Outbreak of Fusarium oxysporum infections in children with cancer: an experience with 7 episodes of catheter-related fungemia
Abstract Background Fusarium species are widely spread in nature as plant pathogens but are also able to cause opportunistic fungal infections in humans. We report a cluster of Fusarium oxysporum bloodstream infections in a single pediatric cancer center. Methods All clinical and epidemiological dat...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Fabianne Carlesse [verfasserIn] Anna-Paula C. Amaral [verfasserIn] Sarah S. Gonçalves [verfasserIn] Hemilio Xafranski [verfasserIn] Maria-Lucia M. Lee [verfasserIn] Victor Zecchin [verfasserIn] Antonio S. Petrilli [verfasserIn] Abdullah M. Al-Hatmi [verfasserIn] Ferry Hagen [verfasserIn] Jacques F. Meis [verfasserIn] Arnaldo L. Colombo [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017 |
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| Übergeordnetes Werk: |
In: Antimicrobial Resistance and Infection Control - BMC, 2012, 6(2017), 1, Seite 7 |
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| Übergeordnetes Werk: |
volume:6 ; year:2017 ; number:1 ; pages:7 |
| Links: |
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| DOI / URN: |
10.1186/s13756-017-0247-3 |
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DOAJ071327207 |
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| 520 | |a Abstract Background Fusarium species are widely spread in nature as plant pathogens but are also able to cause opportunistic fungal infections in humans. We report a cluster of Fusarium oxysporum bloodstream infections in a single pediatric cancer center. Methods All clinical and epidemiological data related to an outbreak involving seven cases of fungemia by Fusarium oxysporum during October 2013 and February 2014 were analysed. All cultured isolates (n = 14) were identified to species level by sequencing of the TEF1 and RPB2 genes. Genotyping of the outbreak isolates was performed by amplified fragment length polymorphism fingerprinting. Results In a 5-month period 7 febrile pediatric cancer patients were diagnosed with catheter-related Fusarium oxysporum bloodstream infections. In a time span of 11 years, only 6 other infections due to Fusarium were documented and all were caused by a different species, Fusarium solani. None of the pediatric cancer patients had neutropenia at the time of diagnosis and all became febrile within two days after catheter manipulation in a specially designed room. Extensive environmental sampling in this room and the hospital did not gave a clue to the source. The outbreak was terminated after implementation of a multidisciplinary central line insertion care bundle. All Fusarium strains from blood and catheter tips were genetically related by amplified fragment length polymorphism fingerprinting. All patients survived the infection after prompt catheter removal and antifungal therapy. Conclusion A cluster with, genotypical identical, Fusarium oxysporum strains infecting 7 children with cancer, was most probably catheter-related. The environmental source was not discovered but strict infection control measures and catheter care terminated the outbreak. | ||
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| 650 | 4 | |a Fusarium oxysporum | |
| 650 | 4 | |a Catheter-related Fusarium fungemia | |
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| 700 | 0 | |a Jacques F. Meis |e verfasserin |4 aut | |
| 700 | 0 | |a Arnaldo L. Colombo |e verfasserin |4 aut | |
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10.1186/s13756-017-0247-3 doi (DE-627)DOAJ071327207 (DE-599)DOAJ64a13fddb8d64d259da34c9f45d3936d DE-627 ger DE-627 rakwb eng RC109-216 Fabianne Carlesse verfasserin aut Outbreak of Fusarium oxysporum infections in children with cancer: an experience with 7 episodes of catheter-related fungemia 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Fusarium species are widely spread in nature as plant pathogens but are also able to cause opportunistic fungal infections in humans. We report a cluster of Fusarium oxysporum bloodstream infections in a single pediatric cancer center. Methods All clinical and epidemiological data related to an outbreak involving seven cases of fungemia by Fusarium oxysporum during October 2013 and February 2014 were analysed. All cultured isolates (n = 14) were identified to species level by sequencing of the TEF1 and RPB2 genes. Genotyping of the outbreak isolates was performed by amplified fragment length polymorphism fingerprinting. Results In a 5-month period 7 febrile pediatric cancer patients were diagnosed with catheter-related Fusarium oxysporum bloodstream infections. In a time span of 11 years, only 6 other infections due to Fusarium were documented and all were caused by a different species, Fusarium solani. None of the pediatric cancer patients had neutropenia at the time of diagnosis and all became febrile within two days after catheter manipulation in a specially designed room. Extensive environmental sampling in this room and the hospital did not gave a clue to the source. The outbreak was terminated after implementation of a multidisciplinary central line insertion care bundle. All Fusarium strains from blood and catheter tips were genetically related by amplified fragment length polymorphism fingerprinting. All patients survived the infection after prompt catheter removal and antifungal therapy. Conclusion A cluster with, genotypical identical, Fusarium oxysporum strains infecting 7 children with cancer, was most probably catheter-related. The environmental source was not discovered but strict infection control measures and catheter care terminated the outbreak. Fusariosis Fusarium sp. Fusarium oxysporum Catheter-related Fusarium fungemia Pediatric invasive fungal infections Infectious and parasitic diseases Anna-Paula C. Amaral verfasserin aut Sarah S. Gonçalves verfasserin aut Hemilio Xafranski verfasserin aut Maria-Lucia M. Lee verfasserin aut Victor Zecchin verfasserin aut Antonio S. Petrilli verfasserin aut Abdullah M. Al-Hatmi verfasserin aut Ferry Hagen verfasserin aut Jacques F. Meis verfasserin aut Arnaldo L. Colombo verfasserin aut In Antimicrobial Resistance and Infection Control BMC, 2012 6(2017), 1, Seite 7 (DE-627)718716140 (DE-600)2666706-X 20472994 nnns volume:6 year:2017 number:1 pages:7 https://doi.org/10.1186/s13756-017-0247-3 kostenfrei https://doaj.org/article/64a13fddb8d64d259da34c9f45d3936d kostenfrei http://link.springer.com/article/10.1186/s13756-017-0247-3 kostenfrei https://doaj.org/toc/2047-2994 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2017 1 7 |
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10.1186/s13756-017-0247-3 doi (DE-627)DOAJ071327207 (DE-599)DOAJ64a13fddb8d64d259da34c9f45d3936d DE-627 ger DE-627 rakwb eng RC109-216 Fabianne Carlesse verfasserin aut Outbreak of Fusarium oxysporum infections in children with cancer: an experience with 7 episodes of catheter-related fungemia 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Fusarium species are widely spread in nature as plant pathogens but are also able to cause opportunistic fungal infections in humans. We report a cluster of Fusarium oxysporum bloodstream infections in a single pediatric cancer center. Methods All clinical and epidemiological data related to an outbreak involving seven cases of fungemia by Fusarium oxysporum during October 2013 and February 2014 were analysed. All cultured isolates (n = 14) were identified to species level by sequencing of the TEF1 and RPB2 genes. Genotyping of the outbreak isolates was performed by amplified fragment length polymorphism fingerprinting. Results In a 5-month period 7 febrile pediatric cancer patients were diagnosed with catheter-related Fusarium oxysporum bloodstream infections. In a time span of 11 years, only 6 other infections due to Fusarium were documented and all were caused by a different species, Fusarium solani. None of the pediatric cancer patients had neutropenia at the time of diagnosis and all became febrile within two days after catheter manipulation in a specially designed room. Extensive environmental sampling in this room and the hospital did not gave a clue to the source. The outbreak was terminated after implementation of a multidisciplinary central line insertion care bundle. All Fusarium strains from blood and catheter tips were genetically related by amplified fragment length polymorphism fingerprinting. All patients survived the infection after prompt catheter removal and antifungal therapy. Conclusion A cluster with, genotypical identical, Fusarium oxysporum strains infecting 7 children with cancer, was most probably catheter-related. The environmental source was not discovered but strict infection control measures and catheter care terminated the outbreak. Fusariosis Fusarium sp. Fusarium oxysporum Catheter-related Fusarium fungemia Pediatric invasive fungal infections Infectious and parasitic diseases Anna-Paula C. Amaral verfasserin aut Sarah S. Gonçalves verfasserin aut Hemilio Xafranski verfasserin aut Maria-Lucia M. Lee verfasserin aut Victor Zecchin verfasserin aut Antonio S. Petrilli verfasserin aut Abdullah M. Al-Hatmi verfasserin aut Ferry Hagen verfasserin aut Jacques F. Meis verfasserin aut Arnaldo L. Colombo verfasserin aut In Antimicrobial Resistance and Infection Control BMC, 2012 6(2017), 1, Seite 7 (DE-627)718716140 (DE-600)2666706-X 20472994 nnns volume:6 year:2017 number:1 pages:7 https://doi.org/10.1186/s13756-017-0247-3 kostenfrei https://doaj.org/article/64a13fddb8d64d259da34c9f45d3936d kostenfrei http://link.springer.com/article/10.1186/s13756-017-0247-3 kostenfrei https://doaj.org/toc/2047-2994 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2017 1 7 |
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10.1186/s13756-017-0247-3 doi (DE-627)DOAJ071327207 (DE-599)DOAJ64a13fddb8d64d259da34c9f45d3936d DE-627 ger DE-627 rakwb eng RC109-216 Fabianne Carlesse verfasserin aut Outbreak of Fusarium oxysporum infections in children with cancer: an experience with 7 episodes of catheter-related fungemia 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Fusarium species are widely spread in nature as plant pathogens but are also able to cause opportunistic fungal infections in humans. We report a cluster of Fusarium oxysporum bloodstream infections in a single pediatric cancer center. Methods All clinical and epidemiological data related to an outbreak involving seven cases of fungemia by Fusarium oxysporum during October 2013 and February 2014 were analysed. All cultured isolates (n = 14) were identified to species level by sequencing of the TEF1 and RPB2 genes. Genotyping of the outbreak isolates was performed by amplified fragment length polymorphism fingerprinting. Results In a 5-month period 7 febrile pediatric cancer patients were diagnosed with catheter-related Fusarium oxysporum bloodstream infections. In a time span of 11 years, only 6 other infections due to Fusarium were documented and all were caused by a different species, Fusarium solani. None of the pediatric cancer patients had neutropenia at the time of diagnosis and all became febrile within two days after catheter manipulation in a specially designed room. Extensive environmental sampling in this room and the hospital did not gave a clue to the source. The outbreak was terminated after implementation of a multidisciplinary central line insertion care bundle. All Fusarium strains from blood and catheter tips were genetically related by amplified fragment length polymorphism fingerprinting. All patients survived the infection after prompt catheter removal and antifungal therapy. Conclusion A cluster with, genotypical identical, Fusarium oxysporum strains infecting 7 children with cancer, was most probably catheter-related. The environmental source was not discovered but strict infection control measures and catheter care terminated the outbreak. Fusariosis Fusarium sp. Fusarium oxysporum Catheter-related Fusarium fungemia Pediatric invasive fungal infections Infectious and parasitic diseases Anna-Paula C. Amaral verfasserin aut Sarah S. Gonçalves verfasserin aut Hemilio Xafranski verfasserin aut Maria-Lucia M. Lee verfasserin aut Victor Zecchin verfasserin aut Antonio S. Petrilli verfasserin aut Abdullah M. Al-Hatmi verfasserin aut Ferry Hagen verfasserin aut Jacques F. Meis verfasserin aut Arnaldo L. Colombo verfasserin aut In Antimicrobial Resistance and Infection Control BMC, 2012 6(2017), 1, Seite 7 (DE-627)718716140 (DE-600)2666706-X 20472994 nnns volume:6 year:2017 number:1 pages:7 https://doi.org/10.1186/s13756-017-0247-3 kostenfrei https://doaj.org/article/64a13fddb8d64d259da34c9f45d3936d kostenfrei http://link.springer.com/article/10.1186/s13756-017-0247-3 kostenfrei https://doaj.org/toc/2047-2994 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2017 1 7 |
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10.1186/s13756-017-0247-3 doi (DE-627)DOAJ071327207 (DE-599)DOAJ64a13fddb8d64d259da34c9f45d3936d DE-627 ger DE-627 rakwb eng RC109-216 Fabianne Carlesse verfasserin aut Outbreak of Fusarium oxysporum infections in children with cancer: an experience with 7 episodes of catheter-related fungemia 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Fusarium species are widely spread in nature as plant pathogens but are also able to cause opportunistic fungal infections in humans. We report a cluster of Fusarium oxysporum bloodstream infections in a single pediatric cancer center. Methods All clinical and epidemiological data related to an outbreak involving seven cases of fungemia by Fusarium oxysporum during October 2013 and February 2014 were analysed. All cultured isolates (n = 14) were identified to species level by sequencing of the TEF1 and RPB2 genes. Genotyping of the outbreak isolates was performed by amplified fragment length polymorphism fingerprinting. Results In a 5-month period 7 febrile pediatric cancer patients were diagnosed with catheter-related Fusarium oxysporum bloodstream infections. In a time span of 11 years, only 6 other infections due to Fusarium were documented and all were caused by a different species, Fusarium solani. None of the pediatric cancer patients had neutropenia at the time of diagnosis and all became febrile within two days after catheter manipulation in a specially designed room. Extensive environmental sampling in this room and the hospital did not gave a clue to the source. The outbreak was terminated after implementation of a multidisciplinary central line insertion care bundle. All Fusarium strains from blood and catheter tips were genetically related by amplified fragment length polymorphism fingerprinting. All patients survived the infection after prompt catheter removal and antifungal therapy. Conclusion A cluster with, genotypical identical, Fusarium oxysporum strains infecting 7 children with cancer, was most probably catheter-related. The environmental source was not discovered but strict infection control measures and catheter care terminated the outbreak. Fusariosis Fusarium sp. Fusarium oxysporum Catheter-related Fusarium fungemia Pediatric invasive fungal infections Infectious and parasitic diseases Anna-Paula C. Amaral verfasserin aut Sarah S. Gonçalves verfasserin aut Hemilio Xafranski verfasserin aut Maria-Lucia M. Lee verfasserin aut Victor Zecchin verfasserin aut Antonio S. Petrilli verfasserin aut Abdullah M. Al-Hatmi verfasserin aut Ferry Hagen verfasserin aut Jacques F. Meis verfasserin aut Arnaldo L. Colombo verfasserin aut In Antimicrobial Resistance and Infection Control BMC, 2012 6(2017), 1, Seite 7 (DE-627)718716140 (DE-600)2666706-X 20472994 nnns volume:6 year:2017 number:1 pages:7 https://doi.org/10.1186/s13756-017-0247-3 kostenfrei https://doaj.org/article/64a13fddb8d64d259da34c9f45d3936d kostenfrei http://link.springer.com/article/10.1186/s13756-017-0247-3 kostenfrei https://doaj.org/toc/2047-2994 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2017 1 7 |
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10.1186/s13756-017-0247-3 doi (DE-627)DOAJ071327207 (DE-599)DOAJ64a13fddb8d64d259da34c9f45d3936d DE-627 ger DE-627 rakwb eng RC109-216 Fabianne Carlesse verfasserin aut Outbreak of Fusarium oxysporum infections in children with cancer: an experience with 7 episodes of catheter-related fungemia 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Fusarium species are widely spread in nature as plant pathogens but are also able to cause opportunistic fungal infections in humans. We report a cluster of Fusarium oxysporum bloodstream infections in a single pediatric cancer center. Methods All clinical and epidemiological data related to an outbreak involving seven cases of fungemia by Fusarium oxysporum during October 2013 and February 2014 were analysed. All cultured isolates (n = 14) were identified to species level by sequencing of the TEF1 and RPB2 genes. Genotyping of the outbreak isolates was performed by amplified fragment length polymorphism fingerprinting. Results In a 5-month period 7 febrile pediatric cancer patients were diagnosed with catheter-related Fusarium oxysporum bloodstream infections. In a time span of 11 years, only 6 other infections due to Fusarium were documented and all were caused by a different species, Fusarium solani. None of the pediatric cancer patients had neutropenia at the time of diagnosis and all became febrile within two days after catheter manipulation in a specially designed room. Extensive environmental sampling in this room and the hospital did not gave a clue to the source. The outbreak was terminated after implementation of a multidisciplinary central line insertion care bundle. All Fusarium strains from blood and catheter tips were genetically related by amplified fragment length polymorphism fingerprinting. All patients survived the infection after prompt catheter removal and antifungal therapy. Conclusion A cluster with, genotypical identical, Fusarium oxysporum strains infecting 7 children with cancer, was most probably catheter-related. The environmental source was not discovered but strict infection control measures and catheter care terminated the outbreak. Fusariosis Fusarium sp. Fusarium oxysporum Catheter-related Fusarium fungemia Pediatric invasive fungal infections Infectious and parasitic diseases Anna-Paula C. Amaral verfasserin aut Sarah S. Gonçalves verfasserin aut Hemilio Xafranski verfasserin aut Maria-Lucia M. Lee verfasserin aut Victor Zecchin verfasserin aut Antonio S. Petrilli verfasserin aut Abdullah M. Al-Hatmi verfasserin aut Ferry Hagen verfasserin aut Jacques F. Meis verfasserin aut Arnaldo L. Colombo verfasserin aut In Antimicrobial Resistance and Infection Control BMC, 2012 6(2017), 1, Seite 7 (DE-627)718716140 (DE-600)2666706-X 20472994 nnns volume:6 year:2017 number:1 pages:7 https://doi.org/10.1186/s13756-017-0247-3 kostenfrei https://doaj.org/article/64a13fddb8d64d259da34c9f45d3936d kostenfrei http://link.springer.com/article/10.1186/s13756-017-0247-3 kostenfrei https://doaj.org/toc/2047-2994 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2017 1 7 |
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Fabianne Carlesse |
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verfasserin |
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outbreak of fusarium oxysporum infections in children with cancer: an experience with 7 episodes of catheter-related fungemia |
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RC109-216 |
| title_auth |
Outbreak of Fusarium oxysporum infections in children with cancer: an experience with 7 episodes of catheter-related fungemia |
| abstract |
Abstract Background Fusarium species are widely spread in nature as plant pathogens but are also able to cause opportunistic fungal infections in humans. We report a cluster of Fusarium oxysporum bloodstream infections in a single pediatric cancer center. Methods All clinical and epidemiological data related to an outbreak involving seven cases of fungemia by Fusarium oxysporum during October 2013 and February 2014 were analysed. All cultured isolates (n = 14) were identified to species level by sequencing of the TEF1 and RPB2 genes. Genotyping of the outbreak isolates was performed by amplified fragment length polymorphism fingerprinting. Results In a 5-month period 7 febrile pediatric cancer patients were diagnosed with catheter-related Fusarium oxysporum bloodstream infections. In a time span of 11 years, only 6 other infections due to Fusarium were documented and all were caused by a different species, Fusarium solani. None of the pediatric cancer patients had neutropenia at the time of diagnosis and all became febrile within two days after catheter manipulation in a specially designed room. Extensive environmental sampling in this room and the hospital did not gave a clue to the source. The outbreak was terminated after implementation of a multidisciplinary central line insertion care bundle. All Fusarium strains from blood and catheter tips were genetically related by amplified fragment length polymorphism fingerprinting. All patients survived the infection after prompt catheter removal and antifungal therapy. Conclusion A cluster with, genotypical identical, Fusarium oxysporum strains infecting 7 children with cancer, was most probably catheter-related. The environmental source was not discovered but strict infection control measures and catheter care terminated the outbreak. |
| abstractGer |
Abstract Background Fusarium species are widely spread in nature as plant pathogens but are also able to cause opportunistic fungal infections in humans. We report a cluster of Fusarium oxysporum bloodstream infections in a single pediatric cancer center. Methods All clinical and epidemiological data related to an outbreak involving seven cases of fungemia by Fusarium oxysporum during October 2013 and February 2014 were analysed. All cultured isolates (n = 14) were identified to species level by sequencing of the TEF1 and RPB2 genes. Genotyping of the outbreak isolates was performed by amplified fragment length polymorphism fingerprinting. Results In a 5-month period 7 febrile pediatric cancer patients were diagnosed with catheter-related Fusarium oxysporum bloodstream infections. In a time span of 11 years, only 6 other infections due to Fusarium were documented and all were caused by a different species, Fusarium solani. None of the pediatric cancer patients had neutropenia at the time of diagnosis and all became febrile within two days after catheter manipulation in a specially designed room. Extensive environmental sampling in this room and the hospital did not gave a clue to the source. The outbreak was terminated after implementation of a multidisciplinary central line insertion care bundle. All Fusarium strains from blood and catheter tips were genetically related by amplified fragment length polymorphism fingerprinting. All patients survived the infection after prompt catheter removal and antifungal therapy. Conclusion A cluster with, genotypical identical, Fusarium oxysporum strains infecting 7 children with cancer, was most probably catheter-related. The environmental source was not discovered but strict infection control measures and catheter care terminated the outbreak. |
| abstract_unstemmed |
Abstract Background Fusarium species are widely spread in nature as plant pathogens but are also able to cause opportunistic fungal infections in humans. We report a cluster of Fusarium oxysporum bloodstream infections in a single pediatric cancer center. Methods All clinical and epidemiological data related to an outbreak involving seven cases of fungemia by Fusarium oxysporum during October 2013 and February 2014 were analysed. All cultured isolates (n = 14) were identified to species level by sequencing of the TEF1 and RPB2 genes. Genotyping of the outbreak isolates was performed by amplified fragment length polymorphism fingerprinting. Results In a 5-month period 7 febrile pediatric cancer patients were diagnosed with catheter-related Fusarium oxysporum bloodstream infections. In a time span of 11 years, only 6 other infections due to Fusarium were documented and all were caused by a different species, Fusarium solani. None of the pediatric cancer patients had neutropenia at the time of diagnosis and all became febrile within two days after catheter manipulation in a specially designed room. Extensive environmental sampling in this room and the hospital did not gave a clue to the source. The outbreak was terminated after implementation of a multidisciplinary central line insertion care bundle. All Fusarium strains from blood and catheter tips were genetically related by amplified fragment length polymorphism fingerprinting. All patients survived the infection after prompt catheter removal and antifungal therapy. Conclusion A cluster with, genotypical identical, Fusarium oxysporum strains infecting 7 children with cancer, was most probably catheter-related. The environmental source was not discovered but strict infection control measures and catheter care terminated the outbreak. |
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Outbreak of Fusarium oxysporum infections in children with cancer: an experience with 7 episodes of catheter-related fungemia |
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https://doi.org/10.1186/s13756-017-0247-3 https://doaj.org/article/64a13fddb8d64d259da34c9f45d3936d http://link.springer.com/article/10.1186/s13756-017-0247-3 https://doaj.org/toc/2047-2994 |
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Anna-Paula C. Amaral Sarah S. Gonçalves Hemilio Xafranski Maria-Lucia M. Lee Victor Zecchin Antonio S. Petrilli Abdullah M. Al-Hatmi Ferry Hagen Jacques F. Meis Arnaldo L. Colombo |
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Anna-Paula C. Amaral Sarah S. Gonçalves Hemilio Xafranski Maria-Lucia M. Lee Victor Zecchin Antonio S. Petrilli Abdullah M. Al-Hatmi Ferry Hagen Jacques F. Meis Arnaldo L. Colombo |
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2024-07-03T19:39:47.918Z |
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