Positive Interaction between H<sub<2</sub<O<sub<2</sub< and Ca<sup<2+</sup< Mediates Melatonin-Induced CBF Pathway and Cold Tolerance in Watermelon (<i<Citrullus lanatus</i< L.)

Cold stress is a major environmental factor that detrimentally affects plant growth and development. Melatonin has been shown to confer plant tolerance to cold stress through activating the C-REPEAT BINDING FACTOR (CBF) pathway; however, the underlying modes that enable this function remain obscure. In this study, we investigated the role of H<sub<2</sub<O<sub<2</sub< and Ca<sup<2+</sup< signaling in the melatonin-induced CBF pathway and cold tolerance in watermelon (<i<Citrullus lanatus</i< L.) through pharmacological, physiological, and genetic approaches. According to the results, melatonin induced H<sub<2</sub<O<sub<2</sub< accumulation, which was associated with the upregulation of <i<respiratory burst oxidase homolog D</i< (<i<ClRBOHD</i<) during the early response to cold stress in watermelon. Besides, melatonin and H<sub<2</sub<O<sub<2</sub< induced the accumulation of cytoplasmic free Ca<sup<2+</sup< ([Ca<sup<2+</sup<]<sub<cyt</sub<) in response to cold. This was associated with the upregulation of <i<cyclic nucleotide-gated ion channel 2</i< (<i<ClCNGC2</i<) in watermelon. However, blocking of Ca<sup<2+</sup< influx channels abolished melatonin- or H<sub<2</sub<O<sub<2</sub<-induced CBF pathway and cold tolerance. Ca<sup<2+</sup< also induced <i<ClRBOHD</i< expression and H<sub<2</sub<O<sub<2</sub< accumulation in early response to cold stress in watermelon. Inhibition of H<sub<2</sub<O<sub<2</sub< production in watermelon by RBOH inhibitor or in Arabidopsis by <i<AtRBOHD</i< knockout compromised melatonin-induced [Ca<sup<2+</sup<]<sub<cyt</sub< accumulation and melatonin- or Ca<sup<2+</sup<-induced CBF pathway and cold tolerance. Overall, these findings indicate that melatonin induces <i<RBOHD</i<-dependent H<sub<2</sub<O<sub<2</sub< generation in early response to cold stress. Increased H<sub<2</sub<O<sub<2</sub< promotes [Ca<sup<2+</sup<]<sub<cyt</sub< accumulation, which in turn induces H<sub<2</sub<O<sub<2</sub< accumulation via <i<RBOHD</i<, forming a reciprocal positive-regulatory loop that mediates melatonin-induced CBF pathway and subsequent cold tolerance. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Jingjing Chang [verfasserIn] Yanliang Guo [verfasserIn] Jiayue Li [verfasserIn] Zhuangzhuang Su [verfasserIn] Chunxia Wang [verfasserIn] Ruimin Zhang [verfasserIn] Chunhua Wei [verfasserIn] Jianxiang Ma [verfasserIn] Xian Zhang [verfasserIn] Hao Li [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	melatonin hydrogen peroxide calcium signal CBF-responsive pathway respiratory burst oxidase homolog D cold stress

Übergeordnetes Werk:	In: Antioxidants - MDPI AG, 2013, 10(2021), 9, p 1457
Übergeordnetes Werk:	volume:10 ; year:2021 ; number:9, p 1457

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/antiox10091457

Katalog-ID:	DOAJ070967083

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245	1	0	\|a Positive Interaction between H<sub<2</sub<O<sub<2</sub< and Ca<sup<2+</sup< Mediates Melatonin-Induced CBF Pathway and Cold Tolerance in Watermelon (<i<Citrullus lanatus</i< L.)
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520			\|a Cold stress is a major environmental factor that detrimentally affects plant growth and development. Melatonin has been shown to confer plant tolerance to cold stress through activating the C-REPEAT BINDING FACTOR (CBF) pathway; however, the underlying modes that enable this function remain obscure. In this study, we investigated the role of H<sub<2</sub<O<sub<2</sub< and Ca<sup<2+</sup< signaling in the melatonin-induced CBF pathway and cold tolerance in watermelon (<i<Citrullus lanatus</i< L.) through pharmacological, physiological, and genetic approaches. According to the results, melatonin induced H<sub<2</sub<O<sub<2</sub< accumulation, which was associated with the upregulation of <i<respiratory burst oxidase homolog D</i< (<i<ClRBOHD</i<) during the early response to cold stress in watermelon. Besides, melatonin and H<sub<2</sub<O<sub<2</sub< induced the accumulation of cytoplasmic free Ca<sup<2+</sup< ([Ca<sup<2+</sup<]<sub<cyt</sub<) in response to cold. This was associated with the upregulation of <i<cyclic nucleotide-gated ion channel 2</i< (<i<ClCNGC2</i<) in watermelon. However, blocking of Ca<sup<2+</sup< influx channels abolished melatonin- or H<sub<2</sub<O<sub<2</sub<-induced CBF pathway and cold tolerance. Ca<sup<2+</sup< also induced <i<ClRBOHD</i< expression and H<sub<2</sub<O<sub<2</sub< accumulation in early response to cold stress in watermelon. Inhibition of H<sub<2</sub<O<sub<2</sub< production in watermelon by RBOH inhibitor or in Arabidopsis by <i<AtRBOHD</i< knockout compromised melatonin-induced [Ca<sup<2+</sup<]<sub<cyt</sub< accumulation and melatonin- or Ca<sup<2+</sup<-induced CBF pathway and cold tolerance. Overall, these findings indicate that melatonin induces <i<RBOHD</i<-dependent H<sub<2</sub<O<sub<2</sub< generation in early response to cold stress. Increased H<sub<2</sub<O<sub<2</sub< promotes [Ca<sup<2+</sup<]<sub<cyt</sub< accumulation, which in turn induces H<sub<2</sub<O<sub<2</sub< accumulation via <i<RBOHD</i<, forming a reciprocal positive-regulatory loop that mediates melatonin-induced CBF pathway and subsequent cold tolerance.
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allfields	10.3390/antiox10091457 doi (DE-627)DOAJ070967083 (DE-599)DOAJ83a35dd80af0428e88d1d676cba183e7 DE-627 ger DE-627 rakwb eng RM1-950 Jingjing Chang verfasserin aut Positive Interaction between H<sub<2</sub<O<sub<2</sub< and Ca<sup<2+</sup< Mediates Melatonin-Induced CBF Pathway and Cold Tolerance in Watermelon (<i<Citrullus lanatus</i< L.) 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cold stress is a major environmental factor that detrimentally affects plant growth and development. Melatonin has been shown to confer plant tolerance to cold stress through activating the C-REPEAT BINDING FACTOR (CBF) pathway; however, the underlying modes that enable this function remain obscure. In this study, we investigated the role of H<sub<2</sub<O<sub<2</sub< and Ca<sup<2+</sup< signaling in the melatonin-induced CBF pathway and cold tolerance in watermelon (<i<Citrullus lanatus</i< L.) through pharmacological, physiological, and genetic approaches. According to the results, melatonin induced H<sub<2</sub<O<sub<2</sub< accumulation, which was associated with the upregulation of <i<respiratory burst oxidase homolog D</i< (<i<ClRBOHD</i<) during the early response to cold stress in watermelon. Besides, melatonin and H<sub<2</sub<O<sub<2</sub< induced the accumulation of cytoplasmic free Ca<sup<2+</sup< ([Ca<sup<2+</sup<]<sub<cyt</sub<) in response to cold. This was associated with the upregulation of <i<cyclic nucleotide-gated ion channel 2</i< (<i<ClCNGC2</i<) in watermelon. However, blocking of Ca<sup<2+</sup< influx channels abolished melatonin- or H<sub<2</sub<O<sub<2</sub<-induced CBF pathway and cold tolerance. Ca<sup<2+</sup< also induced <i<ClRBOHD</i< expression and H<sub<2</sub<O<sub<2</sub< accumulation in early response to cold stress in watermelon. Inhibition of H<sub<2</sub<O<sub<2</sub< production in watermelon by RBOH inhibitor or in Arabidopsis by <i<AtRBOHD</i< knockout compromised melatonin-induced [Ca<sup<2+</sup<]<sub<cyt</sub< accumulation and melatonin- or Ca<sup<2+</sup<-induced CBF pathway and cold tolerance. Overall, these findings indicate that melatonin induces <i<RBOHD</i<-dependent H<sub<2</sub<O<sub<2</sub< generation in early response to cold stress. Increased H<sub<2</sub<O<sub<2</sub< promotes [Ca<sup<2+</sup<]<sub<cyt</sub< accumulation, which in turn induces H<sub<2</sub<O<sub<2</sub< accumulation via <i<RBOHD</i<, forming a reciprocal positive-regulatory loop that mediates melatonin-induced CBF pathway and subsequent cold tolerance. melatonin hydrogen peroxide calcium signal CBF-responsive pathway respiratory burst oxidase homolog D cold stress Therapeutics. Pharmacology Yanliang Guo verfasserin aut Jiayue Li verfasserin aut Zhuangzhuang Su verfasserin aut Chunxia Wang verfasserin aut Ruimin Zhang verfasserin aut Chunhua Wei verfasserin aut Jianxiang Ma verfasserin aut Xian Zhang verfasserin aut Hao Li verfasserin aut In Antioxidants MDPI AG, 2013 10(2021), 9, p 1457 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:10 year:2021 number:9, p 1457 https://doi.org/10.3390/antiox10091457 kostenfrei https://doaj.org/article/83a35dd80af0428e88d1d676cba183e7 kostenfrei https://www.mdpi.com/2076-3921/10/9/1457 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 9, p 1457
spelling	10.3390/antiox10091457 doi (DE-627)DOAJ070967083 (DE-599)DOAJ83a35dd80af0428e88d1d676cba183e7 DE-627 ger DE-627 rakwb eng RM1-950 Jingjing Chang verfasserin aut Positive Interaction between H<sub<2</sub<O<sub<2</sub< and Ca<sup<2+</sup< Mediates Melatonin-Induced CBF Pathway and Cold Tolerance in Watermelon (<i<Citrullus lanatus</i< L.) 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cold stress is a major environmental factor that detrimentally affects plant growth and development. Melatonin has been shown to confer plant tolerance to cold stress through activating the C-REPEAT BINDING FACTOR (CBF) pathway; however, the underlying modes that enable this function remain obscure. In this study, we investigated the role of H<sub<2</sub<O<sub<2</sub< and Ca<sup<2+</sup< signaling in the melatonin-induced CBF pathway and cold tolerance in watermelon (<i<Citrullus lanatus</i< L.) through pharmacological, physiological, and genetic approaches. According to the results, melatonin induced H<sub<2</sub<O<sub<2</sub< accumulation, which was associated with the upregulation of <i<respiratory burst oxidase homolog D</i< (<i<ClRBOHD</i<) during the early response to cold stress in watermelon. Besides, melatonin and H<sub<2</sub<O<sub<2</sub< induced the accumulation of cytoplasmic free Ca<sup<2+</sup< ([Ca<sup<2+</sup<]<sub<cyt</sub<) in response to cold. This was associated with the upregulation of <i<cyclic nucleotide-gated ion channel 2</i< (<i<ClCNGC2</i<) in watermelon. However, blocking of Ca<sup<2+</sup< influx channels abolished melatonin- or H<sub<2</sub<O<sub<2</sub<-induced CBF pathway and cold tolerance. Ca<sup<2+</sup< also induced <i<ClRBOHD</i< expression and H<sub<2</sub<O<sub<2</sub< accumulation in early response to cold stress in watermelon. Inhibition of H<sub<2</sub<O<sub<2</sub< production in watermelon by RBOH inhibitor or in Arabidopsis by <i<AtRBOHD</i< knockout compromised melatonin-induced [Ca<sup<2+</sup<]<sub<cyt</sub< accumulation and melatonin- or Ca<sup<2+</sup<-induced CBF pathway and cold tolerance. Overall, these findings indicate that melatonin induces <i<RBOHD</i<-dependent H<sub<2</sub<O<sub<2</sub< generation in early response to cold stress. Increased H<sub<2</sub<O<sub<2</sub< promotes [Ca<sup<2+</sup<]<sub<cyt</sub< accumulation, which in turn induces H<sub<2</sub<O<sub<2</sub< accumulation via <i<RBOHD</i<, forming a reciprocal positive-regulatory loop that mediates melatonin-induced CBF pathway and subsequent cold tolerance. melatonin hydrogen peroxide calcium signal CBF-responsive pathway respiratory burst oxidase homolog D cold stress Therapeutics. Pharmacology Yanliang Guo verfasserin aut Jiayue Li verfasserin aut Zhuangzhuang Su verfasserin aut Chunxia Wang verfasserin aut Ruimin Zhang verfasserin aut Chunhua Wei verfasserin aut Jianxiang Ma verfasserin aut Xian Zhang verfasserin aut Hao Li verfasserin aut In Antioxidants MDPI AG, 2013 10(2021), 9, p 1457 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:10 year:2021 number:9, p 1457 https://doi.org/10.3390/antiox10091457 kostenfrei https://doaj.org/article/83a35dd80af0428e88d1d676cba183e7 kostenfrei https://www.mdpi.com/2076-3921/10/9/1457 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 9, p 1457
allfields_unstemmed	10.3390/antiox10091457 doi (DE-627)DOAJ070967083 (DE-599)DOAJ83a35dd80af0428e88d1d676cba183e7 DE-627 ger DE-627 rakwb eng RM1-950 Jingjing Chang verfasserin aut Positive Interaction between H<sub<2</sub<O<sub<2</sub< and Ca<sup<2+</sup< Mediates Melatonin-Induced CBF Pathway and Cold Tolerance in Watermelon (<i<Citrullus lanatus</i< L.) 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cold stress is a major environmental factor that detrimentally affects plant growth and development. Melatonin has been shown to confer plant tolerance to cold stress through activating the C-REPEAT BINDING FACTOR (CBF) pathway; however, the underlying modes that enable this function remain obscure. In this study, we investigated the role of H<sub<2</sub<O<sub<2</sub< and Ca<sup<2+</sup< signaling in the melatonin-induced CBF pathway and cold tolerance in watermelon (<i<Citrullus lanatus</i< L.) through pharmacological, physiological, and genetic approaches. According to the results, melatonin induced H<sub<2</sub<O<sub<2</sub< accumulation, which was associated with the upregulation of <i<respiratory burst oxidase homolog D</i< (<i<ClRBOHD</i<) during the early response to cold stress in watermelon. Besides, melatonin and H<sub<2</sub<O<sub<2</sub< induced the accumulation of cytoplasmic free Ca<sup<2+</sup< ([Ca<sup<2+</sup<]<sub<cyt</sub<) in response to cold. This was associated with the upregulation of <i<cyclic nucleotide-gated ion channel 2</i< (<i<ClCNGC2</i<) in watermelon. However, blocking of Ca<sup<2+</sup< influx channels abolished melatonin- or H<sub<2</sub<O<sub<2</sub<-induced CBF pathway and cold tolerance. Ca<sup<2+</sup< also induced <i<ClRBOHD</i< expression and H<sub<2</sub<O<sub<2</sub< accumulation in early response to cold stress in watermelon. Inhibition of H<sub<2</sub<O<sub<2</sub< production in watermelon by RBOH inhibitor or in Arabidopsis by <i<AtRBOHD</i< knockout compromised melatonin-induced [Ca<sup<2+</sup<]<sub<cyt</sub< accumulation and melatonin- or Ca<sup<2+</sup<-induced CBF pathway and cold tolerance. Overall, these findings indicate that melatonin induces <i<RBOHD</i<-dependent H<sub<2</sub<O<sub<2</sub< generation in early response to cold stress. Increased H<sub<2</sub<O<sub<2</sub< promotes [Ca<sup<2+</sup<]<sub<cyt</sub< accumulation, which in turn induces H<sub<2</sub<O<sub<2</sub< accumulation via <i<RBOHD</i<, forming a reciprocal positive-regulatory loop that mediates melatonin-induced CBF pathway and subsequent cold tolerance. melatonin hydrogen peroxide calcium signal CBF-responsive pathway respiratory burst oxidase homolog D cold stress Therapeutics. Pharmacology Yanliang Guo verfasserin aut Jiayue Li verfasserin aut Zhuangzhuang Su verfasserin aut Chunxia Wang verfasserin aut Ruimin Zhang verfasserin aut Chunhua Wei verfasserin aut Jianxiang Ma verfasserin aut Xian Zhang verfasserin aut Hao Li verfasserin aut In Antioxidants MDPI AG, 2013 10(2021), 9, p 1457 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:10 year:2021 number:9, p 1457 https://doi.org/10.3390/antiox10091457 kostenfrei https://doaj.org/article/83a35dd80af0428e88d1d676cba183e7 kostenfrei https://www.mdpi.com/2076-3921/10/9/1457 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 9, p 1457
allfieldsGer	10.3390/antiox10091457 doi (DE-627)DOAJ070967083 (DE-599)DOAJ83a35dd80af0428e88d1d676cba183e7 DE-627 ger DE-627 rakwb eng RM1-950 Jingjing Chang verfasserin aut Positive Interaction between H<sub<2</sub<O<sub<2</sub< and Ca<sup<2+</sup< Mediates Melatonin-Induced CBF Pathway and Cold Tolerance in Watermelon (<i<Citrullus lanatus</i< L.) 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cold stress is a major environmental factor that detrimentally affects plant growth and development. Melatonin has been shown to confer plant tolerance to cold stress through activating the C-REPEAT BINDING FACTOR (CBF) pathway; however, the underlying modes that enable this function remain obscure. In this study, we investigated the role of H<sub<2</sub<O<sub<2</sub< and Ca<sup<2+</sup< signaling in the melatonin-induced CBF pathway and cold tolerance in watermelon (<i<Citrullus lanatus</i< L.) through pharmacological, physiological, and genetic approaches. According to the results, melatonin induced H<sub<2</sub<O<sub<2</sub< accumulation, which was associated with the upregulation of <i<respiratory burst oxidase homolog D</i< (<i<ClRBOHD</i<) during the early response to cold stress in watermelon. Besides, melatonin and H<sub<2</sub<O<sub<2</sub< induced the accumulation of cytoplasmic free Ca<sup<2+</sup< ([Ca<sup<2+</sup<]<sub<cyt</sub<) in response to cold. This was associated with the upregulation of <i<cyclic nucleotide-gated ion channel 2</i< (<i<ClCNGC2</i<) in watermelon. However, blocking of Ca<sup<2+</sup< influx channels abolished melatonin- or H<sub<2</sub<O<sub<2</sub<-induced CBF pathway and cold tolerance. Ca<sup<2+</sup< also induced <i<ClRBOHD</i< expression and H<sub<2</sub<O<sub<2</sub< accumulation in early response to cold stress in watermelon. Inhibition of H<sub<2</sub<O<sub<2</sub< production in watermelon by RBOH inhibitor or in Arabidopsis by <i<AtRBOHD</i< knockout compromised melatonin-induced [Ca<sup<2+</sup<]<sub<cyt</sub< accumulation and melatonin- or Ca<sup<2+</sup<-induced CBF pathway and cold tolerance. Overall, these findings indicate that melatonin induces <i<RBOHD</i<-dependent H<sub<2</sub<O<sub<2</sub< generation in early response to cold stress. Increased H<sub<2</sub<O<sub<2</sub< promotes [Ca<sup<2+</sup<]<sub<cyt</sub< accumulation, which in turn induces H<sub<2</sub<O<sub<2</sub< accumulation via <i<RBOHD</i<, forming a reciprocal positive-regulatory loop that mediates melatonin-induced CBF pathway and subsequent cold tolerance. melatonin hydrogen peroxide calcium signal CBF-responsive pathway respiratory burst oxidase homolog D cold stress Therapeutics. Pharmacology Yanliang Guo verfasserin aut Jiayue Li verfasserin aut Zhuangzhuang Su verfasserin aut Chunxia Wang verfasserin aut Ruimin Zhang verfasserin aut Chunhua Wei verfasserin aut Jianxiang Ma verfasserin aut Xian Zhang verfasserin aut Hao Li verfasserin aut In Antioxidants MDPI AG, 2013 10(2021), 9, p 1457 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:10 year:2021 number:9, p 1457 https://doi.org/10.3390/antiox10091457 kostenfrei https://doaj.org/article/83a35dd80af0428e88d1d676cba183e7 kostenfrei https://www.mdpi.com/2076-3921/10/9/1457 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 9, p 1457
allfieldsSound	10.3390/antiox10091457 doi (DE-627)DOAJ070967083 (DE-599)DOAJ83a35dd80af0428e88d1d676cba183e7 DE-627 ger DE-627 rakwb eng RM1-950 Jingjing Chang verfasserin aut Positive Interaction between H<sub<2</sub<O<sub<2</sub< and Ca<sup<2+</sup< Mediates Melatonin-Induced CBF Pathway and Cold Tolerance in Watermelon (<i<Citrullus lanatus</i< L.) 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cold stress is a major environmental factor that detrimentally affects plant growth and development. Melatonin has been shown to confer plant tolerance to cold stress through activating the C-REPEAT BINDING FACTOR (CBF) pathway; however, the underlying modes that enable this function remain obscure. In this study, we investigated the role of H<sub<2</sub<O<sub<2</sub< and Ca<sup<2+</sup< signaling in the melatonin-induced CBF pathway and cold tolerance in watermelon (<i<Citrullus lanatus</i< L.) through pharmacological, physiological, and genetic approaches. According to the results, melatonin induced H<sub<2</sub<O<sub<2</sub< accumulation, which was associated with the upregulation of <i<respiratory burst oxidase homolog D</i< (<i<ClRBOHD</i<) during the early response to cold stress in watermelon. Besides, melatonin and H<sub<2</sub<O<sub<2</sub< induced the accumulation of cytoplasmic free Ca<sup<2+</sup< ([Ca<sup<2+</sup<]<sub<cyt</sub<) in response to cold. This was associated with the upregulation of <i<cyclic nucleotide-gated ion channel 2</i< (<i<ClCNGC2</i<) in watermelon. However, blocking of Ca<sup<2+</sup< influx channels abolished melatonin- or H<sub<2</sub<O<sub<2</sub<-induced CBF pathway and cold tolerance. Ca<sup<2+</sup< also induced <i<ClRBOHD</i< expression and H<sub<2</sub<O<sub<2</sub< accumulation in early response to cold stress in watermelon. Inhibition of H<sub<2</sub<O<sub<2</sub< production in watermelon by RBOH inhibitor or in Arabidopsis by <i<AtRBOHD</i< knockout compromised melatonin-induced [Ca<sup<2+</sup<]<sub<cyt</sub< accumulation and melatonin- or Ca<sup<2+</sup<-induced CBF pathway and cold tolerance. Overall, these findings indicate that melatonin induces <i<RBOHD</i<-dependent H<sub<2</sub<O<sub<2</sub< generation in early response to cold stress. Increased H<sub<2</sub<O<sub<2</sub< promotes [Ca<sup<2+</sup<]<sub<cyt</sub< accumulation, which in turn induces H<sub<2</sub<O<sub<2</sub< accumulation via <i<RBOHD</i<, forming a reciprocal positive-regulatory loop that mediates melatonin-induced CBF pathway and subsequent cold tolerance. melatonin hydrogen peroxide calcium signal CBF-responsive pathway respiratory burst oxidase homolog D cold stress Therapeutics. Pharmacology Yanliang Guo verfasserin aut Jiayue Li verfasserin aut Zhuangzhuang Su verfasserin aut Chunxia Wang verfasserin aut Ruimin Zhang verfasserin aut Chunhua Wei verfasserin aut Jianxiang Ma verfasserin aut Xian Zhang verfasserin aut Hao Li verfasserin aut In Antioxidants MDPI AG, 2013 10(2021), 9, p 1457 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:10 year:2021 number:9, p 1457 https://doi.org/10.3390/antiox10091457 kostenfrei https://doaj.org/article/83a35dd80af0428e88d1d676cba183e7 kostenfrei https://www.mdpi.com/2076-3921/10/9/1457 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 9, p 1457
language	English
source	In Antioxidants 10(2021), 9, p 1457 volume:10 year:2021 number:9, p 1457
sourceStr	In Antioxidants 10(2021), 9, p 1457 volume:10 year:2021 number:9, p 1457
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	melatonin hydrogen peroxide calcium signal CBF-responsive pathway respiratory burst oxidase homolog D cold stress Therapeutics. Pharmacology
isfreeaccess_bool	true
container_title	Antioxidants
authorswithroles_txt_mv	Jingjing Chang @@aut@@ Yanliang Guo @@aut@@ Jiayue Li @@aut@@ Zhuangzhuang Su @@aut@@ Chunxia Wang @@aut@@ Ruimin Zhang @@aut@@ Chunhua Wei @@aut@@ Jianxiang Ma @@aut@@ Xian Zhang @@aut@@ Hao Li @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	737287578
id	DOAJ070967083
language_de	englisch
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Melatonin has been shown to confer plant tolerance to cold stress through activating the C-REPEAT BINDING FACTOR (CBF) pathway; however, the underlying modes that enable this function remain obscure. In this study, we investigated the role of H<sub<2</sub<O<sub<2</sub< and Ca<sup<2+</sup< signaling in the melatonin-induced CBF pathway and cold tolerance in watermelon (<i<Citrullus lanatus</i< L.) through pharmacological, physiological, and genetic approaches. According to the results, melatonin induced H<sub<2</sub<O<sub<2</sub< accumulation, which was associated with the upregulation of <i<respiratory burst oxidase homolog D</i< (<i<ClRBOHD</i<) during the early response to cold stress in watermelon. Besides, melatonin and H<sub<2</sub<O<sub<2</sub< induced the accumulation of cytoplasmic free Ca<sup<2+</sup< ([Ca<sup<2+</sup<]<sub<cyt</sub<) in response to cold. This was associated with the upregulation of <i<cyclic nucleotide-gated ion channel 2</i< (<i<ClCNGC2</i<) in watermelon. 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callnumber-first	R - Medicine
author	Jingjing Chang
spellingShingle	Jingjing Chang misc RM1-950 misc melatonin misc hydrogen peroxide misc calcium signal misc CBF-responsive pathway misc respiratory burst oxidase homolog D misc cold stress misc Therapeutics. Pharmacology Positive Interaction between H<sub<2</sub<O<sub<2</sub< and Ca<sup<2+</sup< Mediates Melatonin-Induced CBF Pathway and Cold Tolerance in Watermelon (<i<Citrullus lanatus</i< L.)
authorStr	Jingjing Chang
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topic_title	RM1-950 Positive Interaction between H<sub<2</sub<O<sub<2</sub< and Ca<sup<2+</sup< Mediates Melatonin-Induced CBF Pathway and Cold Tolerance in Watermelon (<i<Citrullus lanatus</i< L.) melatonin hydrogen peroxide calcium signal CBF-responsive pathway respiratory burst oxidase homolog D cold stress
topic	misc RM1-950 misc melatonin misc hydrogen peroxide misc calcium signal misc CBF-responsive pathway misc respiratory burst oxidase homolog D misc cold stress misc Therapeutics. Pharmacology
topic_unstemmed	misc RM1-950 misc melatonin misc hydrogen peroxide misc calcium signal misc CBF-responsive pathway misc respiratory burst oxidase homolog D misc cold stress misc Therapeutics. Pharmacology
topic_browse	misc RM1-950 misc melatonin misc hydrogen peroxide misc calcium signal misc CBF-responsive pathway misc respiratory burst oxidase homolog D misc cold stress misc Therapeutics. Pharmacology
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title	Positive Interaction between H<sub<2</sub<O<sub<2</sub< and Ca<sup<2+</sup< Mediates Melatonin-Induced CBF Pathway and Cold Tolerance in Watermelon (<i<Citrullus lanatus</i< L.)
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title_full	Positive Interaction between H<sub<2</sub<O<sub<2</sub< and Ca<sup<2+</sup< Mediates Melatonin-Induced CBF Pathway and Cold Tolerance in Watermelon (<i<Citrullus lanatus</i< L.)
author_sort	Jingjing Chang
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author_browse	Jingjing Chang Yanliang Guo Jiayue Li Zhuangzhuang Su Chunxia Wang Ruimin Zhang Chunhua Wei Jianxiang Ma Xian Zhang Hao Li
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author-letter	Jingjing Chang
doi_str_mv	10.3390/antiox10091457
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title_sort	positive interaction between h<sub<2</sub<o<sub<2</sub< and ca<sup<2+</sup< mediates melatonin-induced cbf pathway and cold tolerance in watermelon (<i<citrullus lanatus</i< l.)
callnumber	RM1-950
title_auth	Positive Interaction between H<sub<2</sub<O<sub<2</sub< and Ca<sup<2+</sup< Mediates Melatonin-Induced CBF Pathway and Cold Tolerance in Watermelon (<i<Citrullus lanatus</i< L.)
abstract	Cold stress is a major environmental factor that detrimentally affects plant growth and development. Melatonin has been shown to confer plant tolerance to cold stress through activating the C-REPEAT BINDING FACTOR (CBF) pathway; however, the underlying modes that enable this function remain obscure. In this study, we investigated the role of H<sub<2</sub<O<sub<2</sub< and Ca<sup<2+</sup< signaling in the melatonin-induced CBF pathway and cold tolerance in watermelon (<i<Citrullus lanatus</i< L.) through pharmacological, physiological, and genetic approaches. According to the results, melatonin induced H<sub<2</sub<O<sub<2</sub< accumulation, which was associated with the upregulation of <i<respiratory burst oxidase homolog D</i< (<i<ClRBOHD</i<) during the early response to cold stress in watermelon. Besides, melatonin and H<sub<2</sub<O<sub<2</sub< induced the accumulation of cytoplasmic free Ca<sup<2+</sup< ([Ca<sup<2+</sup<]<sub<cyt</sub<) in response to cold. This was associated with the upregulation of <i<cyclic nucleotide-gated ion channel 2</i< (<i<ClCNGC2</i<) in watermelon. However, blocking of Ca<sup<2+</sup< influx channels abolished melatonin- or H<sub<2</sub<O<sub<2</sub<-induced CBF pathway and cold tolerance. Ca<sup<2+</sup< also induced <i<ClRBOHD</i< expression and H<sub<2</sub<O<sub<2</sub< accumulation in early response to cold stress in watermelon. Inhibition of H<sub<2</sub<O<sub<2</sub< production in watermelon by RBOH inhibitor or in Arabidopsis by <i<AtRBOHD</i< knockout compromised melatonin-induced [Ca<sup<2+</sup<]<sub<cyt</sub< accumulation and melatonin- or Ca<sup<2+</sup<-induced CBF pathway and cold tolerance. Overall, these findings indicate that melatonin induces <i<RBOHD</i<-dependent H<sub<2</sub<O<sub<2</sub< generation in early response to cold stress. Increased H<sub<2</sub<O<sub<2</sub< promotes [Ca<sup<2+</sup<]<sub<cyt</sub< accumulation, which in turn induces H<sub<2</sub<O<sub<2</sub< accumulation via <i<RBOHD</i<, forming a reciprocal positive-regulatory loop that mediates melatonin-induced CBF pathway and subsequent cold tolerance.
abstractGer	Cold stress is a major environmental factor that detrimentally affects plant growth and development. Melatonin has been shown to confer plant tolerance to cold stress through activating the C-REPEAT BINDING FACTOR (CBF) pathway; however, the underlying modes that enable this function remain obscure. In this study, we investigated the role of H<sub<2</sub<O<sub<2</sub< and Ca<sup<2+</sup< signaling in the melatonin-induced CBF pathway and cold tolerance in watermelon (<i<Citrullus lanatus</i< L.) through pharmacological, physiological, and genetic approaches. According to the results, melatonin induced H<sub<2</sub<O<sub<2</sub< accumulation, which was associated with the upregulation of <i<respiratory burst oxidase homolog D</i< (<i<ClRBOHD</i<) during the early response to cold stress in watermelon. Besides, melatonin and H<sub<2</sub<O<sub<2</sub< induced the accumulation of cytoplasmic free Ca<sup<2+</sup< ([Ca<sup<2+</sup<]<sub<cyt</sub<) in response to cold. This was associated with the upregulation of <i<cyclic nucleotide-gated ion channel 2</i< (<i<ClCNGC2</i<) in watermelon. However, blocking of Ca<sup<2+</sup< influx channels abolished melatonin- or H<sub<2</sub<O<sub<2</sub<-induced CBF pathway and cold tolerance. Ca<sup<2+</sup< also induced <i<ClRBOHD</i< expression and H<sub<2</sub<O<sub<2</sub< accumulation in early response to cold stress in watermelon. Inhibition of H<sub<2</sub<O<sub<2</sub< production in watermelon by RBOH inhibitor or in Arabidopsis by <i<AtRBOHD</i< knockout compromised melatonin-induced [Ca<sup<2+</sup<]<sub<cyt</sub< accumulation and melatonin- or Ca<sup<2+</sup<-induced CBF pathway and cold tolerance. Overall, these findings indicate that melatonin induces <i<RBOHD</i<-dependent H<sub<2</sub<O<sub<2</sub< generation in early response to cold stress. Increased H<sub<2</sub<O<sub<2</sub< promotes [Ca<sup<2+</sup<]<sub<cyt</sub< accumulation, which in turn induces H<sub<2</sub<O<sub<2</sub< accumulation via <i<RBOHD</i<, forming a reciprocal positive-regulatory loop that mediates melatonin-induced CBF pathway and subsequent cold tolerance.
abstract_unstemmed	Cold stress is a major environmental factor that detrimentally affects plant growth and development. Melatonin has been shown to confer plant tolerance to cold stress through activating the C-REPEAT BINDING FACTOR (CBF) pathway; however, the underlying modes that enable this function remain obscure. In this study, we investigated the role of H<sub<2</sub<O<sub<2</sub< and Ca<sup<2+</sup< signaling in the melatonin-induced CBF pathway and cold tolerance in watermelon (<i<Citrullus lanatus</i< L.) through pharmacological, physiological, and genetic approaches. According to the results, melatonin induced H<sub<2</sub<O<sub<2</sub< accumulation, which was associated with the upregulation of <i<respiratory burst oxidase homolog D</i< (<i<ClRBOHD</i<) during the early response to cold stress in watermelon. Besides, melatonin and H<sub<2</sub<O<sub<2</sub< induced the accumulation of cytoplasmic free Ca<sup<2+</sup< ([Ca<sup<2+</sup<]<sub<cyt</sub<) in response to cold. This was associated with the upregulation of <i<cyclic nucleotide-gated ion channel 2</i< (<i<ClCNGC2</i<) in watermelon. However, blocking of Ca<sup<2+</sup< influx channels abolished melatonin- or H<sub<2</sub<O<sub<2</sub<-induced CBF pathway and cold tolerance. Ca<sup<2+</sup< also induced <i<ClRBOHD</i< expression and H<sub<2</sub<O<sub<2</sub< accumulation in early response to cold stress in watermelon. Inhibition of H<sub<2</sub<O<sub<2</sub< production in watermelon by RBOH inhibitor or in Arabidopsis by <i<AtRBOHD</i< knockout compromised melatonin-induced [Ca<sup<2+</sup<]<sub<cyt</sub< accumulation and melatonin- or Ca<sup<2+</sup<-induced CBF pathway and cold tolerance. Overall, these findings indicate that melatonin induces <i<RBOHD</i<-dependent H<sub<2</sub<O<sub<2</sub< generation in early response to cold stress. Increased H<sub<2</sub<O<sub<2</sub< promotes [Ca<sup<2+</sup<]<sub<cyt</sub< accumulation, which in turn induces H<sub<2</sub<O<sub<2</sub< accumulation via <i<RBOHD</i<, forming a reciprocal positive-regulatory loop that mediates melatonin-induced CBF pathway and subsequent cold tolerance.
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container_issue	9, p 1457
title_short	Positive Interaction between H<sub<2</sub<O<sub<2</sub< and Ca<sup<2+</sup< Mediates Melatonin-Induced CBF Pathway and Cold Tolerance in Watermelon (<i<Citrullus lanatus</i< L.)
url	https://doi.org/10.3390/antiox10091457 https://doaj.org/article/83a35dd80af0428e88d1d676cba183e7 https://www.mdpi.com/2076-3921/10/9/1457 https://doaj.org/toc/2076-3921
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Positive Interaction between H<sub<2</sub<O<sub<2</sub< and Ca<sup<2+</sup< Mediates Melatonin-Induced CBF Pathway and Cold Tolerance in Watermelon (<i<Citrullus lanatus</i< L.)

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