Vitamin A/Retinol and Maintenance of Pluripotency of Stem Cells

Retinol, the alcohol form of vitamin A is a key dietary component that plays a critical role in vertebrate development, cell differentiation, reproduction, vision and immune system. Natural and synthetic analogs of retinol, called retinoids, have generally been associated with the cell differentiati...
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Gespeichert in:

Autor*in:	Jaspal S. Khillan [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2014

Schlagwörter:	vitamin A retinol retinoic acid embryonic stem cells cancer stem cells PI3 kinase signaling OCT4 NANOG SOX2 Insulin like growth factor 1 receptor (IGF1R)

Übergeordnetes Werk:	In: Nutrients - MDPI AG, 2009, 6(2014), 3, Seite 1209-1222
Übergeordnetes Werk:	volume:6 ; year:2014 ; number:3 ; pages:1209-1222

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/nu6031209

Katalog-ID:	DOAJ073265772

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callnumber-first	T - Technology
author	Jaspal S. Khillan
spellingShingle	Jaspal S. Khillan misc TX341-641 misc vitamin A misc retinol misc retinoic acid misc embryonic stem cells misc cancer stem cells misc PI3 kinase signaling misc OCT4 misc NANOG misc SOX2 misc Insulin like growth factor 1 receptor (IGF1R) misc Nutrition. Foods and food supply Vitamin A/Retinol and Maintenance of Pluripotency of Stem Cells
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topic_title	TX341-641 Vitamin A/Retinol and Maintenance of Pluripotency of Stem Cells vitamin A retinol retinoic acid embryonic stem cells cancer stem cells PI3 kinase signaling OCT4 NANOG SOX2 Insulin like growth factor 1 receptor (IGF1R)
topic	misc TX341-641 misc vitamin A misc retinol misc retinoic acid misc embryonic stem cells misc cancer stem cells misc PI3 kinase signaling misc OCT4 misc NANOG misc SOX2 misc Insulin like growth factor 1 receptor (IGF1R) misc Nutrition. Foods and food supply
topic_unstemmed	misc TX341-641 misc vitamin A misc retinol misc retinoic acid misc embryonic stem cells misc cancer stem cells misc PI3 kinase signaling misc OCT4 misc NANOG misc SOX2 misc Insulin like growth factor 1 receptor (IGF1R) misc Nutrition. Foods and food supply
topic_browse	misc TX341-641 misc vitamin A misc retinol misc retinoic acid misc embryonic stem cells misc cancer stem cells misc PI3 kinase signaling misc OCT4 misc NANOG misc SOX2 misc Insulin like growth factor 1 receptor (IGF1R) misc Nutrition. Foods and food supply
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title	Vitamin A/Retinol and Maintenance of Pluripotency of Stem Cells
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title_full	Vitamin A/Retinol and Maintenance of Pluripotency of Stem Cells
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title_sort	vitamin a/retinol and maintenance of pluripotency of stem cells
callnumber	TX341-641
title_auth	Vitamin A/Retinol and Maintenance of Pluripotency of Stem Cells
abstract	Retinol, the alcohol form of vitamin A is a key dietary component that plays a critical role in vertebrate development, cell differentiation, reproduction, vision and immune system. Natural and synthetic analogs of retinol, called retinoids, have generally been associated with the cell differentiation via retinoic acid which is the most potent metabolite of retinol. However, a direct function of retinol has not been fully investigated. New evidence has now emerged that retinol supports the self-renewal of stem cells including embryonic stem cells (ESCs), germ line stem cells (GSCs) and cancer stem cells (CSCs) by activating the endogenous machinery for self-renewal by a retinoic acid independent mechanism. The studies have also revealed that stem cells do not contain enzymes that are responsible for metabolizing retinol into retinoic acid. This new function of retinol may have important implications for stem cell biology which can be exploited for quantitative production of pure population of pluripotent stem cells for regenerative medicine as well as clinical applications for cancer therapeutics.
abstractGer	Retinol, the alcohol form of vitamin A is a key dietary component that plays a critical role in vertebrate development, cell differentiation, reproduction, vision and immune system. Natural and synthetic analogs of retinol, called retinoids, have generally been associated with the cell differentiation via retinoic acid which is the most potent metabolite of retinol. However, a direct function of retinol has not been fully investigated. New evidence has now emerged that retinol supports the self-renewal of stem cells including embryonic stem cells (ESCs), germ line stem cells (GSCs) and cancer stem cells (CSCs) by activating the endogenous machinery for self-renewal by a retinoic acid independent mechanism. The studies have also revealed that stem cells do not contain enzymes that are responsible for metabolizing retinol into retinoic acid. This new function of retinol may have important implications for stem cell biology which can be exploited for quantitative production of pure population of pluripotent stem cells for regenerative medicine as well as clinical applications for cancer therapeutics.
abstract_unstemmed	Retinol, the alcohol form of vitamin A is a key dietary component that plays a critical role in vertebrate development, cell differentiation, reproduction, vision and immune system. Natural and synthetic analogs of retinol, called retinoids, have generally been associated with the cell differentiation via retinoic acid which is the most potent metabolite of retinol. However, a direct function of retinol has not been fully investigated. New evidence has now emerged that retinol supports the self-renewal of stem cells including embryonic stem cells (ESCs), germ line stem cells (GSCs) and cancer stem cells (CSCs) by activating the endogenous machinery for self-renewal by a retinoic acid independent mechanism. The studies have also revealed that stem cells do not contain enzymes that are responsible for metabolizing retinol into retinoic acid. This new function of retinol may have important implications for stem cell biology which can be exploited for quantitative production of pure population of pluripotent stem cells for regenerative medicine as well as clinical applications for cancer therapeutics.
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title_short	Vitamin A/Retinol and Maintenance of Pluripotency of Stem Cells
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Vitamin A/Retinol and Maintenance of Pluripotency of Stem Cells

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