The 1800 MHz Radiofrequency Electromagnetic Fields Can Lead to a Reduction in the Number of CD4+T Cells, IL-2, IL-10, and IL-17a on PBMC Cultures

Although there have been many studies on the effects of electromagnetic fields on humans, scientists still have no agreement on the effects found because several studies showed no statistically significant effects. The effects of radiofrequency electromagnetic fields exposure on the immune system ar...
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Autor*in:	Maimun Z Arthamin [verfasserIn] Anis Sulalah [verfasserIn] Resvina Resvina [verfasserIn] Chomsin Widodo [verfasserIn] Agustina T Endharti [verfasserIn] Edi Widjajanto [verfasserIn] Tedy Juliandhy [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	1800 MHz radiofrequency electromagnetic fields (RF-EMF) Cluster of differentiation 4 (CD4) T cells Interleukin-2 (IL-2) Interleukin-10 (IL-10) Interleukin-17a (IL-17a)

Übergeordnetes Werk:	In: Acta Medica Iranica - Tehran University of Medical Sciences, 2005, 58(2020), 9
Übergeordnetes Werk:	volume:58 ; year:2020 ; number:9

Links:	Link aufrufen Link aufrufen Journal toc Journal toc

Katalog-ID:	DOAJ072696370

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allfields	(DE-627)DOAJ072696370 (DE-599)DOAJ9ce90d2bde7a45ebbccf20e74b81f85b DE-627 ger DE-627 rakwb eng R5-920 Maimun Z Arthamin verfasserin aut The 1800 MHz Radiofrequency Electromagnetic Fields Can Lead to a Reduction in the Number of CD4+T Cells, IL-2, IL-10, and IL-17a on PBMC Cultures 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Although there have been many studies on the effects of electromagnetic fields on humans, scientists still have no agreement on the effects found because several studies showed no statistically significant effects. The effects of radiofrequency electromagnetic fields exposure on the immune system are varied, ranging from no effects to genotoxic effects on lymphocytes. Our study aimed to investigate whether exposure to 1800 MHz radiofrequency electromagnetic fields (RF-EMF) in variable durations and distances could lead to the dysregulation of T helper 1, 2, and 17. The peripheral blood mononuclear cells (PBMCs) cultures from healthy human subjects were exposed to 1800 MHz RF-EMF, with durations of 15, 30, 45, and 60 minutes and distances of 5 and 25 cm. We evaluated the effects of RF-EMF exposure on the number of CD4+ T cells, IL-2, IL-10, and IL-17a after 48 hours of culture with the flow cytometer. The closer the distance, the lower the number of CD4+ T cells. The longer the exposure, the lower the number of CD4+ T cells and the number of IL-2, IL-10, and IL-17a decreases significantly. CD4+ T cells expressing IL-2 increased significantly with the increase of the duration of 1800 MHz RF-EMF exposure (15, 30, and 45 min), but decreased at 60 minutes of exposure when compared to PBMCs without exposure. Sixty minutes of PBMC exposure to RF-EMF with a distance of 5 cm causes a significant reduction in the number of CD4+ T cells, the expression of IL-2, IL-10, and IL-17a. 1800 MHz radiofrequency electromagnetic fields (RF-EMF) Cluster of differentiation 4 (CD4) T cells Interleukin-2 (IL-2) Interleukin-10 (IL-10) Interleukin-17a (IL-17a) Medicine (General) Anis Sulalah verfasserin aut Resvina Resvina verfasserin aut Chomsin Widodo verfasserin aut Agustina T Endharti verfasserin aut Edi Widjajanto verfasserin aut Tedy Juliandhy verfasserin aut In Acta Medica Iranica Tehran University of Medical Sciences, 2005 58(2020), 9 (DE-627)492276110 (DE-600)2194585-8 17359694 nnns volume:58 year:2020 number:9 https://doaj.org/article/9ce90d2bde7a45ebbccf20e74b81f85b kostenfrei https://acta.tums.ac.ir/index.php/acta/article/view/8261 kostenfrei https://doaj.org/toc/0044-6025 Journal toc kostenfrei https://doaj.org/toc/1735-9694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 58 2020 9
spelling	(DE-627)DOAJ072696370 (DE-599)DOAJ9ce90d2bde7a45ebbccf20e74b81f85b DE-627 ger DE-627 rakwb eng R5-920 Maimun Z Arthamin verfasserin aut The 1800 MHz Radiofrequency Electromagnetic Fields Can Lead to a Reduction in the Number of CD4+T Cells, IL-2, IL-10, and IL-17a on PBMC Cultures 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Although there have been many studies on the effects of electromagnetic fields on humans, scientists still have no agreement on the effects found because several studies showed no statistically significant effects. The effects of radiofrequency electromagnetic fields exposure on the immune system are varied, ranging from no effects to genotoxic effects on lymphocytes. Our study aimed to investigate whether exposure to 1800 MHz radiofrequency electromagnetic fields (RF-EMF) in variable durations and distances could lead to the dysregulation of T helper 1, 2, and 17. The peripheral blood mononuclear cells (PBMCs) cultures from healthy human subjects were exposed to 1800 MHz RF-EMF, with durations of 15, 30, 45, and 60 minutes and distances of 5 and 25 cm. We evaluated the effects of RF-EMF exposure on the number of CD4+ T cells, IL-2, IL-10, and IL-17a after 48 hours of culture with the flow cytometer. The closer the distance, the lower the number of CD4+ T cells. The longer the exposure, the lower the number of CD4+ T cells and the number of IL-2, IL-10, and IL-17a decreases significantly. CD4+ T cells expressing IL-2 increased significantly with the increase of the duration of 1800 MHz RF-EMF exposure (15, 30, and 45 min), but decreased at 60 minutes of exposure when compared to PBMCs without exposure. Sixty minutes of PBMC exposure to RF-EMF with a distance of 5 cm causes a significant reduction in the number of CD4+ T cells, the expression of IL-2, IL-10, and IL-17a. 1800 MHz radiofrequency electromagnetic fields (RF-EMF) Cluster of differentiation 4 (CD4) T cells Interleukin-2 (IL-2) Interleukin-10 (IL-10) Interleukin-17a (IL-17a) Medicine (General) Anis Sulalah verfasserin aut Resvina Resvina verfasserin aut Chomsin Widodo verfasserin aut Agustina T Endharti verfasserin aut Edi Widjajanto verfasserin aut Tedy Juliandhy verfasserin aut In Acta Medica Iranica Tehran University of Medical Sciences, 2005 58(2020), 9 (DE-627)492276110 (DE-600)2194585-8 17359694 nnns volume:58 year:2020 number:9 https://doaj.org/article/9ce90d2bde7a45ebbccf20e74b81f85b kostenfrei https://acta.tums.ac.ir/index.php/acta/article/view/8261 kostenfrei https://doaj.org/toc/0044-6025 Journal toc kostenfrei https://doaj.org/toc/1735-9694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 58 2020 9
allfields_unstemmed	(DE-627)DOAJ072696370 (DE-599)DOAJ9ce90d2bde7a45ebbccf20e74b81f85b DE-627 ger DE-627 rakwb eng R5-920 Maimun Z Arthamin verfasserin aut The 1800 MHz Radiofrequency Electromagnetic Fields Can Lead to a Reduction in the Number of CD4+T Cells, IL-2, IL-10, and IL-17a on PBMC Cultures 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Although there have been many studies on the effects of electromagnetic fields on humans, scientists still have no agreement on the effects found because several studies showed no statistically significant effects. The effects of radiofrequency electromagnetic fields exposure on the immune system are varied, ranging from no effects to genotoxic effects on lymphocytes. Our study aimed to investigate whether exposure to 1800 MHz radiofrequency electromagnetic fields (RF-EMF) in variable durations and distances could lead to the dysregulation of T helper 1, 2, and 17. The peripheral blood mononuclear cells (PBMCs) cultures from healthy human subjects were exposed to 1800 MHz RF-EMF, with durations of 15, 30, 45, and 60 minutes and distances of 5 and 25 cm. We evaluated the effects of RF-EMF exposure on the number of CD4+ T cells, IL-2, IL-10, and IL-17a after 48 hours of culture with the flow cytometer. The closer the distance, the lower the number of CD4+ T cells. The longer the exposure, the lower the number of CD4+ T cells and the number of IL-2, IL-10, and IL-17a decreases significantly. CD4+ T cells expressing IL-2 increased significantly with the increase of the duration of 1800 MHz RF-EMF exposure (15, 30, and 45 min), but decreased at 60 minutes of exposure when compared to PBMCs without exposure. Sixty minutes of PBMC exposure to RF-EMF with a distance of 5 cm causes a significant reduction in the number of CD4+ T cells, the expression of IL-2, IL-10, and IL-17a. 1800 MHz radiofrequency electromagnetic fields (RF-EMF) Cluster of differentiation 4 (CD4) T cells Interleukin-2 (IL-2) Interleukin-10 (IL-10) Interleukin-17a (IL-17a) Medicine (General) Anis Sulalah verfasserin aut Resvina Resvina verfasserin aut Chomsin Widodo verfasserin aut Agustina T Endharti verfasserin aut Edi Widjajanto verfasserin aut Tedy Juliandhy verfasserin aut In Acta Medica Iranica Tehran University of Medical Sciences, 2005 58(2020), 9 (DE-627)492276110 (DE-600)2194585-8 17359694 nnns volume:58 year:2020 number:9 https://doaj.org/article/9ce90d2bde7a45ebbccf20e74b81f85b kostenfrei https://acta.tums.ac.ir/index.php/acta/article/view/8261 kostenfrei https://doaj.org/toc/0044-6025 Journal toc kostenfrei https://doaj.org/toc/1735-9694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 58 2020 9
allfieldsGer	(DE-627)DOAJ072696370 (DE-599)DOAJ9ce90d2bde7a45ebbccf20e74b81f85b DE-627 ger DE-627 rakwb eng R5-920 Maimun Z Arthamin verfasserin aut The 1800 MHz Radiofrequency Electromagnetic Fields Can Lead to a Reduction in the Number of CD4+T Cells, IL-2, IL-10, and IL-17a on PBMC Cultures 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Although there have been many studies on the effects of electromagnetic fields on humans, scientists still have no agreement on the effects found because several studies showed no statistically significant effects. The effects of radiofrequency electromagnetic fields exposure on the immune system are varied, ranging from no effects to genotoxic effects on lymphocytes. Our study aimed to investigate whether exposure to 1800 MHz radiofrequency electromagnetic fields (RF-EMF) in variable durations and distances could lead to the dysregulation of T helper 1, 2, and 17. The peripheral blood mononuclear cells (PBMCs) cultures from healthy human subjects were exposed to 1800 MHz RF-EMF, with durations of 15, 30, 45, and 60 minutes and distances of 5 and 25 cm. We evaluated the effects of RF-EMF exposure on the number of CD4+ T cells, IL-2, IL-10, and IL-17a after 48 hours of culture with the flow cytometer. The closer the distance, the lower the number of CD4+ T cells. The longer the exposure, the lower the number of CD4+ T cells and the number of IL-2, IL-10, and IL-17a decreases significantly. CD4+ T cells expressing IL-2 increased significantly with the increase of the duration of 1800 MHz RF-EMF exposure (15, 30, and 45 min), but decreased at 60 minutes of exposure when compared to PBMCs without exposure. Sixty minutes of PBMC exposure to RF-EMF with a distance of 5 cm causes a significant reduction in the number of CD4+ T cells, the expression of IL-2, IL-10, and IL-17a. 1800 MHz radiofrequency electromagnetic fields (RF-EMF) Cluster of differentiation 4 (CD4) T cells Interleukin-2 (IL-2) Interleukin-10 (IL-10) Interleukin-17a (IL-17a) Medicine (General) Anis Sulalah verfasserin aut Resvina Resvina verfasserin aut Chomsin Widodo verfasserin aut Agustina T Endharti verfasserin aut Edi Widjajanto verfasserin aut Tedy Juliandhy verfasserin aut In Acta Medica Iranica Tehran University of Medical Sciences, 2005 58(2020), 9 (DE-627)492276110 (DE-600)2194585-8 17359694 nnns volume:58 year:2020 number:9 https://doaj.org/article/9ce90d2bde7a45ebbccf20e74b81f85b kostenfrei https://acta.tums.ac.ir/index.php/acta/article/view/8261 kostenfrei https://doaj.org/toc/0044-6025 Journal toc kostenfrei https://doaj.org/toc/1735-9694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 58 2020 9
allfieldsSound	(DE-627)DOAJ072696370 (DE-599)DOAJ9ce90d2bde7a45ebbccf20e74b81f85b DE-627 ger DE-627 rakwb eng R5-920 Maimun Z Arthamin verfasserin aut The 1800 MHz Radiofrequency Electromagnetic Fields Can Lead to a Reduction in the Number of CD4+T Cells, IL-2, IL-10, and IL-17a on PBMC Cultures 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Although there have been many studies on the effects of electromagnetic fields on humans, scientists still have no agreement on the effects found because several studies showed no statistically significant effects. The effects of radiofrequency electromagnetic fields exposure on the immune system are varied, ranging from no effects to genotoxic effects on lymphocytes. Our study aimed to investigate whether exposure to 1800 MHz radiofrequency electromagnetic fields (RF-EMF) in variable durations and distances could lead to the dysregulation of T helper 1, 2, and 17. The peripheral blood mononuclear cells (PBMCs) cultures from healthy human subjects were exposed to 1800 MHz RF-EMF, with durations of 15, 30, 45, and 60 minutes and distances of 5 and 25 cm. We evaluated the effects of RF-EMF exposure on the number of CD4+ T cells, IL-2, IL-10, and IL-17a after 48 hours of culture with the flow cytometer. The closer the distance, the lower the number of CD4+ T cells. The longer the exposure, the lower the number of CD4+ T cells and the number of IL-2, IL-10, and IL-17a decreases significantly. CD4+ T cells expressing IL-2 increased significantly with the increase of the duration of 1800 MHz RF-EMF exposure (15, 30, and 45 min), but decreased at 60 minutes of exposure when compared to PBMCs without exposure. Sixty minutes of PBMC exposure to RF-EMF with a distance of 5 cm causes a significant reduction in the number of CD4+ T cells, the expression of IL-2, IL-10, and IL-17a. 1800 MHz radiofrequency electromagnetic fields (RF-EMF) Cluster of differentiation 4 (CD4) T cells Interleukin-2 (IL-2) Interleukin-10 (IL-10) Interleukin-17a (IL-17a) Medicine (General) Anis Sulalah verfasserin aut Resvina Resvina verfasserin aut Chomsin Widodo verfasserin aut Agustina T Endharti verfasserin aut Edi Widjajanto verfasserin aut Tedy Juliandhy verfasserin aut In Acta Medica Iranica Tehran University of Medical Sciences, 2005 58(2020), 9 (DE-627)492276110 (DE-600)2194585-8 17359694 nnns volume:58 year:2020 number:9 https://doaj.org/article/9ce90d2bde7a45ebbccf20e74b81f85b kostenfrei https://acta.tums.ac.ir/index.php/acta/article/view/8261 kostenfrei https://doaj.org/toc/0044-6025 Journal toc kostenfrei https://doaj.org/toc/1735-9694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 58 2020 9
language	English
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author	Maimun Z Arthamin
spellingShingle	Maimun Z Arthamin misc R5-920 misc 1800 MHz radiofrequency electromagnetic fields (RF-EMF) misc Cluster of differentiation 4 (CD4) T cells misc Interleukin-2 (IL-2) misc Interleukin-10 (IL-10) misc Interleukin-17a (IL-17a) misc Medicine (General) The 1800 MHz Radiofrequency Electromagnetic Fields Can Lead to a Reduction in the Number of CD4+T Cells, IL-2, IL-10, and IL-17a on PBMC Cultures
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topic_title	R5-920 The 1800 MHz Radiofrequency Electromagnetic Fields Can Lead to a Reduction in the Number of CD4+T Cells, IL-2, IL-10, and IL-17a on PBMC Cultures 1800 MHz radiofrequency electromagnetic fields (RF-EMF) Cluster of differentiation 4 (CD4) T cells Interleukin-2 (IL-2) Interleukin-10 (IL-10) Interleukin-17a (IL-17a)
topic	misc R5-920 misc 1800 MHz radiofrequency electromagnetic fields (RF-EMF) misc Cluster of differentiation 4 (CD4) T cells misc Interleukin-2 (IL-2) misc Interleukin-10 (IL-10) misc Interleukin-17a (IL-17a) misc Medicine (General)
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title	The 1800 MHz Radiofrequency Electromagnetic Fields Can Lead to a Reduction in the Number of CD4+T Cells, IL-2, IL-10, and IL-17a on PBMC Cultures
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title_full	The 1800 MHz Radiofrequency Electromagnetic Fields Can Lead to a Reduction in the Number of CD4+T Cells, IL-2, IL-10, and IL-17a on PBMC Cultures
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title_sort	1800 mhz radiofrequency electromagnetic fields can lead to a reduction in the number of cd4+t cells, il-2, il-10, and il-17a on pbmc cultures
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title_auth	The 1800 MHz Radiofrequency Electromagnetic Fields Can Lead to a Reduction in the Number of CD4+T Cells, IL-2, IL-10, and IL-17a on PBMC Cultures
abstract	Although there have been many studies on the effects of electromagnetic fields on humans, scientists still have no agreement on the effects found because several studies showed no statistically significant effects. The effects of radiofrequency electromagnetic fields exposure on the immune system are varied, ranging from no effects to genotoxic effects on lymphocytes. Our study aimed to investigate whether exposure to 1800 MHz radiofrequency electromagnetic fields (RF-EMF) in variable durations and distances could lead to the dysregulation of T helper 1, 2, and 17. The peripheral blood mononuclear cells (PBMCs) cultures from healthy human subjects were exposed to 1800 MHz RF-EMF, with durations of 15, 30, 45, and 60 minutes and distances of 5 and 25 cm. We evaluated the effects of RF-EMF exposure on the number of CD4+ T cells, IL-2, IL-10, and IL-17a after 48 hours of culture with the flow cytometer. The closer the distance, the lower the number of CD4+ T cells. The longer the exposure, the lower the number of CD4+ T cells and the number of IL-2, IL-10, and IL-17a decreases significantly. CD4+ T cells expressing IL-2 increased significantly with the increase of the duration of 1800 MHz RF-EMF exposure (15, 30, and 45 min), but decreased at 60 minutes of exposure when compared to PBMCs without exposure. Sixty minutes of PBMC exposure to RF-EMF with a distance of 5 cm causes a significant reduction in the number of CD4+ T cells, the expression of IL-2, IL-10, and IL-17a.
abstractGer	Although there have been many studies on the effects of electromagnetic fields on humans, scientists still have no agreement on the effects found because several studies showed no statistically significant effects. The effects of radiofrequency electromagnetic fields exposure on the immune system are varied, ranging from no effects to genotoxic effects on lymphocytes. Our study aimed to investigate whether exposure to 1800 MHz radiofrequency electromagnetic fields (RF-EMF) in variable durations and distances could lead to the dysregulation of T helper 1, 2, and 17. The peripheral blood mononuclear cells (PBMCs) cultures from healthy human subjects were exposed to 1800 MHz RF-EMF, with durations of 15, 30, 45, and 60 minutes and distances of 5 and 25 cm. We evaluated the effects of RF-EMF exposure on the number of CD4+ T cells, IL-2, IL-10, and IL-17a after 48 hours of culture with the flow cytometer. The closer the distance, the lower the number of CD4+ T cells. The longer the exposure, the lower the number of CD4+ T cells and the number of IL-2, IL-10, and IL-17a decreases significantly. CD4+ T cells expressing IL-2 increased significantly with the increase of the duration of 1800 MHz RF-EMF exposure (15, 30, and 45 min), but decreased at 60 minutes of exposure when compared to PBMCs without exposure. Sixty minutes of PBMC exposure to RF-EMF with a distance of 5 cm causes a significant reduction in the number of CD4+ T cells, the expression of IL-2, IL-10, and IL-17a.
abstract_unstemmed	Although there have been many studies on the effects of electromagnetic fields on humans, scientists still have no agreement on the effects found because several studies showed no statistically significant effects. The effects of radiofrequency electromagnetic fields exposure on the immune system are varied, ranging from no effects to genotoxic effects on lymphocytes. Our study aimed to investigate whether exposure to 1800 MHz radiofrequency electromagnetic fields (RF-EMF) in variable durations and distances could lead to the dysregulation of T helper 1, 2, and 17. The peripheral blood mononuclear cells (PBMCs) cultures from healthy human subjects were exposed to 1800 MHz RF-EMF, with durations of 15, 30, 45, and 60 minutes and distances of 5 and 25 cm. We evaluated the effects of RF-EMF exposure on the number of CD4+ T cells, IL-2, IL-10, and IL-17a after 48 hours of culture with the flow cytometer. The closer the distance, the lower the number of CD4+ T cells. The longer the exposure, the lower the number of CD4+ T cells and the number of IL-2, IL-10, and IL-17a decreases significantly. CD4+ T cells expressing IL-2 increased significantly with the increase of the duration of 1800 MHz RF-EMF exposure (15, 30, and 45 min), but decreased at 60 minutes of exposure when compared to PBMCs without exposure. Sixty minutes of PBMC exposure to RF-EMF with a distance of 5 cm causes a significant reduction in the number of CD4+ T cells, the expression of IL-2, IL-10, and IL-17a.
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title_short	The 1800 MHz Radiofrequency Electromagnetic Fields Can Lead to a Reduction in the Number of CD4+T Cells, IL-2, IL-10, and IL-17a on PBMC Cultures
url	https://doaj.org/article/9ce90d2bde7a45ebbccf20e74b81f85b https://acta.tums.ac.ir/index.php/acta/article/view/8261 https://doaj.org/toc/0044-6025 https://doaj.org/toc/1735-9694
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author2	Anis Sulalah Resvina Resvina Chomsin Widodo Agustina T Endharti Edi Widjajanto Tedy Juliandhy
author2Str	Anis Sulalah Resvina Resvina Chomsin Widodo Agustina T Endharti Edi Widjajanto Tedy Juliandhy
ppnlink	492276110
callnumber-subject	R - General Medicine
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callnumber-a	R5-920
up_date	2024-07-03T13:33:26.883Z
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