Zhankuic Acids A, B and C from <i<Taiwanofungus Camphoratus</i< Act as Cytotoxicity Enhancers by Regulating P-Glycoprotein in Multi-Drug Resistant Cancer Cells

<b<: </b<Since P-glycoprotein (P-gp)-related multidrug resistance (MDR) remains the most important unsolved problem in cancer treatment, scientists are attempting to find potential structures from natural resources. The aim of the present study was to elucidate whether the triterpenoids...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Yu-Ning Teng [verfasserIn] Yen-Hsiang Wang [verfasserIn] Tian-Shung Wu [verfasserIn] Hsin-Yi Hung [verfasserIn] Chin-Chuan Hung [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	multidrug resistance p-glycoprotein taiwanofungus camphoratus zhankuic acid

Übergeordnetes Werk:	In: Biomolecules - MDPI AG, 2013, 9(2019), 12, p 759
Übergeordnetes Werk:	volume:9 ; year:2019 ; number:12, p 759

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/biom9120759

Katalog-ID:	DOAJ072161582

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allfields	10.3390/biom9120759 doi (DE-627)DOAJ072161582 (DE-599)DOAJ2beb5579c6394ba5a4543ff446015d9e DE-627 ger DE-627 rakwb eng QR1-502 Yu-Ning Teng verfasserin aut Zhankuic Acids A, B and C from <i<Taiwanofungus Camphoratus</i< Act as Cytotoxicity Enhancers by Regulating P-Glycoprotein in Multi-Drug Resistant Cancer Cells 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <b<: </b<Since P-glycoprotein (P-gp)-related multidrug resistance (MDR) remains the most important unsolved problem in cancer treatment, scientists are attempting to find potential structures from natural resources. The aim of the present study was to elucidate whether the triterpenoids from Taiwanofungus camphoratus could reverse cancer MDR by influencing P-gp efflux pump. Substrates efflux assay and P-gp ATPase activity assay were conducted to reveal the molecular mechanisms of P-gp inhibition, while SRB assay, cell cycle analyses and apoptosis analyses were performed to confirm the cancer MDR modulating effects. The results indicated that Zhankuic acids A, B and C (ZA-A, ZA-B and ZA-C) impacted P-gp efflux function in competitive, noncompetitive and competitive manners, respectively. Furthermore, these triterpenoids all demonstrated inhibitory patterns on both basal P-gp ATPase activity and verapamil-stimulated ATPase activity. In terms of MDR reversal effects, ZA-A sensitized the P-gp over-expressing cell line (ABCB1/Flp-In<sup<TM</sup<-293) and MDR cancer cell line (KB/VIN) toward clinically used chemotherapeutic drugs, including doxorubicin, paclitaxel and vincristine, exhibiting the best cytotoxicity enhancing ability among investigated triterpenoids. The present study demonstrated that ZA-A, ZA-B and ZA-C, popular triterpenoids from T. camphoratus, effectively modulated the drug efflux transporter P-gp and reversed the cancer MDR issue. multidrug resistance p-glycoprotein taiwanofungus camphoratus zhankuic acid Microbiology Yen-Hsiang Wang verfasserin aut Tian-Shung Wu verfasserin aut Hsin-Yi Hung verfasserin aut Chin-Chuan Hung verfasserin aut In Biomolecules MDPI AG, 2013 9(2019), 12, p 759 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:9 year:2019 number:12, p 759 https://doi.org/10.3390/biom9120759 kostenfrei https://doaj.org/article/2beb5579c6394ba5a4543ff446015d9e kostenfrei https://www.mdpi.com/2218-273X/9/12/759 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2019 12, p 759
spelling	10.3390/biom9120759 doi (DE-627)DOAJ072161582 (DE-599)DOAJ2beb5579c6394ba5a4543ff446015d9e DE-627 ger DE-627 rakwb eng QR1-502 Yu-Ning Teng verfasserin aut Zhankuic Acids A, B and C from <i<Taiwanofungus Camphoratus</i< Act as Cytotoxicity Enhancers by Regulating P-Glycoprotein in Multi-Drug Resistant Cancer Cells 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <b<: </b<Since P-glycoprotein (P-gp)-related multidrug resistance (MDR) remains the most important unsolved problem in cancer treatment, scientists are attempting to find potential structures from natural resources. The aim of the present study was to elucidate whether the triterpenoids from Taiwanofungus camphoratus could reverse cancer MDR by influencing P-gp efflux pump. Substrates efflux assay and P-gp ATPase activity assay were conducted to reveal the molecular mechanisms of P-gp inhibition, while SRB assay, cell cycle analyses and apoptosis analyses were performed to confirm the cancer MDR modulating effects. The results indicated that Zhankuic acids A, B and C (ZA-A, ZA-B and ZA-C) impacted P-gp efflux function in competitive, noncompetitive and competitive manners, respectively. Furthermore, these triterpenoids all demonstrated inhibitory patterns on both basal P-gp ATPase activity and verapamil-stimulated ATPase activity. In terms of MDR reversal effects, ZA-A sensitized the P-gp over-expressing cell line (ABCB1/Flp-In<sup<TM</sup<-293) and MDR cancer cell line (KB/VIN) toward clinically used chemotherapeutic drugs, including doxorubicin, paclitaxel and vincristine, exhibiting the best cytotoxicity enhancing ability among investigated triterpenoids. The present study demonstrated that ZA-A, ZA-B and ZA-C, popular triterpenoids from T. camphoratus, effectively modulated the drug efflux transporter P-gp and reversed the cancer MDR issue. multidrug resistance p-glycoprotein taiwanofungus camphoratus zhankuic acid Microbiology Yen-Hsiang Wang verfasserin aut Tian-Shung Wu verfasserin aut Hsin-Yi Hung verfasserin aut Chin-Chuan Hung verfasserin aut In Biomolecules MDPI AG, 2013 9(2019), 12, p 759 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:9 year:2019 number:12, p 759 https://doi.org/10.3390/biom9120759 kostenfrei https://doaj.org/article/2beb5579c6394ba5a4543ff446015d9e kostenfrei https://www.mdpi.com/2218-273X/9/12/759 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2019 12, p 759
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allfieldsSound	10.3390/biom9120759 doi (DE-627)DOAJ072161582 (DE-599)DOAJ2beb5579c6394ba5a4543ff446015d9e DE-627 ger DE-627 rakwb eng QR1-502 Yu-Ning Teng verfasserin aut Zhankuic Acids A, B and C from <i<Taiwanofungus Camphoratus</i< Act as Cytotoxicity Enhancers by Regulating P-Glycoprotein in Multi-Drug Resistant Cancer Cells 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <b<: </b<Since P-glycoprotein (P-gp)-related multidrug resistance (MDR) remains the most important unsolved problem in cancer treatment, scientists are attempting to find potential structures from natural resources. The aim of the present study was to elucidate whether the triterpenoids from Taiwanofungus camphoratus could reverse cancer MDR by influencing P-gp efflux pump. Substrates efflux assay and P-gp ATPase activity assay were conducted to reveal the molecular mechanisms of P-gp inhibition, while SRB assay, cell cycle analyses and apoptosis analyses were performed to confirm the cancer MDR modulating effects. The results indicated that Zhankuic acids A, B and C (ZA-A, ZA-B and ZA-C) impacted P-gp efflux function in competitive, noncompetitive and competitive manners, respectively. Furthermore, these triterpenoids all demonstrated inhibitory patterns on both basal P-gp ATPase activity and verapamil-stimulated ATPase activity. In terms of MDR reversal effects, ZA-A sensitized the P-gp over-expressing cell line (ABCB1/Flp-In<sup<TM</sup<-293) and MDR cancer cell line (KB/VIN) toward clinically used chemotherapeutic drugs, including doxorubicin, paclitaxel and vincristine, exhibiting the best cytotoxicity enhancing ability among investigated triterpenoids. The present study demonstrated that ZA-A, ZA-B and ZA-C, popular triterpenoids from T. camphoratus, effectively modulated the drug efflux transporter P-gp and reversed the cancer MDR issue. multidrug resistance p-glycoprotein taiwanofungus camphoratus zhankuic acid Microbiology Yen-Hsiang Wang verfasserin aut Tian-Shung Wu verfasserin aut Hsin-Yi Hung verfasserin aut Chin-Chuan Hung verfasserin aut In Biomolecules MDPI AG, 2013 9(2019), 12, p 759 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:9 year:2019 number:12, p 759 https://doi.org/10.3390/biom9120759 kostenfrei https://doaj.org/article/2beb5579c6394ba5a4543ff446015d9e kostenfrei https://www.mdpi.com/2218-273X/9/12/759 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2019 12, p 759
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source	In Biomolecules 9(2019), 12, p 759 volume:9 year:2019 number:12, p 759
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authorswithroles_txt_mv	Yu-Ning Teng @@aut@@ Yen-Hsiang Wang @@aut@@ Tian-Shung Wu @@aut@@ Hsin-Yi Hung @@aut@@ Chin-Chuan Hung @@aut@@
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callnumber-first	Q - Science
author	Yu-Ning Teng
spellingShingle	Yu-Ning Teng misc QR1-502 misc multidrug resistance misc p-glycoprotein misc taiwanofungus camphoratus misc zhankuic acid misc Microbiology Zhankuic Acids A, B and C from <i<Taiwanofungus Camphoratus</i< Act as Cytotoxicity Enhancers by Regulating P-Glycoprotein in Multi-Drug Resistant Cancer Cells
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topic_title	QR1-502 Zhankuic Acids A, B and C from <i<Taiwanofungus Camphoratus</i< Act as Cytotoxicity Enhancers by Regulating P-Glycoprotein in Multi-Drug Resistant Cancer Cells multidrug resistance p-glycoprotein taiwanofungus camphoratus zhankuic acid
topic	misc QR1-502 misc multidrug resistance misc p-glycoprotein misc taiwanofungus camphoratus misc zhankuic acid misc Microbiology
topic_unstemmed	misc QR1-502 misc multidrug resistance misc p-glycoprotein misc taiwanofungus camphoratus misc zhankuic acid misc Microbiology
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title	Zhankuic Acids A, B and C from <i<Taiwanofungus Camphoratus</i< Act as Cytotoxicity Enhancers by Regulating P-Glycoprotein in Multi-Drug Resistant Cancer Cells
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title_full	Zhankuic Acids A, B and C from <i<Taiwanofungus Camphoratus</i< Act as Cytotoxicity Enhancers by Regulating P-Glycoprotein in Multi-Drug Resistant Cancer Cells
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title_sort	zhankuic acids a, b and c from <i<taiwanofungus camphoratus</i< act as cytotoxicity enhancers by regulating p-glycoprotein in multi-drug resistant cancer cells
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title_auth	Zhankuic Acids A, B and C from <i<Taiwanofungus Camphoratus</i< Act as Cytotoxicity Enhancers by Regulating P-Glycoprotein in Multi-Drug Resistant Cancer Cells
abstract	<b<: </b<Since P-glycoprotein (P-gp)-related multidrug resistance (MDR) remains the most important unsolved problem in cancer treatment, scientists are attempting to find potential structures from natural resources. The aim of the present study was to elucidate whether the triterpenoids from Taiwanofungus camphoratus could reverse cancer MDR by influencing P-gp efflux pump. Substrates efflux assay and P-gp ATPase activity assay were conducted to reveal the molecular mechanisms of P-gp inhibition, while SRB assay, cell cycle analyses and apoptosis analyses were performed to confirm the cancer MDR modulating effects. The results indicated that Zhankuic acids A, B and C (ZA-A, ZA-B and ZA-C) impacted P-gp efflux function in competitive, noncompetitive and competitive manners, respectively. Furthermore, these triterpenoids all demonstrated inhibitory patterns on both basal P-gp ATPase activity and verapamil-stimulated ATPase activity. In terms of MDR reversal effects, ZA-A sensitized the P-gp over-expressing cell line (ABCB1/Flp-In<sup<TM</sup<-293) and MDR cancer cell line (KB/VIN) toward clinically used chemotherapeutic drugs, including doxorubicin, paclitaxel and vincristine, exhibiting the best cytotoxicity enhancing ability among investigated triterpenoids. The present study demonstrated that ZA-A, ZA-B and ZA-C, popular triterpenoids from T. camphoratus, effectively modulated the drug efflux transporter P-gp and reversed the cancer MDR issue.
abstractGer	<b<: </b<Since P-glycoprotein (P-gp)-related multidrug resistance (MDR) remains the most important unsolved problem in cancer treatment, scientists are attempting to find potential structures from natural resources. The aim of the present study was to elucidate whether the triterpenoids from Taiwanofungus camphoratus could reverse cancer MDR by influencing P-gp efflux pump. Substrates efflux assay and P-gp ATPase activity assay were conducted to reveal the molecular mechanisms of P-gp inhibition, while SRB assay, cell cycle analyses and apoptosis analyses were performed to confirm the cancer MDR modulating effects. The results indicated that Zhankuic acids A, B and C (ZA-A, ZA-B and ZA-C) impacted P-gp efflux function in competitive, noncompetitive and competitive manners, respectively. Furthermore, these triterpenoids all demonstrated inhibitory patterns on both basal P-gp ATPase activity and verapamil-stimulated ATPase activity. In terms of MDR reversal effects, ZA-A sensitized the P-gp over-expressing cell line (ABCB1/Flp-In<sup<TM</sup<-293) and MDR cancer cell line (KB/VIN) toward clinically used chemotherapeutic drugs, including doxorubicin, paclitaxel and vincristine, exhibiting the best cytotoxicity enhancing ability among investigated triterpenoids. The present study demonstrated that ZA-A, ZA-B and ZA-C, popular triterpenoids from T. camphoratus, effectively modulated the drug efflux transporter P-gp and reversed the cancer MDR issue.
abstract_unstemmed	<b<: </b<Since P-glycoprotein (P-gp)-related multidrug resistance (MDR) remains the most important unsolved problem in cancer treatment, scientists are attempting to find potential structures from natural resources. The aim of the present study was to elucidate whether the triterpenoids from Taiwanofungus camphoratus could reverse cancer MDR by influencing P-gp efflux pump. Substrates efflux assay and P-gp ATPase activity assay were conducted to reveal the molecular mechanisms of P-gp inhibition, while SRB assay, cell cycle analyses and apoptosis analyses were performed to confirm the cancer MDR modulating effects. The results indicated that Zhankuic acids A, B and C (ZA-A, ZA-B and ZA-C) impacted P-gp efflux function in competitive, noncompetitive and competitive manners, respectively. Furthermore, these triterpenoids all demonstrated inhibitory patterns on both basal P-gp ATPase activity and verapamil-stimulated ATPase activity. In terms of MDR reversal effects, ZA-A sensitized the P-gp over-expressing cell line (ABCB1/Flp-In<sup<TM</sup<-293) and MDR cancer cell line (KB/VIN) toward clinically used chemotherapeutic drugs, including doxorubicin, paclitaxel and vincristine, exhibiting the best cytotoxicity enhancing ability among investigated triterpenoids. The present study demonstrated that ZA-A, ZA-B and ZA-C, popular triterpenoids from T. camphoratus, effectively modulated the drug efflux transporter P-gp and reversed the cancer MDR issue.
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title_short	Zhankuic Acids A, B and C from <i<Taiwanofungus Camphoratus</i< Act as Cytotoxicity Enhancers by Regulating P-Glycoprotein in Multi-Drug Resistant Cancer Cells
url	https://doi.org/10.3390/biom9120759 https://doaj.org/article/2beb5579c6394ba5a4543ff446015d9e https://www.mdpi.com/2218-273X/9/12/759 https://doaj.org/toc/2218-273X
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Zhankuic Acids A, B and C from <i<Taiwanofungus Camphoratus</i< Act as Cytotoxicity Enhancers by Regulating P-Glycoprotein in Multi-Drug Resistant Cancer Cells

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