@@ Bradley R. Ringeisen @@aut@@ Emily R. Petersen @@aut@@ Jaimee R. Compton @@aut@@ Nina L. McAuliff @@aut@@ Tomasz A. Leski @@aut@@ Chris R. Taitt @@aut@@ David A. Stenger @@aut@@ Christopher A. Myers @@aut@@ Erin Hansen @@aut@@ Michelle Ricketts @@aut@@ Chelsea Hoegberg @@aut@@ Kamonthip Homdayjanakul @@aut@@ Rashid Ansumana @@aut@@ Joseph M. Lamin @@aut@@ Umaru Bangura @@aut@@ Joseph Lahai @@aut@@ Victoria Baio @@aut@@ Direk Limmathurotsakul @@aut@@ Gumphol Wongsuvan @@aut@@ Viriya Hantrakun @@aut@@ Supaporn Wacharapluesadee @@aut@@ Anek Mungaomklang @@aut@@ Opass Putcharoen @@aut@@ Pratoomtong Yatoom @@aut@@ Kriengsak Kruthakool @@aut@@ Robert D. Hontz @@aut@@ Christopher Mores @@aut@@ Crystyan Siles @@aut@@ Amy Morrison @@aut@@ Mark Mayo @@aut@@ Bart J. Currie @@aut@@ Kathryn H. Jacobsen @@aut@@ Kathleen Quinn @@aut@@ Jerold Blutman @@aut@@ Flavia Amariei @@aut@@ John Hannan @@aut@@ |
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Shawn P. Mulvaney Lisa A. Fitzgerald Leila J. Hamdan Bradley R. Ringeisen Emily R. Petersen Jaimee R. Compton Nina L. McAuliff Tomasz A. Leski Chris R. Taitt David A. Stenger Christopher A. Myers Erin Hansen Michelle Ricketts Chelsea Hoegberg Kamonthip Homdayjanakul Rashid Ansumana Joseph M. Lamin Umaru Bangura Joseph Lahai Victoria Baio Direk Limmathurotsakul Gumphol Wongsuvan Viriya Hantrakun Supaporn Wacharapluesadee Anek Mungaomklang Opass Putcharoen Pratoomtong Yatoom Kriengsak Kruthakool Robert D. Hontz Christopher Mores Crystyan Siles Amy Morrison Mark Mayo Bart J. Currie Kathryn H. Jacobsen Kathleen Quinn Jerold Blutman Flavia Amariei John Hannan |
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rapid design and fielding of four diagnostic technologies in sierra leone, thailand, peru, and australia: successes and challenges faced introducing these biosensors |
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Rapid design and fielding of four diagnostic technologies in Sierra Leone, Thailand, Peru, and Australia: Successes and challenges faced introducing these biosensors |
abstract |
Febrile illnesses are among the most common reasons for visits to hospitals and clinics worldwide. Since fevers can arise from a wide range of diseases, identifying the causative pathogen is essential not only for effective personal treatment but also for early detection of outbreaks. The Defense Threat Reduction Agency (DTRA) tasked a coalition of commercial, academic, and government researchers with moving diagnostic technology concepts from ideation to field use as rapidly as possible using scientifically sound evaluations. DTRA's 24 Month Challenge program examined <30 technologies before fielding four technologies on four continents. <10,000 in field test results were recorded. Here we discuss our tiered evaluation system to assess candidate technologies developed by commercial partners and the process of field testing those technologies at various front-line clinics in Sierra Leone, Thailand, Peru, and Australia. We discuss successes and challenges for introducing two multiplexed lateral flow immunoassay (LFI) tests that detect malaria, dengue fever, melioidosis, and the plague. Additionally we discuss the use of a LFI reader that assisted the interpretation of the assay, communicated results to a data cloud, and greatly facilitated reach-back support. Lastly, we discuss the concurrent field testing of a multiplexed PCR assay on the FilmArray platform, which had an assay pouch specially designed for the 24 Month Challenge. Either standard-of-care or gold-standard testing were run alongside our fielded technologies to benchmark their performance. Keywords: Diagnostic device, Lateral flow immunoassay, Nested PCR, Field testing, Malaria, Dengue fever |
abstractGer |
Febrile illnesses are among the most common reasons for visits to hospitals and clinics worldwide. Since fevers can arise from a wide range of diseases, identifying the causative pathogen is essential not only for effective personal treatment but also for early detection of outbreaks. The Defense Threat Reduction Agency (DTRA) tasked a coalition of commercial, academic, and government researchers with moving diagnostic technology concepts from ideation to field use as rapidly as possible using scientifically sound evaluations. DTRA's 24 Month Challenge program examined <30 technologies before fielding four technologies on four continents. <10,000 in field test results were recorded. Here we discuss our tiered evaluation system to assess candidate technologies developed by commercial partners and the process of field testing those technologies at various front-line clinics in Sierra Leone, Thailand, Peru, and Australia. We discuss successes and challenges for introducing two multiplexed lateral flow immunoassay (LFI) tests that detect malaria, dengue fever, melioidosis, and the plague. Additionally we discuss the use of a LFI reader that assisted the interpretation of the assay, communicated results to a data cloud, and greatly facilitated reach-back support. Lastly, we discuss the concurrent field testing of a multiplexed PCR assay on the FilmArray platform, which had an assay pouch specially designed for the 24 Month Challenge. Either standard-of-care or gold-standard testing were run alongside our fielded technologies to benchmark their performance. Keywords: Diagnostic device, Lateral flow immunoassay, Nested PCR, Field testing, Malaria, Dengue fever |
abstract_unstemmed |
Febrile illnesses are among the most common reasons for visits to hospitals and clinics worldwide. Since fevers can arise from a wide range of diseases, identifying the causative pathogen is essential not only for effective personal treatment but also for early detection of outbreaks. The Defense Threat Reduction Agency (DTRA) tasked a coalition of commercial, academic, and government researchers with moving diagnostic technology concepts from ideation to field use as rapidly as possible using scientifically sound evaluations. DTRA's 24 Month Challenge program examined <30 technologies before fielding four technologies on four continents. <10,000 in field test results were recorded. Here we discuss our tiered evaluation system to assess candidate technologies developed by commercial partners and the process of field testing those technologies at various front-line clinics in Sierra Leone, Thailand, Peru, and Australia. We discuss successes and challenges for introducing two multiplexed lateral flow immunoassay (LFI) tests that detect malaria, dengue fever, melioidosis, and the plague. Additionally we discuss the use of a LFI reader that assisted the interpretation of the assay, communicated results to a data cloud, and greatly facilitated reach-back support. Lastly, we discuss the concurrent field testing of a multiplexed PCR assay on the FilmArray platform, which had an assay pouch specially designed for the 24 Month Challenge. Either standard-of-care or gold-standard testing were run alongside our fielded technologies to benchmark their performance. Keywords: Diagnostic device, Lateral flow immunoassay, Nested PCR, Field testing, Malaria, Dengue fever |
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title_short |
Rapid design and fielding of four diagnostic technologies in Sierra Leone, Thailand, Peru, and Australia: Successes and challenges faced introducing these biosensors |
url |
https://doi.org/10.1016/j.sbsr.2018.06.003 https://doaj.org/article/605f4a559eb742698527fcf3cbfe043a http://www.sciencedirect.com/science/article/pii/S2214180418300412 https://doaj.org/toc/2214-1804 |
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Lisa A. Fitzgerald Leila J. Hamdan Bradley R. Ringeisen Emily R. Petersen Jaimee R. Compton Nina L. McAuliff Tomasz A. Leski Chris R. Taitt David A. Stenger Christopher A. Myers Erin Hansen Michelle Ricketts Chelsea Hoegberg Kamonthip Homdayjanakul Rashid Ansumana Joseph M. Lamin Umaru Bangura Joseph Lahai Victoria Baio Direk Limmathurotsakul Gumphol Wongsuvan Viriya Hantrakun Supaporn Wacharapluesadee Anek Mungaomklang Opass Putcharoen Pratoomtong Yatoom Kriengsak Kruthakool Robert D. Hontz Christopher Mores Crystyan Siles Amy Morrison Mark Mayo Bart J. Currie Kathryn H. Jacobsen Kathleen Quinn Jerold Blutman Flavia Amariei John Hannan |
author2Str |
Lisa A. Fitzgerald Leila J. Hamdan Bradley R. Ringeisen Emily R. Petersen Jaimee R. Compton Nina L. McAuliff Tomasz A. Leski Chris R. Taitt David A. Stenger Christopher A. Myers Erin Hansen Michelle Ricketts Chelsea Hoegberg Kamonthip Homdayjanakul Rashid Ansumana Joseph M. Lamin Umaru Bangura Joseph Lahai Victoria Baio Direk Limmathurotsakul Gumphol Wongsuvan Viriya Hantrakun Supaporn Wacharapluesadee Anek Mungaomklang Opass Putcharoen Pratoomtong Yatoom Kriengsak Kruthakool Robert D. Hontz Christopher Mores Crystyan Siles Amy Morrison Mark Mayo Bart J. Currie Kathryn H. Jacobsen Kathleen Quinn Jerold Blutman Flavia Amariei John Hannan |
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TA - General and Civil Engineering |
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doi_str |
10.1016/j.sbsr.2018.06.003 |
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TA1-2040 |
up_date |
2024-07-03T17:31:28.626Z |
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|
score |
7.4006386 |