Mitochondrial Dysfunction and Aging: Insights from the Analysis of Extracellular Vesicles
The progressive decline of cell function and integrity, manifesting clinically as increased vulnerability to adverse outcomes and death, is core to biological aging. Mitochondrial dysfunction, oxidative stress, altered intercellular communication (including chronic low-grade inflammation), genomic i...
Ausführliche Beschreibung
Autor*in: |
Anna Picca [verfasserIn] Flora Guerra [verfasserIn] Riccardo Calvani [verfasserIn] Cecilia Bucci [verfasserIn] Maria Rita Lo Monaco [verfasserIn] Anna Rita Bentivoglio [verfasserIn] Hélio José Coelho-Júnior [verfasserIn] Francesco Landi [verfasserIn] Roberto Bernabei [verfasserIn] Emanuele Marzetti [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2019 |
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Übergeordnetes Werk: |
In: International Journal of Molecular Sciences - MDPI AG, 2003, 20(2019), 4, p 805 |
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Übergeordnetes Werk: |
volume:20 ; year:2019 ; number:4, p 805 |
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DOI / URN: |
10.3390/ijms20040805 |
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Katalog-ID: |
DOAJ072951664 |
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10.3390/ijms20040805 doi (DE-627)DOAJ072951664 (DE-599)DOAJe18ef86387594eb4951389c587ac7a4f DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Anna Picca verfasserin aut Mitochondrial Dysfunction and Aging: Insights from the Analysis of Extracellular Vesicles 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The progressive decline of cell function and integrity, manifesting clinically as increased vulnerability to adverse outcomes and death, is core to biological aging. Mitochondrial dysfunction, oxidative stress, altered intercellular communication (including chronic low-grade inflammation), genomic instability, telomere attrition, loss of proteostasis, altered nutrient sensing, epigenetic alterations, and stem cell exhaustion have been proposed as hallmarks of aging. These “aging pillars„ are not mutually exclusive, making the matter intricate and leaving numerous unanswered questions. The characterization of circulating extracellular vesicles (EVs) has recently allowed specific secretory phenotypes associated with aging to be identified. As such, EVs may serve as novel biomarkers for capturing the complexity of aging. Besides the mitochondrial⁻lysosomal axis, EV trafficking has been proposed as an additional layer in mitochondrial quality control. Indeed, disruption of the mitochondrial⁻lysosomal axis coupled with abnormal EV secretion may play a role in the pathogenesis of aging and several disease conditions. Here, we discuss (1) the mechanisms of EV generation; (2) the relationship between the mitochondrial⁻lysosomal axis and EV trafficking in the setting of mitochondrial quality control; and (3) the prospect of using EVs as aging biomarkers and as delivery systems for therapeutics against age-related conditions. biomarkers mitophagy mitochondrial biogenesis mitochondrial dynamics mitochondrial quality control mitochondrial-derived vesicles (MDVs) exosomes mitochondrial–lysosomal axis Biology (General) Chemistry Flora Guerra verfasserin aut Riccardo Calvani verfasserin aut Cecilia Bucci verfasserin aut Maria Rita Lo Monaco verfasserin aut Anna Rita Bentivoglio verfasserin aut Hélio José Coelho-Júnior verfasserin aut Francesco Landi verfasserin aut Roberto Bernabei verfasserin aut Emanuele Marzetti verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 20(2019), 4, p 805 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:20 year:2019 number:4, p 805 https://doi.org/10.3390/ijms20040805 kostenfrei https://doaj.org/article/e18ef86387594eb4951389c587ac7a4f kostenfrei https://www.mdpi.com/1422-0067/20/4/805 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019 4, p 805 |
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10.3390/ijms20040805 doi (DE-627)DOAJ072951664 (DE-599)DOAJe18ef86387594eb4951389c587ac7a4f DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Anna Picca verfasserin aut Mitochondrial Dysfunction and Aging: Insights from the Analysis of Extracellular Vesicles 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The progressive decline of cell function and integrity, manifesting clinically as increased vulnerability to adverse outcomes and death, is core to biological aging. Mitochondrial dysfunction, oxidative stress, altered intercellular communication (including chronic low-grade inflammation), genomic instability, telomere attrition, loss of proteostasis, altered nutrient sensing, epigenetic alterations, and stem cell exhaustion have been proposed as hallmarks of aging. These “aging pillars„ are not mutually exclusive, making the matter intricate and leaving numerous unanswered questions. The characterization of circulating extracellular vesicles (EVs) has recently allowed specific secretory phenotypes associated with aging to be identified. As such, EVs may serve as novel biomarkers for capturing the complexity of aging. Besides the mitochondrial⁻lysosomal axis, EV trafficking has been proposed as an additional layer in mitochondrial quality control. Indeed, disruption of the mitochondrial⁻lysosomal axis coupled with abnormal EV secretion may play a role in the pathogenesis of aging and several disease conditions. Here, we discuss (1) the mechanisms of EV generation; (2) the relationship between the mitochondrial⁻lysosomal axis and EV trafficking in the setting of mitochondrial quality control; and (3) the prospect of using EVs as aging biomarkers and as delivery systems for therapeutics against age-related conditions. biomarkers mitophagy mitochondrial biogenesis mitochondrial dynamics mitochondrial quality control mitochondrial-derived vesicles (MDVs) exosomes mitochondrial–lysosomal axis Biology (General) Chemistry Flora Guerra verfasserin aut Riccardo Calvani verfasserin aut Cecilia Bucci verfasserin aut Maria Rita Lo Monaco verfasserin aut Anna Rita Bentivoglio verfasserin aut Hélio José Coelho-Júnior verfasserin aut Francesco Landi verfasserin aut Roberto Bernabei verfasserin aut Emanuele Marzetti verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 20(2019), 4, p 805 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:20 year:2019 number:4, p 805 https://doi.org/10.3390/ijms20040805 kostenfrei https://doaj.org/article/e18ef86387594eb4951389c587ac7a4f kostenfrei https://www.mdpi.com/1422-0067/20/4/805 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019 4, p 805 |
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10.3390/ijms20040805 doi (DE-627)DOAJ072951664 (DE-599)DOAJe18ef86387594eb4951389c587ac7a4f DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Anna Picca verfasserin aut Mitochondrial Dysfunction and Aging: Insights from the Analysis of Extracellular Vesicles 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The progressive decline of cell function and integrity, manifesting clinically as increased vulnerability to adverse outcomes and death, is core to biological aging. Mitochondrial dysfunction, oxidative stress, altered intercellular communication (including chronic low-grade inflammation), genomic instability, telomere attrition, loss of proteostasis, altered nutrient sensing, epigenetic alterations, and stem cell exhaustion have been proposed as hallmarks of aging. These “aging pillars„ are not mutually exclusive, making the matter intricate and leaving numerous unanswered questions. The characterization of circulating extracellular vesicles (EVs) has recently allowed specific secretory phenotypes associated with aging to be identified. As such, EVs may serve as novel biomarkers for capturing the complexity of aging. Besides the mitochondrial⁻lysosomal axis, EV trafficking has been proposed as an additional layer in mitochondrial quality control. Indeed, disruption of the mitochondrial⁻lysosomal axis coupled with abnormal EV secretion may play a role in the pathogenesis of aging and several disease conditions. Here, we discuss (1) the mechanisms of EV generation; (2) the relationship between the mitochondrial⁻lysosomal axis and EV trafficking in the setting of mitochondrial quality control; and (3) the prospect of using EVs as aging biomarkers and as delivery systems for therapeutics against age-related conditions. biomarkers mitophagy mitochondrial biogenesis mitochondrial dynamics mitochondrial quality control mitochondrial-derived vesicles (MDVs) exosomes mitochondrial–lysosomal axis Biology (General) Chemistry Flora Guerra verfasserin aut Riccardo Calvani verfasserin aut Cecilia Bucci verfasserin aut Maria Rita Lo Monaco verfasserin aut Anna Rita Bentivoglio verfasserin aut Hélio José Coelho-Júnior verfasserin aut Francesco Landi verfasserin aut Roberto Bernabei verfasserin aut Emanuele Marzetti verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 20(2019), 4, p 805 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:20 year:2019 number:4, p 805 https://doi.org/10.3390/ijms20040805 kostenfrei https://doaj.org/article/e18ef86387594eb4951389c587ac7a4f kostenfrei https://www.mdpi.com/1422-0067/20/4/805 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019 4, p 805 |
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2019-01-01T00:00:00Z |
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Mitochondrial Dysfunction and Aging: Insights from the Analysis of Extracellular Vesicles |
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The progressive decline of cell function and integrity, manifesting clinically as increased vulnerability to adverse outcomes and death, is core to biological aging. Mitochondrial dysfunction, oxidative stress, altered intercellular communication (including chronic low-grade inflammation), genomic instability, telomere attrition, loss of proteostasis, altered nutrient sensing, epigenetic alterations, and stem cell exhaustion have been proposed as hallmarks of aging. These “aging pillars„ are not mutually exclusive, making the matter intricate and leaving numerous unanswered questions. The characterization of circulating extracellular vesicles (EVs) has recently allowed specific secretory phenotypes associated with aging to be identified. As such, EVs may serve as novel biomarkers for capturing the complexity of aging. Besides the mitochondrial⁻lysosomal axis, EV trafficking has been proposed as an additional layer in mitochondrial quality control. Indeed, disruption of the mitochondrial⁻lysosomal axis coupled with abnormal EV secretion may play a role in the pathogenesis of aging and several disease conditions. Here, we discuss (1) the mechanisms of EV generation; (2) the relationship between the mitochondrial⁻lysosomal axis and EV trafficking in the setting of mitochondrial quality control; and (3) the prospect of using EVs as aging biomarkers and as delivery systems for therapeutics against age-related conditions. |
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The progressive decline of cell function and integrity, manifesting clinically as increased vulnerability to adverse outcomes and death, is core to biological aging. Mitochondrial dysfunction, oxidative stress, altered intercellular communication (including chronic low-grade inflammation), genomic instability, telomere attrition, loss of proteostasis, altered nutrient sensing, epigenetic alterations, and stem cell exhaustion have been proposed as hallmarks of aging. These “aging pillars„ are not mutually exclusive, making the matter intricate and leaving numerous unanswered questions. The characterization of circulating extracellular vesicles (EVs) has recently allowed specific secretory phenotypes associated with aging to be identified. As such, EVs may serve as novel biomarkers for capturing the complexity of aging. Besides the mitochondrial⁻lysosomal axis, EV trafficking has been proposed as an additional layer in mitochondrial quality control. Indeed, disruption of the mitochondrial⁻lysosomal axis coupled with abnormal EV secretion may play a role in the pathogenesis of aging and several disease conditions. Here, we discuss (1) the mechanisms of EV generation; (2) the relationship between the mitochondrial⁻lysosomal axis and EV trafficking in the setting of mitochondrial quality control; and (3) the prospect of using EVs as aging biomarkers and as delivery systems for therapeutics against age-related conditions. |
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The progressive decline of cell function and integrity, manifesting clinically as increased vulnerability to adverse outcomes and death, is core to biological aging. Mitochondrial dysfunction, oxidative stress, altered intercellular communication (including chronic low-grade inflammation), genomic instability, telomere attrition, loss of proteostasis, altered nutrient sensing, epigenetic alterations, and stem cell exhaustion have been proposed as hallmarks of aging. These “aging pillars„ are not mutually exclusive, making the matter intricate and leaving numerous unanswered questions. The characterization of circulating extracellular vesicles (EVs) has recently allowed specific secretory phenotypes associated with aging to be identified. As such, EVs may serve as novel biomarkers for capturing the complexity of aging. Besides the mitochondrial⁻lysosomal axis, EV trafficking has been proposed as an additional layer in mitochondrial quality control. Indeed, disruption of the mitochondrial⁻lysosomal axis coupled with abnormal EV secretion may play a role in the pathogenesis of aging and several disease conditions. Here, we discuss (1) the mechanisms of EV generation; (2) the relationship between the mitochondrial⁻lysosomal axis and EV trafficking in the setting of mitochondrial quality control; and (3) the prospect of using EVs as aging biomarkers and as delivery systems for therapeutics against age-related conditions. |
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