LONG-NONCODING RNAs in gastroesophageal cancers

Despite continuing improvements in multimodal therapies, gastro-esophageal malignances remain widely prevalent in the population and is characterized by poor overall and disease-free survival rates. Due to the lack of understanding about the pathogenesis and absence of reliable markers, gastro-esoph...
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Gespeichert in:

Autor*in:	Giuseppe Nicolò Fanelli [verfasserIn] Pierluigi Gasparini [verfasserIn] Irene Coati [verfasserIn] Ri Cui [verfasserIn] Hubert Pakula [verfasserIn] Basudev Chowdhury [verfasserIn] Nicola Valeri [verfasserIn] Fotios Loupakis [verfasserIn] Juozas Kupcinskas [verfasserIn] Rocco Cappellesso [verfasserIn] Matteo Fassan [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Übergeordnetes Werk:	In: Non-coding RNA Research - KeAi Communications Co., Ltd., 2017, 3(2018), 4, Seite 195-212
Übergeordnetes Werk:	volume:3 ; year:2018 ; number:4 ; pages:195-212

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.ncrna.2018.10.001

Katalog-ID:	DOAJ072572000

Internformat


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spelling	10.1016/j.ncrna.2018.10.001 doi (DE-627)DOAJ072572000 (DE-599)DOAJ62d7cf31705549c99a0fcc1d5cfc0afe DE-627 ger DE-627 rakwb eng QH426-470 Giuseppe Nicolò Fanelli verfasserin aut LONG-NONCODING RNAs in gastroesophageal cancers 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Despite continuing improvements in multimodal therapies, gastro-esophageal malignances remain widely prevalent in the population and is characterized by poor overall and disease-free survival rates. Due to the lack of understanding about the pathogenesis and absence of reliable markers, gastro-esophageal cancers are associated with delayed diagnosis. The increasing understanding about cancer's molecular landscape in the recent years, offers the possibility of identifying ‘targetable’ molecular events and in particular facilitates novel treatment strategies and development of biomarkers for early stage diagnosis. At least 98% of our genome is actively transcribed into non-coding RNAs encompassing long non-coding RNAs (lncRNAs) constituted of transcripts longer than 200 nucleotides with no protein-coding capacity. Many studies have demonstrated that lncRNAs are functional genomic elements playing pivotal roles in main oncogenic processes. LncRNA can act at multiple levels developing a complex molecular network that can modulate directly or indirectly the expression of genes involved in tumorigenesis. In this review, we focus on lncRNAs as emerging players in gastro-esophageal carcinogenesis and critically assess their potential as reliable noninvasive biomarkers and in next generation targeted therapies. Keywords: Gastric cancer, Esophageal cancer, Long noncoding RNAs, Biomarkers Genetics Pierluigi Gasparini verfasserin aut Irene Coati verfasserin aut Ri Cui verfasserin aut Hubert Pakula verfasserin aut Basudev Chowdhury verfasserin aut Nicola Valeri verfasserin aut Fotios Loupakis verfasserin aut Juozas Kupcinskas verfasserin aut Rocco Cappellesso verfasserin aut Matteo Fassan verfasserin aut In Non-coding RNA Research KeAi Communications Co., Ltd., 2017 3(2018), 4, Seite 195-212 (DE-627)880045264 (DE-600)2884193-1 24680540 nnns volume:3 year:2018 number:4 pages:195-212 https://doi.org/10.1016/j.ncrna.2018.10.001 kostenfrei https://doaj.org/article/62d7cf31705549c99a0fcc1d5cfc0afe kostenfrei http://www.sciencedirect.com/science/article/pii/S2468054018300866 kostenfrei https://doaj.org/toc/2468-0540 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2018 4 195-212
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allfieldsSound	10.1016/j.ncrna.2018.10.001 doi (DE-627)DOAJ072572000 (DE-599)DOAJ62d7cf31705549c99a0fcc1d5cfc0afe DE-627 ger DE-627 rakwb eng QH426-470 Giuseppe Nicolò Fanelli verfasserin aut LONG-NONCODING RNAs in gastroesophageal cancers 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Despite continuing improvements in multimodal therapies, gastro-esophageal malignances remain widely prevalent in the population and is characterized by poor overall and disease-free survival rates. Due to the lack of understanding about the pathogenesis and absence of reliable markers, gastro-esophageal cancers are associated with delayed diagnosis. The increasing understanding about cancer's molecular landscape in the recent years, offers the possibility of identifying ‘targetable’ molecular events and in particular facilitates novel treatment strategies and development of biomarkers for early stage diagnosis. At least 98% of our genome is actively transcribed into non-coding RNAs encompassing long non-coding RNAs (lncRNAs) constituted of transcripts longer than 200 nucleotides with no protein-coding capacity. Many studies have demonstrated that lncRNAs are functional genomic elements playing pivotal roles in main oncogenic processes. LncRNA can act at multiple levels developing a complex molecular network that can modulate directly or indirectly the expression of genes involved in tumorigenesis. In this review, we focus on lncRNAs as emerging players in gastro-esophageal carcinogenesis and critically assess their potential as reliable noninvasive biomarkers and in next generation targeted therapies. Keywords: Gastric cancer, Esophageal cancer, Long noncoding RNAs, Biomarkers Genetics Pierluigi Gasparini verfasserin aut Irene Coati verfasserin aut Ri Cui verfasserin aut Hubert Pakula verfasserin aut Basudev Chowdhury verfasserin aut Nicola Valeri verfasserin aut Fotios Loupakis verfasserin aut Juozas Kupcinskas verfasserin aut Rocco Cappellesso verfasserin aut Matteo Fassan verfasserin aut In Non-coding RNA Research KeAi Communications Co., Ltd., 2017 3(2018), 4, Seite 195-212 (DE-627)880045264 (DE-600)2884193-1 24680540 nnns volume:3 year:2018 number:4 pages:195-212 https://doi.org/10.1016/j.ncrna.2018.10.001 kostenfrei https://doaj.org/article/62d7cf31705549c99a0fcc1d5cfc0afe kostenfrei http://www.sciencedirect.com/science/article/pii/S2468054018300866 kostenfrei https://doaj.org/toc/2468-0540 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2018 4 195-212
language	English
source	In Non-coding RNA Research 3(2018), 4, Seite 195-212 volume:3 year:2018 number:4 pages:195-212
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authorswithroles_txt_mv	Giuseppe Nicolò Fanelli @@aut@@ Pierluigi Gasparini @@aut@@ Irene Coati @@aut@@ Ri Cui @@aut@@ Hubert Pakula @@aut@@ Basudev Chowdhury @@aut@@ Nicola Valeri @@aut@@ Fotios Loupakis @@aut@@ Juozas Kupcinskas @@aut@@ Rocco Cappellesso @@aut@@ Matteo Fassan @@aut@@
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author	Giuseppe Nicolò Fanelli
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topic_title	QH426-470 LONG-NONCODING RNAs in gastroesophageal cancers
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title	LONG-NONCODING RNAs in gastroesophageal cancers
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title_full	LONG-NONCODING RNAs in gastroesophageal cancers
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author_browse	Giuseppe Nicolò Fanelli Pierluigi Gasparini Irene Coati Ri Cui Hubert Pakula Basudev Chowdhury Nicola Valeri Fotios Loupakis Juozas Kupcinskas Rocco Cappellesso Matteo Fassan
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title_sort	long-noncoding rnas in gastroesophageal cancers
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title_auth	LONG-NONCODING RNAs in gastroesophageal cancers
abstract	Despite continuing improvements in multimodal therapies, gastro-esophageal malignances remain widely prevalent in the population and is characterized by poor overall and disease-free survival rates. Due to the lack of understanding about the pathogenesis and absence of reliable markers, gastro-esophageal cancers are associated with delayed diagnosis. The increasing understanding about cancer's molecular landscape in the recent years, offers the possibility of identifying ‘targetable’ molecular events and in particular facilitates novel treatment strategies and development of biomarkers for early stage diagnosis. At least 98% of our genome is actively transcribed into non-coding RNAs encompassing long non-coding RNAs (lncRNAs) constituted of transcripts longer than 200 nucleotides with no protein-coding capacity. Many studies have demonstrated that lncRNAs are functional genomic elements playing pivotal roles in main oncogenic processes. LncRNA can act at multiple levels developing a complex molecular network that can modulate directly or indirectly the expression of genes involved in tumorigenesis. In this review, we focus on lncRNAs as emerging players in gastro-esophageal carcinogenesis and critically assess their potential as reliable noninvasive biomarkers and in next generation targeted therapies. Keywords: Gastric cancer, Esophageal cancer, Long noncoding RNAs, Biomarkers
abstractGer	Despite continuing improvements in multimodal therapies, gastro-esophageal malignances remain widely prevalent in the population and is characterized by poor overall and disease-free survival rates. Due to the lack of understanding about the pathogenesis and absence of reliable markers, gastro-esophageal cancers are associated with delayed diagnosis. The increasing understanding about cancer's molecular landscape in the recent years, offers the possibility of identifying ‘targetable’ molecular events and in particular facilitates novel treatment strategies and development of biomarkers for early stage diagnosis. At least 98% of our genome is actively transcribed into non-coding RNAs encompassing long non-coding RNAs (lncRNAs) constituted of transcripts longer than 200 nucleotides with no protein-coding capacity. Many studies have demonstrated that lncRNAs are functional genomic elements playing pivotal roles in main oncogenic processes. LncRNA can act at multiple levels developing a complex molecular network that can modulate directly or indirectly the expression of genes involved in tumorigenesis. In this review, we focus on lncRNAs as emerging players in gastro-esophageal carcinogenesis and critically assess their potential as reliable noninvasive biomarkers and in next generation targeted therapies. Keywords: Gastric cancer, Esophageal cancer, Long noncoding RNAs, Biomarkers
abstract_unstemmed	Despite continuing improvements in multimodal therapies, gastro-esophageal malignances remain widely prevalent in the population and is characterized by poor overall and disease-free survival rates. Due to the lack of understanding about the pathogenesis and absence of reliable markers, gastro-esophageal cancers are associated with delayed diagnosis. The increasing understanding about cancer's molecular landscape in the recent years, offers the possibility of identifying ‘targetable’ molecular events and in particular facilitates novel treatment strategies and development of biomarkers for early stage diagnosis. At least 98% of our genome is actively transcribed into non-coding RNAs encompassing long non-coding RNAs (lncRNAs) constituted of transcripts longer than 200 nucleotides with no protein-coding capacity. Many studies have demonstrated that lncRNAs are functional genomic elements playing pivotal roles in main oncogenic processes. LncRNA can act at multiple levels developing a complex molecular network that can modulate directly or indirectly the expression of genes involved in tumorigenesis. In this review, we focus on lncRNAs as emerging players in gastro-esophageal carcinogenesis and critically assess their potential as reliable noninvasive biomarkers and in next generation targeted therapies. Keywords: Gastric cancer, Esophageal cancer, Long noncoding RNAs, Biomarkers
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title_short	LONG-NONCODING RNAs in gastroesophageal cancers
url	https://doi.org/10.1016/j.ncrna.2018.10.001 https://doaj.org/article/62d7cf31705549c99a0fcc1d5cfc0afe http://www.sciencedirect.com/science/article/pii/S2468054018300866 https://doaj.org/toc/2468-0540
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up_date	2024-07-04T01:35:06.615Z
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