A step beyond the hygiene hypothesis—immune-mediated classes determined in a population-based study
Abstract Background Comorbidity patterns of childhood infections, atopic diseases, and adverse childhood experiences (ACE) are related to immune system programming conditions. The aim of this study was to make a step beyond the hygiene hypothesis and to comprehensively classify these patterns with l...
Ausführliche Beschreibung
Autor*in: |
Vladeta Ajdacic-Gross [verfasserIn] Margot Mutsch [verfasserIn] Stephanie Rodgers [verfasserIn] Anja Tesic [verfasserIn] Mario Müller [verfasserIn] Erich Seifritz [verfasserIn] En-Young N. Wagner [verfasserIn] Roland von Känel [verfasserIn] Markus A. Landolt [verfasserIn] Nina Steinemann [verfasserIn] Viktor von Wyl [verfasserIn] Enrique Castelao [verfasserIn] Marie-Pierre F. Strippoli [verfasserIn] Jennifer Glaus [verfasserIn] Caroline Vandeleur [verfasserIn] Pedro M. Marques-Vidal [verfasserIn] Peter Vollenweider [verfasserIn] Martin Preisig [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
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2019 |
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In: BMC Medicine - BMC, 2003, 17(2019), 1, Seite 15 |
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Übergeordnetes Werk: |
volume:17 ; year:2019 ; number:1 ; pages:15 |
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DOI / URN: |
10.1186/s12916-019-1311-z |
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Katalog-ID: |
DOAJ072411007 |
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520 | |a Abstract Background Comorbidity patterns of childhood infections, atopic diseases, and adverse childhood experiences (ACE) are related to immune system programming conditions. The aim of this study was to make a step beyond the hygiene hypothesis and to comprehensively classify these patterns with latent class analysis (LCA). A second aim was to characterize the classes by associations with immunological, clinical, and sociodemographic variables. Methods LCA was applied to data from the CoLaus|PsyCoLaus study (N = 4874, age range 35–82 years) separately for men and women. It was based on survey information on chickenpox, measles, mumps, rubella, herpes simplex, pertussis, scarlet fever, hay fever, asthma, eczema, urticaria, drug allergy, interparental violence, parental maltreatment, and trauma in early childhood. Subsequently, we examined how immune-mediated classes were reflected in leukocyte counts, inflammatory markers (IL-1β, IL-6, TNF-α, hsCRP), chronic inflammatory diseases, and mental disorders, and how they differed across social classes and birth cohorts. Results LCA results with five classes were selected for further analysis. Latent classes were similar in both sexes and were labeled according to their associations as neutral, resilient, atopic, mixed (comprising infectious and atopic diseases), and ACE class. They came across with specific differences in biomarker levels. Mental disorders typically displayed increased lifetime prevalence rates in the atopic, the mixed, and the ACE classes, and decreased rates in the resilient class. The same patterns were apparent in chronic inflammatory diseases, except that the ACE class was relevant specifically in women but not in men. Conclusions This is the first study to systematically determine immune-mediated classes that evolve early in life. They display characteristic associations with biomarker levels and somatic and psychiatric diseases occurring later in life. Moreover, they show different distributions across social classes and allow to better understand the mechanisms beyond the changes in the prevalence of chronic somatic and psychiatric diseases. | ||
650 | 4 | |a Immune system | |
650 | 4 | |a Latent class analysis | |
650 | 4 | |a Hygiene hypothesis | |
650 | 4 | |a Chronic diseases | |
650 | 4 | |a Mental disorders | |
650 | 4 | |a Biomarkers | |
653 | 0 | |a Medicine | |
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700 | 0 | |a Margot Mutsch |e verfasserin |4 aut | |
700 | 0 | |a Stephanie Rodgers |e verfasserin |4 aut | |
700 | 0 | |a Anja Tesic |e verfasserin |4 aut | |
700 | 0 | |a Mario Müller |e verfasserin |4 aut | |
700 | 0 | |a Erich Seifritz |e verfasserin |4 aut | |
700 | 0 | |a En-Young N. Wagner |e verfasserin |4 aut | |
700 | 0 | |a Roland von Känel |e verfasserin |4 aut | |
700 | 0 | |a Markus A. Landolt |e verfasserin |4 aut | |
700 | 0 | |a Nina Steinemann |e verfasserin |4 aut | |
700 | 0 | |a Viktor von Wyl |e verfasserin |4 aut | |
700 | 0 | |a Enrique Castelao |e verfasserin |4 aut | |
700 | 0 | |a Marie-Pierre F. Strippoli |e verfasserin |4 aut | |
700 | 0 | |a Jennifer Glaus |e verfasserin |4 aut | |
700 | 0 | |a Caroline Vandeleur |e verfasserin |4 aut | |
700 | 0 | |a Pedro M. Marques-Vidal |e verfasserin |4 aut | |
700 | 0 | |a Peter Vollenweider |e verfasserin |4 aut | |
700 | 0 | |a Martin Preisig |e verfasserin |4 aut | |
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10.1186/s12916-019-1311-z doi (DE-627)DOAJ072411007 (DE-599)DOAJfe11bdc1aa7a4074bf58f1eb816eaa52 DE-627 ger DE-627 rakwb eng Vladeta Ajdacic-Gross verfasserin aut A step beyond the hygiene hypothesis—immune-mediated classes determined in a population-based study 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Comorbidity patterns of childhood infections, atopic diseases, and adverse childhood experiences (ACE) are related to immune system programming conditions. The aim of this study was to make a step beyond the hygiene hypothesis and to comprehensively classify these patterns with latent class analysis (LCA). A second aim was to characterize the classes by associations with immunological, clinical, and sociodemographic variables. Methods LCA was applied to data from the CoLaus|PsyCoLaus study (N = 4874, age range 35–82 years) separately for men and women. It was based on survey information on chickenpox, measles, mumps, rubella, herpes simplex, pertussis, scarlet fever, hay fever, asthma, eczema, urticaria, drug allergy, interparental violence, parental maltreatment, and trauma in early childhood. Subsequently, we examined how immune-mediated classes were reflected in leukocyte counts, inflammatory markers (IL-1β, IL-6, TNF-α, hsCRP), chronic inflammatory diseases, and mental disorders, and how they differed across social classes and birth cohorts. Results LCA results with five classes were selected for further analysis. Latent classes were similar in both sexes and were labeled according to their associations as neutral, resilient, atopic, mixed (comprising infectious and atopic diseases), and ACE class. They came across with specific differences in biomarker levels. Mental disorders typically displayed increased lifetime prevalence rates in the atopic, the mixed, and the ACE classes, and decreased rates in the resilient class. The same patterns were apparent in chronic inflammatory diseases, except that the ACE class was relevant specifically in women but not in men. Conclusions This is the first study to systematically determine immune-mediated classes that evolve early in life. They display characteristic associations with biomarker levels and somatic and psychiatric diseases occurring later in life. Moreover, they show different distributions across social classes and allow to better understand the mechanisms beyond the changes in the prevalence of chronic somatic and psychiatric diseases. Immune system Latent class analysis Hygiene hypothesis Chronic diseases Mental disorders Biomarkers Medicine R Margot Mutsch verfasserin aut Stephanie Rodgers verfasserin aut Anja Tesic verfasserin aut Mario Müller verfasserin aut Erich Seifritz verfasserin aut En-Young N. Wagner verfasserin aut Roland von Känel verfasserin aut Markus A. Landolt verfasserin aut Nina Steinemann verfasserin aut Viktor von Wyl verfasserin aut Enrique Castelao verfasserin aut Marie-Pierre F. Strippoli verfasserin aut Jennifer Glaus verfasserin aut Caroline Vandeleur verfasserin aut Pedro M. Marques-Vidal verfasserin aut Peter Vollenweider verfasserin aut Martin Preisig verfasserin aut In BMC Medicine BMC, 2003 17(2019), 1, Seite 15 (DE-627)377271225 (DE-600)2131669-7 17417015 nnns volume:17 year:2019 number:1 pages:15 https://doi.org/10.1186/s12916-019-1311-z kostenfrei https://doaj.org/article/fe11bdc1aa7a4074bf58f1eb816eaa52 kostenfrei http://link.springer.com/article/10.1186/s12916-019-1311-z kostenfrei https://doaj.org/toc/1741-7015 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2019 1 15 |
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10.1186/s12916-019-1311-z doi (DE-627)DOAJ072411007 (DE-599)DOAJfe11bdc1aa7a4074bf58f1eb816eaa52 DE-627 ger DE-627 rakwb eng Vladeta Ajdacic-Gross verfasserin aut A step beyond the hygiene hypothesis—immune-mediated classes determined in a population-based study 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Comorbidity patterns of childhood infections, atopic diseases, and adverse childhood experiences (ACE) are related to immune system programming conditions. The aim of this study was to make a step beyond the hygiene hypothesis and to comprehensively classify these patterns with latent class analysis (LCA). A second aim was to characterize the classes by associations with immunological, clinical, and sociodemographic variables. Methods LCA was applied to data from the CoLaus|PsyCoLaus study (N = 4874, age range 35–82 years) separately for men and women. It was based on survey information on chickenpox, measles, mumps, rubella, herpes simplex, pertussis, scarlet fever, hay fever, asthma, eczema, urticaria, drug allergy, interparental violence, parental maltreatment, and trauma in early childhood. Subsequently, we examined how immune-mediated classes were reflected in leukocyte counts, inflammatory markers (IL-1β, IL-6, TNF-α, hsCRP), chronic inflammatory diseases, and mental disorders, and how they differed across social classes and birth cohorts. Results LCA results with five classes were selected for further analysis. Latent classes were similar in both sexes and were labeled according to their associations as neutral, resilient, atopic, mixed (comprising infectious and atopic diseases), and ACE class. They came across with specific differences in biomarker levels. Mental disorders typically displayed increased lifetime prevalence rates in the atopic, the mixed, and the ACE classes, and decreased rates in the resilient class. The same patterns were apparent in chronic inflammatory diseases, except that the ACE class was relevant specifically in women but not in men. Conclusions This is the first study to systematically determine immune-mediated classes that evolve early in life. They display characteristic associations with biomarker levels and somatic and psychiatric diseases occurring later in life. Moreover, they show different distributions across social classes and allow to better understand the mechanisms beyond the changes in the prevalence of chronic somatic and psychiatric diseases. Immune system Latent class analysis Hygiene hypothesis Chronic diseases Mental disorders Biomarkers Medicine R Margot Mutsch verfasserin aut Stephanie Rodgers verfasserin aut Anja Tesic verfasserin aut Mario Müller verfasserin aut Erich Seifritz verfasserin aut En-Young N. Wagner verfasserin aut Roland von Känel verfasserin aut Markus A. Landolt verfasserin aut Nina Steinemann verfasserin aut Viktor von Wyl verfasserin aut Enrique Castelao verfasserin aut Marie-Pierre F. Strippoli verfasserin aut Jennifer Glaus verfasserin aut Caroline Vandeleur verfasserin aut Pedro M. Marques-Vidal verfasserin aut Peter Vollenweider verfasserin aut Martin Preisig verfasserin aut In BMC Medicine BMC, 2003 17(2019), 1, Seite 15 (DE-627)377271225 (DE-600)2131669-7 17417015 nnns volume:17 year:2019 number:1 pages:15 https://doi.org/10.1186/s12916-019-1311-z kostenfrei https://doaj.org/article/fe11bdc1aa7a4074bf58f1eb816eaa52 kostenfrei http://link.springer.com/article/10.1186/s12916-019-1311-z kostenfrei https://doaj.org/toc/1741-7015 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2019 1 15 |
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10.1186/s12916-019-1311-z doi (DE-627)DOAJ072411007 (DE-599)DOAJfe11bdc1aa7a4074bf58f1eb816eaa52 DE-627 ger DE-627 rakwb eng Vladeta Ajdacic-Gross verfasserin aut A step beyond the hygiene hypothesis—immune-mediated classes determined in a population-based study 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Comorbidity patterns of childhood infections, atopic diseases, and adverse childhood experiences (ACE) are related to immune system programming conditions. The aim of this study was to make a step beyond the hygiene hypothesis and to comprehensively classify these patterns with latent class analysis (LCA). A second aim was to characterize the classes by associations with immunological, clinical, and sociodemographic variables. Methods LCA was applied to data from the CoLaus|PsyCoLaus study (N = 4874, age range 35–82 years) separately for men and women. It was based on survey information on chickenpox, measles, mumps, rubella, herpes simplex, pertussis, scarlet fever, hay fever, asthma, eczema, urticaria, drug allergy, interparental violence, parental maltreatment, and trauma in early childhood. Subsequently, we examined how immune-mediated classes were reflected in leukocyte counts, inflammatory markers (IL-1β, IL-6, TNF-α, hsCRP), chronic inflammatory diseases, and mental disorders, and how they differed across social classes and birth cohorts. Results LCA results with five classes were selected for further analysis. Latent classes were similar in both sexes and were labeled according to their associations as neutral, resilient, atopic, mixed (comprising infectious and atopic diseases), and ACE class. They came across with specific differences in biomarker levels. Mental disorders typically displayed increased lifetime prevalence rates in the atopic, the mixed, and the ACE classes, and decreased rates in the resilient class. The same patterns were apparent in chronic inflammatory diseases, except that the ACE class was relevant specifically in women but not in men. Conclusions This is the first study to systematically determine immune-mediated classes that evolve early in life. They display characteristic associations with biomarker levels and somatic and psychiatric diseases occurring later in life. Moreover, they show different distributions across social classes and allow to better understand the mechanisms beyond the changes in the prevalence of chronic somatic and psychiatric diseases. Immune system Latent class analysis Hygiene hypothesis Chronic diseases Mental disorders Biomarkers Medicine R Margot Mutsch verfasserin aut Stephanie Rodgers verfasserin aut Anja Tesic verfasserin aut Mario Müller verfasserin aut Erich Seifritz verfasserin aut En-Young N. Wagner verfasserin aut Roland von Känel verfasserin aut Markus A. Landolt verfasserin aut Nina Steinemann verfasserin aut Viktor von Wyl verfasserin aut Enrique Castelao verfasserin aut Marie-Pierre F. Strippoli verfasserin aut Jennifer Glaus verfasserin aut Caroline Vandeleur verfasserin aut Pedro M. Marques-Vidal verfasserin aut Peter Vollenweider verfasserin aut Martin Preisig verfasserin aut In BMC Medicine BMC, 2003 17(2019), 1, Seite 15 (DE-627)377271225 (DE-600)2131669-7 17417015 nnns volume:17 year:2019 number:1 pages:15 https://doi.org/10.1186/s12916-019-1311-z kostenfrei https://doaj.org/article/fe11bdc1aa7a4074bf58f1eb816eaa52 kostenfrei http://link.springer.com/article/10.1186/s12916-019-1311-z kostenfrei https://doaj.org/toc/1741-7015 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2019 1 15 |
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10.1186/s12916-019-1311-z doi (DE-627)DOAJ072411007 (DE-599)DOAJfe11bdc1aa7a4074bf58f1eb816eaa52 DE-627 ger DE-627 rakwb eng Vladeta Ajdacic-Gross verfasserin aut A step beyond the hygiene hypothesis—immune-mediated classes determined in a population-based study 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Comorbidity patterns of childhood infections, atopic diseases, and adverse childhood experiences (ACE) are related to immune system programming conditions. The aim of this study was to make a step beyond the hygiene hypothesis and to comprehensively classify these patterns with latent class analysis (LCA). A second aim was to characterize the classes by associations with immunological, clinical, and sociodemographic variables. Methods LCA was applied to data from the CoLaus|PsyCoLaus study (N = 4874, age range 35–82 years) separately for men and women. It was based on survey information on chickenpox, measles, mumps, rubella, herpes simplex, pertussis, scarlet fever, hay fever, asthma, eczema, urticaria, drug allergy, interparental violence, parental maltreatment, and trauma in early childhood. Subsequently, we examined how immune-mediated classes were reflected in leukocyte counts, inflammatory markers (IL-1β, IL-6, TNF-α, hsCRP), chronic inflammatory diseases, and mental disorders, and how they differed across social classes and birth cohorts. Results LCA results with five classes were selected for further analysis. Latent classes were similar in both sexes and were labeled according to their associations as neutral, resilient, atopic, mixed (comprising infectious and atopic diseases), and ACE class. They came across with specific differences in biomarker levels. Mental disorders typically displayed increased lifetime prevalence rates in the atopic, the mixed, and the ACE classes, and decreased rates in the resilient class. The same patterns were apparent in chronic inflammatory diseases, except that the ACE class was relevant specifically in women but not in men. Conclusions This is the first study to systematically determine immune-mediated classes that evolve early in life. They display characteristic associations with biomarker levels and somatic and psychiatric diseases occurring later in life. Moreover, they show different distributions across social classes and allow to better understand the mechanisms beyond the changes in the prevalence of chronic somatic and psychiatric diseases. Immune system Latent class analysis Hygiene hypothesis Chronic diseases Mental disorders Biomarkers Medicine R Margot Mutsch verfasserin aut Stephanie Rodgers verfasserin aut Anja Tesic verfasserin aut Mario Müller verfasserin aut Erich Seifritz verfasserin aut En-Young N. Wagner verfasserin aut Roland von Känel verfasserin aut Markus A. Landolt verfasserin aut Nina Steinemann verfasserin aut Viktor von Wyl verfasserin aut Enrique Castelao verfasserin aut Marie-Pierre F. Strippoli verfasserin aut Jennifer Glaus verfasserin aut Caroline Vandeleur verfasserin aut Pedro M. Marques-Vidal verfasserin aut Peter Vollenweider verfasserin aut Martin Preisig verfasserin aut In BMC Medicine BMC, 2003 17(2019), 1, Seite 15 (DE-627)377271225 (DE-600)2131669-7 17417015 nnns volume:17 year:2019 number:1 pages:15 https://doi.org/10.1186/s12916-019-1311-z kostenfrei https://doaj.org/article/fe11bdc1aa7a4074bf58f1eb816eaa52 kostenfrei http://link.springer.com/article/10.1186/s12916-019-1311-z kostenfrei https://doaj.org/toc/1741-7015 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2019 1 15 |
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10.1186/s12916-019-1311-z doi (DE-627)DOAJ072411007 (DE-599)DOAJfe11bdc1aa7a4074bf58f1eb816eaa52 DE-627 ger DE-627 rakwb eng Vladeta Ajdacic-Gross verfasserin aut A step beyond the hygiene hypothesis—immune-mediated classes determined in a population-based study 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Comorbidity patterns of childhood infections, atopic diseases, and adverse childhood experiences (ACE) are related to immune system programming conditions. The aim of this study was to make a step beyond the hygiene hypothesis and to comprehensively classify these patterns with latent class analysis (LCA). A second aim was to characterize the classes by associations with immunological, clinical, and sociodemographic variables. Methods LCA was applied to data from the CoLaus|PsyCoLaus study (N = 4874, age range 35–82 years) separately for men and women. It was based on survey information on chickenpox, measles, mumps, rubella, herpes simplex, pertussis, scarlet fever, hay fever, asthma, eczema, urticaria, drug allergy, interparental violence, parental maltreatment, and trauma in early childhood. Subsequently, we examined how immune-mediated classes were reflected in leukocyte counts, inflammatory markers (IL-1β, IL-6, TNF-α, hsCRP), chronic inflammatory diseases, and mental disorders, and how they differed across social classes and birth cohorts. Results LCA results with five classes were selected for further analysis. Latent classes were similar in both sexes and were labeled according to their associations as neutral, resilient, atopic, mixed (comprising infectious and atopic diseases), and ACE class. They came across with specific differences in biomarker levels. Mental disorders typically displayed increased lifetime prevalence rates in the atopic, the mixed, and the ACE classes, and decreased rates in the resilient class. The same patterns were apparent in chronic inflammatory diseases, except that the ACE class was relevant specifically in women but not in men. Conclusions This is the first study to systematically determine immune-mediated classes that evolve early in life. They display characteristic associations with biomarker levels and somatic and psychiatric diseases occurring later in life. Moreover, they show different distributions across social classes and allow to better understand the mechanisms beyond the changes in the prevalence of chronic somatic and psychiatric diseases. Immune system Latent class analysis Hygiene hypothesis Chronic diseases Mental disorders Biomarkers Medicine R Margot Mutsch verfasserin aut Stephanie Rodgers verfasserin aut Anja Tesic verfasserin aut Mario Müller verfasserin aut Erich Seifritz verfasserin aut En-Young N. Wagner verfasserin aut Roland von Känel verfasserin aut Markus A. Landolt verfasserin aut Nina Steinemann verfasserin aut Viktor von Wyl verfasserin aut Enrique Castelao verfasserin aut Marie-Pierre F. Strippoli verfasserin aut Jennifer Glaus verfasserin aut Caroline Vandeleur verfasserin aut Pedro M. Marques-Vidal verfasserin aut Peter Vollenweider verfasserin aut Martin Preisig verfasserin aut In BMC Medicine BMC, 2003 17(2019), 1, Seite 15 (DE-627)377271225 (DE-600)2131669-7 17417015 nnns volume:17 year:2019 number:1 pages:15 https://doi.org/10.1186/s12916-019-1311-z kostenfrei https://doaj.org/article/fe11bdc1aa7a4074bf58f1eb816eaa52 kostenfrei http://link.springer.com/article/10.1186/s12916-019-1311-z kostenfrei https://doaj.org/toc/1741-7015 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2019 1 15 |
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Vladeta Ajdacic-Gross @@aut@@ Margot Mutsch @@aut@@ Stephanie Rodgers @@aut@@ Anja Tesic @@aut@@ Mario Müller @@aut@@ Erich Seifritz @@aut@@ En-Young N. Wagner @@aut@@ Roland von Känel @@aut@@ Markus A. Landolt @@aut@@ Nina Steinemann @@aut@@ Viktor von Wyl @@aut@@ Enrique Castelao @@aut@@ Marie-Pierre F. Strippoli @@aut@@ Jennifer Glaus @@aut@@ Caroline Vandeleur @@aut@@ Pedro M. Marques-Vidal @@aut@@ Peter Vollenweider @@aut@@ Martin Preisig @@aut@@ |
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Vladeta Ajdacic-Gross Margot Mutsch Stephanie Rodgers Anja Tesic Mario Müller Erich Seifritz En-Young N. Wagner Roland von Känel Markus A. Landolt Nina Steinemann Viktor von Wyl Enrique Castelao Marie-Pierre F. Strippoli Jennifer Glaus Caroline Vandeleur Pedro M. Marques-Vidal Peter Vollenweider Martin Preisig |
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step beyond the hygiene hypothesis—immune-mediated classes determined in a population-based study |
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A step beyond the hygiene hypothesis—immune-mediated classes determined in a population-based study |
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Abstract Background Comorbidity patterns of childhood infections, atopic diseases, and adverse childhood experiences (ACE) are related to immune system programming conditions. The aim of this study was to make a step beyond the hygiene hypothesis and to comprehensively classify these patterns with latent class analysis (LCA). A second aim was to characterize the classes by associations with immunological, clinical, and sociodemographic variables. Methods LCA was applied to data from the CoLaus|PsyCoLaus study (N = 4874, age range 35–82 years) separately for men and women. It was based on survey information on chickenpox, measles, mumps, rubella, herpes simplex, pertussis, scarlet fever, hay fever, asthma, eczema, urticaria, drug allergy, interparental violence, parental maltreatment, and trauma in early childhood. Subsequently, we examined how immune-mediated classes were reflected in leukocyte counts, inflammatory markers (IL-1β, IL-6, TNF-α, hsCRP), chronic inflammatory diseases, and mental disorders, and how they differed across social classes and birth cohorts. Results LCA results with five classes were selected for further analysis. Latent classes were similar in both sexes and were labeled according to their associations as neutral, resilient, atopic, mixed (comprising infectious and atopic diseases), and ACE class. They came across with specific differences in biomarker levels. Mental disorders typically displayed increased lifetime prevalence rates in the atopic, the mixed, and the ACE classes, and decreased rates in the resilient class. The same patterns were apparent in chronic inflammatory diseases, except that the ACE class was relevant specifically in women but not in men. Conclusions This is the first study to systematically determine immune-mediated classes that evolve early in life. They display characteristic associations with biomarker levels and somatic and psychiatric diseases occurring later in life. Moreover, they show different distributions across social classes and allow to better understand the mechanisms beyond the changes in the prevalence of chronic somatic and psychiatric diseases. |
abstractGer |
Abstract Background Comorbidity patterns of childhood infections, atopic diseases, and adverse childhood experiences (ACE) are related to immune system programming conditions. The aim of this study was to make a step beyond the hygiene hypothesis and to comprehensively classify these patterns with latent class analysis (LCA). A second aim was to characterize the classes by associations with immunological, clinical, and sociodemographic variables. Methods LCA was applied to data from the CoLaus|PsyCoLaus study (N = 4874, age range 35–82 years) separately for men and women. It was based on survey information on chickenpox, measles, mumps, rubella, herpes simplex, pertussis, scarlet fever, hay fever, asthma, eczema, urticaria, drug allergy, interparental violence, parental maltreatment, and trauma in early childhood. Subsequently, we examined how immune-mediated classes were reflected in leukocyte counts, inflammatory markers (IL-1β, IL-6, TNF-α, hsCRP), chronic inflammatory diseases, and mental disorders, and how they differed across social classes and birth cohorts. Results LCA results with five classes were selected for further analysis. Latent classes were similar in both sexes and were labeled according to their associations as neutral, resilient, atopic, mixed (comprising infectious and atopic diseases), and ACE class. They came across with specific differences in biomarker levels. Mental disorders typically displayed increased lifetime prevalence rates in the atopic, the mixed, and the ACE classes, and decreased rates in the resilient class. The same patterns were apparent in chronic inflammatory diseases, except that the ACE class was relevant specifically in women but not in men. Conclusions This is the first study to systematically determine immune-mediated classes that evolve early in life. They display characteristic associations with biomarker levels and somatic and psychiatric diseases occurring later in life. Moreover, they show different distributions across social classes and allow to better understand the mechanisms beyond the changes in the prevalence of chronic somatic and psychiatric diseases. |
abstract_unstemmed |
Abstract Background Comorbidity patterns of childhood infections, atopic diseases, and adverse childhood experiences (ACE) are related to immune system programming conditions. The aim of this study was to make a step beyond the hygiene hypothesis and to comprehensively classify these patterns with latent class analysis (LCA). A second aim was to characterize the classes by associations with immunological, clinical, and sociodemographic variables. Methods LCA was applied to data from the CoLaus|PsyCoLaus study (N = 4874, age range 35–82 years) separately for men and women. It was based on survey information on chickenpox, measles, mumps, rubella, herpes simplex, pertussis, scarlet fever, hay fever, asthma, eczema, urticaria, drug allergy, interparental violence, parental maltreatment, and trauma in early childhood. Subsequently, we examined how immune-mediated classes were reflected in leukocyte counts, inflammatory markers (IL-1β, IL-6, TNF-α, hsCRP), chronic inflammatory diseases, and mental disorders, and how they differed across social classes and birth cohorts. Results LCA results with five classes were selected for further analysis. Latent classes were similar in both sexes and were labeled according to their associations as neutral, resilient, atopic, mixed (comprising infectious and atopic diseases), and ACE class. They came across with specific differences in biomarker levels. Mental disorders typically displayed increased lifetime prevalence rates in the atopic, the mixed, and the ACE classes, and decreased rates in the resilient class. The same patterns were apparent in chronic inflammatory diseases, except that the ACE class was relevant specifically in women but not in men. Conclusions This is the first study to systematically determine immune-mediated classes that evolve early in life. They display characteristic associations with biomarker levels and somatic and psychiatric diseases occurring later in life. Moreover, they show different distributions across social classes and allow to better understand the mechanisms beyond the changes in the prevalence of chronic somatic and psychiatric diseases. |
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A step beyond the hygiene hypothesis—immune-mediated classes determined in a population-based study |
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