The evidence for increased L1 activity in the site of human adult brain neurogenesis.
Retroelement activity is a common source of polymorphisms in human genome. The mechanism whereby retroelements contribute to the intraindividual genetic heterogeneity by inserting into the DNA of somatic cells is gaining increasing attention. Brain tissues are suspected to accumulate genetic heterog...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Alexey A Kurnosov [verfasserIn] Svetlana V Ustyugova [verfasserIn] Vadim I Nazarov [verfasserIn] Anastasia A Minervina [verfasserIn] Alexander Yu Komkov [verfasserIn] Mikhail Shugay [verfasserIn] Mikhail V Pogorelyy [verfasserIn] Konstantin V Khodosevich [verfasserIn] Ilgar Z Mamedov [verfasserIn] Yuri B Lebedev [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Übergeordnetes Werk: |
In: PLoS ONE - Public Library of Science (PLoS), 2007, 10(2015), 2, p e0117854 |
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| Übergeordnetes Werk: |
volume:10 ; year:2015 ; number:2, p e0117854 |
| Links: |
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| DOI / URN: |
10.1371/journal.pone.0117854 |
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DOAJ073040754 |
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10.1371/journal.pone.0117854 doi (DE-627)DOAJ073040754 (DE-599)DOAJ561520f0c2dc4361b08872ccaa5b61b7 DE-627 ger DE-627 rakwb eng Alexey A Kurnosov verfasserin aut The evidence for increased L1 activity in the site of human adult brain neurogenesis. 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Retroelement activity is a common source of polymorphisms in human genome. The mechanism whereby retroelements contribute to the intraindividual genetic heterogeneity by inserting into the DNA of somatic cells is gaining increasing attention. Brain tissues are suspected to accumulate genetic heterogeneity as a result of the retroelements somatic activity. This study aims to expand our understanding of the role retroelements play in generating somatic mosaicism of neural tissues. Whole-genome Alu and L1 profiling of genomic DNA extracted from the cerebellum, frontal cortex, subventricular zone, dentate gyrus, and the myocardium revealed hundreds of somatic insertions in each of the analyzed tissues. Interestingly, the highest concentration of such insertions was detected in the dentate gyrus-the hotspot of adult neurogenesis. Insertions of retroelements and their activity could produce genetically diverse neuronal subsets, which can be involved in hippocampal-dependent learning and memory. Medicine R Science Q Svetlana V Ustyugova verfasserin aut Vadim I Nazarov verfasserin aut Anastasia A Minervina verfasserin aut Alexander Yu Komkov verfasserin aut Mikhail Shugay verfasserin aut Mikhail V Pogorelyy verfasserin aut Konstantin V Khodosevich verfasserin aut Ilgar Z Mamedov verfasserin aut Yuri B Lebedev verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 10(2015), 2, p e0117854 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:10 year:2015 number:2, p e0117854 https://doi.org/10.1371/journal.pone.0117854 kostenfrei https://doaj.org/article/561520f0c2dc4361b08872ccaa5b61b7 kostenfrei http://europepmc.org/articles/PMC4331437?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2015 2, p e0117854 |
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10.1371/journal.pone.0117854 doi (DE-627)DOAJ073040754 (DE-599)DOAJ561520f0c2dc4361b08872ccaa5b61b7 DE-627 ger DE-627 rakwb eng Alexey A Kurnosov verfasserin aut The evidence for increased L1 activity in the site of human adult brain neurogenesis. 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Retroelement activity is a common source of polymorphisms in human genome. The mechanism whereby retroelements contribute to the intraindividual genetic heterogeneity by inserting into the DNA of somatic cells is gaining increasing attention. Brain tissues are suspected to accumulate genetic heterogeneity as a result of the retroelements somatic activity. This study aims to expand our understanding of the role retroelements play in generating somatic mosaicism of neural tissues. Whole-genome Alu and L1 profiling of genomic DNA extracted from the cerebellum, frontal cortex, subventricular zone, dentate gyrus, and the myocardium revealed hundreds of somatic insertions in each of the analyzed tissues. Interestingly, the highest concentration of such insertions was detected in the dentate gyrus-the hotspot of adult neurogenesis. Insertions of retroelements and their activity could produce genetically diverse neuronal subsets, which can be involved in hippocampal-dependent learning and memory. Medicine R Science Q Svetlana V Ustyugova verfasserin aut Vadim I Nazarov verfasserin aut Anastasia A Minervina verfasserin aut Alexander Yu Komkov verfasserin aut Mikhail Shugay verfasserin aut Mikhail V Pogorelyy verfasserin aut Konstantin V Khodosevich verfasserin aut Ilgar Z Mamedov verfasserin aut Yuri B Lebedev verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 10(2015), 2, p e0117854 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:10 year:2015 number:2, p e0117854 https://doi.org/10.1371/journal.pone.0117854 kostenfrei https://doaj.org/article/561520f0c2dc4361b08872ccaa5b61b7 kostenfrei http://europepmc.org/articles/PMC4331437?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2015 2, p e0117854 |
| allfields_unstemmed |
10.1371/journal.pone.0117854 doi (DE-627)DOAJ073040754 (DE-599)DOAJ561520f0c2dc4361b08872ccaa5b61b7 DE-627 ger DE-627 rakwb eng Alexey A Kurnosov verfasserin aut The evidence for increased L1 activity in the site of human adult brain neurogenesis. 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Retroelement activity is a common source of polymorphisms in human genome. The mechanism whereby retroelements contribute to the intraindividual genetic heterogeneity by inserting into the DNA of somatic cells is gaining increasing attention. Brain tissues are suspected to accumulate genetic heterogeneity as a result of the retroelements somatic activity. This study aims to expand our understanding of the role retroelements play in generating somatic mosaicism of neural tissues. Whole-genome Alu and L1 profiling of genomic DNA extracted from the cerebellum, frontal cortex, subventricular zone, dentate gyrus, and the myocardium revealed hundreds of somatic insertions in each of the analyzed tissues. Interestingly, the highest concentration of such insertions was detected in the dentate gyrus-the hotspot of adult neurogenesis. Insertions of retroelements and their activity could produce genetically diverse neuronal subsets, which can be involved in hippocampal-dependent learning and memory. Medicine R Science Q Svetlana V Ustyugova verfasserin aut Vadim I Nazarov verfasserin aut Anastasia A Minervina verfasserin aut Alexander Yu Komkov verfasserin aut Mikhail Shugay verfasserin aut Mikhail V Pogorelyy verfasserin aut Konstantin V Khodosevich verfasserin aut Ilgar Z Mamedov verfasserin aut Yuri B Lebedev verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 10(2015), 2, p e0117854 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:10 year:2015 number:2, p e0117854 https://doi.org/10.1371/journal.pone.0117854 kostenfrei https://doaj.org/article/561520f0c2dc4361b08872ccaa5b61b7 kostenfrei http://europepmc.org/articles/PMC4331437?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2015 2, p e0117854 |
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10.1371/journal.pone.0117854 doi (DE-627)DOAJ073040754 (DE-599)DOAJ561520f0c2dc4361b08872ccaa5b61b7 DE-627 ger DE-627 rakwb eng Alexey A Kurnosov verfasserin aut The evidence for increased L1 activity in the site of human adult brain neurogenesis. 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Retroelement activity is a common source of polymorphisms in human genome. The mechanism whereby retroelements contribute to the intraindividual genetic heterogeneity by inserting into the DNA of somatic cells is gaining increasing attention. Brain tissues are suspected to accumulate genetic heterogeneity as a result of the retroelements somatic activity. This study aims to expand our understanding of the role retroelements play in generating somatic mosaicism of neural tissues. Whole-genome Alu and L1 profiling of genomic DNA extracted from the cerebellum, frontal cortex, subventricular zone, dentate gyrus, and the myocardium revealed hundreds of somatic insertions in each of the analyzed tissues. Interestingly, the highest concentration of such insertions was detected in the dentate gyrus-the hotspot of adult neurogenesis. Insertions of retroelements and their activity could produce genetically diverse neuronal subsets, which can be involved in hippocampal-dependent learning and memory. Medicine R Science Q Svetlana V Ustyugova verfasserin aut Vadim I Nazarov verfasserin aut Anastasia A Minervina verfasserin aut Alexander Yu Komkov verfasserin aut Mikhail Shugay verfasserin aut Mikhail V Pogorelyy verfasserin aut Konstantin V Khodosevich verfasserin aut Ilgar Z Mamedov verfasserin aut Yuri B Lebedev verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 10(2015), 2, p e0117854 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:10 year:2015 number:2, p e0117854 https://doi.org/10.1371/journal.pone.0117854 kostenfrei https://doaj.org/article/561520f0c2dc4361b08872ccaa5b61b7 kostenfrei http://europepmc.org/articles/PMC4331437?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2015 2, p e0117854 |
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The evidence for increased L1 activity in the site of human adult brain neurogenesis |
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Alexey A Kurnosov |
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Alexey A Kurnosov Svetlana V Ustyugova Vadim I Nazarov Anastasia A Minervina Alexander Yu Komkov Mikhail Shugay Mikhail V Pogorelyy Konstantin V Khodosevich Ilgar Z Mamedov Yuri B Lebedev |
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Alexey A Kurnosov |
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evidence for increased l1 activity in the site of human adult brain neurogenesis |
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The evidence for increased L1 activity in the site of human adult brain neurogenesis. |
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Retroelement activity is a common source of polymorphisms in human genome. The mechanism whereby retroelements contribute to the intraindividual genetic heterogeneity by inserting into the DNA of somatic cells is gaining increasing attention. Brain tissues are suspected to accumulate genetic heterogeneity as a result of the retroelements somatic activity. This study aims to expand our understanding of the role retroelements play in generating somatic mosaicism of neural tissues. Whole-genome Alu and L1 profiling of genomic DNA extracted from the cerebellum, frontal cortex, subventricular zone, dentate gyrus, and the myocardium revealed hundreds of somatic insertions in each of the analyzed tissues. Interestingly, the highest concentration of such insertions was detected in the dentate gyrus-the hotspot of adult neurogenesis. Insertions of retroelements and their activity could produce genetically diverse neuronal subsets, which can be involved in hippocampal-dependent learning and memory. |
| abstractGer |
Retroelement activity is a common source of polymorphisms in human genome. The mechanism whereby retroelements contribute to the intraindividual genetic heterogeneity by inserting into the DNA of somatic cells is gaining increasing attention. Brain tissues are suspected to accumulate genetic heterogeneity as a result of the retroelements somatic activity. This study aims to expand our understanding of the role retroelements play in generating somatic mosaicism of neural tissues. Whole-genome Alu and L1 profiling of genomic DNA extracted from the cerebellum, frontal cortex, subventricular zone, dentate gyrus, and the myocardium revealed hundreds of somatic insertions in each of the analyzed tissues. Interestingly, the highest concentration of such insertions was detected in the dentate gyrus-the hotspot of adult neurogenesis. Insertions of retroelements and their activity could produce genetically diverse neuronal subsets, which can be involved in hippocampal-dependent learning and memory. |
| abstract_unstemmed |
Retroelement activity is a common source of polymorphisms in human genome. The mechanism whereby retroelements contribute to the intraindividual genetic heterogeneity by inserting into the DNA of somatic cells is gaining increasing attention. Brain tissues are suspected to accumulate genetic heterogeneity as a result of the retroelements somatic activity. This study aims to expand our understanding of the role retroelements play in generating somatic mosaicism of neural tissues. Whole-genome Alu and L1 profiling of genomic DNA extracted from the cerebellum, frontal cortex, subventricular zone, dentate gyrus, and the myocardium revealed hundreds of somatic insertions in each of the analyzed tissues. Interestingly, the highest concentration of such insertions was detected in the dentate gyrus-the hotspot of adult neurogenesis. Insertions of retroelements and their activity could produce genetically diverse neuronal subsets, which can be involved in hippocampal-dependent learning and memory. |
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The evidence for increased L1 activity in the site of human adult brain neurogenesis. |
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Svetlana V Ustyugova Vadim I Nazarov Anastasia A Minervina Alexander Yu Komkov Mikhail Shugay Mikhail V Pogorelyy Konstantin V Khodosevich Ilgar Z Mamedov Yuri B Lebedev |
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