miR-221/222 as biomarkers and targets for therapeutic intervention on cancer and other diseases: A systematic review

Among deregulated microRNAs (miRs) in human malignancies, miR-221 has been widely investigated for its oncogenic role and as a promising biomarker. Moreover, recent evidence suggests miR-221 as a fine-tuner of chronic liver injury and inflammation-related events. Available information also supports...
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Autor*in:	Maria Teresa Di Martino [verfasserIn] Mariamena Arbitrio [verfasserIn] Daniele Caracciolo [verfasserIn] Alessia Cordua [verfasserIn] Onofrio Cuomo [verfasserIn] Katia Grillone [verfasserIn] Caterina Riillo [verfasserIn] Giulio Caridà [verfasserIn] Francesca Scionti [verfasserIn] Caterina Labanca [verfasserIn] Caterina Romeo [verfasserIn] Maria Anna Siciliano [verfasserIn] Maria D'Apolito [verfasserIn] Cristina Napoli [verfasserIn] Martina Montesano [verfasserIn] Valentina Farenza [verfasserIn] Valentina Uppolo [verfasserIn] Michele Tafuni [verfasserIn] Federica Falcone [verfasserIn] Giuseppe D'Aquino [verfasserIn] Natale Daniele Calandruccio [verfasserIn] Francesco Luciano [verfasserIn] Licia Pensabene [verfasserIn] Pierosandro Tagliaferri [verfasserIn] Pierfrancesco Tassone [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	miR-221 miR-221/222 miRs miR microRNA miR therapeutics

Übergeordnetes Werk:	In: Molecular Therapy: Nucleic Acids - Elsevier, 2013, 27(2022), Seite 1191-1224
Übergeordnetes Werk:	volume:27 ; year:2022 ; pages:1191-1224

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.omtn.2022.02.005

Katalog-ID:	DOAJ071552286

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allfields_unstemmed	10.1016/j.omtn.2022.02.005 doi (DE-627)DOAJ071552286 (DE-599)DOAJ3c736b7269e24e3894170eed8e9340d9 DE-627 ger DE-627 rakwb eng RM1-950 Maria Teresa Di Martino verfasserin aut miR-221/222 as biomarkers and targets for therapeutic intervention on cancer and other diseases: A systematic review 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Among deregulated microRNAs (miRs) in human malignancies, miR-221 has been widely investigated for its oncogenic role and as a promising biomarker. Moreover, recent evidence suggests miR-221 as a fine-tuner of chronic liver injury and inflammation-related events. Available information also supports the potential of miR-221 silencing as promising therapeutic intervention. In this systematic review, we selected papers from the principal databases (PubMed, MedLine, Medscape, ASCO, ESMO) between January 2012 and December 2020, using the keywords “miR-221” and the specific keywords related to the most important hematologic and solid malignancies, and some non-malignant diseases, to define and characterize deregulated miR-221 as a valuable therapeutic target in the modern vision of molecular medicine. We found a major role of miR-221 in this view. miR-221 miR-221/222 miRs miR microRNA miR therapeutics Therapeutics. Pharmacology Mariamena Arbitrio verfasserin aut Daniele Caracciolo verfasserin aut Alessia Cordua verfasserin aut Onofrio Cuomo verfasserin aut Katia Grillone verfasserin aut Caterina Riillo verfasserin aut Giulio Caridà verfasserin aut Francesca Scionti verfasserin aut Caterina Labanca verfasserin aut Caterina Romeo verfasserin aut Maria Anna Siciliano verfasserin aut Maria D'Apolito verfasserin aut Cristina Napoli verfasserin aut Martina Montesano verfasserin aut Valentina Farenza verfasserin aut Valentina Uppolo verfasserin aut Michele Tafuni verfasserin aut Federica Falcone verfasserin aut Giuseppe D'Aquino verfasserin aut Natale Daniele Calandruccio verfasserin aut Francesco Luciano verfasserin aut Licia Pensabene verfasserin aut Pierosandro Tagliaferri verfasserin aut Pierfrancesco Tassone verfasserin aut In Molecular Therapy: Nucleic Acids Elsevier, 2013 27(2022), Seite 1191-1224 (DE-627)718632702 (DE-600)2662631-7 21622531 nnns volume:27 year:2022 pages:1191-1224 https://doi.org/10.1016/j.omtn.2022.02.005 kostenfrei https://doaj.org/article/3c736b7269e24e3894170eed8e9340d9 kostenfrei http://www.sciencedirect.com/science/article/pii/S2162253122000336 kostenfrei https://doaj.org/toc/2162-2531 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 27 2022 1191-1224
allfieldsGer	10.1016/j.omtn.2022.02.005 doi (DE-627)DOAJ071552286 (DE-599)DOAJ3c736b7269e24e3894170eed8e9340d9 DE-627 ger DE-627 rakwb eng RM1-950 Maria Teresa Di Martino verfasserin aut miR-221/222 as biomarkers and targets for therapeutic intervention on cancer and other diseases: A systematic review 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Among deregulated microRNAs (miRs) in human malignancies, miR-221 has been widely investigated for its oncogenic role and as a promising biomarker. Moreover, recent evidence suggests miR-221 as a fine-tuner of chronic liver injury and inflammation-related events. Available information also supports the potential of miR-221 silencing as promising therapeutic intervention. In this systematic review, we selected papers from the principal databases (PubMed, MedLine, Medscape, ASCO, ESMO) between January 2012 and December 2020, using the keywords “miR-221” and the specific keywords related to the most important hematologic and solid malignancies, and some non-malignant diseases, to define and characterize deregulated miR-221 as a valuable therapeutic target in the modern vision of molecular medicine. We found a major role of miR-221 in this view. miR-221 miR-221/222 miRs miR microRNA miR therapeutics Therapeutics. Pharmacology Mariamena Arbitrio verfasserin aut Daniele Caracciolo verfasserin aut Alessia Cordua verfasserin aut Onofrio Cuomo verfasserin aut Katia Grillone verfasserin aut Caterina Riillo verfasserin aut Giulio Caridà verfasserin aut Francesca Scionti verfasserin aut Caterina Labanca verfasserin aut Caterina Romeo verfasserin aut Maria Anna Siciliano verfasserin aut Maria D'Apolito verfasserin aut Cristina Napoli verfasserin aut Martina Montesano verfasserin aut Valentina Farenza verfasserin aut Valentina Uppolo verfasserin aut Michele Tafuni verfasserin aut Federica Falcone verfasserin aut Giuseppe D'Aquino verfasserin aut Natale Daniele Calandruccio verfasserin aut Francesco Luciano verfasserin aut Licia Pensabene verfasserin aut Pierosandro Tagliaferri verfasserin aut Pierfrancesco Tassone verfasserin aut In Molecular Therapy: Nucleic Acids Elsevier, 2013 27(2022), Seite 1191-1224 (DE-627)718632702 (DE-600)2662631-7 21622531 nnns volume:27 year:2022 pages:1191-1224 https://doi.org/10.1016/j.omtn.2022.02.005 kostenfrei https://doaj.org/article/3c736b7269e24e3894170eed8e9340d9 kostenfrei http://www.sciencedirect.com/science/article/pii/S2162253122000336 kostenfrei https://doaj.org/toc/2162-2531 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 27 2022 1191-1224
allfieldsSound	10.1016/j.omtn.2022.02.005 doi (DE-627)DOAJ071552286 (DE-599)DOAJ3c736b7269e24e3894170eed8e9340d9 DE-627 ger DE-627 rakwb eng RM1-950 Maria Teresa Di Martino verfasserin aut miR-221/222 as biomarkers and targets for therapeutic intervention on cancer and other diseases: A systematic review 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Among deregulated microRNAs (miRs) in human malignancies, miR-221 has been widely investigated for its oncogenic role and as a promising biomarker. Moreover, recent evidence suggests miR-221 as a fine-tuner of chronic liver injury and inflammation-related events. Available information also supports the potential of miR-221 silencing as promising therapeutic intervention. In this systematic review, we selected papers from the principal databases (PubMed, MedLine, Medscape, ASCO, ESMO) between January 2012 and December 2020, using the keywords “miR-221” and the specific keywords related to the most important hematologic and solid malignancies, and some non-malignant diseases, to define and characterize deregulated miR-221 as a valuable therapeutic target in the modern vision of molecular medicine. We found a major role of miR-221 in this view. miR-221 miR-221/222 miRs miR microRNA miR therapeutics Therapeutics. Pharmacology Mariamena Arbitrio verfasserin aut Daniele Caracciolo verfasserin aut Alessia Cordua verfasserin aut Onofrio Cuomo verfasserin aut Katia Grillone verfasserin aut Caterina Riillo verfasserin aut Giulio Caridà verfasserin aut Francesca Scionti verfasserin aut Caterina Labanca verfasserin aut Caterina Romeo verfasserin aut Maria Anna Siciliano verfasserin aut Maria D'Apolito verfasserin aut Cristina Napoli verfasserin aut Martina Montesano verfasserin aut Valentina Farenza verfasserin aut Valentina Uppolo verfasserin aut Michele Tafuni verfasserin aut Federica Falcone verfasserin aut Giuseppe D'Aquino verfasserin aut Natale Daniele Calandruccio verfasserin aut Francesco Luciano verfasserin aut Licia Pensabene verfasserin aut Pierosandro Tagliaferri verfasserin aut Pierfrancesco Tassone verfasserin aut In Molecular Therapy: Nucleic Acids Elsevier, 2013 27(2022), Seite 1191-1224 (DE-627)718632702 (DE-600)2662631-7 21622531 nnns volume:27 year:2022 pages:1191-1224 https://doi.org/10.1016/j.omtn.2022.02.005 kostenfrei https://doaj.org/article/3c736b7269e24e3894170eed8e9340d9 kostenfrei http://www.sciencedirect.com/science/article/pii/S2162253122000336 kostenfrei https://doaj.org/toc/2162-2531 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 27 2022 1191-1224
language	English
source	In Molecular Therapy: Nucleic Acids 27(2022), Seite 1191-1224 volume:27 year:2022 pages:1191-1224
sourceStr	In Molecular Therapy: Nucleic Acids 27(2022), Seite 1191-1224 volume:27 year:2022 pages:1191-1224
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	miR-221 miR-221/222 miRs miR microRNA miR therapeutics Therapeutics. Pharmacology
isfreeaccess_bool	true
container_title	Molecular Therapy: Nucleic Acids
authorswithroles_txt_mv	Maria Teresa Di Martino @@aut@@ Mariamena Arbitrio @@aut@@ Daniele Caracciolo @@aut@@ Alessia Cordua @@aut@@ Onofrio Cuomo @@aut@@ Katia Grillone @@aut@@ Caterina Riillo @@aut@@ Giulio Caridà @@aut@@ Francesca Scionti @@aut@@ Caterina Labanca @@aut@@ Caterina Romeo @@aut@@ Maria Anna Siciliano @@aut@@ Maria D'Apolito @@aut@@ Cristina Napoli @@aut@@ Martina Montesano @@aut@@ Valentina Farenza @@aut@@ Valentina Uppolo @@aut@@ Michele Tafuni @@aut@@ Federica Falcone @@aut@@ Giuseppe D'Aquino @@aut@@ Natale Daniele Calandruccio @@aut@@ Francesco Luciano @@aut@@ Licia Pensabene @@aut@@ Pierosandro Tagliaferri @@aut@@ Pierfrancesco Tassone @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	718632702
id	DOAJ071552286
language_de	englisch
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callnumber-first	R - Medicine
author	Maria Teresa Di Martino
spellingShingle	Maria Teresa Di Martino misc RM1-950 misc miR-221 misc miR-221/222 misc miRs misc miR misc microRNA misc miR therapeutics misc Therapeutics. Pharmacology miR-221/222 as biomarkers and targets for therapeutic intervention on cancer and other diseases: A systematic review
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topic_title	RM1-950 miR-221/222 as biomarkers and targets for therapeutic intervention on cancer and other diseases: A systematic review miR-221 miR-221/222 miRs miR microRNA miR therapeutics
topic	misc RM1-950 misc miR-221 misc miR-221/222 misc miRs misc miR misc microRNA misc miR therapeutics misc Therapeutics. Pharmacology
topic_unstemmed	misc RM1-950 misc miR-221 misc miR-221/222 misc miRs misc miR misc microRNA misc miR therapeutics misc Therapeutics. Pharmacology
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title	miR-221/222 as biomarkers and targets for therapeutic intervention on cancer and other diseases: A systematic review
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title_full	miR-221/222 as biomarkers and targets for therapeutic intervention on cancer and other diseases: A systematic review
author_sort	Maria Teresa Di Martino
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author_browse	Maria Teresa Di Martino Mariamena Arbitrio Daniele Caracciolo Alessia Cordua Onofrio Cuomo Katia Grillone Caterina Riillo Giulio Caridà Francesca Scionti Caterina Labanca Caterina Romeo Maria Anna Siciliano Maria D'Apolito Cristina Napoli Martina Montesano Valentina Farenza Valentina Uppolo Michele Tafuni Federica Falcone Giuseppe D'Aquino Natale Daniele Calandruccio Francesco Luciano Licia Pensabene Pierosandro Tagliaferri Pierfrancesco Tassone
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title_sort	mir-221/222 as biomarkers and targets for therapeutic intervention on cancer and other diseases: a systematic review
callnumber	RM1-950
title_auth	miR-221/222 as biomarkers and targets for therapeutic intervention on cancer and other diseases: A systematic review
abstract	Among deregulated microRNAs (miRs) in human malignancies, miR-221 has been widely investigated for its oncogenic role and as a promising biomarker. Moreover, recent evidence suggests miR-221 as a fine-tuner of chronic liver injury and inflammation-related events. Available information also supports the potential of miR-221 silencing as promising therapeutic intervention. In this systematic review, we selected papers from the principal databases (PubMed, MedLine, Medscape, ASCO, ESMO) between January 2012 and December 2020, using the keywords “miR-221” and the specific keywords related to the most important hematologic and solid malignancies, and some non-malignant diseases, to define and characterize deregulated miR-221 as a valuable therapeutic target in the modern vision of molecular medicine. We found a major role of miR-221 in this view.
abstractGer	Among deregulated microRNAs (miRs) in human malignancies, miR-221 has been widely investigated for its oncogenic role and as a promising biomarker. Moreover, recent evidence suggests miR-221 as a fine-tuner of chronic liver injury and inflammation-related events. Available information also supports the potential of miR-221 silencing as promising therapeutic intervention. In this systematic review, we selected papers from the principal databases (PubMed, MedLine, Medscape, ASCO, ESMO) between January 2012 and December 2020, using the keywords “miR-221” and the specific keywords related to the most important hematologic and solid malignancies, and some non-malignant diseases, to define and characterize deregulated miR-221 as a valuable therapeutic target in the modern vision of molecular medicine. We found a major role of miR-221 in this view.
abstract_unstemmed	Among deregulated microRNAs (miRs) in human malignancies, miR-221 has been widely investigated for its oncogenic role and as a promising biomarker. Moreover, recent evidence suggests miR-221 as a fine-tuner of chronic liver injury and inflammation-related events. Available information also supports the potential of miR-221 silencing as promising therapeutic intervention. In this systematic review, we selected papers from the principal databases (PubMed, MedLine, Medscape, ASCO, ESMO) between January 2012 and December 2020, using the keywords “miR-221” and the specific keywords related to the most important hematologic and solid malignancies, and some non-malignant diseases, to define and characterize deregulated miR-221 as a valuable therapeutic target in the modern vision of molecular medicine. We found a major role of miR-221 in this view.
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title_short	miR-221/222 as biomarkers and targets for therapeutic intervention on cancer and other diseases: A systematic review
url	https://doi.org/10.1016/j.omtn.2022.02.005 https://doaj.org/article/3c736b7269e24e3894170eed8e9340d9 http://www.sciencedirect.com/science/article/pii/S2162253122000336 https://doaj.org/toc/2162-2531
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up_date	2024-07-03T20:53:32.043Z
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miR-221/222 as biomarkers and targets for therapeutic intervention on cancer and other diseases: A systematic review

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