Clinical trials in otology: Examining trends and framework for prioritization

Objective: To characterize otologic clinical trials and examine otologic clinical trial trends from 2008 to 2018 using the clinicaltrials.gov database. Methods: Data was collected from clinicaltrials.gov and included all clinical trials that focused on otology from 2008 to 2018. Outcome measures inc...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Jake Altshuler [verfasserIn] Rohan Viswanathan [verfasserIn] Divya B. Dasani [verfasserIn] Katherine Webb [verfasserIn] Tam Ramsey [verfasserIn] Varun Patel [verfasserIn] Randall Ruffner [verfasserIn] Jason Mouzakes [verfasserIn] David Foyt [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Otology Clinical trials Otology trend

Übergeordnetes Werk:	In: Journal of Otology - Elsevier, 2016, 16(2021), 2, Seite 95-98
Übergeordnetes Werk:	volume:16 ; year:2021 ; number:2 ; pages:95-98

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.joto.2020.11.003

Katalog-ID:	DOAJ071378154

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allfields	10.1016/j.joto.2020.11.003 doi (DE-627)DOAJ071378154 (DE-599)DOAJee579e9b90184ca389e57f9320f5e7ed DE-627 ger DE-627 rakwb eng RF1-547 Jake Altshuler verfasserin aut Clinical trials in otology: Examining trends and framework for prioritization 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To characterize otologic clinical trials and examine otologic clinical trial trends from 2008 to 2018 using the clinicaltrials.gov database. Methods: Data was collected from clinicaltrials.gov and included all clinical trials that focused on otology from 2008 to 2018. Outcome measures include status of trials, funding sources, details regarding otologic conditions studied, and trends in clinical trials. Results: There were 992 otology clinical trials from 2008 to 2018.457 (46.1%) were completed and 94 (9.5%) were discontinued. Industry remained the highest (76.5%) contributor to otology clinical trials. The otologic conditions studied, from most common to least common, include hearing loss (40.6%), vestibulopathy (18.8%), tinnitus (18.8%), and otitis media (15.1%). The number of otology clinical trials increased by an average of 12.0 trials per year from 2008 to 2018 (p < 0.001). The number of otology clinical trials focusing on hearing loss and vestibulopathy significantly increased over the studied period (p < 0.001), while those focusing on tinnitus and otitis media did not (p = 0.09 and p = 0.20, respectively). The majority of clinical trials on each of these four conditions focused on treatment options. Conclusion: Our study describes trends in otology clinical trials registered on clinicaltrials.gov from 2008 through 2018. The total number of clinical trials over this time period increased significantly, driven by trials investigating hearing loss and vestibulopathy. Furthermore, most clinical trials were industry-sponsored and focused on treatment modalities. Our study provides an outline of otology clinical trials registered in a US web-based database, which may be of use for the development of future clinical trials. Otology Clinical trials Otology trend Otorhinolaryngology Rohan Viswanathan verfasserin aut Divya B. Dasani verfasserin aut Katherine Webb verfasserin aut Tam Ramsey verfasserin aut Varun Patel verfasserin aut Randall Ruffner verfasserin aut Jason Mouzakes verfasserin aut David Foyt verfasserin aut In Journal of Otology Elsevier, 2016 16(2021), 2, Seite 95-98 (DE-627)665673639 (DE-600)2621477-5 16722930 nnns volume:16 year:2021 number:2 pages:95-98 https://doi.org/10.1016/j.joto.2020.11.003 kostenfrei https://doaj.org/article/ee579e9b90184ca389e57f9320f5e7ed kostenfrei http://www.sciencedirect.com/science/article/pii/S1672293020301136 kostenfrei https://doaj.org/toc/1672-2930 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2021 2 95-98
spelling	10.1016/j.joto.2020.11.003 doi (DE-627)DOAJ071378154 (DE-599)DOAJee579e9b90184ca389e57f9320f5e7ed DE-627 ger DE-627 rakwb eng RF1-547 Jake Altshuler verfasserin aut Clinical trials in otology: Examining trends and framework for prioritization 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To characterize otologic clinical trials and examine otologic clinical trial trends from 2008 to 2018 using the clinicaltrials.gov database. Methods: Data was collected from clinicaltrials.gov and included all clinical trials that focused on otology from 2008 to 2018. Outcome measures include status of trials, funding sources, details regarding otologic conditions studied, and trends in clinical trials. Results: There were 992 otology clinical trials from 2008 to 2018.457 (46.1%) were completed and 94 (9.5%) were discontinued. Industry remained the highest (76.5%) contributor to otology clinical trials. The otologic conditions studied, from most common to least common, include hearing loss (40.6%), vestibulopathy (18.8%), tinnitus (18.8%), and otitis media (15.1%). The number of otology clinical trials increased by an average of 12.0 trials per year from 2008 to 2018 (p < 0.001). The number of otology clinical trials focusing on hearing loss and vestibulopathy significantly increased over the studied period (p < 0.001), while those focusing on tinnitus and otitis media did not (p = 0.09 and p = 0.20, respectively). The majority of clinical trials on each of these four conditions focused on treatment options. Conclusion: Our study describes trends in otology clinical trials registered on clinicaltrials.gov from 2008 through 2018. The total number of clinical trials over this time period increased significantly, driven by trials investigating hearing loss and vestibulopathy. Furthermore, most clinical trials were industry-sponsored and focused on treatment modalities. Our study provides an outline of otology clinical trials registered in a US web-based database, which may be of use for the development of future clinical trials. Otology Clinical trials Otology trend Otorhinolaryngology Rohan Viswanathan verfasserin aut Divya B. Dasani verfasserin aut Katherine Webb verfasserin aut Tam Ramsey verfasserin aut Varun Patel verfasserin aut Randall Ruffner verfasserin aut Jason Mouzakes verfasserin aut David Foyt verfasserin aut In Journal of Otology Elsevier, 2016 16(2021), 2, Seite 95-98 (DE-627)665673639 (DE-600)2621477-5 16722930 nnns volume:16 year:2021 number:2 pages:95-98 https://doi.org/10.1016/j.joto.2020.11.003 kostenfrei https://doaj.org/article/ee579e9b90184ca389e57f9320f5e7ed kostenfrei http://www.sciencedirect.com/science/article/pii/S1672293020301136 kostenfrei https://doaj.org/toc/1672-2930 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2021 2 95-98
allfields_unstemmed	10.1016/j.joto.2020.11.003 doi (DE-627)DOAJ071378154 (DE-599)DOAJee579e9b90184ca389e57f9320f5e7ed DE-627 ger DE-627 rakwb eng RF1-547 Jake Altshuler verfasserin aut Clinical trials in otology: Examining trends and framework for prioritization 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To characterize otologic clinical trials and examine otologic clinical trial trends from 2008 to 2018 using the clinicaltrials.gov database. Methods: Data was collected from clinicaltrials.gov and included all clinical trials that focused on otology from 2008 to 2018. Outcome measures include status of trials, funding sources, details regarding otologic conditions studied, and trends in clinical trials. Results: There were 992 otology clinical trials from 2008 to 2018.457 (46.1%) were completed and 94 (9.5%) were discontinued. Industry remained the highest (76.5%) contributor to otology clinical trials. The otologic conditions studied, from most common to least common, include hearing loss (40.6%), vestibulopathy (18.8%), tinnitus (18.8%), and otitis media (15.1%). The number of otology clinical trials increased by an average of 12.0 trials per year from 2008 to 2018 (p < 0.001). The number of otology clinical trials focusing on hearing loss and vestibulopathy significantly increased over the studied period (p < 0.001), while those focusing on tinnitus and otitis media did not (p = 0.09 and p = 0.20, respectively). The majority of clinical trials on each of these four conditions focused on treatment options. Conclusion: Our study describes trends in otology clinical trials registered on clinicaltrials.gov from 2008 through 2018. The total number of clinical trials over this time period increased significantly, driven by trials investigating hearing loss and vestibulopathy. Furthermore, most clinical trials were industry-sponsored and focused on treatment modalities. Our study provides an outline of otology clinical trials registered in a US web-based database, which may be of use for the development of future clinical trials. Otology Clinical trials Otology trend Otorhinolaryngology Rohan Viswanathan verfasserin aut Divya B. Dasani verfasserin aut Katherine Webb verfasserin aut Tam Ramsey verfasserin aut Varun Patel verfasserin aut Randall Ruffner verfasserin aut Jason Mouzakes verfasserin aut David Foyt verfasserin aut In Journal of Otology Elsevier, 2016 16(2021), 2, Seite 95-98 (DE-627)665673639 (DE-600)2621477-5 16722930 nnns volume:16 year:2021 number:2 pages:95-98 https://doi.org/10.1016/j.joto.2020.11.003 kostenfrei https://doaj.org/article/ee579e9b90184ca389e57f9320f5e7ed kostenfrei http://www.sciencedirect.com/science/article/pii/S1672293020301136 kostenfrei https://doaj.org/toc/1672-2930 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2021 2 95-98
allfieldsGer	10.1016/j.joto.2020.11.003 doi (DE-627)DOAJ071378154 (DE-599)DOAJee579e9b90184ca389e57f9320f5e7ed DE-627 ger DE-627 rakwb eng RF1-547 Jake Altshuler verfasserin aut Clinical trials in otology: Examining trends and framework for prioritization 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To characterize otologic clinical trials and examine otologic clinical trial trends from 2008 to 2018 using the clinicaltrials.gov database. Methods: Data was collected from clinicaltrials.gov and included all clinical trials that focused on otology from 2008 to 2018. Outcome measures include status of trials, funding sources, details regarding otologic conditions studied, and trends in clinical trials. Results: There were 992 otology clinical trials from 2008 to 2018.457 (46.1%) were completed and 94 (9.5%) were discontinued. Industry remained the highest (76.5%) contributor to otology clinical trials. The otologic conditions studied, from most common to least common, include hearing loss (40.6%), vestibulopathy (18.8%), tinnitus (18.8%), and otitis media (15.1%). The number of otology clinical trials increased by an average of 12.0 trials per year from 2008 to 2018 (p < 0.001). The number of otology clinical trials focusing on hearing loss and vestibulopathy significantly increased over the studied period (p < 0.001), while those focusing on tinnitus and otitis media did not (p = 0.09 and p = 0.20, respectively). The majority of clinical trials on each of these four conditions focused on treatment options. Conclusion: Our study describes trends in otology clinical trials registered on clinicaltrials.gov from 2008 through 2018. The total number of clinical trials over this time period increased significantly, driven by trials investigating hearing loss and vestibulopathy. Furthermore, most clinical trials were industry-sponsored and focused on treatment modalities. Our study provides an outline of otology clinical trials registered in a US web-based database, which may be of use for the development of future clinical trials. Otology Clinical trials Otology trend Otorhinolaryngology Rohan Viswanathan verfasserin aut Divya B. Dasani verfasserin aut Katherine Webb verfasserin aut Tam Ramsey verfasserin aut Varun Patel verfasserin aut Randall Ruffner verfasserin aut Jason Mouzakes verfasserin aut David Foyt verfasserin aut In Journal of Otology Elsevier, 2016 16(2021), 2, Seite 95-98 (DE-627)665673639 (DE-600)2621477-5 16722930 nnns volume:16 year:2021 number:2 pages:95-98 https://doi.org/10.1016/j.joto.2020.11.003 kostenfrei https://doaj.org/article/ee579e9b90184ca389e57f9320f5e7ed kostenfrei http://www.sciencedirect.com/science/article/pii/S1672293020301136 kostenfrei https://doaj.org/toc/1672-2930 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2021 2 95-98
allfieldsSound	10.1016/j.joto.2020.11.003 doi (DE-627)DOAJ071378154 (DE-599)DOAJee579e9b90184ca389e57f9320f5e7ed DE-627 ger DE-627 rakwb eng RF1-547 Jake Altshuler verfasserin aut Clinical trials in otology: Examining trends and framework for prioritization 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To characterize otologic clinical trials and examine otologic clinical trial trends from 2008 to 2018 using the clinicaltrials.gov database. Methods: Data was collected from clinicaltrials.gov and included all clinical trials that focused on otology from 2008 to 2018. Outcome measures include status of trials, funding sources, details regarding otologic conditions studied, and trends in clinical trials. Results: There were 992 otology clinical trials from 2008 to 2018.457 (46.1%) were completed and 94 (9.5%) were discontinued. Industry remained the highest (76.5%) contributor to otology clinical trials. The otologic conditions studied, from most common to least common, include hearing loss (40.6%), vestibulopathy (18.8%), tinnitus (18.8%), and otitis media (15.1%). The number of otology clinical trials increased by an average of 12.0 trials per year from 2008 to 2018 (p < 0.001). The number of otology clinical trials focusing on hearing loss and vestibulopathy significantly increased over the studied period (p < 0.001), while those focusing on tinnitus and otitis media did not (p = 0.09 and p = 0.20, respectively). The majority of clinical trials on each of these four conditions focused on treatment options. Conclusion: Our study describes trends in otology clinical trials registered on clinicaltrials.gov from 2008 through 2018. The total number of clinical trials over this time period increased significantly, driven by trials investigating hearing loss and vestibulopathy. Furthermore, most clinical trials were industry-sponsored and focused on treatment modalities. Our study provides an outline of otology clinical trials registered in a US web-based database, which may be of use for the development of future clinical trials. Otology Clinical trials Otology trend Otorhinolaryngology Rohan Viswanathan verfasserin aut Divya B. Dasani verfasserin aut Katherine Webb verfasserin aut Tam Ramsey verfasserin aut Varun Patel verfasserin aut Randall Ruffner verfasserin aut Jason Mouzakes verfasserin aut David Foyt verfasserin aut In Journal of Otology Elsevier, 2016 16(2021), 2, Seite 95-98 (DE-627)665673639 (DE-600)2621477-5 16722930 nnns volume:16 year:2021 number:2 pages:95-98 https://doi.org/10.1016/j.joto.2020.11.003 kostenfrei https://doaj.org/article/ee579e9b90184ca389e57f9320f5e7ed kostenfrei http://www.sciencedirect.com/science/article/pii/S1672293020301136 kostenfrei https://doaj.org/toc/1672-2930 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2021 2 95-98
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topic_title	RF1-547 Clinical trials in otology: Examining trends and framework for prioritization Otology Clinical trials Otology trend
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title	Clinical trials in otology: Examining trends and framework for prioritization
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title_full	Clinical trials in otology: Examining trends and framework for prioritization
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title_sort	clinical trials in otology: examining trends and framework for prioritization
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title_auth	Clinical trials in otology: Examining trends and framework for prioritization
abstract	Objective: To characterize otologic clinical trials and examine otologic clinical trial trends from 2008 to 2018 using the clinicaltrials.gov database. Methods: Data was collected from clinicaltrials.gov and included all clinical trials that focused on otology from 2008 to 2018. Outcome measures include status of trials, funding sources, details regarding otologic conditions studied, and trends in clinical trials. Results: There were 992 otology clinical trials from 2008 to 2018.457 (46.1%) were completed and 94 (9.5%) were discontinued. Industry remained the highest (76.5%) contributor to otology clinical trials. The otologic conditions studied, from most common to least common, include hearing loss (40.6%), vestibulopathy (18.8%), tinnitus (18.8%), and otitis media (15.1%). The number of otology clinical trials increased by an average of 12.0 trials per year from 2008 to 2018 (p < 0.001). The number of otology clinical trials focusing on hearing loss and vestibulopathy significantly increased over the studied period (p < 0.001), while those focusing on tinnitus and otitis media did not (p = 0.09 and p = 0.20, respectively). The majority of clinical trials on each of these four conditions focused on treatment options. Conclusion: Our study describes trends in otology clinical trials registered on clinicaltrials.gov from 2008 through 2018. The total number of clinical trials over this time period increased significantly, driven by trials investigating hearing loss and vestibulopathy. Furthermore, most clinical trials were industry-sponsored and focused on treatment modalities. Our study provides an outline of otology clinical trials registered in a US web-based database, which may be of use for the development of future clinical trials.
abstractGer	Objective: To characterize otologic clinical trials and examine otologic clinical trial trends from 2008 to 2018 using the clinicaltrials.gov database. Methods: Data was collected from clinicaltrials.gov and included all clinical trials that focused on otology from 2008 to 2018. Outcome measures include status of trials, funding sources, details regarding otologic conditions studied, and trends in clinical trials. Results: There were 992 otology clinical trials from 2008 to 2018.457 (46.1%) were completed and 94 (9.5%) were discontinued. Industry remained the highest (76.5%) contributor to otology clinical trials. The otologic conditions studied, from most common to least common, include hearing loss (40.6%), vestibulopathy (18.8%), tinnitus (18.8%), and otitis media (15.1%). The number of otology clinical trials increased by an average of 12.0 trials per year from 2008 to 2018 (p < 0.001). The number of otology clinical trials focusing on hearing loss and vestibulopathy significantly increased over the studied period (p < 0.001), while those focusing on tinnitus and otitis media did not (p = 0.09 and p = 0.20, respectively). The majority of clinical trials on each of these four conditions focused on treatment options. Conclusion: Our study describes trends in otology clinical trials registered on clinicaltrials.gov from 2008 through 2018. The total number of clinical trials over this time period increased significantly, driven by trials investigating hearing loss and vestibulopathy. Furthermore, most clinical trials were industry-sponsored and focused on treatment modalities. Our study provides an outline of otology clinical trials registered in a US web-based database, which may be of use for the development of future clinical trials.
abstract_unstemmed	Objective: To characterize otologic clinical trials and examine otologic clinical trial trends from 2008 to 2018 using the clinicaltrials.gov database. Methods: Data was collected from clinicaltrials.gov and included all clinical trials that focused on otology from 2008 to 2018. Outcome measures include status of trials, funding sources, details regarding otologic conditions studied, and trends in clinical trials. Results: There were 992 otology clinical trials from 2008 to 2018.457 (46.1%) were completed and 94 (9.5%) were discontinued. Industry remained the highest (76.5%) contributor to otology clinical trials. The otologic conditions studied, from most common to least common, include hearing loss (40.6%), vestibulopathy (18.8%), tinnitus (18.8%), and otitis media (15.1%). The number of otology clinical trials increased by an average of 12.0 trials per year from 2008 to 2018 (p < 0.001). The number of otology clinical trials focusing on hearing loss and vestibulopathy significantly increased over the studied period (p < 0.001), while those focusing on tinnitus and otitis media did not (p = 0.09 and p = 0.20, respectively). The majority of clinical trials on each of these four conditions focused on treatment options. Conclusion: Our study describes trends in otology clinical trials registered on clinicaltrials.gov from 2008 through 2018. The total number of clinical trials over this time period increased significantly, driven by trials investigating hearing loss and vestibulopathy. Furthermore, most clinical trials were industry-sponsored and focused on treatment modalities. Our study provides an outline of otology clinical trials registered in a US web-based database, which may be of use for the development of future clinical trials.
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title_short	Clinical trials in otology: Examining trends and framework for prioritization
url	https://doi.org/10.1016/j.joto.2020.11.003 https://doaj.org/article/ee579e9b90184ca389e57f9320f5e7ed http://www.sciencedirect.com/science/article/pii/S1672293020301136 https://doaj.org/toc/1672-2930
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author2	Rohan Viswanathan Divya B. Dasani Katherine Webb Tam Ramsey Varun Patel Randall Ruffner Jason Mouzakes David Foyt
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up_date	2024-07-03T19:56:16.005Z
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The majority of clinical trials on each of these four conditions focused on treatment options. Conclusion: Our study describes trends in otology clinical trials registered on clinicaltrials.gov from 2008 through 2018. The total number of clinical trials over this time period increased significantly, driven by trials investigating hearing loss and vestibulopathy. Furthermore, most clinical trials were industry-sponsored and focused on treatment modalities. 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Clinical trials in otology: Examining trends and framework for prioritization

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