The role of platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in ulcerative colitis

Background/Aims Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) can serve as biomarkers for diagnosing and assessing disease activity in ulcerative colitis (UC). We investigated their clinical significance in UC. Methods We analyzed 48 patients with UC who underwent measu...
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Autor*in:	Yujin Jeong [verfasserIn] Seong Ran Jeon [verfasserIn] Hyun Gun Kim [verfasserIn] Jung Rock Moon [verfasserIn] Tae Hee Lee [verfasserIn] Jae Young Jang [verfasserIn] Jun-Hyung Cho [verfasserIn] Jun Seok Park [verfasserIn] Heesu Park [verfasserIn] Ki-hun Lee [verfasserIn] Jin-Oh Kim [verfasserIn] Joon Seong Lee [verfasserIn] Bong Min Ko [verfasserIn] Suyeon Park [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	colitis, ulcerative neutrophil to lymphocyte ratio platelet to lymphocyte ratio fecal calprotectin

Übergeordnetes Werk:	In: Intestinal Research - Korean Association for the Study of Intestinal Diseases, 2017, 19(2021), 1, Seite 62-70
Übergeordnetes Werk:	volume:19 ; year:2021 ; number:1 ; pages:62-70

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.5217/ir.2019.09156

Katalog-ID:	DOAJ071742344

Internformat


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245	1	4	\|a The role of platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in ulcerative colitis
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520			\|a Background/Aims Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) can serve as biomarkers for diagnosing and assessing disease activity in ulcerative colitis (UC). We investigated their clinical significance in UC. Methods We analyzed 48 patients with UC who underwent measurement of fecal calprotectin (FC) and endoscopy and 96 age- and sex-matched healthy controls. NLR and PLR were compared between the patients and healthy controls. The endoscopic activity was divided into 2 groups: group 1 (mild to moderate inflammation) and group 2 (severe inflammation) according to the Mayo endoscopic subscore in UC. Results To diagnose UC, the optimal cutoff of NLR and PLR was 2.26 (sensitivity 54.2%; specificity 90.6%; positive likelihood ratio 5.778, 95% confidence interval [CI] 2.944–11.339; area under the curve [AUC] 0.774, 95% CI, 0.690–0.859) and 179.8 (sensitivity 35.4%; specificity 90.6%; positive likelihood ratio 3.778, 95% CI 1.821–7.838; AUC 0.654, 95% CI 0.556–0.753), respectively. The optimal cutoff to differentiate group 1 and group 2 was 3.44, 175.9, and 453 µg/g for NLR, PLR, and FC, respectively (sensitivity, 63.6% vs. 90.9% vs. 81.8%; specificity, 81.1% vs. 78.4% vs. 73.0%; positive likelihood ratio, 3.364 vs. 4.205 vs. 3.027; AUC, 0.714 vs. 0.897 vs. 0.813). PLR had the highest AUC and positive likelihood ratio. Conclusions NLR and PLR help differentiate patients with UC from healthy controls. NLR, PLR, and FC indicate endoscopic activity and may reflect intestinal mucosal conditions.
650		4	\|a colitis, ulcerative
650		4	\|a neutrophil to lymphocyte ratio
650		4	\|a platelet to lymphocyte ratio
650		4	\|a fecal calprotectin
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653		0	\|a Diseases of the digestive system. Gastroenterology
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700	0		\|a Bong Min Ko \|e verfasserin \|4 aut
700	0		\|a Suyeon Park \|e verfasserin \|4 aut
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allfields	10.5217/ir.2019.09156 doi (DE-627)DOAJ071742344 (DE-599)DOAJc9df80da23594387b5f9f25f7d1dafb6 DE-627 ger DE-627 rakwb eng RC799-869 Yujin Jeong verfasserin aut The role of platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in ulcerative colitis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background/Aims Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) can serve as biomarkers for diagnosing and assessing disease activity in ulcerative colitis (UC). We investigated their clinical significance in UC. Methods We analyzed 48 patients with UC who underwent measurement of fecal calprotectin (FC) and endoscopy and 96 age- and sex-matched healthy controls. NLR and PLR were compared between the patients and healthy controls. The endoscopic activity was divided into 2 groups: group 1 (mild to moderate inflammation) and group 2 (severe inflammation) according to the Mayo endoscopic subscore in UC. Results To diagnose UC, the optimal cutoff of NLR and PLR was 2.26 (sensitivity 54.2%; specificity 90.6%; positive likelihood ratio 5.778, 95% confidence interval [CI] 2.944–11.339; area under the curve [AUC] 0.774, 95% CI, 0.690–0.859) and 179.8 (sensitivity 35.4%; specificity 90.6%; positive likelihood ratio 3.778, 95% CI 1.821–7.838; AUC 0.654, 95% CI 0.556–0.753), respectively. The optimal cutoff to differentiate group 1 and group 2 was 3.44, 175.9, and 453 µg/g for NLR, PLR, and FC, respectively (sensitivity, 63.6% vs. 90.9% vs. 81.8%; specificity, 81.1% vs. 78.4% vs. 73.0%; positive likelihood ratio, 3.364 vs. 4.205 vs. 3.027; AUC, 0.714 vs. 0.897 vs. 0.813). PLR had the highest AUC and positive likelihood ratio. Conclusions NLR and PLR help differentiate patients with UC from healthy controls. NLR, PLR, and FC indicate endoscopic activity and may reflect intestinal mucosal conditions. colitis, ulcerative neutrophil to lymphocyte ratio platelet to lymphocyte ratio fecal calprotectin Medicine R Diseases of the digestive system. Gastroenterology Seong Ran Jeon verfasserin aut Hyun Gun Kim verfasserin aut Jung Rock Moon verfasserin aut Tae Hee Lee verfasserin aut Jae Young Jang verfasserin aut Jun-Hyung Cho verfasserin aut Jun Seok Park verfasserin aut Heesu Park verfasserin aut Ki-hun Lee verfasserin aut Jin-Oh Kim verfasserin aut Joon Seong Lee verfasserin aut Bong Min Ko verfasserin aut Suyeon Park verfasserin aut In Intestinal Research Korean Association for the Study of Intestinal Diseases, 2017 19(2021), 1, Seite 62-70 (DE-627)1696048168 22881956 nnns volume:19 year:2021 number:1 pages:62-70 https://doi.org/10.5217/ir.2019.09156 kostenfrei https://doaj.org/article/c9df80da23594387b5f9f25f7d1dafb6 kostenfrei http://www.irjournal.org/upload/pdf/ir-2019-09156.pdf kostenfrei https://doaj.org/toc/1598-9100 Journal toc kostenfrei https://doaj.org/toc/2288-1956 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2021 1 62-70
spelling	10.5217/ir.2019.09156 doi (DE-627)DOAJ071742344 (DE-599)DOAJc9df80da23594387b5f9f25f7d1dafb6 DE-627 ger DE-627 rakwb eng RC799-869 Yujin Jeong verfasserin aut The role of platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in ulcerative colitis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background/Aims Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) can serve as biomarkers for diagnosing and assessing disease activity in ulcerative colitis (UC). We investigated their clinical significance in UC. Methods We analyzed 48 patients with UC who underwent measurement of fecal calprotectin (FC) and endoscopy and 96 age- and sex-matched healthy controls. NLR and PLR were compared between the patients and healthy controls. The endoscopic activity was divided into 2 groups: group 1 (mild to moderate inflammation) and group 2 (severe inflammation) according to the Mayo endoscopic subscore in UC. Results To diagnose UC, the optimal cutoff of NLR and PLR was 2.26 (sensitivity 54.2%; specificity 90.6%; positive likelihood ratio 5.778, 95% confidence interval [CI] 2.944–11.339; area under the curve [AUC] 0.774, 95% CI, 0.690–0.859) and 179.8 (sensitivity 35.4%; specificity 90.6%; positive likelihood ratio 3.778, 95% CI 1.821–7.838; AUC 0.654, 95% CI 0.556–0.753), respectively. The optimal cutoff to differentiate group 1 and group 2 was 3.44, 175.9, and 453 µg/g for NLR, PLR, and FC, respectively (sensitivity, 63.6% vs. 90.9% vs. 81.8%; specificity, 81.1% vs. 78.4% vs. 73.0%; positive likelihood ratio, 3.364 vs. 4.205 vs. 3.027; AUC, 0.714 vs. 0.897 vs. 0.813). PLR had the highest AUC and positive likelihood ratio. Conclusions NLR and PLR help differentiate patients with UC from healthy controls. NLR, PLR, and FC indicate endoscopic activity and may reflect intestinal mucosal conditions. colitis, ulcerative neutrophil to lymphocyte ratio platelet to lymphocyte ratio fecal calprotectin Medicine R Diseases of the digestive system. Gastroenterology Seong Ran Jeon verfasserin aut Hyun Gun Kim verfasserin aut Jung Rock Moon verfasserin aut Tae Hee Lee verfasserin aut Jae Young Jang verfasserin aut Jun-Hyung Cho verfasserin aut Jun Seok Park verfasserin aut Heesu Park verfasserin aut Ki-hun Lee verfasserin aut Jin-Oh Kim verfasserin aut Joon Seong Lee verfasserin aut Bong Min Ko verfasserin aut Suyeon Park verfasserin aut In Intestinal Research Korean Association for the Study of Intestinal Diseases, 2017 19(2021), 1, Seite 62-70 (DE-627)1696048168 22881956 nnns volume:19 year:2021 number:1 pages:62-70 https://doi.org/10.5217/ir.2019.09156 kostenfrei https://doaj.org/article/c9df80da23594387b5f9f25f7d1dafb6 kostenfrei http://www.irjournal.org/upload/pdf/ir-2019-09156.pdf kostenfrei https://doaj.org/toc/1598-9100 Journal toc kostenfrei https://doaj.org/toc/2288-1956 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2021 1 62-70
allfields_unstemmed	10.5217/ir.2019.09156 doi (DE-627)DOAJ071742344 (DE-599)DOAJc9df80da23594387b5f9f25f7d1dafb6 DE-627 ger DE-627 rakwb eng RC799-869 Yujin Jeong verfasserin aut The role of platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in ulcerative colitis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background/Aims Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) can serve as biomarkers for diagnosing and assessing disease activity in ulcerative colitis (UC). We investigated their clinical significance in UC. Methods We analyzed 48 patients with UC who underwent measurement of fecal calprotectin (FC) and endoscopy and 96 age- and sex-matched healthy controls. NLR and PLR were compared between the patients and healthy controls. The endoscopic activity was divided into 2 groups: group 1 (mild to moderate inflammation) and group 2 (severe inflammation) according to the Mayo endoscopic subscore in UC. Results To diagnose UC, the optimal cutoff of NLR and PLR was 2.26 (sensitivity 54.2%; specificity 90.6%; positive likelihood ratio 5.778, 95% confidence interval [CI] 2.944–11.339; area under the curve [AUC] 0.774, 95% CI, 0.690–0.859) and 179.8 (sensitivity 35.4%; specificity 90.6%; positive likelihood ratio 3.778, 95% CI 1.821–7.838; AUC 0.654, 95% CI 0.556–0.753), respectively. The optimal cutoff to differentiate group 1 and group 2 was 3.44, 175.9, and 453 µg/g for NLR, PLR, and FC, respectively (sensitivity, 63.6% vs. 90.9% vs. 81.8%; specificity, 81.1% vs. 78.4% vs. 73.0%; positive likelihood ratio, 3.364 vs. 4.205 vs. 3.027; AUC, 0.714 vs. 0.897 vs. 0.813). PLR had the highest AUC and positive likelihood ratio. Conclusions NLR and PLR help differentiate patients with UC from healthy controls. NLR, PLR, and FC indicate endoscopic activity and may reflect intestinal mucosal conditions. colitis, ulcerative neutrophil to lymphocyte ratio platelet to lymphocyte ratio fecal calprotectin Medicine R Diseases of the digestive system. Gastroenterology Seong Ran Jeon verfasserin aut Hyun Gun Kim verfasserin aut Jung Rock Moon verfasserin aut Tae Hee Lee verfasserin aut Jae Young Jang verfasserin aut Jun-Hyung Cho verfasserin aut Jun Seok Park verfasserin aut Heesu Park verfasserin aut Ki-hun Lee verfasserin aut Jin-Oh Kim verfasserin aut Joon Seong Lee verfasserin aut Bong Min Ko verfasserin aut Suyeon Park verfasserin aut In Intestinal Research Korean Association for the Study of Intestinal Diseases, 2017 19(2021), 1, Seite 62-70 (DE-627)1696048168 22881956 nnns volume:19 year:2021 number:1 pages:62-70 https://doi.org/10.5217/ir.2019.09156 kostenfrei https://doaj.org/article/c9df80da23594387b5f9f25f7d1dafb6 kostenfrei http://www.irjournal.org/upload/pdf/ir-2019-09156.pdf kostenfrei https://doaj.org/toc/1598-9100 Journal toc kostenfrei https://doaj.org/toc/2288-1956 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2021 1 62-70
allfieldsGer	10.5217/ir.2019.09156 doi (DE-627)DOAJ071742344 (DE-599)DOAJc9df80da23594387b5f9f25f7d1dafb6 DE-627 ger DE-627 rakwb eng RC799-869 Yujin Jeong verfasserin aut The role of platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in ulcerative colitis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background/Aims Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) can serve as biomarkers for diagnosing and assessing disease activity in ulcerative colitis (UC). We investigated their clinical significance in UC. Methods We analyzed 48 patients with UC who underwent measurement of fecal calprotectin (FC) and endoscopy and 96 age- and sex-matched healthy controls. NLR and PLR were compared between the patients and healthy controls. The endoscopic activity was divided into 2 groups: group 1 (mild to moderate inflammation) and group 2 (severe inflammation) according to the Mayo endoscopic subscore in UC. Results To diagnose UC, the optimal cutoff of NLR and PLR was 2.26 (sensitivity 54.2%; specificity 90.6%; positive likelihood ratio 5.778, 95% confidence interval [CI] 2.944–11.339; area under the curve [AUC] 0.774, 95% CI, 0.690–0.859) and 179.8 (sensitivity 35.4%; specificity 90.6%; positive likelihood ratio 3.778, 95% CI 1.821–7.838; AUC 0.654, 95% CI 0.556–0.753), respectively. The optimal cutoff to differentiate group 1 and group 2 was 3.44, 175.9, and 453 µg/g for NLR, PLR, and FC, respectively (sensitivity, 63.6% vs. 90.9% vs. 81.8%; specificity, 81.1% vs. 78.4% vs. 73.0%; positive likelihood ratio, 3.364 vs. 4.205 vs. 3.027; AUC, 0.714 vs. 0.897 vs. 0.813). PLR had the highest AUC and positive likelihood ratio. Conclusions NLR and PLR help differentiate patients with UC from healthy controls. NLR, PLR, and FC indicate endoscopic activity and may reflect intestinal mucosal conditions. colitis, ulcerative neutrophil to lymphocyte ratio platelet to lymphocyte ratio fecal calprotectin Medicine R Diseases of the digestive system. Gastroenterology Seong Ran Jeon verfasserin aut Hyun Gun Kim verfasserin aut Jung Rock Moon verfasserin aut Tae Hee Lee verfasserin aut Jae Young Jang verfasserin aut Jun-Hyung Cho verfasserin aut Jun Seok Park verfasserin aut Heesu Park verfasserin aut Ki-hun Lee verfasserin aut Jin-Oh Kim verfasserin aut Joon Seong Lee verfasserin aut Bong Min Ko verfasserin aut Suyeon Park verfasserin aut In Intestinal Research Korean Association for the Study of Intestinal Diseases, 2017 19(2021), 1, Seite 62-70 (DE-627)1696048168 22881956 nnns volume:19 year:2021 number:1 pages:62-70 https://doi.org/10.5217/ir.2019.09156 kostenfrei https://doaj.org/article/c9df80da23594387b5f9f25f7d1dafb6 kostenfrei http://www.irjournal.org/upload/pdf/ir-2019-09156.pdf kostenfrei https://doaj.org/toc/1598-9100 Journal toc kostenfrei https://doaj.org/toc/2288-1956 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2021 1 62-70
allfieldsSound	10.5217/ir.2019.09156 doi (DE-627)DOAJ071742344 (DE-599)DOAJc9df80da23594387b5f9f25f7d1dafb6 DE-627 ger DE-627 rakwb eng RC799-869 Yujin Jeong verfasserin aut The role of platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in ulcerative colitis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background/Aims Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) can serve as biomarkers for diagnosing and assessing disease activity in ulcerative colitis (UC). We investigated their clinical significance in UC. Methods We analyzed 48 patients with UC who underwent measurement of fecal calprotectin (FC) and endoscopy and 96 age- and sex-matched healthy controls. NLR and PLR were compared between the patients and healthy controls. The endoscopic activity was divided into 2 groups: group 1 (mild to moderate inflammation) and group 2 (severe inflammation) according to the Mayo endoscopic subscore in UC. Results To diagnose UC, the optimal cutoff of NLR and PLR was 2.26 (sensitivity 54.2%; specificity 90.6%; positive likelihood ratio 5.778, 95% confidence interval [CI] 2.944–11.339; area under the curve [AUC] 0.774, 95% CI, 0.690–0.859) and 179.8 (sensitivity 35.4%; specificity 90.6%; positive likelihood ratio 3.778, 95% CI 1.821–7.838; AUC 0.654, 95% CI 0.556–0.753), respectively. The optimal cutoff to differentiate group 1 and group 2 was 3.44, 175.9, and 453 µg/g for NLR, PLR, and FC, respectively (sensitivity, 63.6% vs. 90.9% vs. 81.8%; specificity, 81.1% vs. 78.4% vs. 73.0%; positive likelihood ratio, 3.364 vs. 4.205 vs. 3.027; AUC, 0.714 vs. 0.897 vs. 0.813). PLR had the highest AUC and positive likelihood ratio. Conclusions NLR and PLR help differentiate patients with UC from healthy controls. NLR, PLR, and FC indicate endoscopic activity and may reflect intestinal mucosal conditions. colitis, ulcerative neutrophil to lymphocyte ratio platelet to lymphocyte ratio fecal calprotectin Medicine R Diseases of the digestive system. Gastroenterology Seong Ran Jeon verfasserin aut Hyun Gun Kim verfasserin aut Jung Rock Moon verfasserin aut Tae Hee Lee verfasserin aut Jae Young Jang verfasserin aut Jun-Hyung Cho verfasserin aut Jun Seok Park verfasserin aut Heesu Park verfasserin aut Ki-hun Lee verfasserin aut Jin-Oh Kim verfasserin aut Joon Seong Lee verfasserin aut Bong Min Ko verfasserin aut Suyeon Park verfasserin aut In Intestinal Research Korean Association for the Study of Intestinal Diseases, 2017 19(2021), 1, Seite 62-70 (DE-627)1696048168 22881956 nnns volume:19 year:2021 number:1 pages:62-70 https://doi.org/10.5217/ir.2019.09156 kostenfrei https://doaj.org/article/c9df80da23594387b5f9f25f7d1dafb6 kostenfrei http://www.irjournal.org/upload/pdf/ir-2019-09156.pdf kostenfrei https://doaj.org/toc/1598-9100 Journal toc kostenfrei https://doaj.org/toc/2288-1956 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2021 1 62-70
language	English
source	In Intestinal Research 19(2021), 1, Seite 62-70 volume:19 year:2021 number:1 pages:62-70
sourceStr	In Intestinal Research 19(2021), 1, Seite 62-70 volume:19 year:2021 number:1 pages:62-70
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	colitis, ulcerative neutrophil to lymphocyte ratio platelet to lymphocyte ratio fecal calprotectin Medicine R Diseases of the digestive system. Gastroenterology
isfreeaccess_bool	true
container_title	Intestinal Research
authorswithroles_txt_mv	Yujin Jeong @@aut@@ Seong Ran Jeon @@aut@@ Hyun Gun Kim @@aut@@ Jung Rock Moon @@aut@@ Tae Hee Lee @@aut@@ Jae Young Jang @@aut@@ Jun-Hyung Cho @@aut@@ Jun Seok Park @@aut@@ Heesu Park @@aut@@ Ki-hun Lee @@aut@@ Jin-Oh Kim @@aut@@ Joon Seong Lee @@aut@@ Bong Min Ko @@aut@@ Suyeon Park @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	1696048168
id	DOAJ071742344
language_de	englisch
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We investigated their clinical significance in UC. Methods We analyzed 48 patients with UC who underwent measurement of fecal calprotectin (FC) and endoscopy and 96 age- and sex-matched healthy controls. NLR and PLR were compared between the patients and healthy controls. The endoscopic activity was divided into 2 groups: group 1 (mild to moderate inflammation) and group 2 (severe inflammation) according to the Mayo endoscopic subscore in UC. Results To diagnose UC, the optimal cutoff of NLR and PLR was 2.26 (sensitivity 54.2%; specificity 90.6%; positive likelihood ratio 5.778, 95% confidence interval [CI] 2.944–11.339; area under the curve [AUC] 0.774, 95% CI, 0.690–0.859) and 179.8 (sensitivity 35.4%; specificity 90.6%; positive likelihood ratio 3.778, 95% CI 1.821–7.838; AUC 0.654, 95% CI 0.556–0.753), respectively. The optimal cutoff to differentiate group 1 and group 2 was 3.44, 175.9, and 453 µg/g for NLR, PLR, and FC, respectively (sensitivity, 63.6% vs. 90.9% vs. 81.8%; specificity, 81.1% vs. 78.4% vs. 73.0%; positive likelihood ratio, 3.364 vs. 4.205 vs. 3.027; AUC, 0.714 vs. 0.897 vs. 0.813). PLR had the highest AUC and positive likelihood ratio. Conclusions NLR and PLR help differentiate patients with UC from healthy controls. 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callnumber-first	R - Medicine
author	Yujin Jeong
spellingShingle	Yujin Jeong misc RC799-869 misc colitis, ulcerative misc neutrophil to lymphocyte ratio misc platelet to lymphocyte ratio misc fecal calprotectin misc Medicine misc R misc Diseases of the digestive system. Gastroenterology The role of platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in ulcerative colitis
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topic_title	RC799-869 The role of platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in ulcerative colitis colitis, ulcerative neutrophil to lymphocyte ratio platelet to lymphocyte ratio fecal calprotectin
topic	misc RC799-869 misc colitis, ulcerative misc neutrophil to lymphocyte ratio misc platelet to lymphocyte ratio misc fecal calprotectin misc Medicine misc R misc Diseases of the digestive system. Gastroenterology
topic_unstemmed	misc RC799-869 misc colitis, ulcerative misc neutrophil to lymphocyte ratio misc platelet to lymphocyte ratio misc fecal calprotectin misc Medicine misc R misc Diseases of the digestive system. Gastroenterology
topic_browse	misc RC799-869 misc colitis, ulcerative misc neutrophil to lymphocyte ratio misc platelet to lymphocyte ratio misc fecal calprotectin misc Medicine misc R misc Diseases of the digestive system. Gastroenterology
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title	The role of platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in ulcerative colitis
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title_full	The role of platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in ulcerative colitis
author_sort	Yujin Jeong
journal	Intestinal Research
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author_browse	Yujin Jeong Seong Ran Jeon Hyun Gun Kim Jung Rock Moon Tae Hee Lee Jae Young Jang Jun-Hyung Cho Jun Seok Park Heesu Park Ki-hun Lee Jin-Oh Kim Joon Seong Lee Bong Min Ko Suyeon Park
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author-letter	Yujin Jeong
doi_str_mv	10.5217/ir.2019.09156
author2-role	verfasserin
title_sort	role of platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in ulcerative colitis
callnumber	RC799-869
title_auth	The role of platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in ulcerative colitis
abstract	Background/Aims Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) can serve as biomarkers for diagnosing and assessing disease activity in ulcerative colitis (UC). We investigated their clinical significance in UC. Methods We analyzed 48 patients with UC who underwent measurement of fecal calprotectin (FC) and endoscopy and 96 age- and sex-matched healthy controls. NLR and PLR were compared between the patients and healthy controls. The endoscopic activity was divided into 2 groups: group 1 (mild to moderate inflammation) and group 2 (severe inflammation) according to the Mayo endoscopic subscore in UC. Results To diagnose UC, the optimal cutoff of NLR and PLR was 2.26 (sensitivity 54.2%; specificity 90.6%; positive likelihood ratio 5.778, 95% confidence interval [CI] 2.944–11.339; area under the curve [AUC] 0.774, 95% CI, 0.690–0.859) and 179.8 (sensitivity 35.4%; specificity 90.6%; positive likelihood ratio 3.778, 95% CI 1.821–7.838; AUC 0.654, 95% CI 0.556–0.753), respectively. The optimal cutoff to differentiate group 1 and group 2 was 3.44, 175.9, and 453 µg/g for NLR, PLR, and FC, respectively (sensitivity, 63.6% vs. 90.9% vs. 81.8%; specificity, 81.1% vs. 78.4% vs. 73.0%; positive likelihood ratio, 3.364 vs. 4.205 vs. 3.027; AUC, 0.714 vs. 0.897 vs. 0.813). PLR had the highest AUC and positive likelihood ratio. Conclusions NLR and PLR help differentiate patients with UC from healthy controls. NLR, PLR, and FC indicate endoscopic activity and may reflect intestinal mucosal conditions.
abstractGer	Background/Aims Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) can serve as biomarkers for diagnosing and assessing disease activity in ulcerative colitis (UC). We investigated their clinical significance in UC. Methods We analyzed 48 patients with UC who underwent measurement of fecal calprotectin (FC) and endoscopy and 96 age- and sex-matched healthy controls. NLR and PLR were compared between the patients and healthy controls. The endoscopic activity was divided into 2 groups: group 1 (mild to moderate inflammation) and group 2 (severe inflammation) according to the Mayo endoscopic subscore in UC. Results To diagnose UC, the optimal cutoff of NLR and PLR was 2.26 (sensitivity 54.2%; specificity 90.6%; positive likelihood ratio 5.778, 95% confidence interval [CI] 2.944–11.339; area under the curve [AUC] 0.774, 95% CI, 0.690–0.859) and 179.8 (sensitivity 35.4%; specificity 90.6%; positive likelihood ratio 3.778, 95% CI 1.821–7.838; AUC 0.654, 95% CI 0.556–0.753), respectively. The optimal cutoff to differentiate group 1 and group 2 was 3.44, 175.9, and 453 µg/g for NLR, PLR, and FC, respectively (sensitivity, 63.6% vs. 90.9% vs. 81.8%; specificity, 81.1% vs. 78.4% vs. 73.0%; positive likelihood ratio, 3.364 vs. 4.205 vs. 3.027; AUC, 0.714 vs. 0.897 vs. 0.813). PLR had the highest AUC and positive likelihood ratio. Conclusions NLR and PLR help differentiate patients with UC from healthy controls. NLR, PLR, and FC indicate endoscopic activity and may reflect intestinal mucosal conditions.
abstract_unstemmed	Background/Aims Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) can serve as biomarkers for diagnosing and assessing disease activity in ulcerative colitis (UC). We investigated their clinical significance in UC. Methods We analyzed 48 patients with UC who underwent measurement of fecal calprotectin (FC) and endoscopy and 96 age- and sex-matched healthy controls. NLR and PLR were compared between the patients and healthy controls. The endoscopic activity was divided into 2 groups: group 1 (mild to moderate inflammation) and group 2 (severe inflammation) according to the Mayo endoscopic subscore in UC. Results To diagnose UC, the optimal cutoff of NLR and PLR was 2.26 (sensitivity 54.2%; specificity 90.6%; positive likelihood ratio 5.778, 95% confidence interval [CI] 2.944–11.339; area under the curve [AUC] 0.774, 95% CI, 0.690–0.859) and 179.8 (sensitivity 35.4%; specificity 90.6%; positive likelihood ratio 3.778, 95% CI 1.821–7.838; AUC 0.654, 95% CI 0.556–0.753), respectively. The optimal cutoff to differentiate group 1 and group 2 was 3.44, 175.9, and 453 µg/g for NLR, PLR, and FC, respectively (sensitivity, 63.6% vs. 90.9% vs. 81.8%; specificity, 81.1% vs. 78.4% vs. 73.0%; positive likelihood ratio, 3.364 vs. 4.205 vs. 3.027; AUC, 0.714 vs. 0.897 vs. 0.813). PLR had the highest AUC and positive likelihood ratio. Conclusions NLR and PLR help differentiate patients with UC from healthy controls. NLR, PLR, and FC indicate endoscopic activity and may reflect intestinal mucosal conditions.
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title_short	The role of platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in ulcerative colitis
url	https://doi.org/10.5217/ir.2019.09156 https://doaj.org/article/c9df80da23594387b5f9f25f7d1dafb6 http://www.irjournal.org/upload/pdf/ir-2019-09156.pdf https://doaj.org/toc/1598-9100 https://doaj.org/toc/2288-1956
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up_date	2024-07-03T21:57:10.189Z
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The role of platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in ulcerative colitis

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