Peculiarities of cardiovascular remodeling in hypertensive patients at high additional risk with concomitant subclinical hypothyroidism
Arterial hypertension affects over 12 million people in Ukraine, which accounts for about 30 % of the adult population, and is a powerful independent risk factor for cardiovascular morbidity and mortality. Subclinical hypothyroidism (SH) is also an independent causative factor of the cardiovascular...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
V. V. Syvolap [verfasserIn] Ye. V. Novikov [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch ; Russisch ; Ukrainisch |
| Erschienen: |
2019 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Zaporožskij Medicinskij Žurnal - Zaporozhye State Medical University, 2016, 21(2019), 1, Seite 13-20 |
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| Übergeordnetes Werk: |
volume:21 ; year:2019 ; number:1 ; pages:13-20 |
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Link aufrufen |
|---|
| DOI / URN: |
10.14739/2310-1210.2019.1.155792 |
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| Katalog-ID: |
DOAJ071829008 |
|---|
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| 245 | 1 | 0 | |a Peculiarities of cardiovascular remodeling in hypertensive patients at high additional risk with concomitant subclinical hypothyroidism |
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| 520 | |a Arterial hypertension affects over 12 million people in Ukraine, which accounts for about 30 % of the adult population, and is a powerful independent risk factor for cardiovascular morbidity and mortality. Subclinical hypothyroidism (SH) is also an independent causative factor of the cardiovascular risk and is associated with the development of ischemic heart disease, myocardial infarction, chronic heart failure and increased mortality from cardiovascular diseases regardless of sex, age or pre-existing cardiac pathology. Therefore, there is a need to study the influence of subclinical hypothyroidism on the cardiovascular remodeling peculiarities in patients with arterial hypertension (AH). Material and methods. The study involved 124 patients with AH stage II divided into two groups. The group of patients with AH without SH included 92 patients (women 81.52 % (75), men 18.48 % (17)) and 32 patients (women 87.5 % (28), men 12.5 % (4)) represented the group with AH and concomitant SH. The groups of patients were comparable in age (P = 0.093), sex (P = 0.44319), height (P = 0.993), weight (P = 0.719), body surface area (P = 0.901), body mass index (P = 0.669). In all patients underwent arterial blood pressure measurement (OMRON 750 IT,Japan), echocardiography and ultrasound of carotid arteries using the original QIMT software on My Lab 50 (Esaote,Italy). Results. In patients with AH with the concomitant SH, in contrast to patients with AH without SH, a significant increase in indexes of the intima-media complex thickness of the right common carotid artery by 8.2% (P < 0.05) and the left common carotid artery by 7.9 % (P < 0.05) was observed. Changes of structural, geometrical and functional indexes of the heart in patients with AH and SH were significant increase in the left atrial size by 3.5 % (P < 0.05), end diastolic size by 3.0 % (P < 0.05) and end systolic size of the left ventricle by 2.3 % (P < 0.05), myocardial mass index by 11.1 % (P < 0.05), index Е/Е´ by 13.0 % (P < 0.05), gradient of transpulmonary flow by 6.6 % (P < 0.05) in comparison to patients with AH without SH. Conclusions. In patients with AH and concomitant SH in contrast to patients with AH without SH, an increase in thickness of the intima-media complex of both common carotid arteries with comparable diameters of vessels has been established, as well as increase in size of the left atrium, left ventricular myocardial mass index mainly due to the left ventricular dilation, Е/Е´ index and pressure gradient in the pulmonary artery suggesting an increase in the end diastolic pressure and the left ventricular diastolic dysfunction. | ||
| 650 | 4 | |a hypothyroidism | |
| 650 | 4 | |a hypertension | |
| 650 | 4 | |a ventricular remodeling | |
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10.14739/2310-1210.2019.1.155792 doi (DE-627)DOAJ071829008 (DE-599)DOAJccd7c48af11b4cc2b78d04dd3edfd24a DE-627 ger DE-627 rakwb eng rus ukr V. V. Syvolap verfasserin aut Peculiarities of cardiovascular remodeling in hypertensive patients at high additional risk with concomitant subclinical hypothyroidism 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Arterial hypertension affects over 12 million people in Ukraine, which accounts for about 30 % of the adult population, and is a powerful independent risk factor for cardiovascular morbidity and mortality. Subclinical hypothyroidism (SH) is also an independent causative factor of the cardiovascular risk and is associated with the development of ischemic heart disease, myocardial infarction, chronic heart failure and increased mortality from cardiovascular diseases regardless of sex, age or pre-existing cardiac pathology. Therefore, there is a need to study the influence of subclinical hypothyroidism on the cardiovascular remodeling peculiarities in patients with arterial hypertension (AH). Material and methods. The study involved 124 patients with AH stage II divided into two groups. The group of patients with AH without SH included 92 patients (women 81.52 % (75), men 18.48 % (17)) and 32 patients (women 87.5 % (28), men 12.5 % (4)) represented the group with AH and concomitant SH. The groups of patients were comparable in age (P = 0.093), sex (P = 0.44319), height (P = 0.993), weight (P = 0.719), body surface area (P = 0.901), body mass index (P = 0.669). In all patients underwent arterial blood pressure measurement (OMRON 750 IT,Japan), echocardiography and ultrasound of carotid arteries using the original QIMT software on My Lab 50 (Esaote,Italy). Results. In patients with AH with the concomitant SH, in contrast to patients with AH without SH, a significant increase in indexes of the intima-media complex thickness of the right common carotid artery by 8.2% (P < 0.05) and the left common carotid artery by 7.9 % (P < 0.05) was observed. Changes of structural, geometrical and functional indexes of the heart in patients with AH and SH were significant increase in the left atrial size by 3.5 % (P < 0.05), end diastolic size by 3.0 % (P < 0.05) and end systolic size of the left ventricle by 2.3 % (P < 0.05), myocardial mass index by 11.1 % (P < 0.05), index Е/Е´ by 13.0 % (P < 0.05), gradient of transpulmonary flow by 6.6 % (P < 0.05) in comparison to patients with AH without SH. Conclusions. In patients with AH and concomitant SH in contrast to patients with AH without SH, an increase in thickness of the intima-media complex of both common carotid arteries with comparable diameters of vessels has been established, as well as increase in size of the left atrium, left ventricular myocardial mass index mainly due to the left ventricular dilation, Е/Е´ index and pressure gradient in the pulmonary artery suggesting an increase in the end diastolic pressure and the left ventricular diastolic dysfunction. hypothyroidism hypertension ventricular remodeling vascular remodeling Medicine R Ye. V. Novikov verfasserin aut In Zaporožskij Medicinskij Žurnal Zaporozhye State Medical University, 2016 21(2019), 1, Seite 13-20 (DE-627)176064269X 23101210 nnns volume:21 year:2019 number:1 pages:13-20 https://doi.org/10.14739/2310-1210.2019.1.155792 kostenfrei https://doaj.org/article/ccd7c48af11b4cc2b78d04dd3edfd24a kostenfrei http://zmj.zsmu.edu.ua/article/view/155792/155840 kostenfrei https://doaj.org/toc/2306-4145 Journal toc kostenfrei https://doaj.org/toc/2310-1210 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 21 2019 1 13-20 |
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10.14739/2310-1210.2019.1.155792 doi (DE-627)DOAJ071829008 (DE-599)DOAJccd7c48af11b4cc2b78d04dd3edfd24a DE-627 ger DE-627 rakwb eng rus ukr V. V. Syvolap verfasserin aut Peculiarities of cardiovascular remodeling in hypertensive patients at high additional risk with concomitant subclinical hypothyroidism 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Arterial hypertension affects over 12 million people in Ukraine, which accounts for about 30 % of the adult population, and is a powerful independent risk factor for cardiovascular morbidity and mortality. Subclinical hypothyroidism (SH) is also an independent causative factor of the cardiovascular risk and is associated with the development of ischemic heart disease, myocardial infarction, chronic heart failure and increased mortality from cardiovascular diseases regardless of sex, age or pre-existing cardiac pathology. Therefore, there is a need to study the influence of subclinical hypothyroidism on the cardiovascular remodeling peculiarities in patients with arterial hypertension (AH). Material and methods. The study involved 124 patients with AH stage II divided into two groups. The group of patients with AH without SH included 92 patients (women 81.52 % (75), men 18.48 % (17)) and 32 patients (women 87.5 % (28), men 12.5 % (4)) represented the group with AH and concomitant SH. The groups of patients were comparable in age (P = 0.093), sex (P = 0.44319), height (P = 0.993), weight (P = 0.719), body surface area (P = 0.901), body mass index (P = 0.669). In all patients underwent arterial blood pressure measurement (OMRON 750 IT,Japan), echocardiography and ultrasound of carotid arteries using the original QIMT software on My Lab 50 (Esaote,Italy). Results. In patients with AH with the concomitant SH, in contrast to patients with AH without SH, a significant increase in indexes of the intima-media complex thickness of the right common carotid artery by 8.2% (P < 0.05) and the left common carotid artery by 7.9 % (P < 0.05) was observed. Changes of structural, geometrical and functional indexes of the heart in patients with AH and SH were significant increase in the left atrial size by 3.5 % (P < 0.05), end diastolic size by 3.0 % (P < 0.05) and end systolic size of the left ventricle by 2.3 % (P < 0.05), myocardial mass index by 11.1 % (P < 0.05), index Е/Е´ by 13.0 % (P < 0.05), gradient of transpulmonary flow by 6.6 % (P < 0.05) in comparison to patients with AH without SH. Conclusions. In patients with AH and concomitant SH in contrast to patients with AH without SH, an increase in thickness of the intima-media complex of both common carotid arteries with comparable diameters of vessels has been established, as well as increase in size of the left atrium, left ventricular myocardial mass index mainly due to the left ventricular dilation, Е/Е´ index and pressure gradient in the pulmonary artery suggesting an increase in the end diastolic pressure and the left ventricular diastolic dysfunction. hypothyroidism hypertension ventricular remodeling vascular remodeling Medicine R Ye. V. Novikov verfasserin aut In Zaporožskij Medicinskij Žurnal Zaporozhye State Medical University, 2016 21(2019), 1, Seite 13-20 (DE-627)176064269X 23101210 nnns volume:21 year:2019 number:1 pages:13-20 https://doi.org/10.14739/2310-1210.2019.1.155792 kostenfrei https://doaj.org/article/ccd7c48af11b4cc2b78d04dd3edfd24a kostenfrei http://zmj.zsmu.edu.ua/article/view/155792/155840 kostenfrei https://doaj.org/toc/2306-4145 Journal toc kostenfrei https://doaj.org/toc/2310-1210 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 21 2019 1 13-20 |
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10.14739/2310-1210.2019.1.155792 doi (DE-627)DOAJ071829008 (DE-599)DOAJccd7c48af11b4cc2b78d04dd3edfd24a DE-627 ger DE-627 rakwb eng rus ukr V. V. Syvolap verfasserin aut Peculiarities of cardiovascular remodeling in hypertensive patients at high additional risk with concomitant subclinical hypothyroidism 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Arterial hypertension affects over 12 million people in Ukraine, which accounts for about 30 % of the adult population, and is a powerful independent risk factor for cardiovascular morbidity and mortality. Subclinical hypothyroidism (SH) is also an independent causative factor of the cardiovascular risk and is associated with the development of ischemic heart disease, myocardial infarction, chronic heart failure and increased mortality from cardiovascular diseases regardless of sex, age or pre-existing cardiac pathology. Therefore, there is a need to study the influence of subclinical hypothyroidism on the cardiovascular remodeling peculiarities in patients with arterial hypertension (AH). Material and methods. The study involved 124 patients with AH stage II divided into two groups. The group of patients with AH without SH included 92 patients (women 81.52 % (75), men 18.48 % (17)) and 32 patients (women 87.5 % (28), men 12.5 % (4)) represented the group with AH and concomitant SH. The groups of patients were comparable in age (P = 0.093), sex (P = 0.44319), height (P = 0.993), weight (P = 0.719), body surface area (P = 0.901), body mass index (P = 0.669). In all patients underwent arterial blood pressure measurement (OMRON 750 IT,Japan), echocardiography and ultrasound of carotid arteries using the original QIMT software on My Lab 50 (Esaote,Italy). Results. In patients with AH with the concomitant SH, in contrast to patients with AH without SH, a significant increase in indexes of the intima-media complex thickness of the right common carotid artery by 8.2% (P < 0.05) and the left common carotid artery by 7.9 % (P < 0.05) was observed. Changes of structural, geometrical and functional indexes of the heart in patients with AH and SH were significant increase in the left atrial size by 3.5 % (P < 0.05), end diastolic size by 3.0 % (P < 0.05) and end systolic size of the left ventricle by 2.3 % (P < 0.05), myocardial mass index by 11.1 % (P < 0.05), index Е/Е´ by 13.0 % (P < 0.05), gradient of transpulmonary flow by 6.6 % (P < 0.05) in comparison to patients with AH without SH. Conclusions. In patients with AH and concomitant SH in contrast to patients with AH without SH, an increase in thickness of the intima-media complex of both common carotid arteries with comparable diameters of vessels has been established, as well as increase in size of the left atrium, left ventricular myocardial mass index mainly due to the left ventricular dilation, Е/Е´ index and pressure gradient in the pulmonary artery suggesting an increase in the end diastolic pressure and the left ventricular diastolic dysfunction. hypothyroidism hypertension ventricular remodeling vascular remodeling Medicine R Ye. V. Novikov verfasserin aut In Zaporožskij Medicinskij Žurnal Zaporozhye State Medical University, 2016 21(2019), 1, Seite 13-20 (DE-627)176064269X 23101210 nnns volume:21 year:2019 number:1 pages:13-20 https://doi.org/10.14739/2310-1210.2019.1.155792 kostenfrei https://doaj.org/article/ccd7c48af11b4cc2b78d04dd3edfd24a kostenfrei http://zmj.zsmu.edu.ua/article/view/155792/155840 kostenfrei https://doaj.org/toc/2306-4145 Journal toc kostenfrei https://doaj.org/toc/2310-1210 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 21 2019 1 13-20 |
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10.14739/2310-1210.2019.1.155792 doi (DE-627)DOAJ071829008 (DE-599)DOAJccd7c48af11b4cc2b78d04dd3edfd24a DE-627 ger DE-627 rakwb eng rus ukr V. V. Syvolap verfasserin aut Peculiarities of cardiovascular remodeling in hypertensive patients at high additional risk with concomitant subclinical hypothyroidism 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Arterial hypertension affects over 12 million people in Ukraine, which accounts for about 30 % of the adult population, and is a powerful independent risk factor for cardiovascular morbidity and mortality. Subclinical hypothyroidism (SH) is also an independent causative factor of the cardiovascular risk and is associated with the development of ischemic heart disease, myocardial infarction, chronic heart failure and increased mortality from cardiovascular diseases regardless of sex, age or pre-existing cardiac pathology. Therefore, there is a need to study the influence of subclinical hypothyroidism on the cardiovascular remodeling peculiarities in patients with arterial hypertension (AH). Material and methods. The study involved 124 patients with AH stage II divided into two groups. The group of patients with AH without SH included 92 patients (women 81.52 % (75), men 18.48 % (17)) and 32 patients (women 87.5 % (28), men 12.5 % (4)) represented the group with AH and concomitant SH. The groups of patients were comparable in age (P = 0.093), sex (P = 0.44319), height (P = 0.993), weight (P = 0.719), body surface area (P = 0.901), body mass index (P = 0.669). In all patients underwent arterial blood pressure measurement (OMRON 750 IT,Japan), echocardiography and ultrasound of carotid arteries using the original QIMT software on My Lab 50 (Esaote,Italy). Results. In patients with AH with the concomitant SH, in contrast to patients with AH without SH, a significant increase in indexes of the intima-media complex thickness of the right common carotid artery by 8.2% (P < 0.05) and the left common carotid artery by 7.9 % (P < 0.05) was observed. Changes of structural, geometrical and functional indexes of the heart in patients with AH and SH were significant increase in the left atrial size by 3.5 % (P < 0.05), end diastolic size by 3.0 % (P < 0.05) and end systolic size of the left ventricle by 2.3 % (P < 0.05), myocardial mass index by 11.1 % (P < 0.05), index Е/Е´ by 13.0 % (P < 0.05), gradient of transpulmonary flow by 6.6 % (P < 0.05) in comparison to patients with AH without SH. Conclusions. In patients with AH and concomitant SH in contrast to patients with AH without SH, an increase in thickness of the intima-media complex of both common carotid arteries with comparable diameters of vessels has been established, as well as increase in size of the left atrium, left ventricular myocardial mass index mainly due to the left ventricular dilation, Е/Е´ index and pressure gradient in the pulmonary artery suggesting an increase in the end diastolic pressure and the left ventricular diastolic dysfunction. hypothyroidism hypertension ventricular remodeling vascular remodeling Medicine R Ye. V. Novikov verfasserin aut In Zaporožskij Medicinskij Žurnal Zaporozhye State Medical University, 2016 21(2019), 1, Seite 13-20 (DE-627)176064269X 23101210 nnns volume:21 year:2019 number:1 pages:13-20 https://doi.org/10.14739/2310-1210.2019.1.155792 kostenfrei https://doaj.org/article/ccd7c48af11b4cc2b78d04dd3edfd24a kostenfrei http://zmj.zsmu.edu.ua/article/view/155792/155840 kostenfrei https://doaj.org/toc/2306-4145 Journal toc kostenfrei https://doaj.org/toc/2310-1210 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 21 2019 1 13-20 |
| allfieldsSound |
10.14739/2310-1210.2019.1.155792 doi (DE-627)DOAJ071829008 (DE-599)DOAJccd7c48af11b4cc2b78d04dd3edfd24a DE-627 ger DE-627 rakwb eng rus ukr V. V. Syvolap verfasserin aut Peculiarities of cardiovascular remodeling in hypertensive patients at high additional risk with concomitant subclinical hypothyroidism 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Arterial hypertension affects over 12 million people in Ukraine, which accounts for about 30 % of the adult population, and is a powerful independent risk factor for cardiovascular morbidity and mortality. Subclinical hypothyroidism (SH) is also an independent causative factor of the cardiovascular risk and is associated with the development of ischemic heart disease, myocardial infarction, chronic heart failure and increased mortality from cardiovascular diseases regardless of sex, age or pre-existing cardiac pathology. Therefore, there is a need to study the influence of subclinical hypothyroidism on the cardiovascular remodeling peculiarities in patients with arterial hypertension (AH). Material and methods. The study involved 124 patients with AH stage II divided into two groups. The group of patients with AH without SH included 92 patients (women 81.52 % (75), men 18.48 % (17)) and 32 patients (women 87.5 % (28), men 12.5 % (4)) represented the group with AH and concomitant SH. The groups of patients were comparable in age (P = 0.093), sex (P = 0.44319), height (P = 0.993), weight (P = 0.719), body surface area (P = 0.901), body mass index (P = 0.669). In all patients underwent arterial blood pressure measurement (OMRON 750 IT,Japan), echocardiography and ultrasound of carotid arteries using the original QIMT software on My Lab 50 (Esaote,Italy). Results. In patients with AH with the concomitant SH, in contrast to patients with AH without SH, a significant increase in indexes of the intima-media complex thickness of the right common carotid artery by 8.2% (P < 0.05) and the left common carotid artery by 7.9 % (P < 0.05) was observed. Changes of structural, geometrical and functional indexes of the heart in patients with AH and SH were significant increase in the left atrial size by 3.5 % (P < 0.05), end diastolic size by 3.0 % (P < 0.05) and end systolic size of the left ventricle by 2.3 % (P < 0.05), myocardial mass index by 11.1 % (P < 0.05), index Е/Е´ by 13.0 % (P < 0.05), gradient of transpulmonary flow by 6.6 % (P < 0.05) in comparison to patients with AH without SH. Conclusions. In patients with AH and concomitant SH in contrast to patients with AH without SH, an increase in thickness of the intima-media complex of both common carotid arteries with comparable diameters of vessels has been established, as well as increase in size of the left atrium, left ventricular myocardial mass index mainly due to the left ventricular dilation, Е/Е´ index and pressure gradient in the pulmonary artery suggesting an increase in the end diastolic pressure and the left ventricular diastolic dysfunction. hypothyroidism hypertension ventricular remodeling vascular remodeling Medicine R Ye. V. Novikov verfasserin aut In Zaporožskij Medicinskij Žurnal Zaporozhye State Medical University, 2016 21(2019), 1, Seite 13-20 (DE-627)176064269X 23101210 nnns volume:21 year:2019 number:1 pages:13-20 https://doi.org/10.14739/2310-1210.2019.1.155792 kostenfrei https://doaj.org/article/ccd7c48af11b4cc2b78d04dd3edfd24a kostenfrei http://zmj.zsmu.edu.ua/article/view/155792/155840 kostenfrei https://doaj.org/toc/2306-4145 Journal toc kostenfrei https://doaj.org/toc/2310-1210 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 21 2019 1 13-20 |
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V. Syvolap</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Peculiarities of cardiovascular remodeling in hypertensive patients at high additional risk with concomitant subclinical hypothyroidism</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2019</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Arterial hypertension affects over 12 million people in Ukraine, which accounts for about 30 % of the adult population, and is a powerful independent risk factor for cardiovascular morbidity and mortality. Subclinical hypothyroidism (SH) is also an independent causative factor of the cardiovascular risk and is associated with the development of ischemic heart disease, myocardial infarction, chronic heart failure and increased mortality from cardiovascular diseases regardless of sex, age or pre-existing cardiac pathology. Therefore, there is a need to study the influence of subclinical hypothyroidism on the cardiovascular remodeling peculiarities in patients with arterial hypertension (AH). Material and methods. The study involved 124 patients with AH stage II divided into two groups. The group of patients with AH without SH included 92 patients (women 81.52 % (75), men 18.48 % (17)) and 32 patients (women 87.5 % (28), men 12.5 % (4)) represented the group with AH and concomitant SH. The groups of patients were comparable in age (P = 0.093), sex (P = 0.44319), height (P = 0.993), weight (P = 0.719), body surface area (P = 0.901), body mass index (P = 0.669). In all patients underwent arterial blood pressure measurement (OMRON 750 IT,Japan), echocardiography and ultrasound of carotid arteries using the original QIMT software on My Lab 50 (Esaote,Italy). Results. In patients with AH with the concomitant SH, in contrast to patients with AH without SH, a significant increase in indexes of the intima-media complex thickness of the right common carotid artery by 8.2% (P < 0.05) and the left common carotid artery by 7.9 % (P < 0.05) was observed. Changes of structural, geometrical and functional indexes of the heart in patients with AH and SH were significant increase in the left atrial size by 3.5 % (P < 0.05), end diastolic size by 3.0 % (P < 0.05) and end systolic size of the left ventricle by 2.3 % (P < 0.05), myocardial mass index by 11.1 % (P < 0.05), index Е/Е´ by 13.0 % (P < 0.05), gradient of transpulmonary flow by 6.6 % (P < 0.05) in comparison to patients with AH without SH. Conclusions. In patients with AH and concomitant SH in contrast to patients with AH without SH, an increase in thickness of the intima-media complex of both common carotid arteries with comparable diameters of vessels has been established, as well as increase in size of the left atrium, left ventricular myocardial mass index mainly due to the left ventricular dilation, Е/Е´ index and pressure gradient in the pulmonary artery suggesting an increase in the end diastolic pressure and the left ventricular diastolic dysfunction.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">hypothyroidism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">hypertension</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">ventricular remodeling</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">vascular remodeling</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Medicine</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">R</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ye. 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peculiarities of cardiovascular remodeling in hypertensive patients at high additional risk with concomitant subclinical hypothyroidism |
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Peculiarities of cardiovascular remodeling in hypertensive patients at high additional risk with concomitant subclinical hypothyroidism |
| abstract |
Arterial hypertension affects over 12 million people in Ukraine, which accounts for about 30 % of the adult population, and is a powerful independent risk factor for cardiovascular morbidity and mortality. Subclinical hypothyroidism (SH) is also an independent causative factor of the cardiovascular risk and is associated with the development of ischemic heart disease, myocardial infarction, chronic heart failure and increased mortality from cardiovascular diseases regardless of sex, age or pre-existing cardiac pathology. Therefore, there is a need to study the influence of subclinical hypothyroidism on the cardiovascular remodeling peculiarities in patients with arterial hypertension (AH). Material and methods. The study involved 124 patients with AH stage II divided into two groups. The group of patients with AH without SH included 92 patients (women 81.52 % (75), men 18.48 % (17)) and 32 patients (women 87.5 % (28), men 12.5 % (4)) represented the group with AH and concomitant SH. The groups of patients were comparable in age (P = 0.093), sex (P = 0.44319), height (P = 0.993), weight (P = 0.719), body surface area (P = 0.901), body mass index (P = 0.669). In all patients underwent arterial blood pressure measurement (OMRON 750 IT,Japan), echocardiography and ultrasound of carotid arteries using the original QIMT software on My Lab 50 (Esaote,Italy). Results. In patients with AH with the concomitant SH, in contrast to patients with AH without SH, a significant increase in indexes of the intima-media complex thickness of the right common carotid artery by 8.2% (P < 0.05) and the left common carotid artery by 7.9 % (P < 0.05) was observed. Changes of structural, geometrical and functional indexes of the heart in patients with AH and SH were significant increase in the left atrial size by 3.5 % (P < 0.05), end diastolic size by 3.0 % (P < 0.05) and end systolic size of the left ventricle by 2.3 % (P < 0.05), myocardial mass index by 11.1 % (P < 0.05), index Е/Е´ by 13.0 % (P < 0.05), gradient of transpulmonary flow by 6.6 % (P < 0.05) in comparison to patients with AH without SH. Conclusions. In patients with AH and concomitant SH in contrast to patients with AH without SH, an increase in thickness of the intima-media complex of both common carotid arteries with comparable diameters of vessels has been established, as well as increase in size of the left atrium, left ventricular myocardial mass index mainly due to the left ventricular dilation, Е/Е´ index and pressure gradient in the pulmonary artery suggesting an increase in the end diastolic pressure and the left ventricular diastolic dysfunction. |
| abstractGer |
Arterial hypertension affects over 12 million people in Ukraine, which accounts for about 30 % of the adult population, and is a powerful independent risk factor for cardiovascular morbidity and mortality. Subclinical hypothyroidism (SH) is also an independent causative factor of the cardiovascular risk and is associated with the development of ischemic heart disease, myocardial infarction, chronic heart failure and increased mortality from cardiovascular diseases regardless of sex, age or pre-existing cardiac pathology. Therefore, there is a need to study the influence of subclinical hypothyroidism on the cardiovascular remodeling peculiarities in patients with arterial hypertension (AH). Material and methods. The study involved 124 patients with AH stage II divided into two groups. The group of patients with AH without SH included 92 patients (women 81.52 % (75), men 18.48 % (17)) and 32 patients (women 87.5 % (28), men 12.5 % (4)) represented the group with AH and concomitant SH. The groups of patients were comparable in age (P = 0.093), sex (P = 0.44319), height (P = 0.993), weight (P = 0.719), body surface area (P = 0.901), body mass index (P = 0.669). In all patients underwent arterial blood pressure measurement (OMRON 750 IT,Japan), echocardiography and ultrasound of carotid arteries using the original QIMT software on My Lab 50 (Esaote,Italy). Results. In patients with AH with the concomitant SH, in contrast to patients with AH without SH, a significant increase in indexes of the intima-media complex thickness of the right common carotid artery by 8.2% (P < 0.05) and the left common carotid artery by 7.9 % (P < 0.05) was observed. Changes of structural, geometrical and functional indexes of the heart in patients with AH and SH were significant increase in the left atrial size by 3.5 % (P < 0.05), end diastolic size by 3.0 % (P < 0.05) and end systolic size of the left ventricle by 2.3 % (P < 0.05), myocardial mass index by 11.1 % (P < 0.05), index Е/Е´ by 13.0 % (P < 0.05), gradient of transpulmonary flow by 6.6 % (P < 0.05) in comparison to patients with AH without SH. Conclusions. In patients with AH and concomitant SH in contrast to patients with AH without SH, an increase in thickness of the intima-media complex of both common carotid arteries with comparable diameters of vessels has been established, as well as increase in size of the left atrium, left ventricular myocardial mass index mainly due to the left ventricular dilation, Е/Е´ index and pressure gradient in the pulmonary artery suggesting an increase in the end diastolic pressure and the left ventricular diastolic dysfunction. |
| abstract_unstemmed |
Arterial hypertension affects over 12 million people in Ukraine, which accounts for about 30 % of the adult population, and is a powerful independent risk factor for cardiovascular morbidity and mortality. Subclinical hypothyroidism (SH) is also an independent causative factor of the cardiovascular risk and is associated with the development of ischemic heart disease, myocardial infarction, chronic heart failure and increased mortality from cardiovascular diseases regardless of sex, age or pre-existing cardiac pathology. Therefore, there is a need to study the influence of subclinical hypothyroidism on the cardiovascular remodeling peculiarities in patients with arterial hypertension (AH). Material and methods. The study involved 124 patients with AH stage II divided into two groups. The group of patients with AH without SH included 92 patients (women 81.52 % (75), men 18.48 % (17)) and 32 patients (women 87.5 % (28), men 12.5 % (4)) represented the group with AH and concomitant SH. The groups of patients were comparable in age (P = 0.093), sex (P = 0.44319), height (P = 0.993), weight (P = 0.719), body surface area (P = 0.901), body mass index (P = 0.669). In all patients underwent arterial blood pressure measurement (OMRON 750 IT,Japan), echocardiography and ultrasound of carotid arteries using the original QIMT software on My Lab 50 (Esaote,Italy). Results. In patients with AH with the concomitant SH, in contrast to patients with AH without SH, a significant increase in indexes of the intima-media complex thickness of the right common carotid artery by 8.2% (P < 0.05) and the left common carotid artery by 7.9 % (P < 0.05) was observed. Changes of structural, geometrical and functional indexes of the heart in patients with AH and SH were significant increase in the left atrial size by 3.5 % (P < 0.05), end diastolic size by 3.0 % (P < 0.05) and end systolic size of the left ventricle by 2.3 % (P < 0.05), myocardial mass index by 11.1 % (P < 0.05), index Е/Е´ by 13.0 % (P < 0.05), gradient of transpulmonary flow by 6.6 % (P < 0.05) in comparison to patients with AH without SH. Conclusions. In patients with AH and concomitant SH in contrast to patients with AH without SH, an increase in thickness of the intima-media complex of both common carotid arteries with comparable diameters of vessels has been established, as well as increase in size of the left atrium, left ventricular myocardial mass index mainly due to the left ventricular dilation, Е/Е´ index and pressure gradient in the pulmonary artery suggesting an increase in the end diastolic pressure and the left ventricular diastolic dysfunction. |
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Subclinical hypothyroidism (SH) is also an independent causative factor of the cardiovascular risk and is associated with the development of ischemic heart disease, myocardial infarction, chronic heart failure and increased mortality from cardiovascular diseases regardless of sex, age or pre-existing cardiac pathology. Therefore, there is a need to study the influence of subclinical hypothyroidism on the cardiovascular remodeling peculiarities in patients with arterial hypertension (AH). Material and methods. The study involved 124 patients with AH stage II divided into two groups. The group of patients with AH without SH included 92 patients (women 81.52 % (75), men 18.48 % (17)) and 32 patients (women 87.5 % (28), men 12.5 % (4)) represented the group with AH and concomitant SH. The groups of patients were comparable in age (P = 0.093), sex (P = 0.44319), height (P = 0.993), weight (P = 0.719), body surface area (P = 0.901), body mass index (P = 0.669). In all patients underwent arterial blood pressure measurement (OMRON 750 IT,Japan), echocardiography and ultrasound of carotid arteries using the original QIMT software on My Lab 50 (Esaote,Italy). Results. In patients with AH with the concomitant SH, in contrast to patients with AH without SH, a significant increase in indexes of the intima-media complex thickness of the right common carotid artery by 8.2% (P < 0.05) and the left common carotid artery by 7.9 % (P < 0.05) was observed. Changes of structural, geometrical and functional indexes of the heart in patients with AH and SH were significant increase in the left atrial size by 3.5 % (P < 0.05), end diastolic size by 3.0 % (P < 0.05) and end systolic size of the left ventricle by 2.3 % (P < 0.05), myocardial mass index by 11.1 % (P < 0.05), index Е/Е´ by 13.0 % (P < 0.05), gradient of transpulmonary flow by 6.6 % (P < 0.05) in comparison to patients with AH without SH. Conclusions. 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