Clinical characteristics and outcomes of chronic nonbacterial osteomyelitis in children: a multicenter case series

Abstract Objective The aim of this study was to evaluate demographic, clinical, laboratory, imaging, histopathology characteristics, and treatment responses of children with Chronic nonbacterial osteomyelitis (CNO). Methods Retrospective multi-center case series study of pediatric patients diagnosed...
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Autor*in:	Le Ma [verfasserIn] Haimei Liu [verfasserIn] Hanyun Tang [verfasserIn] Zhiyong Zhang [verfasserIn] Lixia Zou [verfasserIn] Haiguo Yu [verfasserIn] Li Sun [verfasserIn] Xiaozhong Li [verfasserIn] Xuemei Tang [verfasserIn] Meiping Lu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Autoinflammatory bone disease Chronic nonbacterial osteomyelitis Chronic recurrent multifocal osteomyelitis

Übergeordnetes Werk:	In: Pediatric Rheumatology Online Journal - BMC, 2007, 20(2022), 1, Seite 11
Übergeordnetes Werk:	volume:20 ; year:2022 ; number:1 ; pages:11

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12969-021-00657-4

Katalog-ID:	DOAJ072916036

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520			\|a Abstract Objective The aim of this study was to evaluate demographic, clinical, laboratory, imaging, histopathology characteristics, and treatment responses of children with Chronic nonbacterial osteomyelitis (CNO). Methods Retrospective multi-center case series study of pediatric patients diagnosed with CNO treated at five tertiary centers in south China. Results Totally there were 18 patients diagnosed as CNO between 2014 and 2020. The median age of onset was 9.2 years (range 3.7–13.1) and 55.6% were female. Median delay in diagnosis was 10.9 months (range 1.0–72.0). The most frequent presenting symptoms were bone pain (100%) and fever (44.4%). Most patients had more than one lesion (median of 5, range 1–7). Most frequently affected bones were tibiofibula (88.9%) and femur (77.8%). The MRI characteristics mainly presented as bone edema and hyperintensity in bone marrow. Bone biopsy was conducted in 11 patients (61.1%) with inflammatory cells infiltration manifested as chronic osteomyelitis, and none showed bacterial infection or tumor. In treatment, non-steroid anti-inflamatory drugs (NSAIDs) is used as the first-line drug followed by steriods, methotexate (MTX), salazosulfadimidine (SASP), Bisphosphonates and TNF-α inhibitor. Two refractory cases received combination therapy with Bisphosphonates and TNF-α inhibitor, and achieved good therapeutic effect. Conclusions The present study described a multicenter series of CNO from south China and highlighted the clinical features, laboratory tests, imaging characteristics and treatment outcomes. Increasing awareness of this disease is important to decrease time to diagnosis, improve access to treatment, and reduce complications.
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allfields	10.1186/s12969-021-00657-4 doi (DE-627)DOAJ072916036 (DE-599)DOAJ80fee308fb4f45708c561573b718f680 DE-627 ger DE-627 rakwb eng RJ1-570 RC925-935 Le Ma verfasserin aut Clinical characteristics and outcomes of chronic nonbacterial osteomyelitis in children: a multicenter case series 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Objective The aim of this study was to evaluate demographic, clinical, laboratory, imaging, histopathology characteristics, and treatment responses of children with Chronic nonbacterial osteomyelitis (CNO). Methods Retrospective multi-center case series study of pediatric patients diagnosed with CNO treated at five tertiary centers in south China. Results Totally there were 18 patients diagnosed as CNO between 2014 and 2020. The median age of onset was 9.2 years (range 3.7–13.1) and 55.6% were female. Median delay in diagnosis was 10.9 months (range 1.0–72.0). The most frequent presenting symptoms were bone pain (100%) and fever (44.4%). Most patients had more than one lesion (median of 5, range 1–7). Most frequently affected bones were tibiofibula (88.9%) and femur (77.8%). The MRI characteristics mainly presented as bone edema and hyperintensity in bone marrow. Bone biopsy was conducted in 11 patients (61.1%) with inflammatory cells infiltration manifested as chronic osteomyelitis, and none showed bacterial infection or tumor. In treatment, non-steroid anti-inflamatory drugs (NSAIDs) is used as the first-line drug followed by steriods, methotexate (MTX), salazosulfadimidine (SASP), Bisphosphonates and TNF-α inhibitor. Two refractory cases received combination therapy with Bisphosphonates and TNF-α inhibitor, and achieved good therapeutic effect. Conclusions The present study described a multicenter series of CNO from south China and highlighted the clinical features, laboratory tests, imaging characteristics and treatment outcomes. Increasing awareness of this disease is important to decrease time to diagnosis, improve access to treatment, and reduce complications. Autoinflammatory bone disease Chronic nonbacterial osteomyelitis Chronic recurrent multifocal osteomyelitis Pediatrics Diseases of the musculoskeletal system Haimei Liu verfasserin aut Hanyun Tang verfasserin aut Zhiyong Zhang verfasserin aut Lixia Zou verfasserin aut Haiguo Yu verfasserin aut Li Sun verfasserin aut Xiaozhong Li verfasserin aut Xuemei Tang verfasserin aut Meiping Lu verfasserin aut In Pediatric Rheumatology Online Journal BMC, 2007 20(2022), 1, Seite 11 (DE-627)527833746 (DE-600)2279468-2 15460096 nnns volume:20 year:2022 number:1 pages:11 https://doi.org/10.1186/s12969-021-00657-4 kostenfrei https://doaj.org/article/80fee308fb4f45708c561573b718f680 kostenfrei https://doi.org/10.1186/s12969-021-00657-4 kostenfrei https://doaj.org/toc/1546-0096 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2022 1 11
spelling	10.1186/s12969-021-00657-4 doi (DE-627)DOAJ072916036 (DE-599)DOAJ80fee308fb4f45708c561573b718f680 DE-627 ger DE-627 rakwb eng RJ1-570 RC925-935 Le Ma verfasserin aut Clinical characteristics and outcomes of chronic nonbacterial osteomyelitis in children: a multicenter case series 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Objective The aim of this study was to evaluate demographic, clinical, laboratory, imaging, histopathology characteristics, and treatment responses of children with Chronic nonbacterial osteomyelitis (CNO). Methods Retrospective multi-center case series study of pediatric patients diagnosed with CNO treated at five tertiary centers in south China. Results Totally there were 18 patients diagnosed as CNO between 2014 and 2020. The median age of onset was 9.2 years (range 3.7–13.1) and 55.6% were female. Median delay in diagnosis was 10.9 months (range 1.0–72.0). The most frequent presenting symptoms were bone pain (100%) and fever (44.4%). Most patients had more than one lesion (median of 5, range 1–7). Most frequently affected bones were tibiofibula (88.9%) and femur (77.8%). The MRI characteristics mainly presented as bone edema and hyperintensity in bone marrow. Bone biopsy was conducted in 11 patients (61.1%) with inflammatory cells infiltration manifested as chronic osteomyelitis, and none showed bacterial infection or tumor. In treatment, non-steroid anti-inflamatory drugs (NSAIDs) is used as the first-line drug followed by steriods, methotexate (MTX), salazosulfadimidine (SASP), Bisphosphonates and TNF-α inhibitor. Two refractory cases received combination therapy with Bisphosphonates and TNF-α inhibitor, and achieved good therapeutic effect. Conclusions The present study described a multicenter series of CNO from south China and highlighted the clinical features, laboratory tests, imaging characteristics and treatment outcomes. Increasing awareness of this disease is important to decrease time to diagnosis, improve access to treatment, and reduce complications. Autoinflammatory bone disease Chronic nonbacterial osteomyelitis Chronic recurrent multifocal osteomyelitis Pediatrics Diseases of the musculoskeletal system Haimei Liu verfasserin aut Hanyun Tang verfasserin aut Zhiyong Zhang verfasserin aut Lixia Zou verfasserin aut Haiguo Yu verfasserin aut Li Sun verfasserin aut Xiaozhong Li verfasserin aut Xuemei Tang verfasserin aut Meiping Lu verfasserin aut In Pediatric Rheumatology Online Journal BMC, 2007 20(2022), 1, Seite 11 (DE-627)527833746 (DE-600)2279468-2 15460096 nnns volume:20 year:2022 number:1 pages:11 https://doi.org/10.1186/s12969-021-00657-4 kostenfrei https://doaj.org/article/80fee308fb4f45708c561573b718f680 kostenfrei https://doi.org/10.1186/s12969-021-00657-4 kostenfrei https://doaj.org/toc/1546-0096 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2022 1 11
allfields_unstemmed	10.1186/s12969-021-00657-4 doi (DE-627)DOAJ072916036 (DE-599)DOAJ80fee308fb4f45708c561573b718f680 DE-627 ger DE-627 rakwb eng RJ1-570 RC925-935 Le Ma verfasserin aut Clinical characteristics and outcomes of chronic nonbacterial osteomyelitis in children: a multicenter case series 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Objective The aim of this study was to evaluate demographic, clinical, laboratory, imaging, histopathology characteristics, and treatment responses of children with Chronic nonbacterial osteomyelitis (CNO). Methods Retrospective multi-center case series study of pediatric patients diagnosed with CNO treated at five tertiary centers in south China. Results Totally there were 18 patients diagnosed as CNO between 2014 and 2020. The median age of onset was 9.2 years (range 3.7–13.1) and 55.6% were female. Median delay in diagnosis was 10.9 months (range 1.0–72.0). The most frequent presenting symptoms were bone pain (100%) and fever (44.4%). Most patients had more than one lesion (median of 5, range 1–7). Most frequently affected bones were tibiofibula (88.9%) and femur (77.8%). The MRI characteristics mainly presented as bone edema and hyperintensity in bone marrow. Bone biopsy was conducted in 11 patients (61.1%) with inflammatory cells infiltration manifested as chronic osteomyelitis, and none showed bacterial infection or tumor. In treatment, non-steroid anti-inflamatory drugs (NSAIDs) is used as the first-line drug followed by steriods, methotexate (MTX), salazosulfadimidine (SASP), Bisphosphonates and TNF-α inhibitor. Two refractory cases received combination therapy with Bisphosphonates and TNF-α inhibitor, and achieved good therapeutic effect. Conclusions The present study described a multicenter series of CNO from south China and highlighted the clinical features, laboratory tests, imaging characteristics and treatment outcomes. Increasing awareness of this disease is important to decrease time to diagnosis, improve access to treatment, and reduce complications. Autoinflammatory bone disease Chronic nonbacterial osteomyelitis Chronic recurrent multifocal osteomyelitis Pediatrics Diseases of the musculoskeletal system Haimei Liu verfasserin aut Hanyun Tang verfasserin aut Zhiyong Zhang verfasserin aut Lixia Zou verfasserin aut Haiguo Yu verfasserin aut Li Sun verfasserin aut Xiaozhong Li verfasserin aut Xuemei Tang verfasserin aut Meiping Lu verfasserin aut In Pediatric Rheumatology Online Journal BMC, 2007 20(2022), 1, Seite 11 (DE-627)527833746 (DE-600)2279468-2 15460096 nnns volume:20 year:2022 number:1 pages:11 https://doi.org/10.1186/s12969-021-00657-4 kostenfrei https://doaj.org/article/80fee308fb4f45708c561573b718f680 kostenfrei https://doi.org/10.1186/s12969-021-00657-4 kostenfrei https://doaj.org/toc/1546-0096 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2022 1 11
allfieldsGer	10.1186/s12969-021-00657-4 doi (DE-627)DOAJ072916036 (DE-599)DOAJ80fee308fb4f45708c561573b718f680 DE-627 ger DE-627 rakwb eng RJ1-570 RC925-935 Le Ma verfasserin aut Clinical characteristics and outcomes of chronic nonbacterial osteomyelitis in children: a multicenter case series 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Objective The aim of this study was to evaluate demographic, clinical, laboratory, imaging, histopathology characteristics, and treatment responses of children with Chronic nonbacterial osteomyelitis (CNO). Methods Retrospective multi-center case series study of pediatric patients diagnosed with CNO treated at five tertiary centers in south China. Results Totally there were 18 patients diagnosed as CNO between 2014 and 2020. The median age of onset was 9.2 years (range 3.7–13.1) and 55.6% were female. Median delay in diagnosis was 10.9 months (range 1.0–72.0). The most frequent presenting symptoms were bone pain (100%) and fever (44.4%). Most patients had more than one lesion (median of 5, range 1–7). Most frequently affected bones were tibiofibula (88.9%) and femur (77.8%). The MRI characteristics mainly presented as bone edema and hyperintensity in bone marrow. Bone biopsy was conducted in 11 patients (61.1%) with inflammatory cells infiltration manifested as chronic osteomyelitis, and none showed bacterial infection or tumor. In treatment, non-steroid anti-inflamatory drugs (NSAIDs) is used as the first-line drug followed by steriods, methotexate (MTX), salazosulfadimidine (SASP), Bisphosphonates and TNF-α inhibitor. Two refractory cases received combination therapy with Bisphosphonates and TNF-α inhibitor, and achieved good therapeutic effect. Conclusions The present study described a multicenter series of CNO from south China and highlighted the clinical features, laboratory tests, imaging characteristics and treatment outcomes. Increasing awareness of this disease is important to decrease time to diagnosis, improve access to treatment, and reduce complications. Autoinflammatory bone disease Chronic nonbacterial osteomyelitis Chronic recurrent multifocal osteomyelitis Pediatrics Diseases of the musculoskeletal system Haimei Liu verfasserin aut Hanyun Tang verfasserin aut Zhiyong Zhang verfasserin aut Lixia Zou verfasserin aut Haiguo Yu verfasserin aut Li Sun verfasserin aut Xiaozhong Li verfasserin aut Xuemei Tang verfasserin aut Meiping Lu verfasserin aut In Pediatric Rheumatology Online Journal BMC, 2007 20(2022), 1, Seite 11 (DE-627)527833746 (DE-600)2279468-2 15460096 nnns volume:20 year:2022 number:1 pages:11 https://doi.org/10.1186/s12969-021-00657-4 kostenfrei https://doaj.org/article/80fee308fb4f45708c561573b718f680 kostenfrei https://doi.org/10.1186/s12969-021-00657-4 kostenfrei https://doaj.org/toc/1546-0096 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2022 1 11
allfieldsSound	10.1186/s12969-021-00657-4 doi (DE-627)DOAJ072916036 (DE-599)DOAJ80fee308fb4f45708c561573b718f680 DE-627 ger DE-627 rakwb eng RJ1-570 RC925-935 Le Ma verfasserin aut Clinical characteristics and outcomes of chronic nonbacterial osteomyelitis in children: a multicenter case series 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Objective The aim of this study was to evaluate demographic, clinical, laboratory, imaging, histopathology characteristics, and treatment responses of children with Chronic nonbacterial osteomyelitis (CNO). Methods Retrospective multi-center case series study of pediatric patients diagnosed with CNO treated at five tertiary centers in south China. Results Totally there were 18 patients diagnosed as CNO between 2014 and 2020. The median age of onset was 9.2 years (range 3.7–13.1) and 55.6% were female. Median delay in diagnosis was 10.9 months (range 1.0–72.0). The most frequent presenting symptoms were bone pain (100%) and fever (44.4%). Most patients had more than one lesion (median of 5, range 1–7). Most frequently affected bones were tibiofibula (88.9%) and femur (77.8%). The MRI characteristics mainly presented as bone edema and hyperintensity in bone marrow. Bone biopsy was conducted in 11 patients (61.1%) with inflammatory cells infiltration manifested as chronic osteomyelitis, and none showed bacterial infection or tumor. In treatment, non-steroid anti-inflamatory drugs (NSAIDs) is used as the first-line drug followed by steriods, methotexate (MTX), salazosulfadimidine (SASP), Bisphosphonates and TNF-α inhibitor. Two refractory cases received combination therapy with Bisphosphonates and TNF-α inhibitor, and achieved good therapeutic effect. Conclusions The present study described a multicenter series of CNO from south China and highlighted the clinical features, laboratory tests, imaging characteristics and treatment outcomes. Increasing awareness of this disease is important to decrease time to diagnosis, improve access to treatment, and reduce complications. Autoinflammatory bone disease Chronic nonbacterial osteomyelitis Chronic recurrent multifocal osteomyelitis Pediatrics Diseases of the musculoskeletal system Haimei Liu verfasserin aut Hanyun Tang verfasserin aut Zhiyong Zhang verfasserin aut Lixia Zou verfasserin aut Haiguo Yu verfasserin aut Li Sun verfasserin aut Xiaozhong Li verfasserin aut Xuemei Tang verfasserin aut Meiping Lu verfasserin aut In Pediatric Rheumatology Online Journal BMC, 2007 20(2022), 1, Seite 11 (DE-627)527833746 (DE-600)2279468-2 15460096 nnns volume:20 year:2022 number:1 pages:11 https://doi.org/10.1186/s12969-021-00657-4 kostenfrei https://doaj.org/article/80fee308fb4f45708c561573b718f680 kostenfrei https://doi.org/10.1186/s12969-021-00657-4 kostenfrei https://doaj.org/toc/1546-0096 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2022 1 11
language	English
source	In Pediatric Rheumatology Online Journal 20(2022), 1, Seite 11 volume:20 year:2022 number:1 pages:11
sourceStr	In Pediatric Rheumatology Online Journal 20(2022), 1, Seite 11 volume:20 year:2022 number:1 pages:11
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Autoinflammatory bone disease Chronic nonbacterial osteomyelitis Chronic recurrent multifocal osteomyelitis Pediatrics Diseases of the musculoskeletal system
isfreeaccess_bool	true
container_title	Pediatric Rheumatology Online Journal
authorswithroles_txt_mv	Le Ma @@aut@@ Haimei Liu @@aut@@ Hanyun Tang @@aut@@ Zhiyong Zhang @@aut@@ Lixia Zou @@aut@@ Haiguo Yu @@aut@@ Li Sun @@aut@@ Xiaozhong Li @@aut@@ Xuemei Tang @@aut@@ Meiping Lu @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	527833746
id	DOAJ072916036
language_de	englisch
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callnumber-first	R - Medicine
author	Le Ma
spellingShingle	Le Ma misc RJ1-570 misc RC925-935 misc Autoinflammatory bone disease misc Chronic nonbacterial osteomyelitis misc Chronic recurrent multifocal osteomyelitis misc Pediatrics misc Diseases of the musculoskeletal system Clinical characteristics and outcomes of chronic nonbacterial osteomyelitis in children: a multicenter case series
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topic_title	RJ1-570 RC925-935 Clinical characteristics and outcomes of chronic nonbacterial osteomyelitis in children: a multicenter case series Autoinflammatory bone disease Chronic nonbacterial osteomyelitis Chronic recurrent multifocal osteomyelitis
topic	misc RJ1-570 misc RC925-935 misc Autoinflammatory bone disease misc Chronic nonbacterial osteomyelitis misc Chronic recurrent multifocal osteomyelitis misc Pediatrics misc Diseases of the musculoskeletal system
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title	Clinical characteristics and outcomes of chronic nonbacterial osteomyelitis in children: a multicenter case series
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title_full	Clinical characteristics and outcomes of chronic nonbacterial osteomyelitis in children: a multicenter case series
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author_browse	Le Ma Haimei Liu Hanyun Tang Zhiyong Zhang Lixia Zou Haiguo Yu Li Sun Xiaozhong Li Xuemei Tang Meiping Lu
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title_sort	clinical characteristics and outcomes of chronic nonbacterial osteomyelitis in children: a multicenter case series
callnumber	RJ1-570
title_auth	Clinical characteristics and outcomes of chronic nonbacterial osteomyelitis in children: a multicenter case series
abstract	Abstract Objective The aim of this study was to evaluate demographic, clinical, laboratory, imaging, histopathology characteristics, and treatment responses of children with Chronic nonbacterial osteomyelitis (CNO). Methods Retrospective multi-center case series study of pediatric patients diagnosed with CNO treated at five tertiary centers in south China. Results Totally there were 18 patients diagnosed as CNO between 2014 and 2020. The median age of onset was 9.2 years (range 3.7–13.1) and 55.6% were female. Median delay in diagnosis was 10.9 months (range 1.0–72.0). The most frequent presenting symptoms were bone pain (100%) and fever (44.4%). Most patients had more than one lesion (median of 5, range 1–7). Most frequently affected bones were tibiofibula (88.9%) and femur (77.8%). The MRI characteristics mainly presented as bone edema and hyperintensity in bone marrow. Bone biopsy was conducted in 11 patients (61.1%) with inflammatory cells infiltration manifested as chronic osteomyelitis, and none showed bacterial infection or tumor. In treatment, non-steroid anti-inflamatory drugs (NSAIDs) is used as the first-line drug followed by steriods, methotexate (MTX), salazosulfadimidine (SASP), Bisphosphonates and TNF-α inhibitor. Two refractory cases received combination therapy with Bisphosphonates and TNF-α inhibitor, and achieved good therapeutic effect. Conclusions The present study described a multicenter series of CNO from south China and highlighted the clinical features, laboratory tests, imaging characteristics and treatment outcomes. Increasing awareness of this disease is important to decrease time to diagnosis, improve access to treatment, and reduce complications.
abstractGer	Abstract Objective The aim of this study was to evaluate demographic, clinical, laboratory, imaging, histopathology characteristics, and treatment responses of children with Chronic nonbacterial osteomyelitis (CNO). Methods Retrospective multi-center case series study of pediatric patients diagnosed with CNO treated at five tertiary centers in south China. Results Totally there were 18 patients diagnosed as CNO between 2014 and 2020. The median age of onset was 9.2 years (range 3.7–13.1) and 55.6% were female. Median delay in diagnosis was 10.9 months (range 1.0–72.0). The most frequent presenting symptoms were bone pain (100%) and fever (44.4%). Most patients had more than one lesion (median of 5, range 1–7). Most frequently affected bones were tibiofibula (88.9%) and femur (77.8%). The MRI characteristics mainly presented as bone edema and hyperintensity in bone marrow. Bone biopsy was conducted in 11 patients (61.1%) with inflammatory cells infiltration manifested as chronic osteomyelitis, and none showed bacterial infection or tumor. In treatment, non-steroid anti-inflamatory drugs (NSAIDs) is used as the first-line drug followed by steriods, methotexate (MTX), salazosulfadimidine (SASP), Bisphosphonates and TNF-α inhibitor. Two refractory cases received combination therapy with Bisphosphonates and TNF-α inhibitor, and achieved good therapeutic effect. Conclusions The present study described a multicenter series of CNO from south China and highlighted the clinical features, laboratory tests, imaging characteristics and treatment outcomes. Increasing awareness of this disease is important to decrease time to diagnosis, improve access to treatment, and reduce complications.
abstract_unstemmed	Abstract Objective The aim of this study was to evaluate demographic, clinical, laboratory, imaging, histopathology characteristics, and treatment responses of children with Chronic nonbacterial osteomyelitis (CNO). Methods Retrospective multi-center case series study of pediatric patients diagnosed with CNO treated at five tertiary centers in south China. Results Totally there were 18 patients diagnosed as CNO between 2014 and 2020. The median age of onset was 9.2 years (range 3.7–13.1) and 55.6% were female. Median delay in diagnosis was 10.9 months (range 1.0–72.0). The most frequent presenting symptoms were bone pain (100%) and fever (44.4%). Most patients had more than one lesion (median of 5, range 1–7). Most frequently affected bones were tibiofibula (88.9%) and femur (77.8%). The MRI characteristics mainly presented as bone edema and hyperintensity in bone marrow. Bone biopsy was conducted in 11 patients (61.1%) with inflammatory cells infiltration manifested as chronic osteomyelitis, and none showed bacterial infection or tumor. In treatment, non-steroid anti-inflamatory drugs (NSAIDs) is used as the first-line drug followed by steriods, methotexate (MTX), salazosulfadimidine (SASP), Bisphosphonates and TNF-α inhibitor. Two refractory cases received combination therapy with Bisphosphonates and TNF-α inhibitor, and achieved good therapeutic effect. Conclusions The present study described a multicenter series of CNO from south China and highlighted the clinical features, laboratory tests, imaging characteristics and treatment outcomes. Increasing awareness of this disease is important to decrease time to diagnosis, improve access to treatment, and reduce complications.
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title_short	Clinical characteristics and outcomes of chronic nonbacterial osteomyelitis in children: a multicenter case series
url	https://doi.org/10.1186/s12969-021-00657-4 https://doaj.org/article/80fee308fb4f45708c561573b718f680 https://doaj.org/toc/1546-0096
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author2	Haimei Liu Hanyun Tang Zhiyong Zhang Lixia Zou Haiguo Yu Li Sun Xiaozhong Li Xuemei Tang Meiping Lu
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