Interaction of PTPIP51 with Tubulin, CGI-99 and Nuf2 During Cell Cycle Progression

Protein tyrosine phosphatase interacting protein 51 (PTPIP51), also known as regulator of microtubule dynamics protein 3, was identified as an in vitro and in vivo interaction partner of CGI-99 and Nuf-2. PTPIP51 mRNA is expressed in all stages of the cell cycle; it is highly expressed six hours pos...
Ausführliche Beschreibung

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Autor*in:	Monika Wimmer [verfasserIn] Moritz Eiber [verfasserIn] Michaela Graf [verfasserIn] Alexander Brobeil [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2012

Schlagwörter:	PTPIP51 FAM82A2 FAM82C RMD-3 mitosis cell cycle microtubule CGI-99 Nuf-2 EGFR

Übergeordnetes Werk:	In: Biomolecules - MDPI AG, 2013, 2(2012), 1, Seite 122-142
Übergeordnetes Werk:	volume:2 ; year:2012 ; number:1 ; pages:122-142

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/biom2010122

Katalog-ID:	DOAJ072860359

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520			\|a Protein tyrosine phosphatase interacting protein 51 (PTPIP51), also known as regulator of microtubule dynamics protein 3, was identified as an in vitro and in vivo interaction partner of CGI-99 and Nuf-2. PTPIP51 mRNA is expressed in all stages of the cell cycle; it is highly expressed six hours post-nocodazole treatment and minimally expressed one hour post-nocodazole treatment. Recent investigations located PTPIP51 protein at the equatorial plate. This study reports the localization of the PTPIP51/CGI-99 and the PTPIP51/Nuf-2 complex at the equatorial region during mitosis. Moreover, Duolink proximity ligation assays revealed an association of PTPIP51 with the microtubular cytoskeleton and the spindle apparatus. High amounts of phosphorylated PTPIP51 associated with the spindle poles was seen by confocal microscopy. In parallel a strong interaction of PTPIP51 with the epidermal growth factor receptor phosphorylating PTPIP51 at the tyrosine 176 residue was seen. In the M/G1 transition a high level of interaction between PTPIP51 and PTP1B was registered, thus restoring the interaction of PTPIP51 and Raf-1, depleted in mitotic cells. Summarizing these new facts, we conclude that PTPIP51 is necessary for normal mitotic processes, impacting on chromosomal division and control of the MAPK pathway activity.
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allfields	10.3390/biom2010122 doi (DE-627)DOAJ072860359 (DE-599)DOAJc97ad87bc7b5445ab7163b6e9bc00aa5 DE-627 ger DE-627 rakwb eng QR1-502 Monika Wimmer verfasserin aut Interaction of PTPIP51 with Tubulin, CGI-99 and Nuf2 During Cell Cycle Progression 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Protein tyrosine phosphatase interacting protein 51 (PTPIP51), also known as regulator of microtubule dynamics protein 3, was identified as an in vitro and in vivo interaction partner of CGI-99 and Nuf-2. PTPIP51 mRNA is expressed in all stages of the cell cycle; it is highly expressed six hours post-nocodazole treatment and minimally expressed one hour post-nocodazole treatment. Recent investigations located PTPIP51 protein at the equatorial plate. This study reports the localization of the PTPIP51/CGI-99 and the PTPIP51/Nuf-2 complex at the equatorial region during mitosis. Moreover, Duolink proximity ligation assays revealed an association of PTPIP51 with the microtubular cytoskeleton and the spindle apparatus. High amounts of phosphorylated PTPIP51 associated with the spindle poles was seen by confocal microscopy. In parallel a strong interaction of PTPIP51 with the epidermal growth factor receptor phosphorylating PTPIP51 at the tyrosine 176 residue was seen. In the M/G1 transition a high level of interaction between PTPIP51 and PTP1B was registered, thus restoring the interaction of PTPIP51 and Raf-1, depleted in mitotic cells. Summarizing these new facts, we conclude that PTPIP51 is necessary for normal mitotic processes, impacting on chromosomal division and control of the MAPK pathway activity. PTPIP51 FAM82A2 FAM82C RMD-3 mitosis cell cycle microtubule CGI-99 Nuf-2 EGFR Microbiology Moritz Eiber verfasserin aut Michaela Graf verfasserin aut Alexander Brobeil verfasserin aut In Biomolecules MDPI AG, 2013 2(2012), 1, Seite 122-142 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:2 year:2012 number:1 pages:122-142 https://doi.org/10.3390/biom2010122 kostenfrei https://doaj.org/article/c97ad87bc7b5445ab7163b6e9bc00aa5 kostenfrei http://www.mdpi.com/2218-273X/2/1/122 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2012 1 122-142
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allfields_unstemmed	10.3390/biom2010122 doi (DE-627)DOAJ072860359 (DE-599)DOAJc97ad87bc7b5445ab7163b6e9bc00aa5 DE-627 ger DE-627 rakwb eng QR1-502 Monika Wimmer verfasserin aut Interaction of PTPIP51 with Tubulin, CGI-99 and Nuf2 During Cell Cycle Progression 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Protein tyrosine phosphatase interacting protein 51 (PTPIP51), also known as regulator of microtubule dynamics protein 3, was identified as an in vitro and in vivo interaction partner of CGI-99 and Nuf-2. PTPIP51 mRNA is expressed in all stages of the cell cycle; it is highly expressed six hours post-nocodazole treatment and minimally expressed one hour post-nocodazole treatment. Recent investigations located PTPIP51 protein at the equatorial plate. This study reports the localization of the PTPIP51/CGI-99 and the PTPIP51/Nuf-2 complex at the equatorial region during mitosis. Moreover, Duolink proximity ligation assays revealed an association of PTPIP51 with the microtubular cytoskeleton and the spindle apparatus. High amounts of phosphorylated PTPIP51 associated with the spindle poles was seen by confocal microscopy. In parallel a strong interaction of PTPIP51 with the epidermal growth factor receptor phosphorylating PTPIP51 at the tyrosine 176 residue was seen. In the M/G1 transition a high level of interaction between PTPIP51 and PTP1B was registered, thus restoring the interaction of PTPIP51 and Raf-1, depleted in mitotic cells. Summarizing these new facts, we conclude that PTPIP51 is necessary for normal mitotic processes, impacting on chromosomal division and control of the MAPK pathway activity. PTPIP51 FAM82A2 FAM82C RMD-3 mitosis cell cycle microtubule CGI-99 Nuf-2 EGFR Microbiology Moritz Eiber verfasserin aut Michaela Graf verfasserin aut Alexander Brobeil verfasserin aut In Biomolecules MDPI AG, 2013 2(2012), 1, Seite 122-142 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:2 year:2012 number:1 pages:122-142 https://doi.org/10.3390/biom2010122 kostenfrei https://doaj.org/article/c97ad87bc7b5445ab7163b6e9bc00aa5 kostenfrei http://www.mdpi.com/2218-273X/2/1/122 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2012 1 122-142
allfieldsGer	10.3390/biom2010122 doi (DE-627)DOAJ072860359 (DE-599)DOAJc97ad87bc7b5445ab7163b6e9bc00aa5 DE-627 ger DE-627 rakwb eng QR1-502 Monika Wimmer verfasserin aut Interaction of PTPIP51 with Tubulin, CGI-99 and Nuf2 During Cell Cycle Progression 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Protein tyrosine phosphatase interacting protein 51 (PTPIP51), also known as regulator of microtubule dynamics protein 3, was identified as an in vitro and in vivo interaction partner of CGI-99 and Nuf-2. PTPIP51 mRNA is expressed in all stages of the cell cycle; it is highly expressed six hours post-nocodazole treatment and minimally expressed one hour post-nocodazole treatment. Recent investigations located PTPIP51 protein at the equatorial plate. This study reports the localization of the PTPIP51/CGI-99 and the PTPIP51/Nuf-2 complex at the equatorial region during mitosis. Moreover, Duolink proximity ligation assays revealed an association of PTPIP51 with the microtubular cytoskeleton and the spindle apparatus. High amounts of phosphorylated PTPIP51 associated with the spindle poles was seen by confocal microscopy. In parallel a strong interaction of PTPIP51 with the epidermal growth factor receptor phosphorylating PTPIP51 at the tyrosine 176 residue was seen. In the M/G1 transition a high level of interaction between PTPIP51 and PTP1B was registered, thus restoring the interaction of PTPIP51 and Raf-1, depleted in mitotic cells. Summarizing these new facts, we conclude that PTPIP51 is necessary for normal mitotic processes, impacting on chromosomal division and control of the MAPK pathway activity. PTPIP51 FAM82A2 FAM82C RMD-3 mitosis cell cycle microtubule CGI-99 Nuf-2 EGFR Microbiology Moritz Eiber verfasserin aut Michaela Graf verfasserin aut Alexander Brobeil verfasserin aut In Biomolecules MDPI AG, 2013 2(2012), 1, Seite 122-142 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:2 year:2012 number:1 pages:122-142 https://doi.org/10.3390/biom2010122 kostenfrei https://doaj.org/article/c97ad87bc7b5445ab7163b6e9bc00aa5 kostenfrei http://www.mdpi.com/2218-273X/2/1/122 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2012 1 122-142
allfieldsSound	10.3390/biom2010122 doi (DE-627)DOAJ072860359 (DE-599)DOAJc97ad87bc7b5445ab7163b6e9bc00aa5 DE-627 ger DE-627 rakwb eng QR1-502 Monika Wimmer verfasserin aut Interaction of PTPIP51 with Tubulin, CGI-99 and Nuf2 During Cell Cycle Progression 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Protein tyrosine phosphatase interacting protein 51 (PTPIP51), also known as regulator of microtubule dynamics protein 3, was identified as an in vitro and in vivo interaction partner of CGI-99 and Nuf-2. PTPIP51 mRNA is expressed in all stages of the cell cycle; it is highly expressed six hours post-nocodazole treatment and minimally expressed one hour post-nocodazole treatment. Recent investigations located PTPIP51 protein at the equatorial plate. This study reports the localization of the PTPIP51/CGI-99 and the PTPIP51/Nuf-2 complex at the equatorial region during mitosis. Moreover, Duolink proximity ligation assays revealed an association of PTPIP51 with the microtubular cytoskeleton and the spindle apparatus. High amounts of phosphorylated PTPIP51 associated with the spindle poles was seen by confocal microscopy. In parallel a strong interaction of PTPIP51 with the epidermal growth factor receptor phosphorylating PTPIP51 at the tyrosine 176 residue was seen. In the M/G1 transition a high level of interaction between PTPIP51 and PTP1B was registered, thus restoring the interaction of PTPIP51 and Raf-1, depleted in mitotic cells. Summarizing these new facts, we conclude that PTPIP51 is necessary for normal mitotic processes, impacting on chromosomal division and control of the MAPK pathway activity. PTPIP51 FAM82A2 FAM82C RMD-3 mitosis cell cycle microtubule CGI-99 Nuf-2 EGFR Microbiology Moritz Eiber verfasserin aut Michaela Graf verfasserin aut Alexander Brobeil verfasserin aut In Biomolecules MDPI AG, 2013 2(2012), 1, Seite 122-142 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:2 year:2012 number:1 pages:122-142 https://doi.org/10.3390/biom2010122 kostenfrei https://doaj.org/article/c97ad87bc7b5445ab7163b6e9bc00aa5 kostenfrei http://www.mdpi.com/2218-273X/2/1/122 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2012 1 122-142
language	English
source	In Biomolecules 2(2012), 1, Seite 122-142 volume:2 year:2012 number:1 pages:122-142
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topic_facet	PTPIP51 FAM82A2 FAM82C RMD-3 mitosis cell cycle microtubule CGI-99 Nuf-2 EGFR Microbiology
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container_title	Biomolecules
authorswithroles_txt_mv	Monika Wimmer @@aut@@ Moritz Eiber @@aut@@ Michaela Graf @@aut@@ Alexander Brobeil @@aut@@
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callnumber-first	Q - Science
author	Monika Wimmer
spellingShingle	Monika Wimmer misc QR1-502 misc PTPIP51 misc FAM82A2 misc FAM82C misc RMD-3 misc mitosis misc cell cycle misc microtubule misc CGI-99 misc Nuf-2 misc EGFR misc Microbiology Interaction of PTPIP51 with Tubulin, CGI-99 and Nuf2 During Cell Cycle Progression
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topic_title	QR1-502 Interaction of PTPIP51 with Tubulin, CGI-99 and Nuf2 During Cell Cycle Progression PTPIP51 FAM82A2 FAM82C RMD-3 mitosis cell cycle microtubule CGI-99 Nuf-2 EGFR
topic	misc QR1-502 misc PTPIP51 misc FAM82A2 misc FAM82C misc RMD-3 misc mitosis misc cell cycle misc microtubule misc CGI-99 misc Nuf-2 misc EGFR misc Microbiology
topic_unstemmed	misc QR1-502 misc PTPIP51 misc FAM82A2 misc FAM82C misc RMD-3 misc mitosis misc cell cycle misc microtubule misc CGI-99 misc Nuf-2 misc EGFR misc Microbiology
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title	Interaction of PTPIP51 with Tubulin, CGI-99 and Nuf2 During Cell Cycle Progression
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title_full	Interaction of PTPIP51 with Tubulin, CGI-99 and Nuf2 During Cell Cycle Progression
author_sort	Monika Wimmer
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author_browse	Monika Wimmer Moritz Eiber Michaela Graf Alexander Brobeil
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title_sort	interaction of ptpip51 with tubulin, cgi-99 and nuf2 during cell cycle progression
callnumber	QR1-502
title_auth	Interaction of PTPIP51 with Tubulin, CGI-99 and Nuf2 During Cell Cycle Progression
abstract	Protein tyrosine phosphatase interacting protein 51 (PTPIP51), also known as regulator of microtubule dynamics protein 3, was identified as an in vitro and in vivo interaction partner of CGI-99 and Nuf-2. PTPIP51 mRNA is expressed in all stages of the cell cycle; it is highly expressed six hours post-nocodazole treatment and minimally expressed one hour post-nocodazole treatment. Recent investigations located PTPIP51 protein at the equatorial plate. This study reports the localization of the PTPIP51/CGI-99 and the PTPIP51/Nuf-2 complex at the equatorial region during mitosis. Moreover, Duolink proximity ligation assays revealed an association of PTPIP51 with the microtubular cytoskeleton and the spindle apparatus. High amounts of phosphorylated PTPIP51 associated with the spindle poles was seen by confocal microscopy. In parallel a strong interaction of PTPIP51 with the epidermal growth factor receptor phosphorylating PTPIP51 at the tyrosine 176 residue was seen. In the M/G1 transition a high level of interaction between PTPIP51 and PTP1B was registered, thus restoring the interaction of PTPIP51 and Raf-1, depleted in mitotic cells. Summarizing these new facts, we conclude that PTPIP51 is necessary for normal mitotic processes, impacting on chromosomal division and control of the MAPK pathway activity.
abstractGer	Protein tyrosine phosphatase interacting protein 51 (PTPIP51), also known as regulator of microtubule dynamics protein 3, was identified as an in vitro and in vivo interaction partner of CGI-99 and Nuf-2. PTPIP51 mRNA is expressed in all stages of the cell cycle; it is highly expressed six hours post-nocodazole treatment and minimally expressed one hour post-nocodazole treatment. Recent investigations located PTPIP51 protein at the equatorial plate. This study reports the localization of the PTPIP51/CGI-99 and the PTPIP51/Nuf-2 complex at the equatorial region during mitosis. Moreover, Duolink proximity ligation assays revealed an association of PTPIP51 with the microtubular cytoskeleton and the spindle apparatus. High amounts of phosphorylated PTPIP51 associated with the spindle poles was seen by confocal microscopy. In parallel a strong interaction of PTPIP51 with the epidermal growth factor receptor phosphorylating PTPIP51 at the tyrosine 176 residue was seen. In the M/G1 transition a high level of interaction between PTPIP51 and PTP1B was registered, thus restoring the interaction of PTPIP51 and Raf-1, depleted in mitotic cells. Summarizing these new facts, we conclude that PTPIP51 is necessary for normal mitotic processes, impacting on chromosomal division and control of the MAPK pathway activity.
abstract_unstemmed	Protein tyrosine phosphatase interacting protein 51 (PTPIP51), also known as regulator of microtubule dynamics protein 3, was identified as an in vitro and in vivo interaction partner of CGI-99 and Nuf-2. PTPIP51 mRNA is expressed in all stages of the cell cycle; it is highly expressed six hours post-nocodazole treatment and minimally expressed one hour post-nocodazole treatment. Recent investigations located PTPIP51 protein at the equatorial plate. This study reports the localization of the PTPIP51/CGI-99 and the PTPIP51/Nuf-2 complex at the equatorial region during mitosis. Moreover, Duolink proximity ligation assays revealed an association of PTPIP51 with the microtubular cytoskeleton and the spindle apparatus. High amounts of phosphorylated PTPIP51 associated with the spindle poles was seen by confocal microscopy. In parallel a strong interaction of PTPIP51 with the epidermal growth factor receptor phosphorylating PTPIP51 at the tyrosine 176 residue was seen. In the M/G1 transition a high level of interaction between PTPIP51 and PTP1B was registered, thus restoring the interaction of PTPIP51 and Raf-1, depleted in mitotic cells. Summarizing these new facts, we conclude that PTPIP51 is necessary for normal mitotic processes, impacting on chromosomal division and control of the MAPK pathway activity.
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title_short	Interaction of PTPIP51 with Tubulin, CGI-99 and Nuf2 During Cell Cycle Progression
url	https://doi.org/10.3390/biom2010122 https://doaj.org/article/c97ad87bc7b5445ab7163b6e9bc00aa5 http://www.mdpi.com/2218-273X/2/1/122 https://doaj.org/toc/2218-273X
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up_date	2024-07-03T14:27:49.566Z
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Interaction of PTPIP51 with Tubulin, CGI-99 and Nuf2 During Cell Cycle Progression

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