Green Tea Seed Oil Suppressed Aβ<sub<1–42</sub<-Induced Behavioral and Cognitive Deficit via the Aβ-Related Akt Pathway
The aim of this study was to investigate the availability of seeds, one of the byproducts of green tea, and evaluate the physiological activity of seed oil. The ameliorating effect of green tea seed oil (GTO) was evaluated on H<sub<2</sub<O<sub<2</sub<-induced PC12 cells and...
Ausführliche Beschreibung
Autor*in: |
Jong Min Kim [verfasserIn] Seon Kyeong Park [verfasserIn] Jin Yong Kang [verfasserIn] Su Bin Park [verfasserIn] Seul Ki Yoo [verfasserIn] Hye Ju Han [verfasserIn] Kyoung Hwan Cho [verfasserIn] Jong Cheol Kim [verfasserIn] Ho Jin Heo [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2019 |
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Schlagwörter: |
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Übergeordnetes Werk: |
In: International Journal of Molecular Sciences - MDPI AG, 2003, 20(2019), 8, p 1865 |
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Übergeordnetes Werk: |
volume:20 ; year:2019 ; number:8, p 1865 |
Links: |
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DOI / URN: |
10.3390/ijms20081865 |
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Katalog-ID: |
DOAJ072155973 |
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10.3390/ijms20081865 doi (DE-627)DOAJ072155973 (DE-599)DOAJ7514828db1e44f728229d9c103307813 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Jong Min Kim verfasserin aut Green Tea Seed Oil Suppressed Aβ<sub<1–42</sub<-Induced Behavioral and Cognitive Deficit via the Aβ-Related Akt Pathway 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to investigate the availability of seeds, one of the byproducts of green tea, and evaluate the physiological activity of seed oil. The ameliorating effect of green tea seed oil (GTO) was evaluated on H<sub<2</sub<O<sub<2</sub<-induced PC12 cells and amyloid beta (Aβ)<sub<1–42</sub<-induced ICR mice. GTO showed improvement of cell viability and reduced reactive oxygen species (ROS) production in H<sub<2</sub<O<sub<2</sub<-induced PC12 cells by conducting the 2′,3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and 2′,7′-dichlorofluorescein diacetate (DCF-DA) analysis. Also, administration of GTO (50 and 100 mg/kg body weight) presented protective effects on behavioral and memory dysfunction by conducting Y-maze, passive avoidance, and Morris water maze tests in Aβ-induced ICR mice. GTO protected the antioxidant system by reducing malondialdehyde (MDA) levels, and by increasing superoxide dismutase (SOD) and reducing glutathione (GSH) contents. It significantly regulated the cholinergic system of acetylcholine (ACh) contents, acetylcholinesterase (AChE) activities, and AChE expression. Also, mitochondrial function was improved through the reduced production of ROS and damage of mitochondrial membrane potential (MMP) by regulating the Aβ-related c-Jun N-terminal kinase (JNK)/protein kinase B (Akt) and Akt/apoptosis pathways. This study suggested that GTO may have an ameliorating effect on cognitive dysfunction and neurotoxicity through various physiological activities. green tea seed oil amyloid β neuroprotective effect Aβ-related Akt pathway Biology (General) Chemistry Seon Kyeong Park verfasserin aut Jin Yong Kang verfasserin aut Su Bin Park verfasserin aut Seul Ki Yoo verfasserin aut Hye Ju Han verfasserin aut Kyoung Hwan Cho verfasserin aut Jong Cheol Kim verfasserin aut Ho Jin Heo verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 20(2019), 8, p 1865 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:20 year:2019 number:8, p 1865 https://doi.org/10.3390/ijms20081865 kostenfrei https://doaj.org/article/7514828db1e44f728229d9c103307813 kostenfrei https://www.mdpi.com/1422-0067/20/8/1865 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019 8, p 1865 |
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10.3390/ijms20081865 doi (DE-627)DOAJ072155973 (DE-599)DOAJ7514828db1e44f728229d9c103307813 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Jong Min Kim verfasserin aut Green Tea Seed Oil Suppressed Aβ<sub<1–42</sub<-Induced Behavioral and Cognitive Deficit via the Aβ-Related Akt Pathway 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to investigate the availability of seeds, one of the byproducts of green tea, and evaluate the physiological activity of seed oil. The ameliorating effect of green tea seed oil (GTO) was evaluated on H<sub<2</sub<O<sub<2</sub<-induced PC12 cells and amyloid beta (Aβ)<sub<1–42</sub<-induced ICR mice. GTO showed improvement of cell viability and reduced reactive oxygen species (ROS) production in H<sub<2</sub<O<sub<2</sub<-induced PC12 cells by conducting the 2′,3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and 2′,7′-dichlorofluorescein diacetate (DCF-DA) analysis. Also, administration of GTO (50 and 100 mg/kg body weight) presented protective effects on behavioral and memory dysfunction by conducting Y-maze, passive avoidance, and Morris water maze tests in Aβ-induced ICR mice. GTO protected the antioxidant system by reducing malondialdehyde (MDA) levels, and by increasing superoxide dismutase (SOD) and reducing glutathione (GSH) contents. It significantly regulated the cholinergic system of acetylcholine (ACh) contents, acetylcholinesterase (AChE) activities, and AChE expression. Also, mitochondrial function was improved through the reduced production of ROS and damage of mitochondrial membrane potential (MMP) by regulating the Aβ-related c-Jun N-terminal kinase (JNK)/protein kinase B (Akt) and Akt/apoptosis pathways. This study suggested that GTO may have an ameliorating effect on cognitive dysfunction and neurotoxicity through various physiological activities. green tea seed oil amyloid β neuroprotective effect Aβ-related Akt pathway Biology (General) Chemistry Seon Kyeong Park verfasserin aut Jin Yong Kang verfasserin aut Su Bin Park verfasserin aut Seul Ki Yoo verfasserin aut Hye Ju Han verfasserin aut Kyoung Hwan Cho verfasserin aut Jong Cheol Kim verfasserin aut Ho Jin Heo verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 20(2019), 8, p 1865 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:20 year:2019 number:8, p 1865 https://doi.org/10.3390/ijms20081865 kostenfrei https://doaj.org/article/7514828db1e44f728229d9c103307813 kostenfrei https://www.mdpi.com/1422-0067/20/8/1865 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019 8, p 1865 |
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10.3390/ijms20081865 doi (DE-627)DOAJ072155973 (DE-599)DOAJ7514828db1e44f728229d9c103307813 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Jong Min Kim verfasserin aut Green Tea Seed Oil Suppressed Aβ<sub<1–42</sub<-Induced Behavioral and Cognitive Deficit via the Aβ-Related Akt Pathway 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to investigate the availability of seeds, one of the byproducts of green tea, and evaluate the physiological activity of seed oil. The ameliorating effect of green tea seed oil (GTO) was evaluated on H<sub<2</sub<O<sub<2</sub<-induced PC12 cells and amyloid beta (Aβ)<sub<1–42</sub<-induced ICR mice. GTO showed improvement of cell viability and reduced reactive oxygen species (ROS) production in H<sub<2</sub<O<sub<2</sub<-induced PC12 cells by conducting the 2′,3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and 2′,7′-dichlorofluorescein diacetate (DCF-DA) analysis. Also, administration of GTO (50 and 100 mg/kg body weight) presented protective effects on behavioral and memory dysfunction by conducting Y-maze, passive avoidance, and Morris water maze tests in Aβ-induced ICR mice. GTO protected the antioxidant system by reducing malondialdehyde (MDA) levels, and by increasing superoxide dismutase (SOD) and reducing glutathione (GSH) contents. It significantly regulated the cholinergic system of acetylcholine (ACh) contents, acetylcholinesterase (AChE) activities, and AChE expression. Also, mitochondrial function was improved through the reduced production of ROS and damage of mitochondrial membrane potential (MMP) by regulating the Aβ-related c-Jun N-terminal kinase (JNK)/protein kinase B (Akt) and Akt/apoptosis pathways. This study suggested that GTO may have an ameliorating effect on cognitive dysfunction and neurotoxicity through various physiological activities. green tea seed oil amyloid β neuroprotective effect Aβ-related Akt pathway Biology (General) Chemistry Seon Kyeong Park verfasserin aut Jin Yong Kang verfasserin aut Su Bin Park verfasserin aut Seul Ki Yoo verfasserin aut Hye Ju Han verfasserin aut Kyoung Hwan Cho verfasserin aut Jong Cheol Kim verfasserin aut Ho Jin Heo verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 20(2019), 8, p 1865 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:20 year:2019 number:8, p 1865 https://doi.org/10.3390/ijms20081865 kostenfrei https://doaj.org/article/7514828db1e44f728229d9c103307813 kostenfrei https://www.mdpi.com/1422-0067/20/8/1865 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019 8, p 1865 |
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10.3390/ijms20081865 doi (DE-627)DOAJ072155973 (DE-599)DOAJ7514828db1e44f728229d9c103307813 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Jong Min Kim verfasserin aut Green Tea Seed Oil Suppressed Aβ<sub<1–42</sub<-Induced Behavioral and Cognitive Deficit via the Aβ-Related Akt Pathway 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to investigate the availability of seeds, one of the byproducts of green tea, and evaluate the physiological activity of seed oil. The ameliorating effect of green tea seed oil (GTO) was evaluated on H<sub<2</sub<O<sub<2</sub<-induced PC12 cells and amyloid beta (Aβ)<sub<1–42</sub<-induced ICR mice. GTO showed improvement of cell viability and reduced reactive oxygen species (ROS) production in H<sub<2</sub<O<sub<2</sub<-induced PC12 cells by conducting the 2′,3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and 2′,7′-dichlorofluorescein diacetate (DCF-DA) analysis. Also, administration of GTO (50 and 100 mg/kg body weight) presented protective effects on behavioral and memory dysfunction by conducting Y-maze, passive avoidance, and Morris water maze tests in Aβ-induced ICR mice. GTO protected the antioxidant system by reducing malondialdehyde (MDA) levels, and by increasing superoxide dismutase (SOD) and reducing glutathione (GSH) contents. It significantly regulated the cholinergic system of acetylcholine (ACh) contents, acetylcholinesterase (AChE) activities, and AChE expression. Also, mitochondrial function was improved through the reduced production of ROS and damage of mitochondrial membrane potential (MMP) by regulating the Aβ-related c-Jun N-terminal kinase (JNK)/protein kinase B (Akt) and Akt/apoptosis pathways. This study suggested that GTO may have an ameliorating effect on cognitive dysfunction and neurotoxicity through various physiological activities. green tea seed oil amyloid β neuroprotective effect Aβ-related Akt pathway Biology (General) Chemistry Seon Kyeong Park verfasserin aut Jin Yong Kang verfasserin aut Su Bin Park verfasserin aut Seul Ki Yoo verfasserin aut Hye Ju Han verfasserin aut Kyoung Hwan Cho verfasserin aut Jong Cheol Kim verfasserin aut Ho Jin Heo verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 20(2019), 8, p 1865 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:20 year:2019 number:8, p 1865 https://doi.org/10.3390/ijms20081865 kostenfrei https://doaj.org/article/7514828db1e44f728229d9c103307813 kostenfrei https://www.mdpi.com/1422-0067/20/8/1865 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019 8, p 1865 |
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Green Tea Seed Oil Suppressed Aβ<sub<1–42</sub<-Induced Behavioral and Cognitive Deficit via the Aβ-Related Akt Pathway |
abstract |
The aim of this study was to investigate the availability of seeds, one of the byproducts of green tea, and evaluate the physiological activity of seed oil. The ameliorating effect of green tea seed oil (GTO) was evaluated on H<sub<2</sub<O<sub<2</sub<-induced PC12 cells and amyloid beta (Aβ)<sub<1–42</sub<-induced ICR mice. GTO showed improvement of cell viability and reduced reactive oxygen species (ROS) production in H<sub<2</sub<O<sub<2</sub<-induced PC12 cells by conducting the 2′,3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and 2′,7′-dichlorofluorescein diacetate (DCF-DA) analysis. Also, administration of GTO (50 and 100 mg/kg body weight) presented protective effects on behavioral and memory dysfunction by conducting Y-maze, passive avoidance, and Morris water maze tests in Aβ-induced ICR mice. GTO protected the antioxidant system by reducing malondialdehyde (MDA) levels, and by increasing superoxide dismutase (SOD) and reducing glutathione (GSH) contents. It significantly regulated the cholinergic system of acetylcholine (ACh) contents, acetylcholinesterase (AChE) activities, and AChE expression. Also, mitochondrial function was improved through the reduced production of ROS and damage of mitochondrial membrane potential (MMP) by regulating the Aβ-related c-Jun N-terminal kinase (JNK)/protein kinase B (Akt) and Akt/apoptosis pathways. This study suggested that GTO may have an ameliorating effect on cognitive dysfunction and neurotoxicity through various physiological activities. |
abstractGer |
The aim of this study was to investigate the availability of seeds, one of the byproducts of green tea, and evaluate the physiological activity of seed oil. The ameliorating effect of green tea seed oil (GTO) was evaluated on H<sub<2</sub<O<sub<2</sub<-induced PC12 cells and amyloid beta (Aβ)<sub<1–42</sub<-induced ICR mice. GTO showed improvement of cell viability and reduced reactive oxygen species (ROS) production in H<sub<2</sub<O<sub<2</sub<-induced PC12 cells by conducting the 2′,3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and 2′,7′-dichlorofluorescein diacetate (DCF-DA) analysis. Also, administration of GTO (50 and 100 mg/kg body weight) presented protective effects on behavioral and memory dysfunction by conducting Y-maze, passive avoidance, and Morris water maze tests in Aβ-induced ICR mice. GTO protected the antioxidant system by reducing malondialdehyde (MDA) levels, and by increasing superoxide dismutase (SOD) and reducing glutathione (GSH) contents. It significantly regulated the cholinergic system of acetylcholine (ACh) contents, acetylcholinesterase (AChE) activities, and AChE expression. Also, mitochondrial function was improved through the reduced production of ROS and damage of mitochondrial membrane potential (MMP) by regulating the Aβ-related c-Jun N-terminal kinase (JNK)/protein kinase B (Akt) and Akt/apoptosis pathways. This study suggested that GTO may have an ameliorating effect on cognitive dysfunction and neurotoxicity through various physiological activities. |
abstract_unstemmed |
The aim of this study was to investigate the availability of seeds, one of the byproducts of green tea, and evaluate the physiological activity of seed oil. The ameliorating effect of green tea seed oil (GTO) was evaluated on H<sub<2</sub<O<sub<2</sub<-induced PC12 cells and amyloid beta (Aβ)<sub<1–42</sub<-induced ICR mice. GTO showed improvement of cell viability and reduced reactive oxygen species (ROS) production in H<sub<2</sub<O<sub<2</sub<-induced PC12 cells by conducting the 2′,3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and 2′,7′-dichlorofluorescein diacetate (DCF-DA) analysis. Also, administration of GTO (50 and 100 mg/kg body weight) presented protective effects on behavioral and memory dysfunction by conducting Y-maze, passive avoidance, and Morris water maze tests in Aβ-induced ICR mice. GTO protected the antioxidant system by reducing malondialdehyde (MDA) levels, and by increasing superoxide dismutase (SOD) and reducing glutathione (GSH) contents. It significantly regulated the cholinergic system of acetylcholine (ACh) contents, acetylcholinesterase (AChE) activities, and AChE expression. Also, mitochondrial function was improved through the reduced production of ROS and damage of mitochondrial membrane potential (MMP) by regulating the Aβ-related c-Jun N-terminal kinase (JNK)/protein kinase B (Akt) and Akt/apoptosis pathways. This study suggested that GTO may have an ameliorating effect on cognitive dysfunction and neurotoxicity through various physiological activities. |
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container_issue |
8, p 1865 |
title_short |
Green Tea Seed Oil Suppressed Aβ<sub<1–42</sub<-Induced Behavioral and Cognitive Deficit via the Aβ-Related Akt Pathway |
url |
https://doi.org/10.3390/ijms20081865 https://doaj.org/article/7514828db1e44f728229d9c103307813 https://www.mdpi.com/1422-0067/20/8/1865 https://doaj.org/toc/1422-0067 |
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author2 |
Seon Kyeong Park Jin Yong Kang Su Bin Park Seul Ki Yoo Hye Ju Han Kyoung Hwan Cho Jong Cheol Kim Ho Jin Heo |
author2Str |
Seon Kyeong Park Jin Yong Kang Su Bin Park Seul Ki Yoo Hye Ju Han Kyoung Hwan Cho Jong Cheol Kim Ho Jin Heo |
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doi_str |
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up_date |
2024-07-03T23:57:46.670Z |
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