Preclinical Efficacy and Safety Studies of Formulation SSV-003, a Potent Anti-Viral Herbal Formulation
Yogesh Arun Dound,1 Rajesh Sehgal2 1Research and Development, Shreepad Shree Vallabh SSV Phytopharmaceuticals, Mumbai, Maharashtra, India; 2Research and Development, Pharma Instinct Pvt. Ltd, Noida, Uttar Pradesh, IndiaCorrespondence: Yogesh Arun DoundResearch and Development, Shreepad Shree Vallabh...
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Dound YA [verfasserIn] Sehgal R [verfasserIn] |
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2021 |
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In: Journal of Experimental Pharmacology - Dove Medical Press, 2021, (2021), Seite 913-921 |
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year:2021 ; pages:913-921 |
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DOAJ073485047 |
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| 520 | |a Yogesh Arun Dound,1 Rajesh Sehgal2 1Research and Development, Shreepad Shree Vallabh SSV Phytopharmaceuticals, Mumbai, Maharashtra, India; 2Research and Development, Pharma Instinct Pvt. Ltd, Noida, Uttar Pradesh, IndiaCorrespondence: Yogesh Arun DoundResearch and Development, Shreepad Shree Vallabh SSV Phytopharmaceuticals, 201/2, Old Kashmiri Building, R R Thakur Marg, Majaswadi, Jogeshwari, Mumbai, Mahrashtra, 400060, IndiaEmail yogesh_doundyahoo.comBackground: Recent viral pandemics have challenged the global scientific community to immediately develop new therapies. The fastest approach to develop these is to explore natural products for their efficacies and repurposing of already approved molecules. Keeping global emergency in view, researchers at Shreepad Shree Vallabh SSV Phytopharmaceuticals developed the CurvicTM (SSV-003) formulation, comprising of curcumin, vitamin C, vitamin K2-7, selenomethionine and Zinc.Methods: Researchers have systematically studied the SSV-003 formulation for its in vitro efficacy against influenza A virus (H1N1) (ATCC® VR-219™) and human beta coronavirus (ATCC® VR1558™) using MDCK & HCT-8 cell lines, respectively, in vivo efficacy studies of SSV-003 on influenza A virus infected Balb/c mice, and acute toxicity studies as per OECD guidelines.Results: Formulation SSV-003 showed potent antiviral activities against both the selected virus strains. Its IC50 was significantly lessthan ribavirin against influenza A-H1N1-VR219, with no cytopathic effect. SSV-003 showed IC50 of 2.26 μg/mL against human beta coronavirus, which was near to the IC50 of ribavirin (2.25 μg/mL) and was less than remedisivir (6.23 μg/mL) with no cytopathic effect. In-vivo studies in an influenza A virus infected mice model showed a significantly higher TCID50 value in the infected control group as compared to test groups. Animals treated with SSV-003 showed a dose dependent decrease in TCID50. Formulation SSV-003 at the dose of 500, 1,000, and 1,500 mg/kg body weight showed 85.9%, 94.6%, and 95.1% decreases in infection as compared to the infected control group. Dose-dependent significant increases in CD4+, CD8+ counts, IgG and IgM levels were observed in SSV-003 treated groups as compared to the infected control group and remedisivir treated group. In the acute oral toxicity study, no mortality or morbidity was observed.Conclusion: The data from these preclinical studies provide strong evidence of potent and safe antiviral and immunomodulatory activity of SSV-003.Keywords: curcumin, antiviral, coronavirus, vitamin C | ||
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(DE-627)DOAJ073485047 (DE-599)DOAJ0972ee2683ce42818974fac95ab6ea87 DE-627 ger DE-627 rakwb eng RM1-950 Dound YA verfasserin aut Preclinical Efficacy and Safety Studies of Formulation SSV-003, a Potent Anti-Viral Herbal Formulation 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Yogesh Arun Dound,1 Rajesh Sehgal2 1Research and Development, Shreepad Shree Vallabh SSV Phytopharmaceuticals, Mumbai, Maharashtra, India; 2Research and Development, Pharma Instinct Pvt. Ltd, Noida, Uttar Pradesh, IndiaCorrespondence: Yogesh Arun DoundResearch and Development, Shreepad Shree Vallabh SSV Phytopharmaceuticals, 201/2, Old Kashmiri Building, R R Thakur Marg, Majaswadi, Jogeshwari, Mumbai, Mahrashtra, 400060, IndiaEmail yogesh_doundyahoo.comBackground: Recent viral pandemics have challenged the global scientific community to immediately develop new therapies. The fastest approach to develop these is to explore natural products for their efficacies and repurposing of already approved molecules. Keeping global emergency in view, researchers at Shreepad Shree Vallabh SSV Phytopharmaceuticals developed the CurvicTM (SSV-003) formulation, comprising of curcumin, vitamin C, vitamin K2-7, selenomethionine and Zinc.Methods: Researchers have systematically studied the SSV-003 formulation for its in vitro efficacy against influenza A virus (H1N1) (ATCC® VR-219™) and human beta coronavirus (ATCC® VR1558™) using MDCK & HCT-8 cell lines, respectively, in vivo efficacy studies of SSV-003 on influenza A virus infected Balb/c mice, and acute toxicity studies as per OECD guidelines.Results: Formulation SSV-003 showed potent antiviral activities against both the selected virus strains. Its IC50 was significantly lessthan ribavirin against influenza A-H1N1-VR219, with no cytopathic effect. SSV-003 showed IC50 of 2.26 μg/mL against human beta coronavirus, which was near to the IC50 of ribavirin (2.25 μg/mL) and was less than remedisivir (6.23 μg/mL) with no cytopathic effect. In-vivo studies in an influenza A virus infected mice model showed a significantly higher TCID50 value in the infected control group as compared to test groups. Animals treated with SSV-003 showed a dose dependent decrease in TCID50. Formulation SSV-003 at the dose of 500, 1,000, and 1,500 mg/kg body weight showed 85.9%, 94.6%, and 95.1% decreases in infection as compared to the infected control group. Dose-dependent significant increases in CD4+, CD8+ counts, IgG and IgM levels were observed in SSV-003 treated groups as compared to the infected control group and remedisivir treated group. In the acute oral toxicity study, no mortality or morbidity was observed.Conclusion: The data from these preclinical studies provide strong evidence of potent and safe antiviral and immunomodulatory activity of SSV-003.Keywords: curcumin, antiviral, coronavirus, vitamin C curcumin antiviral corona virus vitamin c Therapeutics. Pharmacology Sehgal R verfasserin aut In Journal of Experimental Pharmacology Dove Medical Press, 2021 (2021), Seite 913-921 (DE-627)642890137 (DE-600)2587465-2 11791454 nnns year:2021 pages:913-921 https://doaj.org/article/0972ee2683ce42818974fac95ab6ea87 kostenfrei https://www.dovepress.com/preclinical-efficacy-and-safety-studies-of-formulation-ssv-003-a-poten-peer-reviewed-fulltext-article-JEP kostenfrei https://doaj.org/toc/1179-1454 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2021 913-921 |
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(DE-627)DOAJ073485047 (DE-599)DOAJ0972ee2683ce42818974fac95ab6ea87 DE-627 ger DE-627 rakwb eng RM1-950 Dound YA verfasserin aut Preclinical Efficacy and Safety Studies of Formulation SSV-003, a Potent Anti-Viral Herbal Formulation 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Yogesh Arun Dound,1 Rajesh Sehgal2 1Research and Development, Shreepad Shree Vallabh SSV Phytopharmaceuticals, Mumbai, Maharashtra, India; 2Research and Development, Pharma Instinct Pvt. Ltd, Noida, Uttar Pradesh, IndiaCorrespondence: Yogesh Arun DoundResearch and Development, Shreepad Shree Vallabh SSV Phytopharmaceuticals, 201/2, Old Kashmiri Building, R R Thakur Marg, Majaswadi, Jogeshwari, Mumbai, Mahrashtra, 400060, IndiaEmail yogesh_doundyahoo.comBackground: Recent viral pandemics have challenged the global scientific community to immediately develop new therapies. The fastest approach to develop these is to explore natural products for their efficacies and repurposing of already approved molecules. Keeping global emergency in view, researchers at Shreepad Shree Vallabh SSV Phytopharmaceuticals developed the CurvicTM (SSV-003) formulation, comprising of curcumin, vitamin C, vitamin K2-7, selenomethionine and Zinc.Methods: Researchers have systematically studied the SSV-003 formulation for its in vitro efficacy against influenza A virus (H1N1) (ATCC® VR-219™) and human beta coronavirus (ATCC® VR1558™) using MDCK & HCT-8 cell lines, respectively, in vivo efficacy studies of SSV-003 on influenza A virus infected Balb/c mice, and acute toxicity studies as per OECD guidelines.Results: Formulation SSV-003 showed potent antiviral activities against both the selected virus strains. Its IC50 was significantly lessthan ribavirin against influenza A-H1N1-VR219, with no cytopathic effect. SSV-003 showed IC50 of 2.26 μg/mL against human beta coronavirus, which was near to the IC50 of ribavirin (2.25 μg/mL) and was less than remedisivir (6.23 μg/mL) with no cytopathic effect. In-vivo studies in an influenza A virus infected mice model showed a significantly higher TCID50 value in the infected control group as compared to test groups. Animals treated with SSV-003 showed a dose dependent decrease in TCID50. Formulation SSV-003 at the dose of 500, 1,000, and 1,500 mg/kg body weight showed 85.9%, 94.6%, and 95.1% decreases in infection as compared to the infected control group. Dose-dependent significant increases in CD4+, CD8+ counts, IgG and IgM levels were observed in SSV-003 treated groups as compared to the infected control group and remedisivir treated group. In the acute oral toxicity study, no mortality or morbidity was observed.Conclusion: The data from these preclinical studies provide strong evidence of potent and safe antiviral and immunomodulatory activity of SSV-003.Keywords: curcumin, antiviral, coronavirus, vitamin C curcumin antiviral corona virus vitamin c Therapeutics. Pharmacology Sehgal R verfasserin aut In Journal of Experimental Pharmacology Dove Medical Press, 2021 (2021), Seite 913-921 (DE-627)642890137 (DE-600)2587465-2 11791454 nnns year:2021 pages:913-921 https://doaj.org/article/0972ee2683ce42818974fac95ab6ea87 kostenfrei https://www.dovepress.com/preclinical-efficacy-and-safety-studies-of-formulation-ssv-003-a-poten-peer-reviewed-fulltext-article-JEP kostenfrei https://doaj.org/toc/1179-1454 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2021 913-921 |
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(DE-627)DOAJ073485047 (DE-599)DOAJ0972ee2683ce42818974fac95ab6ea87 DE-627 ger DE-627 rakwb eng RM1-950 Dound YA verfasserin aut Preclinical Efficacy and Safety Studies of Formulation SSV-003, a Potent Anti-Viral Herbal Formulation 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Yogesh Arun Dound,1 Rajesh Sehgal2 1Research and Development, Shreepad Shree Vallabh SSV Phytopharmaceuticals, Mumbai, Maharashtra, India; 2Research and Development, Pharma Instinct Pvt. Ltd, Noida, Uttar Pradesh, IndiaCorrespondence: Yogesh Arun DoundResearch and Development, Shreepad Shree Vallabh SSV Phytopharmaceuticals, 201/2, Old Kashmiri Building, R R Thakur Marg, Majaswadi, Jogeshwari, Mumbai, Mahrashtra, 400060, IndiaEmail yogesh_doundyahoo.comBackground: Recent viral pandemics have challenged the global scientific community to immediately develop new therapies. The fastest approach to develop these is to explore natural products for their efficacies and repurposing of already approved molecules. Keeping global emergency in view, researchers at Shreepad Shree Vallabh SSV Phytopharmaceuticals developed the CurvicTM (SSV-003) formulation, comprising of curcumin, vitamin C, vitamin K2-7, selenomethionine and Zinc.Methods: Researchers have systematically studied the SSV-003 formulation for its in vitro efficacy against influenza A virus (H1N1) (ATCC® VR-219™) and human beta coronavirus (ATCC® VR1558™) using MDCK & HCT-8 cell lines, respectively, in vivo efficacy studies of SSV-003 on influenza A virus infected Balb/c mice, and acute toxicity studies as per OECD guidelines.Results: Formulation SSV-003 showed potent antiviral activities against both the selected virus strains. Its IC50 was significantly lessthan ribavirin against influenza A-H1N1-VR219, with no cytopathic effect. SSV-003 showed IC50 of 2.26 μg/mL against human beta coronavirus, which was near to the IC50 of ribavirin (2.25 μg/mL) and was less than remedisivir (6.23 μg/mL) with no cytopathic effect. In-vivo studies in an influenza A virus infected mice model showed a significantly higher TCID50 value in the infected control group as compared to test groups. Animals treated with SSV-003 showed a dose dependent decrease in TCID50. Formulation SSV-003 at the dose of 500, 1,000, and 1,500 mg/kg body weight showed 85.9%, 94.6%, and 95.1% decreases in infection as compared to the infected control group. Dose-dependent significant increases in CD4+, CD8+ counts, IgG and IgM levels were observed in SSV-003 treated groups as compared to the infected control group and remedisivir treated group. In the acute oral toxicity study, no mortality or morbidity was observed.Conclusion: The data from these preclinical studies provide strong evidence of potent and safe antiviral and immunomodulatory activity of SSV-003.Keywords: curcumin, antiviral, coronavirus, vitamin C curcumin antiviral corona virus vitamin c Therapeutics. Pharmacology Sehgal R verfasserin aut In Journal of Experimental Pharmacology Dove Medical Press, 2021 (2021), Seite 913-921 (DE-627)642890137 (DE-600)2587465-2 11791454 nnns year:2021 pages:913-921 https://doaj.org/article/0972ee2683ce42818974fac95ab6ea87 kostenfrei https://www.dovepress.com/preclinical-efficacy-and-safety-studies-of-formulation-ssv-003-a-poten-peer-reviewed-fulltext-article-JEP kostenfrei https://doaj.org/toc/1179-1454 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2021 913-921 |
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(DE-627)DOAJ073485047 (DE-599)DOAJ0972ee2683ce42818974fac95ab6ea87 DE-627 ger DE-627 rakwb eng RM1-950 Dound YA verfasserin aut Preclinical Efficacy and Safety Studies of Formulation SSV-003, a Potent Anti-Viral Herbal Formulation 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Yogesh Arun Dound,1 Rajesh Sehgal2 1Research and Development, Shreepad Shree Vallabh SSV Phytopharmaceuticals, Mumbai, Maharashtra, India; 2Research and Development, Pharma Instinct Pvt. Ltd, Noida, Uttar Pradesh, IndiaCorrespondence: Yogesh Arun DoundResearch and Development, Shreepad Shree Vallabh SSV Phytopharmaceuticals, 201/2, Old Kashmiri Building, R R Thakur Marg, Majaswadi, Jogeshwari, Mumbai, Mahrashtra, 400060, IndiaEmail yogesh_doundyahoo.comBackground: Recent viral pandemics have challenged the global scientific community to immediately develop new therapies. The fastest approach to develop these is to explore natural products for their efficacies and repurposing of already approved molecules. Keeping global emergency in view, researchers at Shreepad Shree Vallabh SSV Phytopharmaceuticals developed the CurvicTM (SSV-003) formulation, comprising of curcumin, vitamin C, vitamin K2-7, selenomethionine and Zinc.Methods: Researchers have systematically studied the SSV-003 formulation for its in vitro efficacy against influenza A virus (H1N1) (ATCC® VR-219™) and human beta coronavirus (ATCC® VR1558™) using MDCK & HCT-8 cell lines, respectively, in vivo efficacy studies of SSV-003 on influenza A virus infected Balb/c mice, and acute toxicity studies as per OECD guidelines.Results: Formulation SSV-003 showed potent antiviral activities against both the selected virus strains. Its IC50 was significantly lessthan ribavirin against influenza A-H1N1-VR219, with no cytopathic effect. SSV-003 showed IC50 of 2.26 μg/mL against human beta coronavirus, which was near to the IC50 of ribavirin (2.25 μg/mL) and was less than remedisivir (6.23 μg/mL) with no cytopathic effect. In-vivo studies in an influenza A virus infected mice model showed a significantly higher TCID50 value in the infected control group as compared to test groups. Animals treated with SSV-003 showed a dose dependent decrease in TCID50. Formulation SSV-003 at the dose of 500, 1,000, and 1,500 mg/kg body weight showed 85.9%, 94.6%, and 95.1% decreases in infection as compared to the infected control group. Dose-dependent significant increases in CD4+, CD8+ counts, IgG and IgM levels were observed in SSV-003 treated groups as compared to the infected control group and remedisivir treated group. In the acute oral toxicity study, no mortality or morbidity was observed.Conclusion: The data from these preclinical studies provide strong evidence of potent and safe antiviral and immunomodulatory activity of SSV-003.Keywords: curcumin, antiviral, coronavirus, vitamin C curcumin antiviral corona virus vitamin c Therapeutics. Pharmacology Sehgal R verfasserin aut In Journal of Experimental Pharmacology Dove Medical Press, 2021 (2021), Seite 913-921 (DE-627)642890137 (DE-600)2587465-2 11791454 nnns year:2021 pages:913-921 https://doaj.org/article/0972ee2683ce42818974fac95ab6ea87 kostenfrei https://www.dovepress.com/preclinical-efficacy-and-safety-studies-of-formulation-ssv-003-a-poten-peer-reviewed-fulltext-article-JEP kostenfrei https://doaj.org/toc/1179-1454 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2021 913-921 |
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Keeping global emergency in view, researchers at Shreepad Shree Vallabh SSV Phytopharmaceuticals developed the CurvicTM (SSV-003) formulation, comprising of curcumin, vitamin C, vitamin K2-7, selenomethionine and Zinc.Methods: Researchers have systematically studied the SSV-003 formulation for its in vitro efficacy against influenza A virus (H1N1) (ATCC® VR-219™) and human beta coronavirus (ATCC® VR1558™) using MDCK & HCT-8 cell lines, respectively, in vivo efficacy studies of SSV-003 on influenza A virus infected Balb/c mice, and acute toxicity studies as per OECD guidelines.Results: Formulation SSV-003 showed potent antiviral activities against both the selected virus strains. Its IC50 was significantly lessthan ribavirin against influenza A-H1N1-VR219, with no cytopathic effect. SSV-003 showed IC50 of 2.26 μg/mL against human beta coronavirus, which was near to the IC50 of ribavirin (2.25 μg/mL) and was less than remedisivir (6.23 μg/mL) with no cytopathic effect. 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Preclinical Efficacy and Safety Studies of Formulation SSV-003, a Potent Anti-Viral Herbal Formulation |
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Yogesh Arun Dound,1 Rajesh Sehgal2 1Research and Development, Shreepad Shree Vallabh SSV Phytopharmaceuticals, Mumbai, Maharashtra, India; 2Research and Development, Pharma Instinct Pvt. Ltd, Noida, Uttar Pradesh, IndiaCorrespondence: Yogesh Arun DoundResearch and Development, Shreepad Shree Vallabh SSV Phytopharmaceuticals, 201/2, Old Kashmiri Building, R R Thakur Marg, Majaswadi, Jogeshwari, Mumbai, Mahrashtra, 400060, IndiaEmail yogesh_doundyahoo.comBackground: Recent viral pandemics have challenged the global scientific community to immediately develop new therapies. The fastest approach to develop these is to explore natural products for their efficacies and repurposing of already approved molecules. Keeping global emergency in view, researchers at Shreepad Shree Vallabh SSV Phytopharmaceuticals developed the CurvicTM (SSV-003) formulation, comprising of curcumin, vitamin C, vitamin K2-7, selenomethionine and Zinc.Methods: Researchers have systematically studied the SSV-003 formulation for its in vitro efficacy against influenza A virus (H1N1) (ATCC® VR-219™) and human beta coronavirus (ATCC® VR1558™) using MDCK & HCT-8 cell lines, respectively, in vivo efficacy studies of SSV-003 on influenza A virus infected Balb/c mice, and acute toxicity studies as per OECD guidelines.Results: Formulation SSV-003 showed potent antiviral activities against both the selected virus strains. Its IC50 was significantly lessthan ribavirin against influenza A-H1N1-VR219, with no cytopathic effect. SSV-003 showed IC50 of 2.26 μg/mL against human beta coronavirus, which was near to the IC50 of ribavirin (2.25 μg/mL) and was less than remedisivir (6.23 μg/mL) with no cytopathic effect. In-vivo studies in an influenza A virus infected mice model showed a significantly higher TCID50 value in the infected control group as compared to test groups. Animals treated with SSV-003 showed a dose dependent decrease in TCID50. Formulation SSV-003 at the dose of 500, 1,000, and 1,500 mg/kg body weight showed 85.9%, 94.6%, and 95.1% decreases in infection as compared to the infected control group. Dose-dependent significant increases in CD4+, CD8+ counts, IgG and IgM levels were observed in SSV-003 treated groups as compared to the infected control group and remedisivir treated group. In the acute oral toxicity study, no mortality or morbidity was observed.Conclusion: The data from these preclinical studies provide strong evidence of potent and safe antiviral and immunomodulatory activity of SSV-003.Keywords: curcumin, antiviral, coronavirus, vitamin C |
| abstractGer |
Yogesh Arun Dound,1 Rajesh Sehgal2 1Research and Development, Shreepad Shree Vallabh SSV Phytopharmaceuticals, Mumbai, Maharashtra, India; 2Research and Development, Pharma Instinct Pvt. Ltd, Noida, Uttar Pradesh, IndiaCorrespondence: Yogesh Arun DoundResearch and Development, Shreepad Shree Vallabh SSV Phytopharmaceuticals, 201/2, Old Kashmiri Building, R R Thakur Marg, Majaswadi, Jogeshwari, Mumbai, Mahrashtra, 400060, IndiaEmail yogesh_doundyahoo.comBackground: Recent viral pandemics have challenged the global scientific community to immediately develop new therapies. The fastest approach to develop these is to explore natural products for their efficacies and repurposing of already approved molecules. Keeping global emergency in view, researchers at Shreepad Shree Vallabh SSV Phytopharmaceuticals developed the CurvicTM (SSV-003) formulation, comprising of curcumin, vitamin C, vitamin K2-7, selenomethionine and Zinc.Methods: Researchers have systematically studied the SSV-003 formulation for its in vitro efficacy against influenza A virus (H1N1) (ATCC® VR-219™) and human beta coronavirus (ATCC® VR1558™) using MDCK & HCT-8 cell lines, respectively, in vivo efficacy studies of SSV-003 on influenza A virus infected Balb/c mice, and acute toxicity studies as per OECD guidelines.Results: Formulation SSV-003 showed potent antiviral activities against both the selected virus strains. Its IC50 was significantly lessthan ribavirin against influenza A-H1N1-VR219, with no cytopathic effect. SSV-003 showed IC50 of 2.26 μg/mL against human beta coronavirus, which was near to the IC50 of ribavirin (2.25 μg/mL) and was less than remedisivir (6.23 μg/mL) with no cytopathic effect. In-vivo studies in an influenza A virus infected mice model showed a significantly higher TCID50 value in the infected control group as compared to test groups. Animals treated with SSV-003 showed a dose dependent decrease in TCID50. Formulation SSV-003 at the dose of 500, 1,000, and 1,500 mg/kg body weight showed 85.9%, 94.6%, and 95.1% decreases in infection as compared to the infected control group. Dose-dependent significant increases in CD4+, CD8+ counts, IgG and IgM levels were observed in SSV-003 treated groups as compared to the infected control group and remedisivir treated group. In the acute oral toxicity study, no mortality or morbidity was observed.Conclusion: The data from these preclinical studies provide strong evidence of potent and safe antiviral and immunomodulatory activity of SSV-003.Keywords: curcumin, antiviral, coronavirus, vitamin C |
| abstract_unstemmed |
Yogesh Arun Dound,1 Rajesh Sehgal2 1Research and Development, Shreepad Shree Vallabh SSV Phytopharmaceuticals, Mumbai, Maharashtra, India; 2Research and Development, Pharma Instinct Pvt. Ltd, Noida, Uttar Pradesh, IndiaCorrespondence: Yogesh Arun DoundResearch and Development, Shreepad Shree Vallabh SSV Phytopharmaceuticals, 201/2, Old Kashmiri Building, R R Thakur Marg, Majaswadi, Jogeshwari, Mumbai, Mahrashtra, 400060, IndiaEmail yogesh_doundyahoo.comBackground: Recent viral pandemics have challenged the global scientific community to immediately develop new therapies. The fastest approach to develop these is to explore natural products for their efficacies and repurposing of already approved molecules. Keeping global emergency in view, researchers at Shreepad Shree Vallabh SSV Phytopharmaceuticals developed the CurvicTM (SSV-003) formulation, comprising of curcumin, vitamin C, vitamin K2-7, selenomethionine and Zinc.Methods: Researchers have systematically studied the SSV-003 formulation for its in vitro efficacy against influenza A virus (H1N1) (ATCC® VR-219™) and human beta coronavirus (ATCC® VR1558™) using MDCK & HCT-8 cell lines, respectively, in vivo efficacy studies of SSV-003 on influenza A virus infected Balb/c mice, and acute toxicity studies as per OECD guidelines.Results: Formulation SSV-003 showed potent antiviral activities against both the selected virus strains. Its IC50 was significantly lessthan ribavirin against influenza A-H1N1-VR219, with no cytopathic effect. SSV-003 showed IC50 of 2.26 μg/mL against human beta coronavirus, which was near to the IC50 of ribavirin (2.25 μg/mL) and was less than remedisivir (6.23 μg/mL) with no cytopathic effect. In-vivo studies in an influenza A virus infected mice model showed a significantly higher TCID50 value in the infected control group as compared to test groups. Animals treated with SSV-003 showed a dose dependent decrease in TCID50. Formulation SSV-003 at the dose of 500, 1,000, and 1,500 mg/kg body weight showed 85.9%, 94.6%, and 95.1% decreases in infection as compared to the infected control group. Dose-dependent significant increases in CD4+, CD8+ counts, IgG and IgM levels were observed in SSV-003 treated groups as compared to the infected control group and remedisivir treated group. In the acute oral toxicity study, no mortality or morbidity was observed.Conclusion: The data from these preclinical studies provide strong evidence of potent and safe antiviral and immunomodulatory activity of SSV-003.Keywords: curcumin, antiviral, coronavirus, vitamin C |
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Preclinical Efficacy and Safety Studies of Formulation SSV-003, a Potent Anti-Viral Herbal Formulation |
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https://doaj.org/article/0972ee2683ce42818974fac95ab6ea87 https://www.dovepress.com/preclinical-efficacy-and-safety-studies-of-formulation-ssv-003-a-poten-peer-reviewed-fulltext-article-JEP https://doaj.org/toc/1179-1454 |
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