Carriage Dynamics of Pneumococcal Serotypes in Naturally Colonized Infants in a Rural African Setting During the First Year of Life
Streptococcus pneumoniae (the pneumococcus) carriage precedes invasive disease and influences population-wide strain dynamics, but limited data exist on temporal carriage patterns of serotypes due to the prohibitive costs of longitudinal studies. Here, we report carriage prevalence, clearance and ac...
Ausführliche Beschreibung
Autor*in: |
Chrispin Chaguza [verfasserIn] Madikay Senghore [verfasserIn] Ebrima Bojang [verfasserIn] Stephanie W. Lo [verfasserIn] Chinelo Ebruke [verfasserIn] Rebecca A. Gladstone [verfasserIn] Peggy-Estelle Tientcheu [verfasserIn] Rowan E. Bancroft [verfasserIn] Archibald Worwui [verfasserIn] Ebenezer Foster-Nyarko [verfasserIn] Fatima Ceesay [verfasserIn] Catherine Okoi [verfasserIn] Lesley McGee [verfasserIn] Keith P. Klugman [verfasserIn] Robert F. Breiman [verfasserIn] Michael R. Barer [verfasserIn] Richard A. Adegbola [verfasserIn] Martin Antonio [verfasserIn] Stephen D. Bentley [verfasserIn] Brenda A. Kwambana-Adams [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2021 |
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Übergeordnetes Werk: |
In: Frontiers in Pediatrics - Frontiers Media S.A., 2013, 8(2021) |
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Übergeordnetes Werk: |
volume:8 ; year:2021 |
Links: |
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DOI / URN: |
10.3389/fped.2020.587730 |
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Katalog-ID: |
DOAJ073486256 |
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520 | |a Streptococcus pneumoniae (the pneumococcus) carriage precedes invasive disease and influences population-wide strain dynamics, but limited data exist on temporal carriage patterns of serotypes due to the prohibitive costs of longitudinal studies. Here, we report carriage prevalence, clearance and acquisition rates of pneumococcal serotypes sampled from newborn infants bi-weekly from weeks 1 to 27, and then bi-monthly from weeks 35 to 52 in the Gambia. We used sweep latex agglutination and whole genome sequencing to serotype the isolates. We show rapid pneumococcal acquisition with nearly 31% of the infants colonized by the end of first week after birth and quickly exceeding 95% after 2 months. Co-colonization with multiple serotypes was consistently observed in over 40% of the infants at each sampling point during the first year of life. Overall, the mean acquisition time and carriage duration regardless of serotype was 38 and 24 days, respectively, but varied considerably between serotypes comparable to observations from other regions. Our data will inform disease prevention and control measures including providing baseline data for parameterising infectious disease mathematical models including those assessing the impact of clinical interventions such as pneumococcal conjugate vaccines. | ||
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10.3389/fped.2020.587730 doi (DE-627)DOAJ073486256 (DE-599)DOAJb3fea75bb7bc42ca9d693550857e15cd DE-627 ger DE-627 rakwb eng RJ1-570 Chrispin Chaguza verfasserin aut Carriage Dynamics of Pneumococcal Serotypes in Naturally Colonized Infants in a Rural African Setting During the First Year of Life 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Streptococcus pneumoniae (the pneumococcus) carriage precedes invasive disease and influences population-wide strain dynamics, but limited data exist on temporal carriage patterns of serotypes due to the prohibitive costs of longitudinal studies. Here, we report carriage prevalence, clearance and acquisition rates of pneumococcal serotypes sampled from newborn infants bi-weekly from weeks 1 to 27, and then bi-monthly from weeks 35 to 52 in the Gambia. We used sweep latex agglutination and whole genome sequencing to serotype the isolates. We show rapid pneumococcal acquisition with nearly 31% of the infants colonized by the end of first week after birth and quickly exceeding 95% after 2 months. Co-colonization with multiple serotypes was consistently observed in over 40% of the infants at each sampling point during the first year of life. Overall, the mean acquisition time and carriage duration regardless of serotype was 38 and 24 days, respectively, but varied considerably between serotypes comparable to observations from other regions. Our data will inform disease prevention and control measures including providing baseline data for parameterising infectious disease mathematical models including those assessing the impact of clinical interventions such as pneumococcal conjugate vaccines. pneumococcus serotype carriage duration acquisition Africa infants Pediatrics Chrispin Chaguza verfasserin aut Madikay Senghore verfasserin aut Ebrima Bojang verfasserin aut Stephanie W. Lo verfasserin aut Chinelo Ebruke verfasserin aut Rebecca A. Gladstone verfasserin aut Peggy-Estelle Tientcheu verfasserin aut Rowan E. Bancroft verfasserin aut Archibald Worwui verfasserin aut Ebenezer Foster-Nyarko verfasserin aut Fatima Ceesay verfasserin aut Catherine Okoi verfasserin aut Lesley McGee verfasserin aut Keith P. Klugman verfasserin aut Robert F. Breiman verfasserin aut Michael R. Barer verfasserin aut Richard A. Adegbola verfasserin aut Richard A. Adegbola verfasserin aut Martin Antonio verfasserin aut Martin Antonio verfasserin aut Stephen D. Bentley verfasserin aut Stephen D. Bentley verfasserin aut Brenda A. Kwambana-Adams verfasserin aut Brenda A. Kwambana-Adams verfasserin aut In Frontiers in Pediatrics Frontiers Media S.A., 2013 8(2021) (DE-627)742738744 (DE-600)2711999-3 22962360 nnns volume:8 year:2021 https://doi.org/10.3389/fped.2020.587730 kostenfrei https://doaj.org/article/b3fea75bb7bc42ca9d693550857e15cd kostenfrei https://www.frontiersin.org/articles/10.3389/fped.2020.587730/full kostenfrei https://doaj.org/toc/2296-2360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021 |
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10.3389/fped.2020.587730 doi (DE-627)DOAJ073486256 (DE-599)DOAJb3fea75bb7bc42ca9d693550857e15cd DE-627 ger DE-627 rakwb eng RJ1-570 Chrispin Chaguza verfasserin aut Carriage Dynamics of Pneumococcal Serotypes in Naturally Colonized Infants in a Rural African Setting During the First Year of Life 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Streptococcus pneumoniae (the pneumococcus) carriage precedes invasive disease and influences population-wide strain dynamics, but limited data exist on temporal carriage patterns of serotypes due to the prohibitive costs of longitudinal studies. Here, we report carriage prevalence, clearance and acquisition rates of pneumococcal serotypes sampled from newborn infants bi-weekly from weeks 1 to 27, and then bi-monthly from weeks 35 to 52 in the Gambia. We used sweep latex agglutination and whole genome sequencing to serotype the isolates. We show rapid pneumococcal acquisition with nearly 31% of the infants colonized by the end of first week after birth and quickly exceeding 95% after 2 months. Co-colonization with multiple serotypes was consistently observed in over 40% of the infants at each sampling point during the first year of life. Overall, the mean acquisition time and carriage duration regardless of serotype was 38 and 24 days, respectively, but varied considerably between serotypes comparable to observations from other regions. Our data will inform disease prevention and control measures including providing baseline data for parameterising infectious disease mathematical models including those assessing the impact of clinical interventions such as pneumococcal conjugate vaccines. pneumococcus serotype carriage duration acquisition Africa infants Pediatrics Chrispin Chaguza verfasserin aut Madikay Senghore verfasserin aut Ebrima Bojang verfasserin aut Stephanie W. Lo verfasserin aut Chinelo Ebruke verfasserin aut Rebecca A. Gladstone verfasserin aut Peggy-Estelle Tientcheu verfasserin aut Rowan E. Bancroft verfasserin aut Archibald Worwui verfasserin aut Ebenezer Foster-Nyarko verfasserin aut Fatima Ceesay verfasserin aut Catherine Okoi verfasserin aut Lesley McGee verfasserin aut Keith P. Klugman verfasserin aut Robert F. Breiman verfasserin aut Michael R. Barer verfasserin aut Richard A. Adegbola verfasserin aut Richard A. Adegbola verfasserin aut Martin Antonio verfasserin aut Martin Antonio verfasserin aut Stephen D. Bentley verfasserin aut Stephen D. Bentley verfasserin aut Brenda A. Kwambana-Adams verfasserin aut Brenda A. Kwambana-Adams verfasserin aut In Frontiers in Pediatrics Frontiers Media S.A., 2013 8(2021) (DE-627)742738744 (DE-600)2711999-3 22962360 nnns volume:8 year:2021 https://doi.org/10.3389/fped.2020.587730 kostenfrei https://doaj.org/article/b3fea75bb7bc42ca9d693550857e15cd kostenfrei https://www.frontiersin.org/articles/10.3389/fped.2020.587730/full kostenfrei https://doaj.org/toc/2296-2360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021 |
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10.3389/fped.2020.587730 doi (DE-627)DOAJ073486256 (DE-599)DOAJb3fea75bb7bc42ca9d693550857e15cd DE-627 ger DE-627 rakwb eng RJ1-570 Chrispin Chaguza verfasserin aut Carriage Dynamics of Pneumococcal Serotypes in Naturally Colonized Infants in a Rural African Setting During the First Year of Life 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Streptococcus pneumoniae (the pneumococcus) carriage precedes invasive disease and influences population-wide strain dynamics, but limited data exist on temporal carriage patterns of serotypes due to the prohibitive costs of longitudinal studies. Here, we report carriage prevalence, clearance and acquisition rates of pneumococcal serotypes sampled from newborn infants bi-weekly from weeks 1 to 27, and then bi-monthly from weeks 35 to 52 in the Gambia. We used sweep latex agglutination and whole genome sequencing to serotype the isolates. We show rapid pneumococcal acquisition with nearly 31% of the infants colonized by the end of first week after birth and quickly exceeding 95% after 2 months. Co-colonization with multiple serotypes was consistently observed in over 40% of the infants at each sampling point during the first year of life. Overall, the mean acquisition time and carriage duration regardless of serotype was 38 and 24 days, respectively, but varied considerably between serotypes comparable to observations from other regions. Our data will inform disease prevention and control measures including providing baseline data for parameterising infectious disease mathematical models including those assessing the impact of clinical interventions such as pneumococcal conjugate vaccines. pneumococcus serotype carriage duration acquisition Africa infants Pediatrics Chrispin Chaguza verfasserin aut Madikay Senghore verfasserin aut Ebrima Bojang verfasserin aut Stephanie W. Lo verfasserin aut Chinelo Ebruke verfasserin aut Rebecca A. Gladstone verfasserin aut Peggy-Estelle Tientcheu verfasserin aut Rowan E. Bancroft verfasserin aut Archibald Worwui verfasserin aut Ebenezer Foster-Nyarko verfasserin aut Fatima Ceesay verfasserin aut Catherine Okoi verfasserin aut Lesley McGee verfasserin aut Keith P. Klugman verfasserin aut Robert F. Breiman verfasserin aut Michael R. Barer verfasserin aut Richard A. Adegbola verfasserin aut Richard A. Adegbola verfasserin aut Martin Antonio verfasserin aut Martin Antonio verfasserin aut Stephen D. Bentley verfasserin aut Stephen D. Bentley verfasserin aut Brenda A. Kwambana-Adams verfasserin aut Brenda A. Kwambana-Adams verfasserin aut In Frontiers in Pediatrics Frontiers Media S.A., 2013 8(2021) (DE-627)742738744 (DE-600)2711999-3 22962360 nnns volume:8 year:2021 https://doi.org/10.3389/fped.2020.587730 kostenfrei https://doaj.org/article/b3fea75bb7bc42ca9d693550857e15cd kostenfrei https://www.frontiersin.org/articles/10.3389/fped.2020.587730/full kostenfrei https://doaj.org/toc/2296-2360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021 |
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10.3389/fped.2020.587730 doi (DE-627)DOAJ073486256 (DE-599)DOAJb3fea75bb7bc42ca9d693550857e15cd DE-627 ger DE-627 rakwb eng RJ1-570 Chrispin Chaguza verfasserin aut Carriage Dynamics of Pneumococcal Serotypes in Naturally Colonized Infants in a Rural African Setting During the First Year of Life 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Streptococcus pneumoniae (the pneumococcus) carriage precedes invasive disease and influences population-wide strain dynamics, but limited data exist on temporal carriage patterns of serotypes due to the prohibitive costs of longitudinal studies. Here, we report carriage prevalence, clearance and acquisition rates of pneumococcal serotypes sampled from newborn infants bi-weekly from weeks 1 to 27, and then bi-monthly from weeks 35 to 52 in the Gambia. We used sweep latex agglutination and whole genome sequencing to serotype the isolates. We show rapid pneumococcal acquisition with nearly 31% of the infants colonized by the end of first week after birth and quickly exceeding 95% after 2 months. Co-colonization with multiple serotypes was consistently observed in over 40% of the infants at each sampling point during the first year of life. Overall, the mean acquisition time and carriage duration regardless of serotype was 38 and 24 days, respectively, but varied considerably between serotypes comparable to observations from other regions. Our data will inform disease prevention and control measures including providing baseline data for parameterising infectious disease mathematical models including those assessing the impact of clinical interventions such as pneumococcal conjugate vaccines. pneumococcus serotype carriage duration acquisition Africa infants Pediatrics Chrispin Chaguza verfasserin aut Madikay Senghore verfasserin aut Ebrima Bojang verfasserin aut Stephanie W. Lo verfasserin aut Chinelo Ebruke verfasserin aut Rebecca A. Gladstone verfasserin aut Peggy-Estelle Tientcheu verfasserin aut Rowan E. Bancroft verfasserin aut Archibald Worwui verfasserin aut Ebenezer Foster-Nyarko verfasserin aut Fatima Ceesay verfasserin aut Catherine Okoi verfasserin aut Lesley McGee verfasserin aut Keith P. Klugman verfasserin aut Robert F. Breiman verfasserin aut Michael R. Barer verfasserin aut Richard A. Adegbola verfasserin aut Richard A. Adegbola verfasserin aut Martin Antonio verfasserin aut Martin Antonio verfasserin aut Stephen D. Bentley verfasserin aut Stephen D. Bentley verfasserin aut Brenda A. Kwambana-Adams verfasserin aut Brenda A. Kwambana-Adams verfasserin aut In Frontiers in Pediatrics Frontiers Media S.A., 2013 8(2021) (DE-627)742738744 (DE-600)2711999-3 22962360 nnns volume:8 year:2021 https://doi.org/10.3389/fped.2020.587730 kostenfrei https://doaj.org/article/b3fea75bb7bc42ca9d693550857e15cd kostenfrei https://www.frontiersin.org/articles/10.3389/fped.2020.587730/full kostenfrei https://doaj.org/toc/2296-2360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021 |
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10.3389/fped.2020.587730 doi (DE-627)DOAJ073486256 (DE-599)DOAJb3fea75bb7bc42ca9d693550857e15cd DE-627 ger DE-627 rakwb eng RJ1-570 Chrispin Chaguza verfasserin aut Carriage Dynamics of Pneumococcal Serotypes in Naturally Colonized Infants in a Rural African Setting During the First Year of Life 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Streptococcus pneumoniae (the pneumococcus) carriage precedes invasive disease and influences population-wide strain dynamics, but limited data exist on temporal carriage patterns of serotypes due to the prohibitive costs of longitudinal studies. Here, we report carriage prevalence, clearance and acquisition rates of pneumococcal serotypes sampled from newborn infants bi-weekly from weeks 1 to 27, and then bi-monthly from weeks 35 to 52 in the Gambia. We used sweep latex agglutination and whole genome sequencing to serotype the isolates. We show rapid pneumococcal acquisition with nearly 31% of the infants colonized by the end of first week after birth and quickly exceeding 95% after 2 months. Co-colonization with multiple serotypes was consistently observed in over 40% of the infants at each sampling point during the first year of life. Overall, the mean acquisition time and carriage duration regardless of serotype was 38 and 24 days, respectively, but varied considerably between serotypes comparable to observations from other regions. Our data will inform disease prevention and control measures including providing baseline data for parameterising infectious disease mathematical models including those assessing the impact of clinical interventions such as pneumococcal conjugate vaccines. pneumococcus serotype carriage duration acquisition Africa infants Pediatrics Chrispin Chaguza verfasserin aut Madikay Senghore verfasserin aut Ebrima Bojang verfasserin aut Stephanie W. Lo verfasserin aut Chinelo Ebruke verfasserin aut Rebecca A. Gladstone verfasserin aut Peggy-Estelle Tientcheu verfasserin aut Rowan E. Bancroft verfasserin aut Archibald Worwui verfasserin aut Ebenezer Foster-Nyarko verfasserin aut Fatima Ceesay verfasserin aut Catherine Okoi verfasserin aut Lesley McGee verfasserin aut Keith P. Klugman verfasserin aut Robert F. Breiman verfasserin aut Michael R. Barer verfasserin aut Richard A. Adegbola verfasserin aut Richard A. Adegbola verfasserin aut Martin Antonio verfasserin aut Martin Antonio verfasserin aut Stephen D. Bentley verfasserin aut Stephen D. Bentley verfasserin aut Brenda A. Kwambana-Adams verfasserin aut Brenda A. Kwambana-Adams verfasserin aut In Frontiers in Pediatrics Frontiers Media S.A., 2013 8(2021) (DE-627)742738744 (DE-600)2711999-3 22962360 nnns volume:8 year:2021 https://doi.org/10.3389/fped.2020.587730 kostenfrei https://doaj.org/article/b3fea75bb7bc42ca9d693550857e15cd kostenfrei https://www.frontiersin.org/articles/10.3389/fped.2020.587730/full kostenfrei https://doaj.org/toc/2296-2360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021 |
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Carriage Dynamics of Pneumococcal Serotypes in Naturally Colonized Infants in a Rural African Setting During the First Year of Life |
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Carriage Dynamics of Pneumococcal Serotypes in Naturally Colonized Infants in a Rural African Setting During the First Year of Life |
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Chrispin Chaguza |
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Frontiers in Pediatrics |
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Chrispin Chaguza Madikay Senghore Ebrima Bojang Stephanie W. Lo Chinelo Ebruke Rebecca A. Gladstone Peggy-Estelle Tientcheu Rowan E. Bancroft Archibald Worwui Ebenezer Foster-Nyarko Fatima Ceesay Catherine Okoi Lesley McGee Keith P. Klugman Robert F. Breiman Michael R. Barer Richard A. Adegbola Martin Antonio Stephen D. Bentley Brenda A. Kwambana-Adams |
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Chrispin Chaguza |
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carriage dynamics of pneumococcal serotypes in naturally colonized infants in a rural african setting during the first year of life |
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Carriage Dynamics of Pneumococcal Serotypes in Naturally Colonized Infants in a Rural African Setting During the First Year of Life |
abstract |
Streptococcus pneumoniae (the pneumococcus) carriage precedes invasive disease and influences population-wide strain dynamics, but limited data exist on temporal carriage patterns of serotypes due to the prohibitive costs of longitudinal studies. Here, we report carriage prevalence, clearance and acquisition rates of pneumococcal serotypes sampled from newborn infants bi-weekly from weeks 1 to 27, and then bi-monthly from weeks 35 to 52 in the Gambia. We used sweep latex agglutination and whole genome sequencing to serotype the isolates. We show rapid pneumococcal acquisition with nearly 31% of the infants colonized by the end of first week after birth and quickly exceeding 95% after 2 months. Co-colonization with multiple serotypes was consistently observed in over 40% of the infants at each sampling point during the first year of life. Overall, the mean acquisition time and carriage duration regardless of serotype was 38 and 24 days, respectively, but varied considerably between serotypes comparable to observations from other regions. Our data will inform disease prevention and control measures including providing baseline data for parameterising infectious disease mathematical models including those assessing the impact of clinical interventions such as pneumococcal conjugate vaccines. |
abstractGer |
Streptococcus pneumoniae (the pneumococcus) carriage precedes invasive disease and influences population-wide strain dynamics, but limited data exist on temporal carriage patterns of serotypes due to the prohibitive costs of longitudinal studies. Here, we report carriage prevalence, clearance and acquisition rates of pneumococcal serotypes sampled from newborn infants bi-weekly from weeks 1 to 27, and then bi-monthly from weeks 35 to 52 in the Gambia. We used sweep latex agglutination and whole genome sequencing to serotype the isolates. We show rapid pneumococcal acquisition with nearly 31% of the infants colonized by the end of first week after birth and quickly exceeding 95% after 2 months. Co-colonization with multiple serotypes was consistently observed in over 40% of the infants at each sampling point during the first year of life. Overall, the mean acquisition time and carriage duration regardless of serotype was 38 and 24 days, respectively, but varied considerably between serotypes comparable to observations from other regions. Our data will inform disease prevention and control measures including providing baseline data for parameterising infectious disease mathematical models including those assessing the impact of clinical interventions such as pneumococcal conjugate vaccines. |
abstract_unstemmed |
Streptococcus pneumoniae (the pneumococcus) carriage precedes invasive disease and influences population-wide strain dynamics, but limited data exist on temporal carriage patterns of serotypes due to the prohibitive costs of longitudinal studies. Here, we report carriage prevalence, clearance and acquisition rates of pneumococcal serotypes sampled from newborn infants bi-weekly from weeks 1 to 27, and then bi-monthly from weeks 35 to 52 in the Gambia. We used sweep latex agglutination and whole genome sequencing to serotype the isolates. We show rapid pneumococcal acquisition with nearly 31% of the infants colonized by the end of first week after birth and quickly exceeding 95% after 2 months. Co-colonization with multiple serotypes was consistently observed in over 40% of the infants at each sampling point during the first year of life. Overall, the mean acquisition time and carriage duration regardless of serotype was 38 and 24 days, respectively, but varied considerably between serotypes comparable to observations from other regions. Our data will inform disease prevention and control measures including providing baseline data for parameterising infectious disease mathematical models including those assessing the impact of clinical interventions such as pneumococcal conjugate vaccines. |
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title_short |
Carriage Dynamics of Pneumococcal Serotypes in Naturally Colonized Infants in a Rural African Setting During the First Year of Life |
url |
https://doi.org/10.3389/fped.2020.587730 https://doaj.org/article/b3fea75bb7bc42ca9d693550857e15cd https://www.frontiersin.org/articles/10.3389/fped.2020.587730/full https://doaj.org/toc/2296-2360 |
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Chrispin Chaguza Madikay Senghore Ebrima Bojang Stephanie W. Lo Chinelo Ebruke Rebecca A. Gladstone Peggy-Estelle Tientcheu Rowan E. Bancroft Archibald Worwui Ebenezer Foster-Nyarko Fatima Ceesay Catherine Okoi Lesley McGee Keith P. Klugman Robert F. Breiman Michael R. Barer Richard A. Adegbola Martin Antonio Stephen D. Bentley Brenda A. Kwambana-Adams |
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Chrispin Chaguza Madikay Senghore Ebrima Bojang Stephanie W. Lo Chinelo Ebruke Rebecca A. Gladstone Peggy-Estelle Tientcheu Rowan E. Bancroft Archibald Worwui Ebenezer Foster-Nyarko Fatima Ceesay Catherine Okoi Lesley McGee Keith P. Klugman Robert F. Breiman Michael R. Barer Richard A. Adegbola Martin Antonio Stephen D. Bentley Brenda A. Kwambana-Adams |
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