Shared ancestral susceptibility to colorectal cancer and other nutrition related diseases

<p<Abstract</p< <p<Background</p< <p<The majority of non-syndromic colorectal cancers (CRCs) can be described as a complex disease. A two-stage case–control study on CRC susceptibility was conducted to assess the influence of the ancestral alleles in the polymorphisms previously associated with nutrition-related complex diseases.</p< <p<Methods</p< <p<In stage I, 28 single nucleotide polymorphisms (SNPs) were genotyped in a hospital-based Czech population (1025 CRC cases, 787 controls) using an allele-specific PCR-based genotyping system (KASPar®). In stage II, replication was carried out for the five SNPs with the lowest p values. The replication set consisted of 1798 CRC cases and 1810 controls from a population-based German study (DACHS). Odds ratios (ORs) and 95% confidence intervals (CIs) for associations between genotypes and CRC risk were estimated using logistic regression. To identify signatures of selection, Fay-Wu’s H and Integrated Haplotype Score (iHS) were estimated.</p< <p<Results</p< <p<In the Czech population, carriers of the ancestral alleles of <it<AGT</it< rs699 and <it<CYP3A7</it< rs10211 showed an increased risk of CRC (OR 1.26 and 1.38, respectively; two-sided p≤0.05), whereas carriers of the ancestral allele of <it<ENPP1</it< rs1044498 had a decreased risk (OR 0.79; p≤0.05). For rs1044498, the strongest association was detected in the Czech male subpopulation (OR 0.61; p=0.0015). The associations were not replicated in the German population. Signatures of selection were found for all three analyzed genes.</p< <p<Conclusions</p< <p<Our study showed evidence of association for the ancestral alleles of polymorphisms in AGT and CYP3A7 and for the derived allele of a polymorphism in ENPP1 with an increased risk of CRC in Czechs, but not in Germans. The ancestral alleles of these SNPs have previously been associated with nutrition-related diseases hypertension (AGT and CYP3A7) and insulin resistance (ENPP1). Future studies may shed light on the complex genetic and environmental interactions between different types of nutrition-related diseases.</p< Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Huhn Stefanie [verfasserIn] Bevier Melanie [verfasserIn] Rudolph Anja [verfasserIn] Pardini Barbara [verfasserIn] Naccarati Alessio [verfasserIn] Hein Rebecca [verfasserIn] Hoffmeister Michael [verfasserIn] Vodickova Ludmila [verfasserIn] Novotny Jan [verfasserIn] Brenner Hermann [verfasserIn] Chang-Claude Jenny [verfasserIn] Hemminki Kari [verfasserIn] Vodicka Pavel [verfasserIn] Försti Asta [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2012

Schlagwörter:	Colorectal cancer Nutrition Complex diseases

Übergeordnetes Werk:	In: BMC Medical Genetics - BMC, 2003, 13(2012), 1, p 94
Übergeordnetes Werk:	volume:13 ; year:2012 ; number:1, p 94

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/1471-2350-13-94

Katalog-ID:	DOAJ071010114

Internformat


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520			\|a <p<Abstract</p< <p<Background</p< <p<The majority of non-syndromic colorectal cancers (CRCs) can be described as a complex disease. A two-stage case–control study on CRC susceptibility was conducted to assess the influence of the ancestral alleles in the polymorphisms previously associated with nutrition-related complex diseases.</p< <p<Methods</p< <p<In stage I, 28 single nucleotide polymorphisms (SNPs) were genotyped in a hospital-based Czech population (1025 CRC cases, 787 controls) using an allele-specific PCR-based genotyping system (KASPar®). In stage II, replication was carried out for the five SNPs with the lowest p values. The replication set consisted of 1798 CRC cases and 1810 controls from a population-based German study (DACHS). Odds ratios (ORs) and 95% confidence intervals (CIs) for associations between genotypes and CRC risk were estimated using logistic regression. To identify signatures of selection, Fay-Wu’s H and Integrated Haplotype Score (iHS) were estimated.</p< <p<Results</p< <p<In the Czech population, carriers of the ancestral alleles of <it<AGT</it< rs699 and <it<CYP3A7</it< rs10211 showed an increased risk of CRC (OR 1.26 and 1.38, respectively; two-sided p≤0.05), whereas carriers of the ancestral allele of <it<ENPP1</it< rs1044498 had a decreased risk (OR 0.79; p≤0.05). For rs1044498, the strongest association was detected in the Czech male subpopulation (OR 0.61; p=0.0015). The associations were not replicated in the German population. Signatures of selection were found for all three analyzed genes.</p< <p<Conclusions</p< <p<Our study showed evidence of association for the ancestral alleles of polymorphisms in AGT and CYP3A7 and for the derived allele of a polymorphism in ENPP1 with an increased risk of CRC in Czechs, but not in Germans. The ancestral alleles of these SNPs have previously been associated with nutrition-related diseases hypertension (AGT and CYP3A7) and insulin resistance (ENPP1). Future studies may shed light on the complex genetic and environmental interactions between different types of nutrition-related diseases.</p<
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650		4	\|a Nutrition
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700	0		\|a Hein Rebecca \|e verfasserin \|4 aut
700	0		\|a Hoffmeister Michael \|e verfasserin \|4 aut
700	0		\|a Vodickova Ludmila \|e verfasserin \|4 aut
700	0		\|a Novotny Jan \|e verfasserin \|4 aut
700	0		\|a Brenner Hermann \|e verfasserin \|4 aut
700	0		\|a Chang-Claude Jenny \|e verfasserin \|4 aut
700	0		\|a Hemminki Kari \|e verfasserin \|4 aut
700	0		\|a Vodicka Pavel \|e verfasserin \|4 aut
700	0		\|a Försti Asta \|e verfasserin \|4 aut
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allfields	10.1186/1471-2350-13-94 doi (DE-627)DOAJ071010114 (DE-599)DOAJf8330a728c834d10a116c3fa0b5de766 DE-627 ger DE-627 rakwb eng RC31-1245 QH426-470 Huhn Stefanie verfasserin aut Shared ancestral susceptibility to colorectal cancer and other nutrition related diseases 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The majority of non-syndromic colorectal cancers (CRCs) can be described as a complex disease. A two-stage case–control study on CRC susceptibility was conducted to assess the influence of the ancestral alleles in the polymorphisms previously associated with nutrition-related complex diseases.</p< <p<Methods</p< <p<In stage I, 28 single nucleotide polymorphisms (SNPs) were genotyped in a hospital-based Czech population (1025 CRC cases, 787 controls) using an allele-specific PCR-based genotyping system (KASPar®). In stage II, replication was carried out for the five SNPs with the lowest p values. The replication set consisted of 1798 CRC cases and 1810 controls from a population-based German study (DACHS). Odds ratios (ORs) and 95% confidence intervals (CIs) for associations between genotypes and CRC risk were estimated using logistic regression. To identify signatures of selection, Fay-Wu’s H and Integrated Haplotype Score (iHS) were estimated.</p< <p<Results</p< <p<In the Czech population, carriers of the ancestral alleles of <it<AGT</it< rs699 and <it<CYP3A7</it< rs10211 showed an increased risk of CRC (OR 1.26 and 1.38, respectively; two-sided p≤0.05), whereas carriers of the ancestral allele of <it<ENPP1</it< rs1044498 had a decreased risk (OR 0.79; p≤0.05). For rs1044498, the strongest association was detected in the Czech male subpopulation (OR 0.61; p=0.0015). The associations were not replicated in the German population. Signatures of selection were found for all three analyzed genes.</p< <p<Conclusions</p< <p<Our study showed evidence of association for the ancestral alleles of polymorphisms in AGT and CYP3A7 and for the derived allele of a polymorphism in ENPP1 with an increased risk of CRC in Czechs, but not in Germans. The ancestral alleles of these SNPs have previously been associated with nutrition-related diseases hypertension (AGT and CYP3A7) and insulin resistance (ENPP1). Future studies may shed light on the complex genetic and environmental interactions between different types of nutrition-related diseases.</p< Colorectal cancer Nutrition Complex diseases Internal medicine Genetics Bevier Melanie verfasserin aut Rudolph Anja verfasserin aut Pardini Barbara verfasserin aut Naccarati Alessio verfasserin aut Hein Rebecca verfasserin aut Hoffmeister Michael verfasserin aut Vodickova Ludmila verfasserin aut Novotny Jan verfasserin aut Brenner Hermann verfasserin aut Chang-Claude Jenny verfasserin aut Hemminki Kari verfasserin aut Vodicka Pavel verfasserin aut Försti Asta verfasserin aut In BMC Medical Genetics BMC, 2003 13(2012), 1, p 94 (DE-627)326643788 (DE-600)2041359-2 14712350 nnns volume:13 year:2012 number:1, p 94 https://doi.org/10.1186/1471-2350-13-94 kostenfrei https://doaj.org/article/f8330a728c834d10a116c3fa0b5de766 kostenfrei http://www.biomedcentral.com/1471-2350/13/94 kostenfrei https://doaj.org/toc/1471-2350 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2012 1, p 94
spelling	10.1186/1471-2350-13-94 doi (DE-627)DOAJ071010114 (DE-599)DOAJf8330a728c834d10a116c3fa0b5de766 DE-627 ger DE-627 rakwb eng RC31-1245 QH426-470 Huhn Stefanie verfasserin aut Shared ancestral susceptibility to colorectal cancer and other nutrition related diseases 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The majority of non-syndromic colorectal cancers (CRCs) can be described as a complex disease. A two-stage case–control study on CRC susceptibility was conducted to assess the influence of the ancestral alleles in the polymorphisms previously associated with nutrition-related complex diseases.</p< <p<Methods</p< <p<In stage I, 28 single nucleotide polymorphisms (SNPs) were genotyped in a hospital-based Czech population (1025 CRC cases, 787 controls) using an allele-specific PCR-based genotyping system (KASPar®). In stage II, replication was carried out for the five SNPs with the lowest p values. The replication set consisted of 1798 CRC cases and 1810 controls from a population-based German study (DACHS). Odds ratios (ORs) and 95% confidence intervals (CIs) for associations between genotypes and CRC risk were estimated using logistic regression. To identify signatures of selection, Fay-Wu’s H and Integrated Haplotype Score (iHS) were estimated.</p< <p<Results</p< <p<In the Czech population, carriers of the ancestral alleles of <it<AGT</it< rs699 and <it<CYP3A7</it< rs10211 showed an increased risk of CRC (OR 1.26 and 1.38, respectively; two-sided p≤0.05), whereas carriers of the ancestral allele of <it<ENPP1</it< rs1044498 had a decreased risk (OR 0.79; p≤0.05). For rs1044498, the strongest association was detected in the Czech male subpopulation (OR 0.61; p=0.0015). The associations were not replicated in the German population. Signatures of selection were found for all three analyzed genes.</p< <p<Conclusions</p< <p<Our study showed evidence of association for the ancestral alleles of polymorphisms in AGT and CYP3A7 and for the derived allele of a polymorphism in ENPP1 with an increased risk of CRC in Czechs, but not in Germans. The ancestral alleles of these SNPs have previously been associated with nutrition-related diseases hypertension (AGT and CYP3A7) and insulin resistance (ENPP1). Future studies may shed light on the complex genetic and environmental interactions between different types of nutrition-related diseases.</p< Colorectal cancer Nutrition Complex diseases Internal medicine Genetics Bevier Melanie verfasserin aut Rudolph Anja verfasserin aut Pardini Barbara verfasserin aut Naccarati Alessio verfasserin aut Hein Rebecca verfasserin aut Hoffmeister Michael verfasserin aut Vodickova Ludmila verfasserin aut Novotny Jan verfasserin aut Brenner Hermann verfasserin aut Chang-Claude Jenny verfasserin aut Hemminki Kari verfasserin aut Vodicka Pavel verfasserin aut Försti Asta verfasserin aut In BMC Medical Genetics BMC, 2003 13(2012), 1, p 94 (DE-627)326643788 (DE-600)2041359-2 14712350 nnns volume:13 year:2012 number:1, p 94 https://doi.org/10.1186/1471-2350-13-94 kostenfrei https://doaj.org/article/f8330a728c834d10a116c3fa0b5de766 kostenfrei http://www.biomedcentral.com/1471-2350/13/94 kostenfrei https://doaj.org/toc/1471-2350 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2012 1, p 94
allfields_unstemmed	10.1186/1471-2350-13-94 doi (DE-627)DOAJ071010114 (DE-599)DOAJf8330a728c834d10a116c3fa0b5de766 DE-627 ger DE-627 rakwb eng RC31-1245 QH426-470 Huhn Stefanie verfasserin aut Shared ancestral susceptibility to colorectal cancer and other nutrition related diseases 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The majority of non-syndromic colorectal cancers (CRCs) can be described as a complex disease. A two-stage case–control study on CRC susceptibility was conducted to assess the influence of the ancestral alleles in the polymorphisms previously associated with nutrition-related complex diseases.</p< <p<Methods</p< <p<In stage I, 28 single nucleotide polymorphisms (SNPs) were genotyped in a hospital-based Czech population (1025 CRC cases, 787 controls) using an allele-specific PCR-based genotyping system (KASPar®). In stage II, replication was carried out for the five SNPs with the lowest p values. The replication set consisted of 1798 CRC cases and 1810 controls from a population-based German study (DACHS). Odds ratios (ORs) and 95% confidence intervals (CIs) for associations between genotypes and CRC risk were estimated using logistic regression. To identify signatures of selection, Fay-Wu’s H and Integrated Haplotype Score (iHS) were estimated.</p< <p<Results</p< <p<In the Czech population, carriers of the ancestral alleles of <it<AGT</it< rs699 and <it<CYP3A7</it< rs10211 showed an increased risk of CRC (OR 1.26 and 1.38, respectively; two-sided p≤0.05), whereas carriers of the ancestral allele of <it<ENPP1</it< rs1044498 had a decreased risk (OR 0.79; p≤0.05). For rs1044498, the strongest association was detected in the Czech male subpopulation (OR 0.61; p=0.0015). The associations were not replicated in the German population. Signatures of selection were found for all three analyzed genes.</p< <p<Conclusions</p< <p<Our study showed evidence of association for the ancestral alleles of polymorphisms in AGT and CYP3A7 and for the derived allele of a polymorphism in ENPP1 with an increased risk of CRC in Czechs, but not in Germans. The ancestral alleles of these SNPs have previously been associated with nutrition-related diseases hypertension (AGT and CYP3A7) and insulin resistance (ENPP1). Future studies may shed light on the complex genetic and environmental interactions between different types of nutrition-related diseases.</p< Colorectal cancer Nutrition Complex diseases Internal medicine Genetics Bevier Melanie verfasserin aut Rudolph Anja verfasserin aut Pardini Barbara verfasserin aut Naccarati Alessio verfasserin aut Hein Rebecca verfasserin aut Hoffmeister Michael verfasserin aut Vodickova Ludmila verfasserin aut Novotny Jan verfasserin aut Brenner Hermann verfasserin aut Chang-Claude Jenny verfasserin aut Hemminki Kari verfasserin aut Vodicka Pavel verfasserin aut Försti Asta verfasserin aut In BMC Medical Genetics BMC, 2003 13(2012), 1, p 94 (DE-627)326643788 (DE-600)2041359-2 14712350 nnns volume:13 year:2012 number:1, p 94 https://doi.org/10.1186/1471-2350-13-94 kostenfrei https://doaj.org/article/f8330a728c834d10a116c3fa0b5de766 kostenfrei http://www.biomedcentral.com/1471-2350/13/94 kostenfrei https://doaj.org/toc/1471-2350 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2012 1, p 94
allfieldsGer	10.1186/1471-2350-13-94 doi (DE-627)DOAJ071010114 (DE-599)DOAJf8330a728c834d10a116c3fa0b5de766 DE-627 ger DE-627 rakwb eng RC31-1245 QH426-470 Huhn Stefanie verfasserin aut Shared ancestral susceptibility to colorectal cancer and other nutrition related diseases 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The majority of non-syndromic colorectal cancers (CRCs) can be described as a complex disease. A two-stage case–control study on CRC susceptibility was conducted to assess the influence of the ancestral alleles in the polymorphisms previously associated with nutrition-related complex diseases.</p< <p<Methods</p< <p<In stage I, 28 single nucleotide polymorphisms (SNPs) were genotyped in a hospital-based Czech population (1025 CRC cases, 787 controls) using an allele-specific PCR-based genotyping system (KASPar®). In stage II, replication was carried out for the five SNPs with the lowest p values. The replication set consisted of 1798 CRC cases and 1810 controls from a population-based German study (DACHS). Odds ratios (ORs) and 95% confidence intervals (CIs) for associations between genotypes and CRC risk were estimated using logistic regression. To identify signatures of selection, Fay-Wu’s H and Integrated Haplotype Score (iHS) were estimated.</p< <p<Results</p< <p<In the Czech population, carriers of the ancestral alleles of <it<AGT</it< rs699 and <it<CYP3A7</it< rs10211 showed an increased risk of CRC (OR 1.26 and 1.38, respectively; two-sided p≤0.05), whereas carriers of the ancestral allele of <it<ENPP1</it< rs1044498 had a decreased risk (OR 0.79; p≤0.05). For rs1044498, the strongest association was detected in the Czech male subpopulation (OR 0.61; p=0.0015). The associations were not replicated in the German population. Signatures of selection were found for all three analyzed genes.</p< <p<Conclusions</p< <p<Our study showed evidence of association for the ancestral alleles of polymorphisms in AGT and CYP3A7 and for the derived allele of a polymorphism in ENPP1 with an increased risk of CRC in Czechs, but not in Germans. The ancestral alleles of these SNPs have previously been associated with nutrition-related diseases hypertension (AGT and CYP3A7) and insulin resistance (ENPP1). Future studies may shed light on the complex genetic and environmental interactions between different types of nutrition-related diseases.</p< Colorectal cancer Nutrition Complex diseases Internal medicine Genetics Bevier Melanie verfasserin aut Rudolph Anja verfasserin aut Pardini Barbara verfasserin aut Naccarati Alessio verfasserin aut Hein Rebecca verfasserin aut Hoffmeister Michael verfasserin aut Vodickova Ludmila verfasserin aut Novotny Jan verfasserin aut Brenner Hermann verfasserin aut Chang-Claude Jenny verfasserin aut Hemminki Kari verfasserin aut Vodicka Pavel verfasserin aut Försti Asta verfasserin aut In BMC Medical Genetics BMC, 2003 13(2012), 1, p 94 (DE-627)326643788 (DE-600)2041359-2 14712350 nnns volume:13 year:2012 number:1, p 94 https://doi.org/10.1186/1471-2350-13-94 kostenfrei https://doaj.org/article/f8330a728c834d10a116c3fa0b5de766 kostenfrei http://www.biomedcentral.com/1471-2350/13/94 kostenfrei https://doaj.org/toc/1471-2350 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2012 1, p 94
allfieldsSound	10.1186/1471-2350-13-94 doi (DE-627)DOAJ071010114 (DE-599)DOAJf8330a728c834d10a116c3fa0b5de766 DE-627 ger DE-627 rakwb eng RC31-1245 QH426-470 Huhn Stefanie verfasserin aut Shared ancestral susceptibility to colorectal cancer and other nutrition related diseases 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The majority of non-syndromic colorectal cancers (CRCs) can be described as a complex disease. A two-stage case–control study on CRC susceptibility was conducted to assess the influence of the ancestral alleles in the polymorphisms previously associated with nutrition-related complex diseases.</p< <p<Methods</p< <p<In stage I, 28 single nucleotide polymorphisms (SNPs) were genotyped in a hospital-based Czech population (1025 CRC cases, 787 controls) using an allele-specific PCR-based genotyping system (KASPar®). In stage II, replication was carried out for the five SNPs with the lowest p values. The replication set consisted of 1798 CRC cases and 1810 controls from a population-based German study (DACHS). Odds ratios (ORs) and 95% confidence intervals (CIs) for associations between genotypes and CRC risk were estimated using logistic regression. To identify signatures of selection, Fay-Wu’s H and Integrated Haplotype Score (iHS) were estimated.</p< <p<Results</p< <p<In the Czech population, carriers of the ancestral alleles of <it<AGT</it< rs699 and <it<CYP3A7</it< rs10211 showed an increased risk of CRC (OR 1.26 and 1.38, respectively; two-sided p≤0.05), whereas carriers of the ancestral allele of <it<ENPP1</it< rs1044498 had a decreased risk (OR 0.79; p≤0.05). For rs1044498, the strongest association was detected in the Czech male subpopulation (OR 0.61; p=0.0015). The associations were not replicated in the German population. Signatures of selection were found for all three analyzed genes.</p< <p<Conclusions</p< <p<Our study showed evidence of association for the ancestral alleles of polymorphisms in AGT and CYP3A7 and for the derived allele of a polymorphism in ENPP1 with an increased risk of CRC in Czechs, but not in Germans. The ancestral alleles of these SNPs have previously been associated with nutrition-related diseases hypertension (AGT and CYP3A7) and insulin resistance (ENPP1). Future studies may shed light on the complex genetic and environmental interactions between different types of nutrition-related diseases.</p< Colorectal cancer Nutrition Complex diseases Internal medicine Genetics Bevier Melanie verfasserin aut Rudolph Anja verfasserin aut Pardini Barbara verfasserin aut Naccarati Alessio verfasserin aut Hein Rebecca verfasserin aut Hoffmeister Michael verfasserin aut Vodickova Ludmila verfasserin aut Novotny Jan verfasserin aut Brenner Hermann verfasserin aut Chang-Claude Jenny verfasserin aut Hemminki Kari verfasserin aut Vodicka Pavel verfasserin aut Försti Asta verfasserin aut In BMC Medical Genetics BMC, 2003 13(2012), 1, p 94 (DE-627)326643788 (DE-600)2041359-2 14712350 nnns volume:13 year:2012 number:1, p 94 https://doi.org/10.1186/1471-2350-13-94 kostenfrei https://doaj.org/article/f8330a728c834d10a116c3fa0b5de766 kostenfrei http://www.biomedcentral.com/1471-2350/13/94 kostenfrei https://doaj.org/toc/1471-2350 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2012 1, p 94
language	English
source	In BMC Medical Genetics 13(2012), 1, p 94 volume:13 year:2012 number:1, p 94
sourceStr	In BMC Medical Genetics 13(2012), 1, p 94 volume:13 year:2012 number:1, p 94
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Colorectal cancer Nutrition Complex diseases Internal medicine Genetics
isfreeaccess_bool	true
container_title	BMC Medical Genetics
authorswithroles_txt_mv	Huhn Stefanie @@aut@@ Bevier Melanie @@aut@@ Rudolph Anja @@aut@@ Pardini Barbara @@aut@@ Naccarati Alessio @@aut@@ Hein Rebecca @@aut@@ Hoffmeister Michael @@aut@@ Vodickova Ludmila @@aut@@ Novotny Jan @@aut@@ Brenner Hermann @@aut@@ Chang-Claude Jenny @@aut@@ Hemminki Kari @@aut@@ Vodicka Pavel @@aut@@ Försti Asta @@aut@@
publishDateDaySort_date	2012-01-01T00:00:00Z
hierarchy_top_id	326643788
id	DOAJ071010114
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ071010114</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230309095412.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230228s2012 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1186/1471-2350-13-94</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ071010114</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJf8330a728c834d10a116c3fa0b5de766</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC31-1245</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QH426-470</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Huhn Stefanie</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Shared ancestral susceptibility to colorectal cancer and other nutrition related diseases</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2012</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a"><p<Abstract</p< <p<Background</p< <p<The majority of non-syndromic colorectal cancers (CRCs) can be described as a complex disease. A two-stage case–control study on CRC susceptibility was conducted to assess the influence of the ancestral alleles in the polymorphisms previously associated with nutrition-related complex diseases.</p< <p<Methods</p< <p<In stage I, 28 single nucleotide polymorphisms (SNPs) were genotyped in a hospital-based Czech population (1025 CRC cases, 787 controls) using an allele-specific PCR-based genotyping system (KASPar®). In stage II, replication was carried out for the five SNPs with the lowest p values. The replication set consisted of 1798 CRC cases and 1810 controls from a population-based German study (DACHS). Odds ratios (ORs) and 95% confidence intervals (CIs) for associations between genotypes and CRC risk were estimated using logistic regression. To identify signatures of selection, Fay-Wu’s H and Integrated Haplotype Score (iHS) were estimated.</p< <p<Results</p< <p<In the Czech population, carriers of the ancestral alleles of <it<AGT</it< rs699 and <it<CYP3A7</it< rs10211 showed an increased risk of CRC (OR 1.26 and 1.38, respectively; two-sided p≤0.05), whereas carriers of the ancestral allele of <it<ENPP1</it< rs1044498 had a decreased risk (OR 0.79; p≤0.05). For rs1044498, the strongest association was detected in the Czech male subpopulation (OR 0.61; p=0.0015). The associations were not replicated in the German population. Signatures of selection were found for all three analyzed genes.</p< <p<Conclusions</p< <p<Our study showed evidence of association for the ancestral alleles of polymorphisms in AGT and CYP3A7 and for the derived allele of a polymorphism in ENPP1 with an increased risk of CRC in Czechs, but not in Germans. The ancestral alleles of these SNPs have previously been associated with nutrition-related diseases hypertension (AGT and CYP3A7) and insulin resistance (ENPP1). 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callnumber-first	R - Medicine
author	Huhn Stefanie
spellingShingle	Huhn Stefanie misc RC31-1245 misc QH426-470 misc Colorectal cancer misc Nutrition misc Complex diseases misc Internal medicine misc Genetics Shared ancestral susceptibility to colorectal cancer and other nutrition related diseases
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topic_title	RC31-1245 QH426-470 Shared ancestral susceptibility to colorectal cancer and other nutrition related diseases Colorectal cancer Nutrition Complex diseases
topic	misc RC31-1245 misc QH426-470 misc Colorectal cancer misc Nutrition misc Complex diseases misc Internal medicine misc Genetics
topic_unstemmed	misc RC31-1245 misc QH426-470 misc Colorectal cancer misc Nutrition misc Complex diseases misc Internal medicine misc Genetics
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title	Shared ancestral susceptibility to colorectal cancer and other nutrition related diseases
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title_full	Shared ancestral susceptibility to colorectal cancer and other nutrition related diseases
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author_browse	Huhn Stefanie Bevier Melanie Rudolph Anja Pardini Barbara Naccarati Alessio Hein Rebecca Hoffmeister Michael Vodickova Ludmila Novotny Jan Brenner Hermann Chang-Claude Jenny Hemminki Kari Vodicka Pavel Försti Asta
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title_sort	shared ancestral susceptibility to colorectal cancer and other nutrition related diseases
callnumber	RC31-1245
title_auth	Shared ancestral susceptibility to colorectal cancer and other nutrition related diseases
abstract	<p<Abstract</p< <p<Background</p< <p<The majority of non-syndromic colorectal cancers (CRCs) can be described as a complex disease. A two-stage case–control study on CRC susceptibility was conducted to assess the influence of the ancestral alleles in the polymorphisms previously associated with nutrition-related complex diseases.</p< <p<Methods</p< <p<In stage I, 28 single nucleotide polymorphisms (SNPs) were genotyped in a hospital-based Czech population (1025 CRC cases, 787 controls) using an allele-specific PCR-based genotyping system (KASPar®). In stage II, replication was carried out for the five SNPs with the lowest p values. The replication set consisted of 1798 CRC cases and 1810 controls from a population-based German study (DACHS). Odds ratios (ORs) and 95% confidence intervals (CIs) for associations between genotypes and CRC risk were estimated using logistic regression. To identify signatures of selection, Fay-Wu’s H and Integrated Haplotype Score (iHS) were estimated.</p< <p<Results</p< <p<In the Czech population, carriers of the ancestral alleles of <it<AGT</it< rs699 and <it<CYP3A7</it< rs10211 showed an increased risk of CRC (OR 1.26 and 1.38, respectively; two-sided p≤0.05), whereas carriers of the ancestral allele of <it<ENPP1</it< rs1044498 had a decreased risk (OR 0.79; p≤0.05). For rs1044498, the strongest association was detected in the Czech male subpopulation (OR 0.61; p=0.0015). The associations were not replicated in the German population. Signatures of selection were found for all three analyzed genes.</p< <p<Conclusions</p< <p<Our study showed evidence of association for the ancestral alleles of polymorphisms in AGT and CYP3A7 and for the derived allele of a polymorphism in ENPP1 with an increased risk of CRC in Czechs, but not in Germans. The ancestral alleles of these SNPs have previously been associated with nutrition-related diseases hypertension (AGT and CYP3A7) and insulin resistance (ENPP1). Future studies may shed light on the complex genetic and environmental interactions between different types of nutrition-related diseases.</p<
abstractGer	<p<Abstract</p< <p<Background</p< <p<The majority of non-syndromic colorectal cancers (CRCs) can be described as a complex disease. A two-stage case–control study on CRC susceptibility was conducted to assess the influence of the ancestral alleles in the polymorphisms previously associated with nutrition-related complex diseases.</p< <p<Methods</p< <p<In stage I, 28 single nucleotide polymorphisms (SNPs) were genotyped in a hospital-based Czech population (1025 CRC cases, 787 controls) using an allele-specific PCR-based genotyping system (KASPar®). In stage II, replication was carried out for the five SNPs with the lowest p values. The replication set consisted of 1798 CRC cases and 1810 controls from a population-based German study (DACHS). Odds ratios (ORs) and 95% confidence intervals (CIs) for associations between genotypes and CRC risk were estimated using logistic regression. To identify signatures of selection, Fay-Wu’s H and Integrated Haplotype Score (iHS) were estimated.</p< <p<Results</p< <p<In the Czech population, carriers of the ancestral alleles of <it<AGT</it< rs699 and <it<CYP3A7</it< rs10211 showed an increased risk of CRC (OR 1.26 and 1.38, respectively; two-sided p≤0.05), whereas carriers of the ancestral allele of <it<ENPP1</it< rs1044498 had a decreased risk (OR 0.79; p≤0.05). For rs1044498, the strongest association was detected in the Czech male subpopulation (OR 0.61; p=0.0015). The associations were not replicated in the German population. Signatures of selection were found for all three analyzed genes.</p< <p<Conclusions</p< <p<Our study showed evidence of association for the ancestral alleles of polymorphisms in AGT and CYP3A7 and for the derived allele of a polymorphism in ENPP1 with an increased risk of CRC in Czechs, but not in Germans. The ancestral alleles of these SNPs have previously been associated with nutrition-related diseases hypertension (AGT and CYP3A7) and insulin resistance (ENPP1). Future studies may shed light on the complex genetic and environmental interactions between different types of nutrition-related diseases.</p<
abstract_unstemmed	<p<Abstract</p< <p<Background</p< <p<The majority of non-syndromic colorectal cancers (CRCs) can be described as a complex disease. A two-stage case–control study on CRC susceptibility was conducted to assess the influence of the ancestral alleles in the polymorphisms previously associated with nutrition-related complex diseases.</p< <p<Methods</p< <p<In stage I, 28 single nucleotide polymorphisms (SNPs) were genotyped in a hospital-based Czech population (1025 CRC cases, 787 controls) using an allele-specific PCR-based genotyping system (KASPar®). In stage II, replication was carried out for the five SNPs with the lowest p values. The replication set consisted of 1798 CRC cases and 1810 controls from a population-based German study (DACHS). Odds ratios (ORs) and 95% confidence intervals (CIs) for associations between genotypes and CRC risk were estimated using logistic regression. To identify signatures of selection, Fay-Wu’s H and Integrated Haplotype Score (iHS) were estimated.</p< <p<Results</p< <p<In the Czech population, carriers of the ancestral alleles of <it<AGT</it< rs699 and <it<CYP3A7</it< rs10211 showed an increased risk of CRC (OR 1.26 and 1.38, respectively; two-sided p≤0.05), whereas carriers of the ancestral allele of <it<ENPP1</it< rs1044498 had a decreased risk (OR 0.79; p≤0.05). For rs1044498, the strongest association was detected in the Czech male subpopulation (OR 0.61; p=0.0015). The associations were not replicated in the German population. Signatures of selection were found for all three analyzed genes.</p< <p<Conclusions</p< <p<Our study showed evidence of association for the ancestral alleles of polymorphisms in AGT and CYP3A7 and for the derived allele of a polymorphism in ENPP1 with an increased risk of CRC in Czechs, but not in Germans. The ancestral alleles of these SNPs have previously been associated with nutrition-related diseases hypertension (AGT and CYP3A7) and insulin resistance (ENPP1). Future studies may shed light on the complex genetic and environmental interactions between different types of nutrition-related diseases.</p<
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title_short	Shared ancestral susceptibility to colorectal cancer and other nutrition related diseases
url	https://doi.org/10.1186/1471-2350-13-94 https://doaj.org/article/f8330a728c834d10a116c3fa0b5de766 http://www.biomedcentral.com/1471-2350/13/94 https://doaj.org/toc/1471-2350
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A two-stage case–control study on CRC susceptibility was conducted to assess the influence of the ancestral alleles in the polymorphisms previously associated with nutrition-related complex diseases.</p< <p<Methods</p< <p<In stage I, 28 single nucleotide polymorphisms (SNPs) were genotyped in a hospital-based Czech population (1025 CRC cases, 787 controls) using an allele-specific PCR-based genotyping system (KASPar®). In stage II, replication was carried out for the five SNPs with the lowest p values. The replication set consisted of 1798 CRC cases and 1810 controls from a population-based German study (DACHS). Odds ratios (ORs) and 95% confidence intervals (CIs) for associations between genotypes and CRC risk were estimated using logistic regression. To identify signatures of selection, Fay-Wu’s H and Integrated Haplotype Score (iHS) were estimated.</p< <p<Results</p< <p<In the Czech population, carriers of the ancestral alleles of <it<AGT</it< rs699 and <it<CYP3A7</it< rs10211 showed an increased risk of CRC (OR 1.26 and 1.38, respectively; two-sided p≤0.05), whereas carriers of the ancestral allele of <it<ENPP1</it< rs1044498 had a decreased risk (OR 0.79; p≤0.05). For rs1044498, the strongest association was detected in the Czech male subpopulation (OR 0.61; p=0.0015). The associations were not replicated in the German population. Signatures of selection were found for all three analyzed genes.</p< <p<Conclusions</p< <p<Our study showed evidence of association for the ancestral alleles of polymorphisms in AGT and CYP3A7 and for the derived allele of a polymorphism in ENPP1 with an increased risk of CRC in Czechs, but not in Germans. 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Shared ancestral susceptibility to colorectal cancer and other nutrition related diseases

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