Postponing tumor onset and tumor progression can be achieved by alteration of local tumor immunity
Abstract Background It has been known for years that the same genetic defects drive breast cancer formation, yet, the onset of breast cancer in different individuals among the same population differs greatly in their life spans with unknown mechanisms. Methods We used a MMTV-PyMT mouse model with di...
Ausführliche Beschreibung
Autor*in: |
Yan Mei [verfasserIn] Mingdian Wang [verfasserIn] Guanming Lu [verfasserIn] Jiangchao Li [verfasserIn] Lixia Peng [verfasserIn] Yanhong Lang [verfasserIn] Mingming Yang [verfasserIn] Lingbi Jiang [verfasserIn] Changzhi Li [verfasserIn] Lisheng Zheng [verfasserIn] Zhijie Liu [verfasserIn] Dehuan Xie [verfasserIn] Lingling Guo [verfasserIn] Bijun Huang [verfasserIn] Musheng Zeng [verfasserIn] Yanxia Shi [verfasserIn] Chaonan Qian [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2021 |
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In: Cancer Cell International - BMC, 2003, 21(2021), 1, Seite 12 |
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Übergeordnetes Werk: |
volume:21 ; year:2021 ; number:1 ; pages:12 |
Links: |
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DOI / URN: |
10.1186/s12935-021-01765-7 |
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Katalog-ID: |
DOAJ072964057 |
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520 | |a Abstract Background It has been known for years that the same genetic defects drive breast cancer formation, yet, the onset of breast cancer in different individuals among the same population differs greatly in their life spans with unknown mechanisms. Methods We used a MMTV-PyMT mouse model with different genetic backgrounds (FVB/NJ vs. C57BL/6J) to generate different cancer onset phenotypes, then profiled and analyzed the gene expression of three tumor stages in both Fvb.B6 and Fvb mice to explore the underlying mechanisms. Results We found that in contrast with the FVB/N-Tg (MMTV-PyMT) 634Mul mice (Fvb mice), mammary tumor initiation was significantly delayed and tumor progression was significantly suppressed in the Fvb.B6 mice (generated by crossing FVB/NJ with C57BL/6J mice). Transcriptome sequencing and analysis revealed that the differentially expressed genes were enriched in immune-related pathways. Flow cytometry analysis showed a higher proportion of matured dendritic cells in the Fvb.B6 mice. The plasma levels of interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) were significantly reduced in the Fvb.B6 mice. IL-6 also impaired the maturation of bone marrow dendritic cells (BMDCs) of the Fvb mice in vitro. Conclusion All these findings suggest that immunity levels (characterized by a reduced IL-6 level and intact DC maturation in Fvb.B6 mice) are the key factors affecting tumor onset in a murine mammary cancer model. | ||
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650 | 4 | |a PyMT mouse model | |
650 | 4 | |a Dendritic cells | |
650 | 4 | |a IL-6 | |
650 | 4 | |a Angiogenesis | |
650 | 4 | |a VEGF | |
653 | 0 | |a Neoplasms. Tumors. Oncology. Including cancer and carcinogens | |
653 | 0 | |a Cytology | |
700 | 0 | |a Mingdian Wang |e verfasserin |4 aut | |
700 | 0 | |a Guanming Lu |e verfasserin |4 aut | |
700 | 0 | |a Jiangchao Li |e verfasserin |4 aut | |
700 | 0 | |a Lixia Peng |e verfasserin |4 aut | |
700 | 0 | |a Yanhong Lang |e verfasserin |4 aut | |
700 | 0 | |a Mingming Yang |e verfasserin |4 aut | |
700 | 0 | |a Lingbi Jiang |e verfasserin |4 aut | |
700 | 0 | |a Changzhi Li |e verfasserin |4 aut | |
700 | 0 | |a Lisheng Zheng |e verfasserin |4 aut | |
700 | 0 | |a Zhijie Liu |e verfasserin |4 aut | |
700 | 0 | |a Dehuan Xie |e verfasserin |4 aut | |
700 | 0 | |a Lingling Guo |e verfasserin |4 aut | |
700 | 0 | |a Bijun Huang |e verfasserin |4 aut | |
700 | 0 | |a Musheng Zeng |e verfasserin |4 aut | |
700 | 0 | |a Yanxia Shi |e verfasserin |4 aut | |
700 | 0 | |a Chaonan Qian |e verfasserin |4 aut | |
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10.1186/s12935-021-01765-7 doi (DE-627)DOAJ072964057 (DE-599)DOAJ2234d91dc3164dd3b32b1e93af50f67e DE-627 ger DE-627 rakwb eng RC254-282 QH573-671 Yan Mei verfasserin aut Postponing tumor onset and tumor progression can be achieved by alteration of local tumor immunity 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background It has been known for years that the same genetic defects drive breast cancer formation, yet, the onset of breast cancer in different individuals among the same population differs greatly in their life spans with unknown mechanisms. Methods We used a MMTV-PyMT mouse model with different genetic backgrounds (FVB/NJ vs. C57BL/6J) to generate different cancer onset phenotypes, then profiled and analyzed the gene expression of three tumor stages in both Fvb.B6 and Fvb mice to explore the underlying mechanisms. Results We found that in contrast with the FVB/N-Tg (MMTV-PyMT) 634Mul mice (Fvb mice), mammary tumor initiation was significantly delayed and tumor progression was significantly suppressed in the Fvb.B6 mice (generated by crossing FVB/NJ with C57BL/6J mice). Transcriptome sequencing and analysis revealed that the differentially expressed genes were enriched in immune-related pathways. Flow cytometry analysis showed a higher proportion of matured dendritic cells in the Fvb.B6 mice. The plasma levels of interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) were significantly reduced in the Fvb.B6 mice. IL-6 also impaired the maturation of bone marrow dendritic cells (BMDCs) of the Fvb mice in vitro. Conclusion All these findings suggest that immunity levels (characterized by a reduced IL-6 level and intact DC maturation in Fvb.B6 mice) are the key factors affecting tumor onset in a murine mammary cancer model. Breast cancer PyMT mouse model Dendritic cells IL-6 Angiogenesis VEGF Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cytology Mingdian Wang verfasserin aut Guanming Lu verfasserin aut Jiangchao Li verfasserin aut Lixia Peng verfasserin aut Yanhong Lang verfasserin aut Mingming Yang verfasserin aut Lingbi Jiang verfasserin aut Changzhi Li verfasserin aut Lisheng Zheng verfasserin aut Zhijie Liu verfasserin aut Dehuan Xie verfasserin aut Lingling Guo verfasserin aut Bijun Huang verfasserin aut Musheng Zeng verfasserin aut Yanxia Shi verfasserin aut Chaonan Qian verfasserin aut In Cancer Cell International BMC, 2003 21(2021), 1, Seite 12 (DE-627)355989204 (DE-600)2091573-1 14752867 nnns volume:21 year:2021 number:1 pages:12 https://doi.org/10.1186/s12935-021-01765-7 kostenfrei https://doaj.org/article/2234d91dc3164dd3b32b1e93af50f67e kostenfrei https://doi.org/10.1186/s12935-021-01765-7 kostenfrei https://doaj.org/toc/1475-2867 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2021 1 12 |
spelling |
10.1186/s12935-021-01765-7 doi (DE-627)DOAJ072964057 (DE-599)DOAJ2234d91dc3164dd3b32b1e93af50f67e DE-627 ger DE-627 rakwb eng RC254-282 QH573-671 Yan Mei verfasserin aut Postponing tumor onset and tumor progression can be achieved by alteration of local tumor immunity 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background It has been known for years that the same genetic defects drive breast cancer formation, yet, the onset of breast cancer in different individuals among the same population differs greatly in their life spans with unknown mechanisms. Methods We used a MMTV-PyMT mouse model with different genetic backgrounds (FVB/NJ vs. C57BL/6J) to generate different cancer onset phenotypes, then profiled and analyzed the gene expression of three tumor stages in both Fvb.B6 and Fvb mice to explore the underlying mechanisms. Results We found that in contrast with the FVB/N-Tg (MMTV-PyMT) 634Mul mice (Fvb mice), mammary tumor initiation was significantly delayed and tumor progression was significantly suppressed in the Fvb.B6 mice (generated by crossing FVB/NJ with C57BL/6J mice). Transcriptome sequencing and analysis revealed that the differentially expressed genes were enriched in immune-related pathways. Flow cytometry analysis showed a higher proportion of matured dendritic cells in the Fvb.B6 mice. The plasma levels of interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) were significantly reduced in the Fvb.B6 mice. IL-6 also impaired the maturation of bone marrow dendritic cells (BMDCs) of the Fvb mice in vitro. Conclusion All these findings suggest that immunity levels (characterized by a reduced IL-6 level and intact DC maturation in Fvb.B6 mice) are the key factors affecting tumor onset in a murine mammary cancer model. Breast cancer PyMT mouse model Dendritic cells IL-6 Angiogenesis VEGF Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cytology Mingdian Wang verfasserin aut Guanming Lu verfasserin aut Jiangchao Li verfasserin aut Lixia Peng verfasserin aut Yanhong Lang verfasserin aut Mingming Yang verfasserin aut Lingbi Jiang verfasserin aut Changzhi Li verfasserin aut Lisheng Zheng verfasserin aut Zhijie Liu verfasserin aut Dehuan Xie verfasserin aut Lingling Guo verfasserin aut Bijun Huang verfasserin aut Musheng Zeng verfasserin aut Yanxia Shi verfasserin aut Chaonan Qian verfasserin aut In Cancer Cell International BMC, 2003 21(2021), 1, Seite 12 (DE-627)355989204 (DE-600)2091573-1 14752867 nnns volume:21 year:2021 number:1 pages:12 https://doi.org/10.1186/s12935-021-01765-7 kostenfrei https://doaj.org/article/2234d91dc3164dd3b32b1e93af50f67e kostenfrei https://doi.org/10.1186/s12935-021-01765-7 kostenfrei https://doaj.org/toc/1475-2867 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2021 1 12 |
allfields_unstemmed |
10.1186/s12935-021-01765-7 doi (DE-627)DOAJ072964057 (DE-599)DOAJ2234d91dc3164dd3b32b1e93af50f67e DE-627 ger DE-627 rakwb eng RC254-282 QH573-671 Yan Mei verfasserin aut Postponing tumor onset and tumor progression can be achieved by alteration of local tumor immunity 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background It has been known for years that the same genetic defects drive breast cancer formation, yet, the onset of breast cancer in different individuals among the same population differs greatly in their life spans with unknown mechanisms. Methods We used a MMTV-PyMT mouse model with different genetic backgrounds (FVB/NJ vs. C57BL/6J) to generate different cancer onset phenotypes, then profiled and analyzed the gene expression of three tumor stages in both Fvb.B6 and Fvb mice to explore the underlying mechanisms. Results We found that in contrast with the FVB/N-Tg (MMTV-PyMT) 634Mul mice (Fvb mice), mammary tumor initiation was significantly delayed and tumor progression was significantly suppressed in the Fvb.B6 mice (generated by crossing FVB/NJ with C57BL/6J mice). Transcriptome sequencing and analysis revealed that the differentially expressed genes were enriched in immune-related pathways. Flow cytometry analysis showed a higher proportion of matured dendritic cells in the Fvb.B6 mice. The plasma levels of interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) were significantly reduced in the Fvb.B6 mice. IL-6 also impaired the maturation of bone marrow dendritic cells (BMDCs) of the Fvb mice in vitro. Conclusion All these findings suggest that immunity levels (characterized by a reduced IL-6 level and intact DC maturation in Fvb.B6 mice) are the key factors affecting tumor onset in a murine mammary cancer model. Breast cancer PyMT mouse model Dendritic cells IL-6 Angiogenesis VEGF Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cytology Mingdian Wang verfasserin aut Guanming Lu verfasserin aut Jiangchao Li verfasserin aut Lixia Peng verfasserin aut Yanhong Lang verfasserin aut Mingming Yang verfasserin aut Lingbi Jiang verfasserin aut Changzhi Li verfasserin aut Lisheng Zheng verfasserin aut Zhijie Liu verfasserin aut Dehuan Xie verfasserin aut Lingling Guo verfasserin aut Bijun Huang verfasserin aut Musheng Zeng verfasserin aut Yanxia Shi verfasserin aut Chaonan Qian verfasserin aut In Cancer Cell International BMC, 2003 21(2021), 1, Seite 12 (DE-627)355989204 (DE-600)2091573-1 14752867 nnns volume:21 year:2021 number:1 pages:12 https://doi.org/10.1186/s12935-021-01765-7 kostenfrei https://doaj.org/article/2234d91dc3164dd3b32b1e93af50f67e kostenfrei https://doi.org/10.1186/s12935-021-01765-7 kostenfrei https://doaj.org/toc/1475-2867 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2021 1 12 |
allfieldsGer |
10.1186/s12935-021-01765-7 doi (DE-627)DOAJ072964057 (DE-599)DOAJ2234d91dc3164dd3b32b1e93af50f67e DE-627 ger DE-627 rakwb eng RC254-282 QH573-671 Yan Mei verfasserin aut Postponing tumor onset and tumor progression can be achieved by alteration of local tumor immunity 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background It has been known for years that the same genetic defects drive breast cancer formation, yet, the onset of breast cancer in different individuals among the same population differs greatly in their life spans with unknown mechanisms. Methods We used a MMTV-PyMT mouse model with different genetic backgrounds (FVB/NJ vs. C57BL/6J) to generate different cancer onset phenotypes, then profiled and analyzed the gene expression of three tumor stages in both Fvb.B6 and Fvb mice to explore the underlying mechanisms. Results We found that in contrast with the FVB/N-Tg (MMTV-PyMT) 634Mul mice (Fvb mice), mammary tumor initiation was significantly delayed and tumor progression was significantly suppressed in the Fvb.B6 mice (generated by crossing FVB/NJ with C57BL/6J mice). Transcriptome sequencing and analysis revealed that the differentially expressed genes were enriched in immune-related pathways. Flow cytometry analysis showed a higher proportion of matured dendritic cells in the Fvb.B6 mice. The plasma levels of interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) were significantly reduced in the Fvb.B6 mice. IL-6 also impaired the maturation of bone marrow dendritic cells (BMDCs) of the Fvb mice in vitro. Conclusion All these findings suggest that immunity levels (characterized by a reduced IL-6 level and intact DC maturation in Fvb.B6 mice) are the key factors affecting tumor onset in a murine mammary cancer model. Breast cancer PyMT mouse model Dendritic cells IL-6 Angiogenesis VEGF Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cytology Mingdian Wang verfasserin aut Guanming Lu verfasserin aut Jiangchao Li verfasserin aut Lixia Peng verfasserin aut Yanhong Lang verfasserin aut Mingming Yang verfasserin aut Lingbi Jiang verfasserin aut Changzhi Li verfasserin aut Lisheng Zheng verfasserin aut Zhijie Liu verfasserin aut Dehuan Xie verfasserin aut Lingling Guo verfasserin aut Bijun Huang verfasserin aut Musheng Zeng verfasserin aut Yanxia Shi verfasserin aut Chaonan Qian verfasserin aut In Cancer Cell International BMC, 2003 21(2021), 1, Seite 12 (DE-627)355989204 (DE-600)2091573-1 14752867 nnns volume:21 year:2021 number:1 pages:12 https://doi.org/10.1186/s12935-021-01765-7 kostenfrei https://doaj.org/article/2234d91dc3164dd3b32b1e93af50f67e kostenfrei https://doi.org/10.1186/s12935-021-01765-7 kostenfrei https://doaj.org/toc/1475-2867 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2021 1 12 |
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10.1186/s12935-021-01765-7 doi (DE-627)DOAJ072964057 (DE-599)DOAJ2234d91dc3164dd3b32b1e93af50f67e DE-627 ger DE-627 rakwb eng RC254-282 QH573-671 Yan Mei verfasserin aut Postponing tumor onset and tumor progression can be achieved by alteration of local tumor immunity 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background It has been known for years that the same genetic defects drive breast cancer formation, yet, the onset of breast cancer in different individuals among the same population differs greatly in their life spans with unknown mechanisms. Methods We used a MMTV-PyMT mouse model with different genetic backgrounds (FVB/NJ vs. C57BL/6J) to generate different cancer onset phenotypes, then profiled and analyzed the gene expression of three tumor stages in both Fvb.B6 and Fvb mice to explore the underlying mechanisms. Results We found that in contrast with the FVB/N-Tg (MMTV-PyMT) 634Mul mice (Fvb mice), mammary tumor initiation was significantly delayed and tumor progression was significantly suppressed in the Fvb.B6 mice (generated by crossing FVB/NJ with C57BL/6J mice). Transcriptome sequencing and analysis revealed that the differentially expressed genes were enriched in immune-related pathways. Flow cytometry analysis showed a higher proportion of matured dendritic cells in the Fvb.B6 mice. The plasma levels of interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) were significantly reduced in the Fvb.B6 mice. IL-6 also impaired the maturation of bone marrow dendritic cells (BMDCs) of the Fvb mice in vitro. Conclusion All these findings suggest that immunity levels (characterized by a reduced IL-6 level and intact DC maturation in Fvb.B6 mice) are the key factors affecting tumor onset in a murine mammary cancer model. Breast cancer PyMT mouse model Dendritic cells IL-6 Angiogenesis VEGF Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cytology Mingdian Wang verfasserin aut Guanming Lu verfasserin aut Jiangchao Li verfasserin aut Lixia Peng verfasserin aut Yanhong Lang verfasserin aut Mingming Yang verfasserin aut Lingbi Jiang verfasserin aut Changzhi Li verfasserin aut Lisheng Zheng verfasserin aut Zhijie Liu verfasserin aut Dehuan Xie verfasserin aut Lingling Guo verfasserin aut Bijun Huang verfasserin aut Musheng Zeng verfasserin aut Yanxia Shi verfasserin aut Chaonan Qian verfasserin aut In Cancer Cell International BMC, 2003 21(2021), 1, Seite 12 (DE-627)355989204 (DE-600)2091573-1 14752867 nnns volume:21 year:2021 number:1 pages:12 https://doi.org/10.1186/s12935-021-01765-7 kostenfrei https://doaj.org/article/2234d91dc3164dd3b32b1e93af50f67e kostenfrei https://doi.org/10.1186/s12935-021-01765-7 kostenfrei https://doaj.org/toc/1475-2867 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2021 1 12 |
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Postponing tumor onset and tumor progression can be achieved by alteration of local tumor immunity |
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Yan Mei Mingdian Wang Guanming Lu Jiangchao Li Lixia Peng Yanhong Lang Mingming Yang Lingbi Jiang Changzhi Li Lisheng Zheng Zhijie Liu Dehuan Xie Lingling Guo Bijun Huang Musheng Zeng Yanxia Shi Chaonan Qian |
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postponing tumor onset and tumor progression can be achieved by alteration of local tumor immunity |
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Postponing tumor onset and tumor progression can be achieved by alteration of local tumor immunity |
abstract |
Abstract Background It has been known for years that the same genetic defects drive breast cancer formation, yet, the onset of breast cancer in different individuals among the same population differs greatly in their life spans with unknown mechanisms. Methods We used a MMTV-PyMT mouse model with different genetic backgrounds (FVB/NJ vs. C57BL/6J) to generate different cancer onset phenotypes, then profiled and analyzed the gene expression of three tumor stages in both Fvb.B6 and Fvb mice to explore the underlying mechanisms. Results We found that in contrast with the FVB/N-Tg (MMTV-PyMT) 634Mul mice (Fvb mice), mammary tumor initiation was significantly delayed and tumor progression was significantly suppressed in the Fvb.B6 mice (generated by crossing FVB/NJ with C57BL/6J mice). Transcriptome sequencing and analysis revealed that the differentially expressed genes were enriched in immune-related pathways. Flow cytometry analysis showed a higher proportion of matured dendritic cells in the Fvb.B6 mice. The plasma levels of interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) were significantly reduced in the Fvb.B6 mice. IL-6 also impaired the maturation of bone marrow dendritic cells (BMDCs) of the Fvb mice in vitro. Conclusion All these findings suggest that immunity levels (characterized by a reduced IL-6 level and intact DC maturation in Fvb.B6 mice) are the key factors affecting tumor onset in a murine mammary cancer model. |
abstractGer |
Abstract Background It has been known for years that the same genetic defects drive breast cancer formation, yet, the onset of breast cancer in different individuals among the same population differs greatly in their life spans with unknown mechanisms. Methods We used a MMTV-PyMT mouse model with different genetic backgrounds (FVB/NJ vs. C57BL/6J) to generate different cancer onset phenotypes, then profiled and analyzed the gene expression of three tumor stages in both Fvb.B6 and Fvb mice to explore the underlying mechanisms. Results We found that in contrast with the FVB/N-Tg (MMTV-PyMT) 634Mul mice (Fvb mice), mammary tumor initiation was significantly delayed and tumor progression was significantly suppressed in the Fvb.B6 mice (generated by crossing FVB/NJ with C57BL/6J mice). Transcriptome sequencing and analysis revealed that the differentially expressed genes were enriched in immune-related pathways. Flow cytometry analysis showed a higher proportion of matured dendritic cells in the Fvb.B6 mice. The plasma levels of interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) were significantly reduced in the Fvb.B6 mice. IL-6 also impaired the maturation of bone marrow dendritic cells (BMDCs) of the Fvb mice in vitro. Conclusion All these findings suggest that immunity levels (characterized by a reduced IL-6 level and intact DC maturation in Fvb.B6 mice) are the key factors affecting tumor onset in a murine mammary cancer model. |
abstract_unstemmed |
Abstract Background It has been known for years that the same genetic defects drive breast cancer formation, yet, the onset of breast cancer in different individuals among the same population differs greatly in their life spans with unknown mechanisms. Methods We used a MMTV-PyMT mouse model with different genetic backgrounds (FVB/NJ vs. C57BL/6J) to generate different cancer onset phenotypes, then profiled and analyzed the gene expression of three tumor stages in both Fvb.B6 and Fvb mice to explore the underlying mechanisms. Results We found that in contrast with the FVB/N-Tg (MMTV-PyMT) 634Mul mice (Fvb mice), mammary tumor initiation was significantly delayed and tumor progression was significantly suppressed in the Fvb.B6 mice (generated by crossing FVB/NJ with C57BL/6J mice). Transcriptome sequencing and analysis revealed that the differentially expressed genes were enriched in immune-related pathways. Flow cytometry analysis showed a higher proportion of matured dendritic cells in the Fvb.B6 mice. The plasma levels of interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) were significantly reduced in the Fvb.B6 mice. IL-6 also impaired the maturation of bone marrow dendritic cells (BMDCs) of the Fvb mice in vitro. Conclusion All these findings suggest that immunity levels (characterized by a reduced IL-6 level and intact DC maturation in Fvb.B6 mice) are the key factors affecting tumor onset in a murine mammary cancer model. |
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Postponing tumor onset and tumor progression can be achieved by alteration of local tumor immunity |
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https://doi.org/10.1186/s12935-021-01765-7 https://doaj.org/article/2234d91dc3164dd3b32b1e93af50f67e https://doaj.org/toc/1475-2867 |
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Mingdian Wang Guanming Lu Jiangchao Li Lixia Peng Yanhong Lang Mingming Yang Lingbi Jiang Changzhi Li Lisheng Zheng Zhijie Liu Dehuan Xie Lingling Guo Bijun Huang Musheng Zeng Yanxia Shi Chaonan Qian |
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Mingdian Wang Guanming Lu Jiangchao Li Lixia Peng Yanhong Lang Mingming Yang Lingbi Jiang Changzhi Li Lisheng Zheng Zhijie Liu Dehuan Xie Lingling Guo Bijun Huang Musheng Zeng Yanxia Shi Chaonan Qian |
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