A novel role for the ADHD risk gene latrophilin-3 in learning and memory in Lphn3 knockout rats

Latrophilins (LPHNs) are adhesion G protein-coupled receptors with three isoforms but only LPHN3 is brain specific (caudate, prefrontal cortex, dentate, amygdala, and cerebellum). Variants of LPHN3 are associated with ADHD. Null mutations of Lphn3 in rat, mouse, zebrafish, and Drosophila result in h...
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Autor*in:	Samantha L. Regan [verfasserIn] Emily M. Pitzer [verfasserIn] Jillian R. Hufgard [verfasserIn] Chiho Sugimoto [verfasserIn] Michael T. Williams [verfasserIn] Charles V. Vorhees [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Lphn3 Adgrl-3 Lphn3 knockout rat Cognition Long-term potentiation Spatial learning and memory

Übergeordnetes Werk:	In: Neurobiology of Disease - Elsevier, 2021, 158(2021), Seite 105456-
Übergeordnetes Werk:	volume:158 ; year:2021 ; pages:105456-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.nbd.2021.105456

Katalog-ID:	DOAJ071227261

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spelling	10.1016/j.nbd.2021.105456 doi (DE-627)DOAJ071227261 (DE-599)DOAJ02d801f1a8994218b16fd0930b543a3e DE-627 ger DE-627 rakwb eng RC321-571 Samantha L. Regan verfasserin aut A novel role for the ADHD risk gene latrophilin-3 in learning and memory in Lphn3 knockout rats 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Latrophilins (LPHNs) are adhesion G protein-coupled receptors with three isoforms but only LPHN3 is brain specific (caudate, prefrontal cortex, dentate, amygdala, and cerebellum). Variants of LPHN3 are associated with ADHD. Null mutations of Lphn3 in rat, mouse, zebrafish, and Drosophila result in hyperactivity, but its role in learning and memory (L&M) is largely unknown. Using our Lphn3 knockout (KO) rats we examined the cognitive abilities, long-term potentiation (LTP) in CA1, NMDA receptor expression, and neurohistology from heterozygous breeding pairs. KO rats were impaired in egocentric L&M in the Cincinnati water maze, spatial L&M and cognitive flexibility in the Morris water maze (MWM), with no effects on conditioned freezing, novel object recognition, or temporal order recognition. KO-associated locomotor hyperactivity had no effect on swim speed. KO rats had reduced early-LTP but not late-LTP and had reduced hippocampal NMDA-NR1 expression. In a second experiment, KO rats responded to a light prepulse prior to an acoustic startle pulse, reflecting visual signal detection. In a third experiment, KO rats given extra MWM pretraining and hidden platform overtraining showed no evidence of reaching WT rats' levels of learning. Nissl histology revealed no structural abnormalities in KO rats. LPHN3 has a selective effect on egocentric and allocentric L&M without effects on conditioned freezing or recognition memory. Lphn3 Adgrl-3 Lphn3 knockout rat Cognition Long-term potentiation Spatial learning and memory Neurosciences. Biological psychiatry. Neuropsychiatry Emily M. Pitzer verfasserin aut Jillian R. Hufgard verfasserin aut Chiho Sugimoto verfasserin aut Michael T. Williams verfasserin aut Charles V. Vorhees verfasserin aut In Neurobiology of Disease Elsevier, 2021 158(2021), Seite 105456- (DE-627)268125414 (DE-600)1471408-5 1095953X nnns volume:158 year:2021 pages:105456- https://doi.org/10.1016/j.nbd.2021.105456 kostenfrei https://doaj.org/article/02d801f1a8994218b16fd0930b543a3e kostenfrei http://www.sciencedirect.com/science/article/pii/S0969996121002059 kostenfrei https://doaj.org/toc/1095-953X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 158 2021 105456-
allfields_unstemmed	10.1016/j.nbd.2021.105456 doi (DE-627)DOAJ071227261 (DE-599)DOAJ02d801f1a8994218b16fd0930b543a3e DE-627 ger DE-627 rakwb eng RC321-571 Samantha L. Regan verfasserin aut A novel role for the ADHD risk gene latrophilin-3 in learning and memory in Lphn3 knockout rats 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Latrophilins (LPHNs) are adhesion G protein-coupled receptors with three isoforms but only LPHN3 is brain specific (caudate, prefrontal cortex, dentate, amygdala, and cerebellum). Variants of LPHN3 are associated with ADHD. Null mutations of Lphn3 in rat, mouse, zebrafish, and Drosophila result in hyperactivity, but its role in learning and memory (L&M) is largely unknown. Using our Lphn3 knockout (KO) rats we examined the cognitive abilities, long-term potentiation (LTP) in CA1, NMDA receptor expression, and neurohistology from heterozygous breeding pairs. KO rats were impaired in egocentric L&M in the Cincinnati water maze, spatial L&M and cognitive flexibility in the Morris water maze (MWM), with no effects on conditioned freezing, novel object recognition, or temporal order recognition. KO-associated locomotor hyperactivity had no effect on swim speed. KO rats had reduced early-LTP but not late-LTP and had reduced hippocampal NMDA-NR1 expression. In a second experiment, KO rats responded to a light prepulse prior to an acoustic startle pulse, reflecting visual signal detection. In a third experiment, KO rats given extra MWM pretraining and hidden platform overtraining showed no evidence of reaching WT rats' levels of learning. Nissl histology revealed no structural abnormalities in KO rats. LPHN3 has a selective effect on egocentric and allocentric L&M without effects on conditioned freezing or recognition memory. Lphn3 Adgrl-3 Lphn3 knockout rat Cognition Long-term potentiation Spatial learning and memory Neurosciences. Biological psychiatry. Neuropsychiatry Emily M. Pitzer verfasserin aut Jillian R. Hufgard verfasserin aut Chiho Sugimoto verfasserin aut Michael T. Williams verfasserin aut Charles V. Vorhees verfasserin aut In Neurobiology of Disease Elsevier, 2021 158(2021), Seite 105456- (DE-627)268125414 (DE-600)1471408-5 1095953X nnns volume:158 year:2021 pages:105456- https://doi.org/10.1016/j.nbd.2021.105456 kostenfrei https://doaj.org/article/02d801f1a8994218b16fd0930b543a3e kostenfrei http://www.sciencedirect.com/science/article/pii/S0969996121002059 kostenfrei https://doaj.org/toc/1095-953X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 158 2021 105456-
allfieldsGer	10.1016/j.nbd.2021.105456 doi (DE-627)DOAJ071227261 (DE-599)DOAJ02d801f1a8994218b16fd0930b543a3e DE-627 ger DE-627 rakwb eng RC321-571 Samantha L. Regan verfasserin aut A novel role for the ADHD risk gene latrophilin-3 in learning and memory in Lphn3 knockout rats 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Latrophilins (LPHNs) are adhesion G protein-coupled receptors with three isoforms but only LPHN3 is brain specific (caudate, prefrontal cortex, dentate, amygdala, and cerebellum). Variants of LPHN3 are associated with ADHD. Null mutations of Lphn3 in rat, mouse, zebrafish, and Drosophila result in hyperactivity, but its role in learning and memory (L&M) is largely unknown. Using our Lphn3 knockout (KO) rats we examined the cognitive abilities, long-term potentiation (LTP) in CA1, NMDA receptor expression, and neurohistology from heterozygous breeding pairs. KO rats were impaired in egocentric L&M in the Cincinnati water maze, spatial L&M and cognitive flexibility in the Morris water maze (MWM), with no effects on conditioned freezing, novel object recognition, or temporal order recognition. KO-associated locomotor hyperactivity had no effect on swim speed. KO rats had reduced early-LTP but not late-LTP and had reduced hippocampal NMDA-NR1 expression. In a second experiment, KO rats responded to a light prepulse prior to an acoustic startle pulse, reflecting visual signal detection. In a third experiment, KO rats given extra MWM pretraining and hidden platform overtraining showed no evidence of reaching WT rats' levels of learning. Nissl histology revealed no structural abnormalities in KO rats. LPHN3 has a selective effect on egocentric and allocentric L&M without effects on conditioned freezing or recognition memory. Lphn3 Adgrl-3 Lphn3 knockout rat Cognition Long-term potentiation Spatial learning and memory Neurosciences. Biological psychiatry. Neuropsychiatry Emily M. Pitzer verfasserin aut Jillian R. Hufgard verfasserin aut Chiho Sugimoto verfasserin aut Michael T. Williams verfasserin aut Charles V. Vorhees verfasserin aut In Neurobiology of Disease Elsevier, 2021 158(2021), Seite 105456- (DE-627)268125414 (DE-600)1471408-5 1095953X nnns volume:158 year:2021 pages:105456- https://doi.org/10.1016/j.nbd.2021.105456 kostenfrei https://doaj.org/article/02d801f1a8994218b16fd0930b543a3e kostenfrei http://www.sciencedirect.com/science/article/pii/S0969996121002059 kostenfrei https://doaj.org/toc/1095-953X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 158 2021 105456-
allfieldsSound	10.1016/j.nbd.2021.105456 doi (DE-627)DOAJ071227261 (DE-599)DOAJ02d801f1a8994218b16fd0930b543a3e DE-627 ger DE-627 rakwb eng RC321-571 Samantha L. Regan verfasserin aut A novel role for the ADHD risk gene latrophilin-3 in learning and memory in Lphn3 knockout rats 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Latrophilins (LPHNs) are adhesion G protein-coupled receptors with three isoforms but only LPHN3 is brain specific (caudate, prefrontal cortex, dentate, amygdala, and cerebellum). Variants of LPHN3 are associated with ADHD. Null mutations of Lphn3 in rat, mouse, zebrafish, and Drosophila result in hyperactivity, but its role in learning and memory (L&M) is largely unknown. Using our Lphn3 knockout (KO) rats we examined the cognitive abilities, long-term potentiation (LTP) in CA1, NMDA receptor expression, and neurohistology from heterozygous breeding pairs. KO rats were impaired in egocentric L&M in the Cincinnati water maze, spatial L&M and cognitive flexibility in the Morris water maze (MWM), with no effects on conditioned freezing, novel object recognition, or temporal order recognition. KO-associated locomotor hyperactivity had no effect on swim speed. KO rats had reduced early-LTP but not late-LTP and had reduced hippocampal NMDA-NR1 expression. In a second experiment, KO rats responded to a light prepulse prior to an acoustic startle pulse, reflecting visual signal detection. In a third experiment, KO rats given extra MWM pretraining and hidden platform overtraining showed no evidence of reaching WT rats' levels of learning. Nissl histology revealed no structural abnormalities in KO rats. LPHN3 has a selective effect on egocentric and allocentric L&M without effects on conditioned freezing or recognition memory. Lphn3 Adgrl-3 Lphn3 knockout rat Cognition Long-term potentiation Spatial learning and memory Neurosciences. Biological psychiatry. Neuropsychiatry Emily M. Pitzer verfasserin aut Jillian R. Hufgard verfasserin aut Chiho Sugimoto verfasserin aut Michael T. Williams verfasserin aut Charles V. Vorhees verfasserin aut In Neurobiology of Disease Elsevier, 2021 158(2021), Seite 105456- (DE-627)268125414 (DE-600)1471408-5 1095953X nnns volume:158 year:2021 pages:105456- https://doi.org/10.1016/j.nbd.2021.105456 kostenfrei https://doaj.org/article/02d801f1a8994218b16fd0930b543a3e kostenfrei http://www.sciencedirect.com/science/article/pii/S0969996121002059 kostenfrei https://doaj.org/toc/1095-953X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 158 2021 105456-
language	English
source	In Neurobiology of Disease 158(2021), Seite 105456- volume:158 year:2021 pages:105456-
sourceStr	In Neurobiology of Disease 158(2021), Seite 105456- volume:158 year:2021 pages:105456-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Lphn3 Adgrl-3 Lphn3 knockout rat Cognition Long-term potentiation Spatial learning and memory Neurosciences. Biological psychiatry. Neuropsychiatry
isfreeaccess_bool	true
container_title	Neurobiology of Disease
authorswithroles_txt_mv	Samantha L. Regan @@aut@@ Emily M. Pitzer @@aut@@ Jillian R. Hufgard @@aut@@ Chiho Sugimoto @@aut@@ Michael T. Williams @@aut@@ Charles V. Vorhees @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	268125414
id	DOAJ071227261
language_de	englisch
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callnumber-first	R - Medicine
author	Samantha L. Regan
spellingShingle	Samantha L. Regan misc RC321-571 misc Lphn3 misc Adgrl-3 misc Lphn3 knockout rat misc Cognition misc Long-term potentiation misc Spatial learning and memory misc Neurosciences. Biological psychiatry. Neuropsychiatry A novel role for the ADHD risk gene latrophilin-3 in learning and memory in Lphn3 knockout rats
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topic_title	RC321-571 A novel role for the ADHD risk gene latrophilin-3 in learning and memory in Lphn3 knockout rats Lphn3 Adgrl-3 Lphn3 knockout rat Cognition Long-term potentiation Spatial learning and memory
topic	misc RC321-571 misc Lphn3 misc Adgrl-3 misc Lphn3 knockout rat misc Cognition misc Long-term potentiation misc Spatial learning and memory misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_unstemmed	misc RC321-571 misc Lphn3 misc Adgrl-3 misc Lphn3 knockout rat misc Cognition misc Long-term potentiation misc Spatial learning and memory misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_browse	misc RC321-571 misc Lphn3 misc Adgrl-3 misc Lphn3 knockout rat misc Cognition misc Long-term potentiation misc Spatial learning and memory misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	A novel role for the ADHD risk gene latrophilin-3 in learning and memory in Lphn3 knockout rats
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title_full	A novel role for the ADHD risk gene latrophilin-3 in learning and memory in Lphn3 knockout rats
author_sort	Samantha L. Regan
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author_browse	Samantha L. Regan Emily M. Pitzer Jillian R. Hufgard Chiho Sugimoto Michael T. Williams Charles V. Vorhees
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title_sort	novel role for the adhd risk gene latrophilin-3 in learning and memory in lphn3 knockout rats
callnumber	RC321-571
title_auth	A novel role for the ADHD risk gene latrophilin-3 in learning and memory in Lphn3 knockout rats
abstract	Latrophilins (LPHNs) are adhesion G protein-coupled receptors with three isoforms but only LPHN3 is brain specific (caudate, prefrontal cortex, dentate, amygdala, and cerebellum). Variants of LPHN3 are associated with ADHD. Null mutations of Lphn3 in rat, mouse, zebrafish, and Drosophila result in hyperactivity, but its role in learning and memory (L&M) is largely unknown. Using our Lphn3 knockout (KO) rats we examined the cognitive abilities, long-term potentiation (LTP) in CA1, NMDA receptor expression, and neurohistology from heterozygous breeding pairs. KO rats were impaired in egocentric L&M in the Cincinnati water maze, spatial L&M and cognitive flexibility in the Morris water maze (MWM), with no effects on conditioned freezing, novel object recognition, or temporal order recognition. KO-associated locomotor hyperactivity had no effect on swim speed. KO rats had reduced early-LTP but not late-LTP and had reduced hippocampal NMDA-NR1 expression. In a second experiment, KO rats responded to a light prepulse prior to an acoustic startle pulse, reflecting visual signal detection. In a third experiment, KO rats given extra MWM pretraining and hidden platform overtraining showed no evidence of reaching WT rats' levels of learning. Nissl histology revealed no structural abnormalities in KO rats. LPHN3 has a selective effect on egocentric and allocentric L&M without effects on conditioned freezing or recognition memory.
abstractGer	Latrophilins (LPHNs) are adhesion G protein-coupled receptors with three isoforms but only LPHN3 is brain specific (caudate, prefrontal cortex, dentate, amygdala, and cerebellum). Variants of LPHN3 are associated with ADHD. Null mutations of Lphn3 in rat, mouse, zebrafish, and Drosophila result in hyperactivity, but its role in learning and memory (L&M) is largely unknown. Using our Lphn3 knockout (KO) rats we examined the cognitive abilities, long-term potentiation (LTP) in CA1, NMDA receptor expression, and neurohistology from heterozygous breeding pairs. KO rats were impaired in egocentric L&M in the Cincinnati water maze, spatial L&M and cognitive flexibility in the Morris water maze (MWM), with no effects on conditioned freezing, novel object recognition, or temporal order recognition. KO-associated locomotor hyperactivity had no effect on swim speed. KO rats had reduced early-LTP but not late-LTP and had reduced hippocampal NMDA-NR1 expression. In a second experiment, KO rats responded to a light prepulse prior to an acoustic startle pulse, reflecting visual signal detection. In a third experiment, KO rats given extra MWM pretraining and hidden platform overtraining showed no evidence of reaching WT rats' levels of learning. Nissl histology revealed no structural abnormalities in KO rats. LPHN3 has a selective effect on egocentric and allocentric L&M without effects on conditioned freezing or recognition memory.
abstract_unstemmed	Latrophilins (LPHNs) are adhesion G protein-coupled receptors with three isoforms but only LPHN3 is brain specific (caudate, prefrontal cortex, dentate, amygdala, and cerebellum). Variants of LPHN3 are associated with ADHD. Null mutations of Lphn3 in rat, mouse, zebrafish, and Drosophila result in hyperactivity, but its role in learning and memory (L&M) is largely unknown. Using our Lphn3 knockout (KO) rats we examined the cognitive abilities, long-term potentiation (LTP) in CA1, NMDA receptor expression, and neurohistology from heterozygous breeding pairs. KO rats were impaired in egocentric L&M in the Cincinnati water maze, spatial L&M and cognitive flexibility in the Morris water maze (MWM), with no effects on conditioned freezing, novel object recognition, or temporal order recognition. KO-associated locomotor hyperactivity had no effect on swim speed. KO rats had reduced early-LTP but not late-LTP and had reduced hippocampal NMDA-NR1 expression. In a second experiment, KO rats responded to a light prepulse prior to an acoustic startle pulse, reflecting visual signal detection. In a third experiment, KO rats given extra MWM pretraining and hidden platform overtraining showed no evidence of reaching WT rats' levels of learning. Nissl histology revealed no structural abnormalities in KO rats. LPHN3 has a selective effect on egocentric and allocentric L&M without effects on conditioned freezing or recognition memory.
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title_short	A novel role for the ADHD risk gene latrophilin-3 in learning and memory in Lphn3 knockout rats
url	https://doi.org/10.1016/j.nbd.2021.105456 https://doaj.org/article/02d801f1a8994218b16fd0930b543a3e http://www.sciencedirect.com/science/article/pii/S0969996121002059 https://doaj.org/toc/1095-953X
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author2	Emily M. Pitzer Jillian R. Hufgard Chiho Sugimoto Michael T. Williams Charles V. Vorhees
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A novel role for the ADHD risk gene latrophilin-3 in learning and memory in Lphn3 knockout rats

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