Vascular Dysfunction Induced by Mercury Exposure

Methylmercury (MeHg) causes severe damage to the central nervous system, and there is increasing evidence of the association between MeHg exposure and vascular dysfunction, hemorrhage, and edema in the brain, but not in other organs of patients with acute MeHg intoxication. These observations sugges...
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Autor*in:	Tetsuya Takahashi [verfasserIn] Takayoshi Shimohata [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	blood–brain barrier methylmercury vascular endothelial growth factor

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 20(2019), 10, p 2435
Übergeordnetes Werk:	volume:20 ; year:2019 ; number:10, p 2435

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/ijms20102435

Katalog-ID:	DOAJ073096881

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520			\|a Methylmercury (MeHg) causes severe damage to the central nervous system, and there is increasing evidence of the association between MeHg exposure and vascular dysfunction, hemorrhage, and edema in the brain, but not in other organs of patients with acute MeHg intoxication. These observations suggest that MeHg possibly causes blood–brain barrier (BBB) damage. MeHg penetrates the BBB into the brain parenchyma via active transport systems, mainly the <span style="font-variant: small-caps;"<l</span<-type amino acid transporter 1, on endothelial cell membranes. Recently, exposure to mercury has significantly increased. Numerous reports suggest that long-term low-level MeHg exposure can impair endothelial function and increase the risks of cardiovascular disease. The most widely reported mechanism of MeHg toxicity is oxidative stress and related pathways, such as neuroinflammation. BBB dysfunction has been suggested by both in vitro and in vivo models of MeHg intoxication. Therapy targeted at both maintaining the BBB and suppressing oxidative stress may represent a promising therapeutic strategy for MeHg intoxication. This paper reviews studies on the relationship between MeHg exposure and vascular dysfunction, with a special emphasis on the BBB.
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allfields	10.3390/ijms20102435 doi (DE-627)DOAJ073096881 (DE-599)DOAJ2783fdbd119a4b4ebb30e5955499a748 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Tetsuya Takahashi verfasserin aut Vascular Dysfunction Induced by Mercury Exposure 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Methylmercury (MeHg) causes severe damage to the central nervous system, and there is increasing evidence of the association between MeHg exposure and vascular dysfunction, hemorrhage, and edema in the brain, but not in other organs of patients with acute MeHg intoxication. These observations suggest that MeHg possibly causes blood–brain barrier (BBB) damage. MeHg penetrates the BBB into the brain parenchyma via active transport systems, mainly the <span style="font-variant: small-caps;"<l</span<-type amino acid transporter 1, on endothelial cell membranes. Recently, exposure to mercury has significantly increased. Numerous reports suggest that long-term low-level MeHg exposure can impair endothelial function and increase the risks of cardiovascular disease. The most widely reported mechanism of MeHg toxicity is oxidative stress and related pathways, such as neuroinflammation. BBB dysfunction has been suggested by both in vitro and in vivo models of MeHg intoxication. Therapy targeted at both maintaining the BBB and suppressing oxidative stress may represent a promising therapeutic strategy for MeHg intoxication. This paper reviews studies on the relationship between MeHg exposure and vascular dysfunction, with a special emphasis on the BBB. blood–brain barrier methylmercury vascular endothelial growth factor <span style="font-variant: small-caps"<l</span<-type amino acid transporter 1 Biology (General) Chemistry Takayoshi Shimohata verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 20(2019), 10, p 2435 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:20 year:2019 number:10, p 2435 https://doi.org/10.3390/ijms20102435 kostenfrei https://doaj.org/article/2783fdbd119a4b4ebb30e5955499a748 kostenfrei https://www.mdpi.com/1422-0067/20/10/2435 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019 10, p 2435
spelling	10.3390/ijms20102435 doi (DE-627)DOAJ073096881 (DE-599)DOAJ2783fdbd119a4b4ebb30e5955499a748 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Tetsuya Takahashi verfasserin aut Vascular Dysfunction Induced by Mercury Exposure 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Methylmercury (MeHg) causes severe damage to the central nervous system, and there is increasing evidence of the association between MeHg exposure and vascular dysfunction, hemorrhage, and edema in the brain, but not in other organs of patients with acute MeHg intoxication. These observations suggest that MeHg possibly causes blood–brain barrier (BBB) damage. MeHg penetrates the BBB into the brain parenchyma via active transport systems, mainly the <span style="font-variant: small-caps;"<l</span<-type amino acid transporter 1, on endothelial cell membranes. Recently, exposure to mercury has significantly increased. Numerous reports suggest that long-term low-level MeHg exposure can impair endothelial function and increase the risks of cardiovascular disease. The most widely reported mechanism of MeHg toxicity is oxidative stress and related pathways, such as neuroinflammation. BBB dysfunction has been suggested by both in vitro and in vivo models of MeHg intoxication. Therapy targeted at both maintaining the BBB and suppressing oxidative stress may represent a promising therapeutic strategy for MeHg intoxication. This paper reviews studies on the relationship between MeHg exposure and vascular dysfunction, with a special emphasis on the BBB. blood–brain barrier methylmercury vascular endothelial growth factor <span style="font-variant: small-caps"<l</span<-type amino acid transporter 1 Biology (General) Chemistry Takayoshi Shimohata verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 20(2019), 10, p 2435 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:20 year:2019 number:10, p 2435 https://doi.org/10.3390/ijms20102435 kostenfrei https://doaj.org/article/2783fdbd119a4b4ebb30e5955499a748 kostenfrei https://www.mdpi.com/1422-0067/20/10/2435 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019 10, p 2435
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allfieldsGer	10.3390/ijms20102435 doi (DE-627)DOAJ073096881 (DE-599)DOAJ2783fdbd119a4b4ebb30e5955499a748 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Tetsuya Takahashi verfasserin aut Vascular Dysfunction Induced by Mercury Exposure 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Methylmercury (MeHg) causes severe damage to the central nervous system, and there is increasing evidence of the association between MeHg exposure and vascular dysfunction, hemorrhage, and edema in the brain, but not in other organs of patients with acute MeHg intoxication. These observations suggest that MeHg possibly causes blood–brain barrier (BBB) damage. MeHg penetrates the BBB into the brain parenchyma via active transport systems, mainly the <span style="font-variant: small-caps;"<l</span<-type amino acid transporter 1, on endothelial cell membranes. Recently, exposure to mercury has significantly increased. Numerous reports suggest that long-term low-level MeHg exposure can impair endothelial function and increase the risks of cardiovascular disease. The most widely reported mechanism of MeHg toxicity is oxidative stress and related pathways, such as neuroinflammation. BBB dysfunction has been suggested by both in vitro and in vivo models of MeHg intoxication. Therapy targeted at both maintaining the BBB and suppressing oxidative stress may represent a promising therapeutic strategy for MeHg intoxication. This paper reviews studies on the relationship between MeHg exposure and vascular dysfunction, with a special emphasis on the BBB. blood–brain barrier methylmercury vascular endothelial growth factor <span style="font-variant: small-caps"<l</span<-type amino acid transporter 1 Biology (General) Chemistry Takayoshi Shimohata verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 20(2019), 10, p 2435 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:20 year:2019 number:10, p 2435 https://doi.org/10.3390/ijms20102435 kostenfrei https://doaj.org/article/2783fdbd119a4b4ebb30e5955499a748 kostenfrei https://www.mdpi.com/1422-0067/20/10/2435 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019 10, p 2435
allfieldsSound	10.3390/ijms20102435 doi (DE-627)DOAJ073096881 (DE-599)DOAJ2783fdbd119a4b4ebb30e5955499a748 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Tetsuya Takahashi verfasserin aut Vascular Dysfunction Induced by Mercury Exposure 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Methylmercury (MeHg) causes severe damage to the central nervous system, and there is increasing evidence of the association between MeHg exposure and vascular dysfunction, hemorrhage, and edema in the brain, but not in other organs of patients with acute MeHg intoxication. These observations suggest that MeHg possibly causes blood–brain barrier (BBB) damage. MeHg penetrates the BBB into the brain parenchyma via active transport systems, mainly the <span style="font-variant: small-caps;"<l</span<-type amino acid transporter 1, on endothelial cell membranes. Recently, exposure to mercury has significantly increased. Numerous reports suggest that long-term low-level MeHg exposure can impair endothelial function and increase the risks of cardiovascular disease. The most widely reported mechanism of MeHg toxicity is oxidative stress and related pathways, such as neuroinflammation. BBB dysfunction has been suggested by both in vitro and in vivo models of MeHg intoxication. Therapy targeted at both maintaining the BBB and suppressing oxidative stress may represent a promising therapeutic strategy for MeHg intoxication. This paper reviews studies on the relationship between MeHg exposure and vascular dysfunction, with a special emphasis on the BBB. blood–brain barrier methylmercury vascular endothelial growth factor <span style="font-variant: small-caps"<l</span<-type amino acid transporter 1 Biology (General) Chemistry Takayoshi Shimohata verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 20(2019), 10, p 2435 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:20 year:2019 number:10, p 2435 https://doi.org/10.3390/ijms20102435 kostenfrei https://doaj.org/article/2783fdbd119a4b4ebb30e5955499a748 kostenfrei https://www.mdpi.com/1422-0067/20/10/2435 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019 10, p 2435
language	English
source	In International Journal of Molecular Sciences 20(2019), 10, p 2435 volume:20 year:2019 number:10, p 2435
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topic_facet	blood–brain barrier methylmercury vascular endothelial growth factor <span style="font-variant: small-caps"<l</span<-type amino acid transporter 1 Biology (General) Chemistry
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container_title	International Journal of Molecular Sciences
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callnumber-first	Q - Science
author	Tetsuya Takahashi
spellingShingle	Tetsuya Takahashi misc QH301-705.5 misc QD1-999 misc blood–brain barrier misc methylmercury misc vascular endothelial growth factor misc <span style="font-variant: small-caps"<l</span<-type amino acid transporter 1 misc Biology (General) misc Chemistry Vascular Dysfunction Induced by Mercury Exposure
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topic_title	QH301-705.5 QD1-999 Vascular Dysfunction Induced by Mercury Exposure blood–brain barrier methylmercury vascular endothelial growth factor <span style="font-variant: small-caps"<l</span<-type amino acid transporter 1
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title	Vascular Dysfunction Induced by Mercury Exposure
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title_full	Vascular Dysfunction Induced by Mercury Exposure
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title_sort	vascular dysfunction induced by mercury exposure
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title_auth	Vascular Dysfunction Induced by Mercury Exposure
abstract	Methylmercury (MeHg) causes severe damage to the central nervous system, and there is increasing evidence of the association between MeHg exposure and vascular dysfunction, hemorrhage, and edema in the brain, but not in other organs of patients with acute MeHg intoxication. These observations suggest that MeHg possibly causes blood–brain barrier (BBB) damage. MeHg penetrates the BBB into the brain parenchyma via active transport systems, mainly the <span style="font-variant: small-caps;"<l</span<-type amino acid transporter 1, on endothelial cell membranes. Recently, exposure to mercury has significantly increased. Numerous reports suggest that long-term low-level MeHg exposure can impair endothelial function and increase the risks of cardiovascular disease. The most widely reported mechanism of MeHg toxicity is oxidative stress and related pathways, such as neuroinflammation. BBB dysfunction has been suggested by both in vitro and in vivo models of MeHg intoxication. Therapy targeted at both maintaining the BBB and suppressing oxidative stress may represent a promising therapeutic strategy for MeHg intoxication. This paper reviews studies on the relationship between MeHg exposure and vascular dysfunction, with a special emphasis on the BBB.
abstractGer	Methylmercury (MeHg) causes severe damage to the central nervous system, and there is increasing evidence of the association between MeHg exposure and vascular dysfunction, hemorrhage, and edema in the brain, but not in other organs of patients with acute MeHg intoxication. These observations suggest that MeHg possibly causes blood–brain barrier (BBB) damage. MeHg penetrates the BBB into the brain parenchyma via active transport systems, mainly the <span style="font-variant: small-caps;"<l</span<-type amino acid transporter 1, on endothelial cell membranes. Recently, exposure to mercury has significantly increased. Numerous reports suggest that long-term low-level MeHg exposure can impair endothelial function and increase the risks of cardiovascular disease. The most widely reported mechanism of MeHg toxicity is oxidative stress and related pathways, such as neuroinflammation. BBB dysfunction has been suggested by both in vitro and in vivo models of MeHg intoxication. Therapy targeted at both maintaining the BBB and suppressing oxidative stress may represent a promising therapeutic strategy for MeHg intoxication. This paper reviews studies on the relationship between MeHg exposure and vascular dysfunction, with a special emphasis on the BBB.
abstract_unstemmed	Methylmercury (MeHg) causes severe damage to the central nervous system, and there is increasing evidence of the association between MeHg exposure and vascular dysfunction, hemorrhage, and edema in the brain, but not in other organs of patients with acute MeHg intoxication. These observations suggest that MeHg possibly causes blood–brain barrier (BBB) damage. MeHg penetrates the BBB into the brain parenchyma via active transport systems, mainly the <span style="font-variant: small-caps;"<l</span<-type amino acid transporter 1, on endothelial cell membranes. Recently, exposure to mercury has significantly increased. Numerous reports suggest that long-term low-level MeHg exposure can impair endothelial function and increase the risks of cardiovascular disease. The most widely reported mechanism of MeHg toxicity is oxidative stress and related pathways, such as neuroinflammation. BBB dysfunction has been suggested by both in vitro and in vivo models of MeHg intoxication. Therapy targeted at both maintaining the BBB and suppressing oxidative stress may represent a promising therapeutic strategy for MeHg intoxication. This paper reviews studies on the relationship between MeHg exposure and vascular dysfunction, with a special emphasis on the BBB.
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title_short	Vascular Dysfunction Induced by Mercury Exposure
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