Design of biosensor array with current boost and signal conditioning circuits for HPV detection

Cervical cancer is the major cancer affecting women and is growing at a very significant rate. One of the major challenges in treatment of cervical cancer is its detection in early stages. Human Papilloma Virus (HPV) infections are the major causes of cervical cancer that risks precancerous cell to...
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Autor*in:	P.G. Gopinath [verfasserIn] V.R. Anitha [verfasserIn] S. Aruna Mastani [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Übergeordnetes Werk:	In: Alexandria Engineering Journal - Elsevier, 2016, 57(2018), 2, Seite 671-681
Übergeordnetes Werk:	volume:57 ; year:2018 ; number:2 ; pages:671-681

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.aej.2017.01.012

Katalog-ID:	DOAJ071141766

Internformat


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520			\|a Cervical cancer is the major cancer affecting women and is growing at a very significant rate. One of the major challenges in treatment of cervical cancer is its detection in early stages. Human Papilloma Virus (HPV) infections are the major causes of cervical cancer that risks precancerous cell to cervical cancer cells. Gene-based DNA nanobiosensor is designed to capture the cancer specific antigen and helps in screening process of cancer patients. In this work, a nanobiosensor is designed using Carbon Nanotube Field Effect Transistor (CNTFET) and the signal conditioning circuits designed are interfaced with the sensor for amplifying the bio potential generated with the chemical reaction of the antigen with the antibody placed over the CNTFET channel. The sensor array is designed to have 64 cells that are configured into three categories such as core, periphery and middle sensors to increase the sensitivity of cell detection. Three reference voltages are generated from the current reference circuit for biasing the bottom gates of CNTFETs that produce maximum current due to the electro potential changes in the top gate. The corresponding voltages are further processed to detect the presence of analyte concentration and the sensitivity of the designed sensor array is found to be 130 μA/V. Keywords: Bio sensor, CNTFET, Sensor array, Cervical cancer, HPV
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publishDate	2018
allfields	10.1016/j.aej.2017.01.012 doi (DE-627)DOAJ071141766 (DE-599)DOAJ8ddde5c0d3dc494c90f99e05e17b7da9 DE-627 ger DE-627 rakwb eng TA1-2040 P.G. Gopinath verfasserin aut Design of biosensor array with current boost and signal conditioning circuits for HPV detection 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cervical cancer is the major cancer affecting women and is growing at a very significant rate. One of the major challenges in treatment of cervical cancer is its detection in early stages. Human Papilloma Virus (HPV) infections are the major causes of cervical cancer that risks precancerous cell to cervical cancer cells. Gene-based DNA nanobiosensor is designed to capture the cancer specific antigen and helps in screening process of cancer patients. In this work, a nanobiosensor is designed using Carbon Nanotube Field Effect Transistor (CNTFET) and the signal conditioning circuits designed are interfaced with the sensor for amplifying the bio potential generated with the chemical reaction of the antigen with the antibody placed over the CNTFET channel. The sensor array is designed to have 64 cells that are configured into three categories such as core, periphery and middle sensors to increase the sensitivity of cell detection. Three reference voltages are generated from the current reference circuit for biasing the bottom gates of CNTFETs that produce maximum current due to the electro potential changes in the top gate. The corresponding voltages are further processed to detect the presence of analyte concentration and the sensitivity of the designed sensor array is found to be 130 μA/V. Keywords: Bio sensor, CNTFET, Sensor array, Cervical cancer, HPV Engineering (General). Civil engineering (General) V.R. Anitha verfasserin aut S. Aruna Mastani verfasserin aut In Alexandria Engineering Journal Elsevier, 2016 57(2018), 2, Seite 671-681 (DE-627)669887609 (DE-600)2631413-7 20902670 nnns volume:57 year:2018 number:2 pages:671-681 https://doi.org/10.1016/j.aej.2017.01.012 kostenfrei https://doaj.org/article/8ddde5c0d3dc494c90f99e05e17b7da9 kostenfrei http://www.sciencedirect.com/science/article/pii/S1110016817300157 kostenfrei https://doaj.org/toc/1110-0168 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 57 2018 2 671-681
spelling	10.1016/j.aej.2017.01.012 doi (DE-627)DOAJ071141766 (DE-599)DOAJ8ddde5c0d3dc494c90f99e05e17b7da9 DE-627 ger DE-627 rakwb eng TA1-2040 P.G. Gopinath verfasserin aut Design of biosensor array with current boost and signal conditioning circuits for HPV detection 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cervical cancer is the major cancer affecting women and is growing at a very significant rate. One of the major challenges in treatment of cervical cancer is its detection in early stages. Human Papilloma Virus (HPV) infections are the major causes of cervical cancer that risks precancerous cell to cervical cancer cells. Gene-based DNA nanobiosensor is designed to capture the cancer specific antigen and helps in screening process of cancer patients. In this work, a nanobiosensor is designed using Carbon Nanotube Field Effect Transistor (CNTFET) and the signal conditioning circuits designed are interfaced with the sensor for amplifying the bio potential generated with the chemical reaction of the antigen with the antibody placed over the CNTFET channel. The sensor array is designed to have 64 cells that are configured into three categories such as core, periphery and middle sensors to increase the sensitivity of cell detection. Three reference voltages are generated from the current reference circuit for biasing the bottom gates of CNTFETs that produce maximum current due to the electro potential changes in the top gate. The corresponding voltages are further processed to detect the presence of analyte concentration and the sensitivity of the designed sensor array is found to be 130 μA/V. Keywords: Bio sensor, CNTFET, Sensor array, Cervical cancer, HPV Engineering (General). Civil engineering (General) V.R. Anitha verfasserin aut S. Aruna Mastani verfasserin aut In Alexandria Engineering Journal Elsevier, 2016 57(2018), 2, Seite 671-681 (DE-627)669887609 (DE-600)2631413-7 20902670 nnns volume:57 year:2018 number:2 pages:671-681 https://doi.org/10.1016/j.aej.2017.01.012 kostenfrei https://doaj.org/article/8ddde5c0d3dc494c90f99e05e17b7da9 kostenfrei http://www.sciencedirect.com/science/article/pii/S1110016817300157 kostenfrei https://doaj.org/toc/1110-0168 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 57 2018 2 671-681
allfields_unstemmed	10.1016/j.aej.2017.01.012 doi (DE-627)DOAJ071141766 (DE-599)DOAJ8ddde5c0d3dc494c90f99e05e17b7da9 DE-627 ger DE-627 rakwb eng TA1-2040 P.G. Gopinath verfasserin aut Design of biosensor array with current boost and signal conditioning circuits for HPV detection 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cervical cancer is the major cancer affecting women and is growing at a very significant rate. One of the major challenges in treatment of cervical cancer is its detection in early stages. Human Papilloma Virus (HPV) infections are the major causes of cervical cancer that risks precancerous cell to cervical cancer cells. Gene-based DNA nanobiosensor is designed to capture the cancer specific antigen and helps in screening process of cancer patients. In this work, a nanobiosensor is designed using Carbon Nanotube Field Effect Transistor (CNTFET) and the signal conditioning circuits designed are interfaced with the sensor for amplifying the bio potential generated with the chemical reaction of the antigen with the antibody placed over the CNTFET channel. The sensor array is designed to have 64 cells that are configured into three categories such as core, periphery and middle sensors to increase the sensitivity of cell detection. Three reference voltages are generated from the current reference circuit for biasing the bottom gates of CNTFETs that produce maximum current due to the electro potential changes in the top gate. The corresponding voltages are further processed to detect the presence of analyte concentration and the sensitivity of the designed sensor array is found to be 130 μA/V. Keywords: Bio sensor, CNTFET, Sensor array, Cervical cancer, HPV Engineering (General). Civil engineering (General) V.R. Anitha verfasserin aut S. Aruna Mastani verfasserin aut In Alexandria Engineering Journal Elsevier, 2016 57(2018), 2, Seite 671-681 (DE-627)669887609 (DE-600)2631413-7 20902670 nnns volume:57 year:2018 number:2 pages:671-681 https://doi.org/10.1016/j.aej.2017.01.012 kostenfrei https://doaj.org/article/8ddde5c0d3dc494c90f99e05e17b7da9 kostenfrei http://www.sciencedirect.com/science/article/pii/S1110016817300157 kostenfrei https://doaj.org/toc/1110-0168 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 57 2018 2 671-681
allfieldsGer	10.1016/j.aej.2017.01.012 doi (DE-627)DOAJ071141766 (DE-599)DOAJ8ddde5c0d3dc494c90f99e05e17b7da9 DE-627 ger DE-627 rakwb eng TA1-2040 P.G. Gopinath verfasserin aut Design of biosensor array with current boost and signal conditioning circuits for HPV detection 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cervical cancer is the major cancer affecting women and is growing at a very significant rate. One of the major challenges in treatment of cervical cancer is its detection in early stages. Human Papilloma Virus (HPV) infections are the major causes of cervical cancer that risks precancerous cell to cervical cancer cells. Gene-based DNA nanobiosensor is designed to capture the cancer specific antigen and helps in screening process of cancer patients. In this work, a nanobiosensor is designed using Carbon Nanotube Field Effect Transistor (CNTFET) and the signal conditioning circuits designed are interfaced with the sensor for amplifying the bio potential generated with the chemical reaction of the antigen with the antibody placed over the CNTFET channel. The sensor array is designed to have 64 cells that are configured into three categories such as core, periphery and middle sensors to increase the sensitivity of cell detection. Three reference voltages are generated from the current reference circuit for biasing the bottom gates of CNTFETs that produce maximum current due to the electro potential changes in the top gate. The corresponding voltages are further processed to detect the presence of analyte concentration and the sensitivity of the designed sensor array is found to be 130 μA/V. Keywords: Bio sensor, CNTFET, Sensor array, Cervical cancer, HPV Engineering (General). Civil engineering (General) V.R. Anitha verfasserin aut S. Aruna Mastani verfasserin aut In Alexandria Engineering Journal Elsevier, 2016 57(2018), 2, Seite 671-681 (DE-627)669887609 (DE-600)2631413-7 20902670 nnns volume:57 year:2018 number:2 pages:671-681 https://doi.org/10.1016/j.aej.2017.01.012 kostenfrei https://doaj.org/article/8ddde5c0d3dc494c90f99e05e17b7da9 kostenfrei http://www.sciencedirect.com/science/article/pii/S1110016817300157 kostenfrei https://doaj.org/toc/1110-0168 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 57 2018 2 671-681
allfieldsSound	10.1016/j.aej.2017.01.012 doi (DE-627)DOAJ071141766 (DE-599)DOAJ8ddde5c0d3dc494c90f99e05e17b7da9 DE-627 ger DE-627 rakwb eng TA1-2040 P.G. Gopinath verfasserin aut Design of biosensor array with current boost and signal conditioning circuits for HPV detection 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cervical cancer is the major cancer affecting women and is growing at a very significant rate. One of the major challenges in treatment of cervical cancer is its detection in early stages. Human Papilloma Virus (HPV) infections are the major causes of cervical cancer that risks precancerous cell to cervical cancer cells. Gene-based DNA nanobiosensor is designed to capture the cancer specific antigen and helps in screening process of cancer patients. In this work, a nanobiosensor is designed using Carbon Nanotube Field Effect Transistor (CNTFET) and the signal conditioning circuits designed are interfaced with the sensor for amplifying the bio potential generated with the chemical reaction of the antigen with the antibody placed over the CNTFET channel. The sensor array is designed to have 64 cells that are configured into three categories such as core, periphery and middle sensors to increase the sensitivity of cell detection. Three reference voltages are generated from the current reference circuit for biasing the bottom gates of CNTFETs that produce maximum current due to the electro potential changes in the top gate. The corresponding voltages are further processed to detect the presence of analyte concentration and the sensitivity of the designed sensor array is found to be 130 μA/V. Keywords: Bio sensor, CNTFET, Sensor array, Cervical cancer, HPV Engineering (General). Civil engineering (General) V.R. Anitha verfasserin aut S. Aruna Mastani verfasserin aut In Alexandria Engineering Journal Elsevier, 2016 57(2018), 2, Seite 671-681 (DE-627)669887609 (DE-600)2631413-7 20902670 nnns volume:57 year:2018 number:2 pages:671-681 https://doi.org/10.1016/j.aej.2017.01.012 kostenfrei https://doaj.org/article/8ddde5c0d3dc494c90f99e05e17b7da9 kostenfrei http://www.sciencedirect.com/science/article/pii/S1110016817300157 kostenfrei https://doaj.org/toc/1110-0168 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 57 2018 2 671-681
language	English
source	In Alexandria Engineering Journal 57(2018), 2, Seite 671-681 volume:57 year:2018 number:2 pages:671-681
sourceStr	In Alexandria Engineering Journal 57(2018), 2, Seite 671-681 volume:57 year:2018 number:2 pages:671-681
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Engineering (General). Civil engineering (General)
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container_title	Alexandria Engineering Journal
authorswithroles_txt_mv	P.G. Gopinath @@aut@@ V.R. Anitha @@aut@@ S. Aruna Mastani @@aut@@
publishDateDaySort_date	2018-01-01T00:00:00Z
hierarchy_top_id	669887609
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language_de	englisch
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callnumber-first	T - Technology
author	P.G. Gopinath
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topic_title	TA1-2040 Design of biosensor array with current boost and signal conditioning circuits for HPV detection
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title	Design of biosensor array with current boost and signal conditioning circuits for HPV detection
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title_full	Design of biosensor array with current boost and signal conditioning circuits for HPV detection
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title_sort	design of biosensor array with current boost and signal conditioning circuits for hpv detection
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title_auth	Design of biosensor array with current boost and signal conditioning circuits for HPV detection
abstract	Cervical cancer is the major cancer affecting women and is growing at a very significant rate. One of the major challenges in treatment of cervical cancer is its detection in early stages. Human Papilloma Virus (HPV) infections are the major causes of cervical cancer that risks precancerous cell to cervical cancer cells. Gene-based DNA nanobiosensor is designed to capture the cancer specific antigen and helps in screening process of cancer patients. In this work, a nanobiosensor is designed using Carbon Nanotube Field Effect Transistor (CNTFET) and the signal conditioning circuits designed are interfaced with the sensor for amplifying the bio potential generated with the chemical reaction of the antigen with the antibody placed over the CNTFET channel. The sensor array is designed to have 64 cells that are configured into three categories such as core, periphery and middle sensors to increase the sensitivity of cell detection. Three reference voltages are generated from the current reference circuit for biasing the bottom gates of CNTFETs that produce maximum current due to the electro potential changes in the top gate. The corresponding voltages are further processed to detect the presence of analyte concentration and the sensitivity of the designed sensor array is found to be 130 μA/V. Keywords: Bio sensor, CNTFET, Sensor array, Cervical cancer, HPV
abstractGer	Cervical cancer is the major cancer affecting women and is growing at a very significant rate. One of the major challenges in treatment of cervical cancer is its detection in early stages. Human Papilloma Virus (HPV) infections are the major causes of cervical cancer that risks precancerous cell to cervical cancer cells. Gene-based DNA nanobiosensor is designed to capture the cancer specific antigen and helps in screening process of cancer patients. In this work, a nanobiosensor is designed using Carbon Nanotube Field Effect Transistor (CNTFET) and the signal conditioning circuits designed are interfaced with the sensor for amplifying the bio potential generated with the chemical reaction of the antigen with the antibody placed over the CNTFET channel. The sensor array is designed to have 64 cells that are configured into three categories such as core, periphery and middle sensors to increase the sensitivity of cell detection. Three reference voltages are generated from the current reference circuit for biasing the bottom gates of CNTFETs that produce maximum current due to the electro potential changes in the top gate. The corresponding voltages are further processed to detect the presence of analyte concentration and the sensitivity of the designed sensor array is found to be 130 μA/V. Keywords: Bio sensor, CNTFET, Sensor array, Cervical cancer, HPV
abstract_unstemmed	Cervical cancer is the major cancer affecting women and is growing at a very significant rate. One of the major challenges in treatment of cervical cancer is its detection in early stages. Human Papilloma Virus (HPV) infections are the major causes of cervical cancer that risks precancerous cell to cervical cancer cells. Gene-based DNA nanobiosensor is designed to capture the cancer specific antigen and helps in screening process of cancer patients. In this work, a nanobiosensor is designed using Carbon Nanotube Field Effect Transistor (CNTFET) and the signal conditioning circuits designed are interfaced with the sensor for amplifying the bio potential generated with the chemical reaction of the antigen with the antibody placed over the CNTFET channel. The sensor array is designed to have 64 cells that are configured into three categories such as core, periphery and middle sensors to increase the sensitivity of cell detection. Three reference voltages are generated from the current reference circuit for biasing the bottom gates of CNTFETs that produce maximum current due to the electro potential changes in the top gate. The corresponding voltages are further processed to detect the presence of analyte concentration and the sensitivity of the designed sensor array is found to be 130 μA/V. Keywords: Bio sensor, CNTFET, Sensor array, Cervical cancer, HPV
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title_short	Design of biosensor array with current boost and signal conditioning circuits for HPV detection
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Design of biosensor array with current boost and signal conditioning circuits for HPV detection

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