Is Interleukin 17 (IL-17) Expression A Common Point in the Pathogenesis of Depression and Obesity?
(1) Background: Activated immune-inflammatory pathways play an important role in the pathogenesis of depression and pathological obesity. Obesity might promote production of cytokine interleukin 17, which plays a significant role in neuro-immune reactions. The study aimed at assessing the relationsh...
Ausführliche Beschreibung
Autor*in: |
Katarzyna Bliźniewska-Kowalska [verfasserIn] Bernadeta Szewczyk [verfasserIn] Małgorzata Gałecka [verfasserIn] Kuan-Pin Su [verfasserIn] Michael Maes [verfasserIn] Janusz Szemraj [verfasserIn] Piotr Gałecki [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2020 |
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Übergeordnetes Werk: |
In: Journal of Clinical Medicine - MDPI AG, 2013, 9(2020), 12, p 4018 |
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Übergeordnetes Werk: |
volume:9 ; year:2020 ; number:12, p 4018 |
Links: |
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DOI / URN: |
10.3390/jcm9124018 |
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Katalog-ID: |
DOAJ072271949 |
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10.3390/jcm9124018 doi (DE-627)DOAJ072271949 (DE-599)DOAJ5bbf3b7957bf49b19ef07bd7fb5333b0 DE-627 ger DE-627 rakwb eng Katarzyna Bliźniewska-Kowalska verfasserin aut Is Interleukin 17 (IL-17) Expression A Common Point in the Pathogenesis of Depression and Obesity? 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier (1) Background: Activated immune-inflammatory pathways play an important role in the pathogenesis of depression and pathological obesity. Obesity might promote production of cytokine interleukin 17, which plays a significant role in neuro-immune reactions. The study aimed at assessing the relationship between Body Mass Index (BMI) and IL-17 expression, taking into account the clinical psychiatric variables in patients with depression. (2) Methods: A total of 125 participants took part in the study (95 depressed patients, 30 healthy controls). Data concerning the course of depressive disorders and BMI were collected. The severity of depressive symptoms was assessed using the Hamilton Depression Rating Scale (HDRS). Reverse transcription polymerase chain reaction (RT-PCR) was used to assess IL-17 gene expression at the mRNA levels, while enzyme-linked immunosorbent assay (ELISA) was used to assess IL-17 expression at the protein level. (3) Results: Patients with more hospitalizations showed significantly higher IL-17 mRNA expression levels and higher BMI. However, no correlation between BMI and IL-17 expression was found in depressed patients. (4) Conclusions: Our study revealed that BMI does not affect IL-17 expression in patients with depression. However, further studies should be conducted to evaluate the effects of IL-17 inhibition on adipose tissue and vice versa. depression obesity IL-17 neuro-immune inflammation Medicine R Bernadeta Szewczyk verfasserin aut Małgorzata Gałecka verfasserin aut Kuan-Pin Su verfasserin aut Michael Maes verfasserin aut Janusz Szemraj verfasserin aut Piotr Gałecki verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 9(2020), 12, p 4018 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:9 year:2020 number:12, p 4018 https://doi.org/10.3390/jcm9124018 kostenfrei https://doaj.org/article/5bbf3b7957bf49b19ef07bd7fb5333b0 kostenfrei https://www.mdpi.com/2077-0383/9/12/4018 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 12, p 4018 |
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10.3390/jcm9124018 doi (DE-627)DOAJ072271949 (DE-599)DOAJ5bbf3b7957bf49b19ef07bd7fb5333b0 DE-627 ger DE-627 rakwb eng Katarzyna Bliźniewska-Kowalska verfasserin aut Is Interleukin 17 (IL-17) Expression A Common Point in the Pathogenesis of Depression and Obesity? 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier (1) Background: Activated immune-inflammatory pathways play an important role in the pathogenesis of depression and pathological obesity. Obesity might promote production of cytokine interleukin 17, which plays a significant role in neuro-immune reactions. The study aimed at assessing the relationship between Body Mass Index (BMI) and IL-17 expression, taking into account the clinical psychiatric variables in patients with depression. (2) Methods: A total of 125 participants took part in the study (95 depressed patients, 30 healthy controls). Data concerning the course of depressive disorders and BMI were collected. The severity of depressive symptoms was assessed using the Hamilton Depression Rating Scale (HDRS). Reverse transcription polymerase chain reaction (RT-PCR) was used to assess IL-17 gene expression at the mRNA levels, while enzyme-linked immunosorbent assay (ELISA) was used to assess IL-17 expression at the protein level. (3) Results: Patients with more hospitalizations showed significantly higher IL-17 mRNA expression levels and higher BMI. However, no correlation between BMI and IL-17 expression was found in depressed patients. (4) Conclusions: Our study revealed that BMI does not affect IL-17 expression in patients with depression. However, further studies should be conducted to evaluate the effects of IL-17 inhibition on adipose tissue and vice versa. depression obesity IL-17 neuro-immune inflammation Medicine R Bernadeta Szewczyk verfasserin aut Małgorzata Gałecka verfasserin aut Kuan-Pin Su verfasserin aut Michael Maes verfasserin aut Janusz Szemraj verfasserin aut Piotr Gałecki verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 9(2020), 12, p 4018 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:9 year:2020 number:12, p 4018 https://doi.org/10.3390/jcm9124018 kostenfrei https://doaj.org/article/5bbf3b7957bf49b19ef07bd7fb5333b0 kostenfrei https://www.mdpi.com/2077-0383/9/12/4018 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 12, p 4018 |
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10.3390/jcm9124018 doi (DE-627)DOAJ072271949 (DE-599)DOAJ5bbf3b7957bf49b19ef07bd7fb5333b0 DE-627 ger DE-627 rakwb eng Katarzyna Bliźniewska-Kowalska verfasserin aut Is Interleukin 17 (IL-17) Expression A Common Point in the Pathogenesis of Depression and Obesity? 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier (1) Background: Activated immune-inflammatory pathways play an important role in the pathogenesis of depression and pathological obesity. Obesity might promote production of cytokine interleukin 17, which plays a significant role in neuro-immune reactions. The study aimed at assessing the relationship between Body Mass Index (BMI) and IL-17 expression, taking into account the clinical psychiatric variables in patients with depression. (2) Methods: A total of 125 participants took part in the study (95 depressed patients, 30 healthy controls). Data concerning the course of depressive disorders and BMI were collected. The severity of depressive symptoms was assessed using the Hamilton Depression Rating Scale (HDRS). Reverse transcription polymerase chain reaction (RT-PCR) was used to assess IL-17 gene expression at the mRNA levels, while enzyme-linked immunosorbent assay (ELISA) was used to assess IL-17 expression at the protein level. (3) Results: Patients with more hospitalizations showed significantly higher IL-17 mRNA expression levels and higher BMI. However, no correlation between BMI and IL-17 expression was found in depressed patients. (4) Conclusions: Our study revealed that BMI does not affect IL-17 expression in patients with depression. However, further studies should be conducted to evaluate the effects of IL-17 inhibition on adipose tissue and vice versa. depression obesity IL-17 neuro-immune inflammation Medicine R Bernadeta Szewczyk verfasserin aut Małgorzata Gałecka verfasserin aut Kuan-Pin Su verfasserin aut Michael Maes verfasserin aut Janusz Szemraj verfasserin aut Piotr Gałecki verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 9(2020), 12, p 4018 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:9 year:2020 number:12, p 4018 https://doi.org/10.3390/jcm9124018 kostenfrei https://doaj.org/article/5bbf3b7957bf49b19ef07bd7fb5333b0 kostenfrei https://www.mdpi.com/2077-0383/9/12/4018 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 12, p 4018 |
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10.3390/jcm9124018 doi (DE-627)DOAJ072271949 (DE-599)DOAJ5bbf3b7957bf49b19ef07bd7fb5333b0 DE-627 ger DE-627 rakwb eng Katarzyna Bliźniewska-Kowalska verfasserin aut Is Interleukin 17 (IL-17) Expression A Common Point in the Pathogenesis of Depression and Obesity? 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier (1) Background: Activated immune-inflammatory pathways play an important role in the pathogenesis of depression and pathological obesity. Obesity might promote production of cytokine interleukin 17, which plays a significant role in neuro-immune reactions. The study aimed at assessing the relationship between Body Mass Index (BMI) and IL-17 expression, taking into account the clinical psychiatric variables in patients with depression. (2) Methods: A total of 125 participants took part in the study (95 depressed patients, 30 healthy controls). Data concerning the course of depressive disorders and BMI were collected. The severity of depressive symptoms was assessed using the Hamilton Depression Rating Scale (HDRS). Reverse transcription polymerase chain reaction (RT-PCR) was used to assess IL-17 gene expression at the mRNA levels, while enzyme-linked immunosorbent assay (ELISA) was used to assess IL-17 expression at the protein level. (3) Results: Patients with more hospitalizations showed significantly higher IL-17 mRNA expression levels and higher BMI. However, no correlation between BMI and IL-17 expression was found in depressed patients. (4) Conclusions: Our study revealed that BMI does not affect IL-17 expression in patients with depression. However, further studies should be conducted to evaluate the effects of IL-17 inhibition on adipose tissue and vice versa. depression obesity IL-17 neuro-immune inflammation Medicine R Bernadeta Szewczyk verfasserin aut Małgorzata Gałecka verfasserin aut Kuan-Pin Su verfasserin aut Michael Maes verfasserin aut Janusz Szemraj verfasserin aut Piotr Gałecki verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 9(2020), 12, p 4018 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:9 year:2020 number:12, p 4018 https://doi.org/10.3390/jcm9124018 kostenfrei https://doaj.org/article/5bbf3b7957bf49b19ef07bd7fb5333b0 kostenfrei https://www.mdpi.com/2077-0383/9/12/4018 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 12, p 4018 |
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10.3390/jcm9124018 doi (DE-627)DOAJ072271949 (DE-599)DOAJ5bbf3b7957bf49b19ef07bd7fb5333b0 DE-627 ger DE-627 rakwb eng Katarzyna Bliźniewska-Kowalska verfasserin aut Is Interleukin 17 (IL-17) Expression A Common Point in the Pathogenesis of Depression and Obesity? 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier (1) Background: Activated immune-inflammatory pathways play an important role in the pathogenesis of depression and pathological obesity. Obesity might promote production of cytokine interleukin 17, which plays a significant role in neuro-immune reactions. The study aimed at assessing the relationship between Body Mass Index (BMI) and IL-17 expression, taking into account the clinical psychiatric variables in patients with depression. (2) Methods: A total of 125 participants took part in the study (95 depressed patients, 30 healthy controls). Data concerning the course of depressive disorders and BMI were collected. The severity of depressive symptoms was assessed using the Hamilton Depression Rating Scale (HDRS). Reverse transcription polymerase chain reaction (RT-PCR) was used to assess IL-17 gene expression at the mRNA levels, while enzyme-linked immunosorbent assay (ELISA) was used to assess IL-17 expression at the protein level. (3) Results: Patients with more hospitalizations showed significantly higher IL-17 mRNA expression levels and higher BMI. However, no correlation between BMI and IL-17 expression was found in depressed patients. (4) Conclusions: Our study revealed that BMI does not affect IL-17 expression in patients with depression. However, further studies should be conducted to evaluate the effects of IL-17 inhibition on adipose tissue and vice versa. depression obesity IL-17 neuro-immune inflammation Medicine R Bernadeta Szewczyk verfasserin aut Małgorzata Gałecka verfasserin aut Kuan-Pin Su verfasserin aut Michael Maes verfasserin aut Janusz Szemraj verfasserin aut Piotr Gałecki verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 9(2020), 12, p 4018 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:9 year:2020 number:12, p 4018 https://doi.org/10.3390/jcm9124018 kostenfrei https://doaj.org/article/5bbf3b7957bf49b19ef07bd7fb5333b0 kostenfrei https://www.mdpi.com/2077-0383/9/12/4018 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 12, p 4018 |
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Katarzyna Bliźniewska-Kowalska |
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is interleukin 17 (il-17) expression a common point in the pathogenesis of depression and obesity? |
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Is Interleukin 17 (IL-17) Expression A Common Point in the Pathogenesis of Depression and Obesity? |
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(1) Background: Activated immune-inflammatory pathways play an important role in the pathogenesis of depression and pathological obesity. Obesity might promote production of cytokine interleukin 17, which plays a significant role in neuro-immune reactions. The study aimed at assessing the relationship between Body Mass Index (BMI) and IL-17 expression, taking into account the clinical psychiatric variables in patients with depression. (2) Methods: A total of 125 participants took part in the study (95 depressed patients, 30 healthy controls). Data concerning the course of depressive disorders and BMI were collected. The severity of depressive symptoms was assessed using the Hamilton Depression Rating Scale (HDRS). Reverse transcription polymerase chain reaction (RT-PCR) was used to assess IL-17 gene expression at the mRNA levels, while enzyme-linked immunosorbent assay (ELISA) was used to assess IL-17 expression at the protein level. (3) Results: Patients with more hospitalizations showed significantly higher IL-17 mRNA expression levels and higher BMI. However, no correlation between BMI and IL-17 expression was found in depressed patients. (4) Conclusions: Our study revealed that BMI does not affect IL-17 expression in patients with depression. However, further studies should be conducted to evaluate the effects of IL-17 inhibition on adipose tissue and vice versa. |
abstractGer |
(1) Background: Activated immune-inflammatory pathways play an important role in the pathogenesis of depression and pathological obesity. Obesity might promote production of cytokine interleukin 17, which plays a significant role in neuro-immune reactions. The study aimed at assessing the relationship between Body Mass Index (BMI) and IL-17 expression, taking into account the clinical psychiatric variables in patients with depression. (2) Methods: A total of 125 participants took part in the study (95 depressed patients, 30 healthy controls). Data concerning the course of depressive disorders and BMI were collected. The severity of depressive symptoms was assessed using the Hamilton Depression Rating Scale (HDRS). Reverse transcription polymerase chain reaction (RT-PCR) was used to assess IL-17 gene expression at the mRNA levels, while enzyme-linked immunosorbent assay (ELISA) was used to assess IL-17 expression at the protein level. (3) Results: Patients with more hospitalizations showed significantly higher IL-17 mRNA expression levels and higher BMI. However, no correlation between BMI and IL-17 expression was found in depressed patients. (4) Conclusions: Our study revealed that BMI does not affect IL-17 expression in patients with depression. However, further studies should be conducted to evaluate the effects of IL-17 inhibition on adipose tissue and vice versa. |
abstract_unstemmed |
(1) Background: Activated immune-inflammatory pathways play an important role in the pathogenesis of depression and pathological obesity. Obesity might promote production of cytokine interleukin 17, which plays a significant role in neuro-immune reactions. The study aimed at assessing the relationship between Body Mass Index (BMI) and IL-17 expression, taking into account the clinical psychiatric variables in patients with depression. (2) Methods: A total of 125 participants took part in the study (95 depressed patients, 30 healthy controls). Data concerning the course of depressive disorders and BMI were collected. The severity of depressive symptoms was assessed using the Hamilton Depression Rating Scale (HDRS). Reverse transcription polymerase chain reaction (RT-PCR) was used to assess IL-17 gene expression at the mRNA levels, while enzyme-linked immunosorbent assay (ELISA) was used to assess IL-17 expression at the protein level. (3) Results: Patients with more hospitalizations showed significantly higher IL-17 mRNA expression levels and higher BMI. However, no correlation between BMI and IL-17 expression was found in depressed patients. (4) Conclusions: Our study revealed that BMI does not affect IL-17 expression in patients with depression. However, further studies should be conducted to evaluate the effects of IL-17 inhibition on adipose tissue and vice versa. |
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