The high prevalence of Mycobacterium tuberculosis Beijing strain at an early age and extra-pulmonary tuberculosis cases

Background and Objectives: Tuberculosis (TB) is still responsible for a wide range of deaths worldwide. Beijing genotype is one of the most important and virulent strains in Mycobacterium tuberculosis. This study was designed for determination Beijing genotypes of M. tuberculosis in Golestan provinc...
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Autor*in:	Hanifeh Erie [verfasserIn] Hami Kaboosi [verfasserIn] Naeme Javid [verfasserIn] Hesamaddin Shirzad-Aski [verfasserIn] Masoumeh Taziki [verfasserIn] Maya Babaee Kuchaksaraee [verfasserIn] Ezzat Allah Ghaemi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Mycobacterium tuberculosis Beijing Pulmonary tuberculosis Extra-pulmonary tuberculosis Real-time PCR

Übergeordnetes Werk:	In: Iranian Journal of Microbiology - Tehran University of Medical Sciences, 2020, 9(2018), 6
Übergeordnetes Werk:	volume:9 ; year:2018 ; number:6

Links:	Link aufrufen Link aufrufen Journal toc Journal toc

Katalog-ID:	DOAJ071674942

Internformat


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245	1	4	\|a The high prevalence of Mycobacterium tuberculosis Beijing strain at an early age and extra-pulmonary tuberculosis cases
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520			\|a Background and Objectives: Tuberculosis (TB) is still responsible for a wide range of deaths worldwide. Beijing genotype is one of the most important and virulent strains in Mycobacterium tuberculosis. This study was designed for determination Beijing genotypes of M. tuberculosis in Golestan province, north of Iran. Materials and Methods: In the current descriptive study, 238 clinical MTB isolates, obtained from patients with pulmonary and extra-pulmonary TB in north of Iran, were evaluated. Oligonucleotide primers for the Beijing and non-Beijing genotypes and specific probes for their detection by a real-time PCR method were employed. In addition, an association between the Beijing genotype and possible clinical and demographic factors was evaluated. Results: The method revealed that 33 cases (13.9%) were the Beijing lineage and 205 (86.1%) the non-Beijing genotype. The mean age of patients infected with the Beijing and non-Beijing strains was 37.27 ± 18.3 and 51 ± 21.2 years, respectively; the difference was statistically significant (P = 0.001). In addition, the prevalence of the Beijing strain decreased with age. Patients with a TB infection caused by the Beijing genotype were also more vulnerable to treatment failure. Based on the origin of the samples, the Beijing genotype was more often observed in extra-pulmonary samples compared with Pulmonary ones (P = 0.001). Conclusion: The Beijing genotype of MTB is prevalent in our region especially among young people which could indicate the risk of further expansion in the future.
650		4	\|a Mycobacterium tuberculosis
650		4	\|a Beijing
650		4	\|a Pulmonary tuberculosis
650		4	\|a Extra-pulmonary tuberculosis
650		4	\|a Real-time PCR
653		0	\|a Microbiology
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700	0		\|a Maya Babaee Kuchaksaraee \|e verfasserin \|4 aut
700	0		\|a Ezzat Allah Ghaemi \|e verfasserin \|4 aut
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912			\|a GBV_ILN_105
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912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_602
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912			\|a GBV_ILN_2010
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
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allfields	(DE-627)DOAJ071674942 (DE-599)DOAJeca56059f21f48dba6ec792e32273ec9 DE-627 ger DE-627 rakwb eng QR1-502 Hanifeh Erie verfasserin aut The high prevalence of Mycobacterium tuberculosis Beijing strain at an early age and extra-pulmonary tuberculosis cases 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and Objectives: Tuberculosis (TB) is still responsible for a wide range of deaths worldwide. Beijing genotype is one of the most important and virulent strains in Mycobacterium tuberculosis. This study was designed for determination Beijing genotypes of M. tuberculosis in Golestan province, north of Iran. Materials and Methods: In the current descriptive study, 238 clinical MTB isolates, obtained from patients with pulmonary and extra-pulmonary TB in north of Iran, were evaluated. Oligonucleotide primers for the Beijing and non-Beijing genotypes and specific probes for their detection by a real-time PCR method were employed. In addition, an association between the Beijing genotype and possible clinical and demographic factors was evaluated. Results: The method revealed that 33 cases (13.9%) were the Beijing lineage and 205 (86.1%) the non-Beijing genotype. The mean age of patients infected with the Beijing and non-Beijing strains was 37.27 ± 18.3 and 51 ± 21.2 years, respectively; the difference was statistically significant (P = 0.001). In addition, the prevalence of the Beijing strain decreased with age. Patients with a TB infection caused by the Beijing genotype were also more vulnerable to treatment failure. Based on the origin of the samples, the Beijing genotype was more often observed in extra-pulmonary samples compared with Pulmonary ones (P = 0.001). Conclusion: The Beijing genotype of MTB is prevalent in our region especially among young people which could indicate the risk of further expansion in the future. Mycobacterium tuberculosis Beijing Pulmonary tuberculosis Extra-pulmonary tuberculosis Real-time PCR Microbiology Hami Kaboosi verfasserin aut Naeme Javid verfasserin aut Hesamaddin Shirzad-Aski verfasserin aut Masoumeh Taziki verfasserin aut Maya Babaee Kuchaksaraee verfasserin aut Ezzat Allah Ghaemi verfasserin aut In Iranian Journal of Microbiology Tehran University of Medical Sciences, 2020 9(2018), 6 (DE-627)688077226 (DE-600)2652849-6 20084447 nnns volume:9 year:2018 number:6 https://doaj.org/article/eca56059f21f48dba6ec792e32273ec9 kostenfrei https://ijm.tums.ac.ir/index.php/ijm/article/view/1290 kostenfrei https://doaj.org/toc/2008-3289 Journal toc kostenfrei https://doaj.org/toc/2008-4447 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018 6
spelling	(DE-627)DOAJ071674942 (DE-599)DOAJeca56059f21f48dba6ec792e32273ec9 DE-627 ger DE-627 rakwb eng QR1-502 Hanifeh Erie verfasserin aut The high prevalence of Mycobacterium tuberculosis Beijing strain at an early age and extra-pulmonary tuberculosis cases 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and Objectives: Tuberculosis (TB) is still responsible for a wide range of deaths worldwide. Beijing genotype is one of the most important and virulent strains in Mycobacterium tuberculosis. This study was designed for determination Beijing genotypes of M. tuberculosis in Golestan province, north of Iran. Materials and Methods: In the current descriptive study, 238 clinical MTB isolates, obtained from patients with pulmonary and extra-pulmonary TB in north of Iran, were evaluated. Oligonucleotide primers for the Beijing and non-Beijing genotypes and specific probes for their detection by a real-time PCR method were employed. In addition, an association between the Beijing genotype and possible clinical and demographic factors was evaluated. Results: The method revealed that 33 cases (13.9%) were the Beijing lineage and 205 (86.1%) the non-Beijing genotype. The mean age of patients infected with the Beijing and non-Beijing strains was 37.27 ± 18.3 and 51 ± 21.2 years, respectively; the difference was statistically significant (P = 0.001). In addition, the prevalence of the Beijing strain decreased with age. Patients with a TB infection caused by the Beijing genotype were also more vulnerable to treatment failure. Based on the origin of the samples, the Beijing genotype was more often observed in extra-pulmonary samples compared with Pulmonary ones (P = 0.001). Conclusion: The Beijing genotype of MTB is prevalent in our region especially among young people which could indicate the risk of further expansion in the future. Mycobacterium tuberculosis Beijing Pulmonary tuberculosis Extra-pulmonary tuberculosis Real-time PCR Microbiology Hami Kaboosi verfasserin aut Naeme Javid verfasserin aut Hesamaddin Shirzad-Aski verfasserin aut Masoumeh Taziki verfasserin aut Maya Babaee Kuchaksaraee verfasserin aut Ezzat Allah Ghaemi verfasserin aut In Iranian Journal of Microbiology Tehran University of Medical Sciences, 2020 9(2018), 6 (DE-627)688077226 (DE-600)2652849-6 20084447 nnns volume:9 year:2018 number:6 https://doaj.org/article/eca56059f21f48dba6ec792e32273ec9 kostenfrei https://ijm.tums.ac.ir/index.php/ijm/article/view/1290 kostenfrei https://doaj.org/toc/2008-3289 Journal toc kostenfrei https://doaj.org/toc/2008-4447 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018 6
allfields_unstemmed	(DE-627)DOAJ071674942 (DE-599)DOAJeca56059f21f48dba6ec792e32273ec9 DE-627 ger DE-627 rakwb eng QR1-502 Hanifeh Erie verfasserin aut The high prevalence of Mycobacterium tuberculosis Beijing strain at an early age and extra-pulmonary tuberculosis cases 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and Objectives: Tuberculosis (TB) is still responsible for a wide range of deaths worldwide. Beijing genotype is one of the most important and virulent strains in Mycobacterium tuberculosis. This study was designed for determination Beijing genotypes of M. tuberculosis in Golestan province, north of Iran. Materials and Methods: In the current descriptive study, 238 clinical MTB isolates, obtained from patients with pulmonary and extra-pulmonary TB in north of Iran, were evaluated. Oligonucleotide primers for the Beijing and non-Beijing genotypes and specific probes for their detection by a real-time PCR method were employed. In addition, an association between the Beijing genotype and possible clinical and demographic factors was evaluated. Results: The method revealed that 33 cases (13.9%) were the Beijing lineage and 205 (86.1%) the non-Beijing genotype. The mean age of patients infected with the Beijing and non-Beijing strains was 37.27 ± 18.3 and 51 ± 21.2 years, respectively; the difference was statistically significant (P = 0.001). In addition, the prevalence of the Beijing strain decreased with age. Patients with a TB infection caused by the Beijing genotype were also more vulnerable to treatment failure. Based on the origin of the samples, the Beijing genotype was more often observed in extra-pulmonary samples compared with Pulmonary ones (P = 0.001). Conclusion: The Beijing genotype of MTB is prevalent in our region especially among young people which could indicate the risk of further expansion in the future. Mycobacterium tuberculosis Beijing Pulmonary tuberculosis Extra-pulmonary tuberculosis Real-time PCR Microbiology Hami Kaboosi verfasserin aut Naeme Javid verfasserin aut Hesamaddin Shirzad-Aski verfasserin aut Masoumeh Taziki verfasserin aut Maya Babaee Kuchaksaraee verfasserin aut Ezzat Allah Ghaemi verfasserin aut In Iranian Journal of Microbiology Tehran University of Medical Sciences, 2020 9(2018), 6 (DE-627)688077226 (DE-600)2652849-6 20084447 nnns volume:9 year:2018 number:6 https://doaj.org/article/eca56059f21f48dba6ec792e32273ec9 kostenfrei https://ijm.tums.ac.ir/index.php/ijm/article/view/1290 kostenfrei https://doaj.org/toc/2008-3289 Journal toc kostenfrei https://doaj.org/toc/2008-4447 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018 6
allfieldsGer	(DE-627)DOAJ071674942 (DE-599)DOAJeca56059f21f48dba6ec792e32273ec9 DE-627 ger DE-627 rakwb eng QR1-502 Hanifeh Erie verfasserin aut The high prevalence of Mycobacterium tuberculosis Beijing strain at an early age and extra-pulmonary tuberculosis cases 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and Objectives: Tuberculosis (TB) is still responsible for a wide range of deaths worldwide. Beijing genotype is one of the most important and virulent strains in Mycobacterium tuberculosis. This study was designed for determination Beijing genotypes of M. tuberculosis in Golestan province, north of Iran. Materials and Methods: In the current descriptive study, 238 clinical MTB isolates, obtained from patients with pulmonary and extra-pulmonary TB in north of Iran, were evaluated. Oligonucleotide primers for the Beijing and non-Beijing genotypes and specific probes for their detection by a real-time PCR method were employed. In addition, an association between the Beijing genotype and possible clinical and demographic factors was evaluated. Results: The method revealed that 33 cases (13.9%) were the Beijing lineage and 205 (86.1%) the non-Beijing genotype. The mean age of patients infected with the Beijing and non-Beijing strains was 37.27 ± 18.3 and 51 ± 21.2 years, respectively; the difference was statistically significant (P = 0.001). In addition, the prevalence of the Beijing strain decreased with age. Patients with a TB infection caused by the Beijing genotype were also more vulnerable to treatment failure. Based on the origin of the samples, the Beijing genotype was more often observed in extra-pulmonary samples compared with Pulmonary ones (P = 0.001). Conclusion: The Beijing genotype of MTB is prevalent in our region especially among young people which could indicate the risk of further expansion in the future. Mycobacterium tuberculosis Beijing Pulmonary tuberculosis Extra-pulmonary tuberculosis Real-time PCR Microbiology Hami Kaboosi verfasserin aut Naeme Javid verfasserin aut Hesamaddin Shirzad-Aski verfasserin aut Masoumeh Taziki verfasserin aut Maya Babaee Kuchaksaraee verfasserin aut Ezzat Allah Ghaemi verfasserin aut In Iranian Journal of Microbiology Tehran University of Medical Sciences, 2020 9(2018), 6 (DE-627)688077226 (DE-600)2652849-6 20084447 nnns volume:9 year:2018 number:6 https://doaj.org/article/eca56059f21f48dba6ec792e32273ec9 kostenfrei https://ijm.tums.ac.ir/index.php/ijm/article/view/1290 kostenfrei https://doaj.org/toc/2008-3289 Journal toc kostenfrei https://doaj.org/toc/2008-4447 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018 6
allfieldsSound	(DE-627)DOAJ071674942 (DE-599)DOAJeca56059f21f48dba6ec792e32273ec9 DE-627 ger DE-627 rakwb eng QR1-502 Hanifeh Erie verfasserin aut The high prevalence of Mycobacterium tuberculosis Beijing strain at an early age and extra-pulmonary tuberculosis cases 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and Objectives: Tuberculosis (TB) is still responsible for a wide range of deaths worldwide. Beijing genotype is one of the most important and virulent strains in Mycobacterium tuberculosis. This study was designed for determination Beijing genotypes of M. tuberculosis in Golestan province, north of Iran. Materials and Methods: In the current descriptive study, 238 clinical MTB isolates, obtained from patients with pulmonary and extra-pulmonary TB in north of Iran, were evaluated. Oligonucleotide primers for the Beijing and non-Beijing genotypes and specific probes for their detection by a real-time PCR method were employed. In addition, an association between the Beijing genotype and possible clinical and demographic factors was evaluated. Results: The method revealed that 33 cases (13.9%) were the Beijing lineage and 205 (86.1%) the non-Beijing genotype. The mean age of patients infected with the Beijing and non-Beijing strains was 37.27 ± 18.3 and 51 ± 21.2 years, respectively; the difference was statistically significant (P = 0.001). In addition, the prevalence of the Beijing strain decreased with age. Patients with a TB infection caused by the Beijing genotype were also more vulnerable to treatment failure. Based on the origin of the samples, the Beijing genotype was more often observed in extra-pulmonary samples compared with Pulmonary ones (P = 0.001). Conclusion: The Beijing genotype of MTB is prevalent in our region especially among young people which could indicate the risk of further expansion in the future. Mycobacterium tuberculosis Beijing Pulmonary tuberculosis Extra-pulmonary tuberculosis Real-time PCR Microbiology Hami Kaboosi verfasserin aut Naeme Javid verfasserin aut Hesamaddin Shirzad-Aski verfasserin aut Masoumeh Taziki verfasserin aut Maya Babaee Kuchaksaraee verfasserin aut Ezzat Allah Ghaemi verfasserin aut In Iranian Journal of Microbiology Tehran University of Medical Sciences, 2020 9(2018), 6 (DE-627)688077226 (DE-600)2652849-6 20084447 nnns volume:9 year:2018 number:6 https://doaj.org/article/eca56059f21f48dba6ec792e32273ec9 kostenfrei https://ijm.tums.ac.ir/index.php/ijm/article/view/1290 kostenfrei https://doaj.org/toc/2008-3289 Journal toc kostenfrei https://doaj.org/toc/2008-4447 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018 6
language	English
source	In Iranian Journal of Microbiology 9(2018), 6 volume:9 year:2018 number:6
sourceStr	In Iranian Journal of Microbiology 9(2018), 6 volume:9 year:2018 number:6
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Mycobacterium tuberculosis Beijing Pulmonary tuberculosis Extra-pulmonary tuberculosis Real-time PCR Microbiology
isfreeaccess_bool	true
container_title	Iranian Journal of Microbiology
authorswithroles_txt_mv	Hanifeh Erie @@aut@@ Hami Kaboosi @@aut@@ Naeme Javid @@aut@@ Hesamaddin Shirzad-Aski @@aut@@ Masoumeh Taziki @@aut@@ Maya Babaee Kuchaksaraee @@aut@@ Ezzat Allah Ghaemi @@aut@@
publishDateDaySort_date	2018-01-01T00:00:00Z
hierarchy_top_id	688077226
id	DOAJ071674942
language_de	englisch
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callnumber-first	Q - Science
author	Hanifeh Erie
spellingShingle	Hanifeh Erie misc QR1-502 misc Mycobacterium tuberculosis misc Beijing misc Pulmonary tuberculosis misc Extra-pulmonary tuberculosis misc Real-time PCR misc Microbiology The high prevalence of Mycobacterium tuberculosis Beijing strain at an early age and extra-pulmonary tuberculosis cases
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topic_title	QR1-502 The high prevalence of Mycobacterium tuberculosis Beijing strain at an early age and extra-pulmonary tuberculosis cases Mycobacterium tuberculosis Beijing Pulmonary tuberculosis Extra-pulmonary tuberculosis Real-time PCR
topic	misc QR1-502 misc Mycobacterium tuberculosis misc Beijing misc Pulmonary tuberculosis misc Extra-pulmonary tuberculosis misc Real-time PCR misc Microbiology
topic_unstemmed	misc QR1-502 misc Mycobacterium tuberculosis misc Beijing misc Pulmonary tuberculosis misc Extra-pulmonary tuberculosis misc Real-time PCR misc Microbiology
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title	The high prevalence of Mycobacterium tuberculosis Beijing strain at an early age and extra-pulmonary tuberculosis cases
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title_full	The high prevalence of Mycobacterium tuberculosis Beijing strain at an early age and extra-pulmonary tuberculosis cases
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author_browse	Hanifeh Erie Hami Kaboosi Naeme Javid Hesamaddin Shirzad-Aski Masoumeh Taziki Maya Babaee Kuchaksaraee Ezzat Allah Ghaemi
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title_sort	high prevalence of mycobacterium tuberculosis beijing strain at an early age and extra-pulmonary tuberculosis cases
callnumber	QR1-502
title_auth	The high prevalence of Mycobacterium tuberculosis Beijing strain at an early age and extra-pulmonary tuberculosis cases
abstract	Background and Objectives: Tuberculosis (TB) is still responsible for a wide range of deaths worldwide. Beijing genotype is one of the most important and virulent strains in Mycobacterium tuberculosis. This study was designed for determination Beijing genotypes of M. tuberculosis in Golestan province, north of Iran. Materials and Methods: In the current descriptive study, 238 clinical MTB isolates, obtained from patients with pulmonary and extra-pulmonary TB in north of Iran, were evaluated. Oligonucleotide primers for the Beijing and non-Beijing genotypes and specific probes for their detection by a real-time PCR method were employed. In addition, an association between the Beijing genotype and possible clinical and demographic factors was evaluated. Results: The method revealed that 33 cases (13.9%) were the Beijing lineage and 205 (86.1%) the non-Beijing genotype. The mean age of patients infected with the Beijing and non-Beijing strains was 37.27 ± 18.3 and 51 ± 21.2 years, respectively; the difference was statistically significant (P = 0.001). In addition, the prevalence of the Beijing strain decreased with age. Patients with a TB infection caused by the Beijing genotype were also more vulnerable to treatment failure. Based on the origin of the samples, the Beijing genotype was more often observed in extra-pulmonary samples compared with Pulmonary ones (P = 0.001). Conclusion: The Beijing genotype of MTB is prevalent in our region especially among young people which could indicate the risk of further expansion in the future.
abstractGer	Background and Objectives: Tuberculosis (TB) is still responsible for a wide range of deaths worldwide. Beijing genotype is one of the most important and virulent strains in Mycobacterium tuberculosis. This study was designed for determination Beijing genotypes of M. tuberculosis in Golestan province, north of Iran. Materials and Methods: In the current descriptive study, 238 clinical MTB isolates, obtained from patients with pulmonary and extra-pulmonary TB in north of Iran, were evaluated. Oligonucleotide primers for the Beijing and non-Beijing genotypes and specific probes for their detection by a real-time PCR method were employed. In addition, an association between the Beijing genotype and possible clinical and demographic factors was evaluated. Results: The method revealed that 33 cases (13.9%) were the Beijing lineage and 205 (86.1%) the non-Beijing genotype. The mean age of patients infected with the Beijing and non-Beijing strains was 37.27 ± 18.3 and 51 ± 21.2 years, respectively; the difference was statistically significant (P = 0.001). In addition, the prevalence of the Beijing strain decreased with age. Patients with a TB infection caused by the Beijing genotype were also more vulnerable to treatment failure. Based on the origin of the samples, the Beijing genotype was more often observed in extra-pulmonary samples compared with Pulmonary ones (P = 0.001). Conclusion: The Beijing genotype of MTB is prevalent in our region especially among young people which could indicate the risk of further expansion in the future.
abstract_unstemmed	Background and Objectives: Tuberculosis (TB) is still responsible for a wide range of deaths worldwide. Beijing genotype is one of the most important and virulent strains in Mycobacterium tuberculosis. This study was designed for determination Beijing genotypes of M. tuberculosis in Golestan province, north of Iran. Materials and Methods: In the current descriptive study, 238 clinical MTB isolates, obtained from patients with pulmonary and extra-pulmonary TB in north of Iran, were evaluated. Oligonucleotide primers for the Beijing and non-Beijing genotypes and specific probes for their detection by a real-time PCR method were employed. In addition, an association between the Beijing genotype and possible clinical and demographic factors was evaluated. Results: The method revealed that 33 cases (13.9%) were the Beijing lineage and 205 (86.1%) the non-Beijing genotype. The mean age of patients infected with the Beijing and non-Beijing strains was 37.27 ± 18.3 and 51 ± 21.2 years, respectively; the difference was statistically significant (P = 0.001). In addition, the prevalence of the Beijing strain decreased with age. Patients with a TB infection caused by the Beijing genotype were also more vulnerable to treatment failure. Based on the origin of the samples, the Beijing genotype was more often observed in extra-pulmonary samples compared with Pulmonary ones (P = 0.001). Conclusion: The Beijing genotype of MTB is prevalent in our region especially among young people which could indicate the risk of further expansion in the future.
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title_short	The high prevalence of Mycobacterium tuberculosis Beijing strain at an early age and extra-pulmonary tuberculosis cases
url	https://doaj.org/article/eca56059f21f48dba6ec792e32273ec9 https://ijm.tums.ac.ir/index.php/ijm/article/view/1290 https://doaj.org/toc/2008-3289 https://doaj.org/toc/2008-4447
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The high prevalence of Mycobacterium tuberculosis Beijing strain at an early age and extra-pulmonary tuberculosis cases

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