Green Tea Seed Oil Suppressed Aβ<sub<1–42</sub<-Induced Behavioral and Cognitive Deficit via the Aβ-Related Akt Pathway

The aim of this study was to investigate the availability of seeds, one of the byproducts of green tea, and evaluate the physiological activity of seed oil. The ameliorating effect of green tea seed oil (GTO) was evaluated on H<sub<2</sub<O<sub<2</sub<-induced PC12 cells and...
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Autor*in:	Jong Min Kim [verfasserIn] Seon Kyeong Park [verfasserIn] Jin Yong Kang [verfasserIn] Su Bin Park [verfasserIn] Seul Ki Yoo [verfasserIn] Hye Ju Han [verfasserIn] Kyoung Hwan Cho [verfasserIn] Jong Cheol Kim [verfasserIn] Ho Jin Heo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	green tea seed oil amyloid β neuroprotective effect Aβ-related Akt pathway

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 20(2019), 8, p 1865
Übergeordnetes Werk:	volume:20 ; year:2019 ; number:8, p 1865

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/ijms20081865

Katalog-ID:	DOAJ072155973

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allfields	10.3390/ijms20081865 doi (DE-627)DOAJ072155973 (DE-599)DOAJ7514828db1e44f728229d9c103307813 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Jong Min Kim verfasserin aut Green Tea Seed Oil Suppressed Aβ<sub<1–42</sub<-Induced Behavioral and Cognitive Deficit via the Aβ-Related Akt Pathway 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to investigate the availability of seeds, one of the byproducts of green tea, and evaluate the physiological activity of seed oil. The ameliorating effect of green tea seed oil (GTO) was evaluated on H<sub<2</sub<O<sub<2</sub<-induced PC12 cells and amyloid beta (Aβ)<sub<1–42</sub<-induced ICR mice. GTO showed improvement of cell viability and reduced reactive oxygen species (ROS) production in H<sub<2</sub<O<sub<2</sub<-induced PC12 cells by conducting the 2′,3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and 2′,7′-dichlorofluorescein diacetate (DCF-DA) analysis. Also, administration of GTO (50 and 100 mg/kg body weight) presented protective effects on behavioral and memory dysfunction by conducting Y-maze, passive avoidance, and Morris water maze tests in Aβ-induced ICR mice. GTO protected the antioxidant system by reducing malondialdehyde (MDA) levels, and by increasing superoxide dismutase (SOD) and reducing glutathione (GSH) contents. It significantly regulated the cholinergic system of acetylcholine (ACh) contents, acetylcholinesterase (AChE) activities, and AChE expression. Also, mitochondrial function was improved through the reduced production of ROS and damage of mitochondrial membrane potential (MMP) by regulating the Aβ-related c-Jun N-terminal kinase (JNK)/protein kinase B (Akt) and Akt/apoptosis pathways. This study suggested that GTO may have an ameliorating effect on cognitive dysfunction and neurotoxicity through various physiological activities. green tea seed oil amyloid β neuroprotective effect Aβ-related Akt pathway Biology (General) Chemistry Seon Kyeong Park verfasserin aut Jin Yong Kang verfasserin aut Su Bin Park verfasserin aut Seul Ki Yoo verfasserin aut Hye Ju Han verfasserin aut Kyoung Hwan Cho verfasserin aut Jong Cheol Kim verfasserin aut Ho Jin Heo verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 20(2019), 8, p 1865 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:20 year:2019 number:8, p 1865 https://doi.org/10.3390/ijms20081865 kostenfrei https://doaj.org/article/7514828db1e44f728229d9c103307813 kostenfrei https://www.mdpi.com/1422-0067/20/8/1865 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019 8, p 1865
spelling	10.3390/ijms20081865 doi (DE-627)DOAJ072155973 (DE-599)DOAJ7514828db1e44f728229d9c103307813 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Jong Min Kim verfasserin aut Green Tea Seed Oil Suppressed Aβ<sub<1–42</sub<-Induced Behavioral and Cognitive Deficit via the Aβ-Related Akt Pathway 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to investigate the availability of seeds, one of the byproducts of green tea, and evaluate the physiological activity of seed oil. The ameliorating effect of green tea seed oil (GTO) was evaluated on H<sub<2</sub<O<sub<2</sub<-induced PC12 cells and amyloid beta (Aβ)<sub<1–42</sub<-induced ICR mice. GTO showed improvement of cell viability and reduced reactive oxygen species (ROS) production in H<sub<2</sub<O<sub<2</sub<-induced PC12 cells by conducting the 2′,3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and 2′,7′-dichlorofluorescein diacetate (DCF-DA) analysis. Also, administration of GTO (50 and 100 mg/kg body weight) presented protective effects on behavioral and memory dysfunction by conducting Y-maze, passive avoidance, and Morris water maze tests in Aβ-induced ICR mice. GTO protected the antioxidant system by reducing malondialdehyde (MDA) levels, and by increasing superoxide dismutase (SOD) and reducing glutathione (GSH) contents. It significantly regulated the cholinergic system of acetylcholine (ACh) contents, acetylcholinesterase (AChE) activities, and AChE expression. Also, mitochondrial function was improved through the reduced production of ROS and damage of mitochondrial membrane potential (MMP) by regulating the Aβ-related c-Jun N-terminal kinase (JNK)/protein kinase B (Akt) and Akt/apoptosis pathways. This study suggested that GTO may have an ameliorating effect on cognitive dysfunction and neurotoxicity through various physiological activities. green tea seed oil amyloid β neuroprotective effect Aβ-related Akt pathway Biology (General) Chemistry Seon Kyeong Park verfasserin aut Jin Yong Kang verfasserin aut Su Bin Park verfasserin aut Seul Ki Yoo verfasserin aut Hye Ju Han verfasserin aut Kyoung Hwan Cho verfasserin aut Jong Cheol Kim verfasserin aut Ho Jin Heo verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 20(2019), 8, p 1865 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:20 year:2019 number:8, p 1865 https://doi.org/10.3390/ijms20081865 kostenfrei https://doaj.org/article/7514828db1e44f728229d9c103307813 kostenfrei https://www.mdpi.com/1422-0067/20/8/1865 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019 8, p 1865
allfields_unstemmed	10.3390/ijms20081865 doi (DE-627)DOAJ072155973 (DE-599)DOAJ7514828db1e44f728229d9c103307813 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Jong Min Kim verfasserin aut Green Tea Seed Oil Suppressed Aβ<sub<1–42</sub<-Induced Behavioral and Cognitive Deficit via the Aβ-Related Akt Pathway 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to investigate the availability of seeds, one of the byproducts of green tea, and evaluate the physiological activity of seed oil. The ameliorating effect of green tea seed oil (GTO) was evaluated on H<sub<2</sub<O<sub<2</sub<-induced PC12 cells and amyloid beta (Aβ)<sub<1–42</sub<-induced ICR mice. GTO showed improvement of cell viability and reduced reactive oxygen species (ROS) production in H<sub<2</sub<O<sub<2</sub<-induced PC12 cells by conducting the 2′,3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and 2′,7′-dichlorofluorescein diacetate (DCF-DA) analysis. Also, administration of GTO (50 and 100 mg/kg body weight) presented protective effects on behavioral and memory dysfunction by conducting Y-maze, passive avoidance, and Morris water maze tests in Aβ-induced ICR mice. GTO protected the antioxidant system by reducing malondialdehyde (MDA) levels, and by increasing superoxide dismutase (SOD) and reducing glutathione (GSH) contents. It significantly regulated the cholinergic system of acetylcholine (ACh) contents, acetylcholinesterase (AChE) activities, and AChE expression. Also, mitochondrial function was improved through the reduced production of ROS and damage of mitochondrial membrane potential (MMP) by regulating the Aβ-related c-Jun N-terminal kinase (JNK)/protein kinase B (Akt) and Akt/apoptosis pathways. This study suggested that GTO may have an ameliorating effect on cognitive dysfunction and neurotoxicity through various physiological activities. green tea seed oil amyloid β neuroprotective effect Aβ-related Akt pathway Biology (General) Chemistry Seon Kyeong Park verfasserin aut Jin Yong Kang verfasserin aut Su Bin Park verfasserin aut Seul Ki Yoo verfasserin aut Hye Ju Han verfasserin aut Kyoung Hwan Cho verfasserin aut Jong Cheol Kim verfasserin aut Ho Jin Heo verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 20(2019), 8, p 1865 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:20 year:2019 number:8, p 1865 https://doi.org/10.3390/ijms20081865 kostenfrei https://doaj.org/article/7514828db1e44f728229d9c103307813 kostenfrei https://www.mdpi.com/1422-0067/20/8/1865 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019 8, p 1865
allfieldsGer	10.3390/ijms20081865 doi (DE-627)DOAJ072155973 (DE-599)DOAJ7514828db1e44f728229d9c103307813 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Jong Min Kim verfasserin aut Green Tea Seed Oil Suppressed Aβ<sub<1–42</sub<-Induced Behavioral and Cognitive Deficit via the Aβ-Related Akt Pathway 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to investigate the availability of seeds, one of the byproducts of green tea, and evaluate the physiological activity of seed oil. The ameliorating effect of green tea seed oil (GTO) was evaluated on H<sub<2</sub<O<sub<2</sub<-induced PC12 cells and amyloid beta (Aβ)<sub<1–42</sub<-induced ICR mice. GTO showed improvement of cell viability and reduced reactive oxygen species (ROS) production in H<sub<2</sub<O<sub<2</sub<-induced PC12 cells by conducting the 2′,3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and 2′,7′-dichlorofluorescein diacetate (DCF-DA) analysis. Also, administration of GTO (50 and 100 mg/kg body weight) presented protective effects on behavioral and memory dysfunction by conducting Y-maze, passive avoidance, and Morris water maze tests in Aβ-induced ICR mice. GTO protected the antioxidant system by reducing malondialdehyde (MDA) levels, and by increasing superoxide dismutase (SOD) and reducing glutathione (GSH) contents. It significantly regulated the cholinergic system of acetylcholine (ACh) contents, acetylcholinesterase (AChE) activities, and AChE expression. Also, mitochondrial function was improved through the reduced production of ROS and damage of mitochondrial membrane potential (MMP) by regulating the Aβ-related c-Jun N-terminal kinase (JNK)/protein kinase B (Akt) and Akt/apoptosis pathways. This study suggested that GTO may have an ameliorating effect on cognitive dysfunction and neurotoxicity through various physiological activities. green tea seed oil amyloid β neuroprotective effect Aβ-related Akt pathway Biology (General) Chemistry Seon Kyeong Park verfasserin aut Jin Yong Kang verfasserin aut Su Bin Park verfasserin aut Seul Ki Yoo verfasserin aut Hye Ju Han verfasserin aut Kyoung Hwan Cho verfasserin aut Jong Cheol Kim verfasserin aut Ho Jin Heo verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 20(2019), 8, p 1865 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:20 year:2019 number:8, p 1865 https://doi.org/10.3390/ijms20081865 kostenfrei https://doaj.org/article/7514828db1e44f728229d9c103307813 kostenfrei https://www.mdpi.com/1422-0067/20/8/1865 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019 8, p 1865
allfieldsSound	10.3390/ijms20081865 doi (DE-627)DOAJ072155973 (DE-599)DOAJ7514828db1e44f728229d9c103307813 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Jong Min Kim verfasserin aut Green Tea Seed Oil Suppressed Aβ<sub<1–42</sub<-Induced Behavioral and Cognitive Deficit via the Aβ-Related Akt Pathway 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to investigate the availability of seeds, one of the byproducts of green tea, and evaluate the physiological activity of seed oil. The ameliorating effect of green tea seed oil (GTO) was evaluated on H<sub<2</sub<O<sub<2</sub<-induced PC12 cells and amyloid beta (Aβ)<sub<1–42</sub<-induced ICR mice. GTO showed improvement of cell viability and reduced reactive oxygen species (ROS) production in H<sub<2</sub<O<sub<2</sub<-induced PC12 cells by conducting the 2′,3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and 2′,7′-dichlorofluorescein diacetate (DCF-DA) analysis. Also, administration of GTO (50 and 100 mg/kg body weight) presented protective effects on behavioral and memory dysfunction by conducting Y-maze, passive avoidance, and Morris water maze tests in Aβ-induced ICR mice. GTO protected the antioxidant system by reducing malondialdehyde (MDA) levels, and by increasing superoxide dismutase (SOD) and reducing glutathione (GSH) contents. It significantly regulated the cholinergic system of acetylcholine (ACh) contents, acetylcholinesterase (AChE) activities, and AChE expression. Also, mitochondrial function was improved through the reduced production of ROS and damage of mitochondrial membrane potential (MMP) by regulating the Aβ-related c-Jun N-terminal kinase (JNK)/protein kinase B (Akt) and Akt/apoptosis pathways. This study suggested that GTO may have an ameliorating effect on cognitive dysfunction and neurotoxicity through various physiological activities. green tea seed oil amyloid β neuroprotective effect Aβ-related Akt pathway Biology (General) Chemistry Seon Kyeong Park verfasserin aut Jin Yong Kang verfasserin aut Su Bin Park verfasserin aut Seul Ki Yoo verfasserin aut Hye Ju Han verfasserin aut Kyoung Hwan Cho verfasserin aut Jong Cheol Kim verfasserin aut Ho Jin Heo verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 20(2019), 8, p 1865 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:20 year:2019 number:8, p 1865 https://doi.org/10.3390/ijms20081865 kostenfrei https://doaj.org/article/7514828db1e44f728229d9c103307813 kostenfrei https://www.mdpi.com/1422-0067/20/8/1865 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019 8, p 1865
language	English
source	In International Journal of Molecular Sciences 20(2019), 8, p 1865 volume:20 year:2019 number:8, p 1865
sourceStr	In International Journal of Molecular Sciences 20(2019), 8, p 1865 volume:20 year:2019 number:8, p 1865
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	green tea seed oil amyloid β neuroprotective effect Aβ-related Akt pathway Biology (General) Chemistry
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container_title	International Journal of Molecular Sciences
authorswithroles_txt_mv	Jong Min Kim @@aut@@ Seon Kyeong Park @@aut@@ Jin Yong Kang @@aut@@ Su Bin Park @@aut@@ Seul Ki Yoo @@aut@@ Hye Ju Han @@aut@@ Kyoung Hwan Cho @@aut@@ Jong Cheol Kim @@aut@@ Ho Jin Heo @@aut@@
publishDateDaySort_date	2019-01-01T00:00:00Z
hierarchy_top_id	316340715
id	DOAJ072155973
language_de	englisch
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callnumber-first	Q - Science
author	Jong Min Kim
spellingShingle	Jong Min Kim misc QH301-705.5 misc QD1-999 misc green tea seed oil misc amyloid β misc neuroprotective effect misc Aβ-related Akt pathway misc Biology (General) misc Chemistry Green Tea Seed Oil Suppressed Aβ<sub<1–42</sub<-Induced Behavioral and Cognitive Deficit via the Aβ-Related Akt Pathway
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topic_title	QH301-705.5 QD1-999 Green Tea Seed Oil Suppressed Aβ<sub<1–42</sub<-Induced Behavioral and Cognitive Deficit via the Aβ-Related Akt Pathway green tea seed oil amyloid β neuroprotective effect Aβ-related Akt pathway
topic	misc QH301-705.5 misc QD1-999 misc green tea seed oil misc amyloid β misc neuroprotective effect misc Aβ-related Akt pathway misc Biology (General) misc Chemistry
topic_unstemmed	misc QH301-705.5 misc QD1-999 misc green tea seed oil misc amyloid β misc neuroprotective effect misc Aβ-related Akt pathway misc Biology (General) misc Chemistry
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title	Green Tea Seed Oil Suppressed Aβ<sub<1–42</sub<-Induced Behavioral and Cognitive Deficit via the Aβ-Related Akt Pathway
ctrlnum	(DE-627)DOAJ072155973 (DE-599)DOAJ7514828db1e44f728229d9c103307813
title_full	Green Tea Seed Oil Suppressed Aβ<sub<1–42</sub<-Induced Behavioral and Cognitive Deficit via the Aβ-Related Akt Pathway
author_sort	Jong Min Kim
journal	International Journal of Molecular Sciences
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author_browse	Jong Min Kim Seon Kyeong Park Jin Yong Kang Su Bin Park Seul Ki Yoo Hye Ju Han Kyoung Hwan Cho Jong Cheol Kim Ho Jin Heo
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author-letter	Jong Min Kim
doi_str_mv	10.3390/ijms20081865
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title_sort	green tea seed oil suppressed aβ<sub<1–42</sub<-induced behavioral and cognitive deficit via the aβ-related akt pathway
callnumber	QH301-705.5
title_auth	Green Tea Seed Oil Suppressed Aβ<sub<1–42</sub<-Induced Behavioral and Cognitive Deficit via the Aβ-Related Akt Pathway
abstract	The aim of this study was to investigate the availability of seeds, one of the byproducts of green tea, and evaluate the physiological activity of seed oil. The ameliorating effect of green tea seed oil (GTO) was evaluated on H<sub<2</sub<O<sub<2</sub<-induced PC12 cells and amyloid beta (Aβ)<sub<1–42</sub<-induced ICR mice. GTO showed improvement of cell viability and reduced reactive oxygen species (ROS) production in H<sub<2</sub<O<sub<2</sub<-induced PC12 cells by conducting the 2′,3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and 2′,7′-dichlorofluorescein diacetate (DCF-DA) analysis. Also, administration of GTO (50 and 100 mg/kg body weight) presented protective effects on behavioral and memory dysfunction by conducting Y-maze, passive avoidance, and Morris water maze tests in Aβ-induced ICR mice. GTO protected the antioxidant system by reducing malondialdehyde (MDA) levels, and by increasing superoxide dismutase (SOD) and reducing glutathione (GSH) contents. It significantly regulated the cholinergic system of acetylcholine (ACh) contents, acetylcholinesterase (AChE) activities, and AChE expression. Also, mitochondrial function was improved through the reduced production of ROS and damage of mitochondrial membrane potential (MMP) by regulating the Aβ-related c-Jun N-terminal kinase (JNK)/protein kinase B (Akt) and Akt/apoptosis pathways. This study suggested that GTO may have an ameliorating effect on cognitive dysfunction and neurotoxicity through various physiological activities.
abstractGer	The aim of this study was to investigate the availability of seeds, one of the byproducts of green tea, and evaluate the physiological activity of seed oil. The ameliorating effect of green tea seed oil (GTO) was evaluated on H<sub<2</sub<O<sub<2</sub<-induced PC12 cells and amyloid beta (Aβ)<sub<1–42</sub<-induced ICR mice. GTO showed improvement of cell viability and reduced reactive oxygen species (ROS) production in H<sub<2</sub<O<sub<2</sub<-induced PC12 cells by conducting the 2′,3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and 2′,7′-dichlorofluorescein diacetate (DCF-DA) analysis. Also, administration of GTO (50 and 100 mg/kg body weight) presented protective effects on behavioral and memory dysfunction by conducting Y-maze, passive avoidance, and Morris water maze tests in Aβ-induced ICR mice. GTO protected the antioxidant system by reducing malondialdehyde (MDA) levels, and by increasing superoxide dismutase (SOD) and reducing glutathione (GSH) contents. It significantly regulated the cholinergic system of acetylcholine (ACh) contents, acetylcholinesterase (AChE) activities, and AChE expression. Also, mitochondrial function was improved through the reduced production of ROS and damage of mitochondrial membrane potential (MMP) by regulating the Aβ-related c-Jun N-terminal kinase (JNK)/protein kinase B (Akt) and Akt/apoptosis pathways. This study suggested that GTO may have an ameliorating effect on cognitive dysfunction and neurotoxicity through various physiological activities.
abstract_unstemmed	The aim of this study was to investigate the availability of seeds, one of the byproducts of green tea, and evaluate the physiological activity of seed oil. The ameliorating effect of green tea seed oil (GTO) was evaluated on H<sub<2</sub<O<sub<2</sub<-induced PC12 cells and amyloid beta (Aβ)<sub<1–42</sub<-induced ICR mice. GTO showed improvement of cell viability and reduced reactive oxygen species (ROS) production in H<sub<2</sub<O<sub<2</sub<-induced PC12 cells by conducting the 2′,3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and 2′,7′-dichlorofluorescein diacetate (DCF-DA) analysis. Also, administration of GTO (50 and 100 mg/kg body weight) presented protective effects on behavioral and memory dysfunction by conducting Y-maze, passive avoidance, and Morris water maze tests in Aβ-induced ICR mice. GTO protected the antioxidant system by reducing malondialdehyde (MDA) levels, and by increasing superoxide dismutase (SOD) and reducing glutathione (GSH) contents. It significantly regulated the cholinergic system of acetylcholine (ACh) contents, acetylcholinesterase (AChE) activities, and AChE expression. Also, mitochondrial function was improved through the reduced production of ROS and damage of mitochondrial membrane potential (MMP) by regulating the Aβ-related c-Jun N-terminal kinase (JNK)/protein kinase B (Akt) and Akt/apoptosis pathways. This study suggested that GTO may have an ameliorating effect on cognitive dysfunction and neurotoxicity through various physiological activities.
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container_issue	8, p 1865
title_short	Green Tea Seed Oil Suppressed Aβ<sub<1–42</sub<-Induced Behavioral and Cognitive Deficit via the Aβ-Related Akt Pathway
url	https://doi.org/10.3390/ijms20081865 https://doaj.org/article/7514828db1e44f728229d9c103307813 https://www.mdpi.com/1422-0067/20/8/1865 https://doaj.org/toc/1422-0067
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