Progress of Research on the Relationship between Lung Microbiome and Lung Cancer

The microbiota plays an important role in the biological functions of the human body and is associated with various disease states such as inflammation (gastritis, hepatitis) and cancer (stomach, cervical, liver). The Human Microbiome Project painted a panorama of human microorganisms in its first p...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Zheng SU [verfasserIn] Xinhua JIA [verfasserIn] Yaguang FAN [verfasserIn] Fanghui ZHAO [verfasserIn] Youlin QIAO [verfasserIn]

Format:	E-Artikel
Sprache:	Chinesisch

Erschienen:	2022

Schlagwörter:	lung neoplasms lung microbiome carcinogenesis immunotherapy

Übergeordnetes Werk:	In: Chinese Journal of Lung Cancer - Chinese Anti-Cancer Association; Chinese Antituberculosis Association, 2008, 25(2022), 1, Seite 40-45
Übergeordnetes Werk:	volume:25 ; year:2022 ; number:1 ; pages:40-45

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3779/j.issn.1009-3419.2021.102.53

Katalog-ID:	DOAJ07351635X

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callnumber-first	R - Medicine
author	Zheng SU
spellingShingle	Zheng SU misc RC254-282 misc lung neoplasms misc lung microbiome misc carcinogenesis misc immunotherapy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Progress of Research on the Relationship between Lung Microbiome and Lung Cancer
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topic_title	RC254-282 Progress of Research on the Relationship between Lung Microbiome and Lung Cancer lung neoplasms lung microbiome carcinogenesis immunotherapy
topic	misc RC254-282 misc lung neoplasms misc lung microbiome misc carcinogenesis misc immunotherapy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc lung neoplasms misc lung microbiome misc carcinogenesis misc immunotherapy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title_auth	Progress of Research on the Relationship between Lung Microbiome and Lung Cancer
abstract	The microbiota plays an important role in the biological functions of the human body and is associated with various disease states such as inflammation (gastritis, hepatitis) and cancer (stomach, cervical, liver). The Human Microbiome Project painted a panorama of human microorganisms in its first phase, incorporating body parts such as the nasal cavity, oral cavity, intestine, vagina and skin, while the lungs were considered a sterile environment. However, studies in recent years have confirmed the presence of a rich microbial community in the lung, and the association of this lung microbiota with lung disease has become a hot topic of research. Current research has found that patients with lung cancer have a specific microbiota compared to healthy individuals or patients with lung disease. Even in patients with lung cancer, a lung microbiota specific to the tumor site is present. In addition, different pathological types and metastatic status of lung cancer can lead to differences in microbiota. Mechanistic studies have found that the lung microbiota may influence lung cancer development by affecting the immune response. Clinical studies on lung microbiota and immunotherapy are still in the preliminary stage. More relevant studies are needed in the future to provide high-quality evidence to further understand the oncogenic mechanisms of lung microbiota and provide new ideas for clinical treatment. This paper briefly reviews the progress of lung microbiota research in terms of its relevance to lung cancer, possible molecular mechanisms and applications in clinical treatment, and provides an outlook for future research.
abstractGer	The microbiota plays an important role in the biological functions of the human body and is associated with various disease states such as inflammation (gastritis, hepatitis) and cancer (stomach, cervical, liver). The Human Microbiome Project painted a panorama of human microorganisms in its first phase, incorporating body parts such as the nasal cavity, oral cavity, intestine, vagina and skin, while the lungs were considered a sterile environment. However, studies in recent years have confirmed the presence of a rich microbial community in the lung, and the association of this lung microbiota with lung disease has become a hot topic of research. Current research has found that patients with lung cancer have a specific microbiota compared to healthy individuals or patients with lung disease. Even in patients with lung cancer, a lung microbiota specific to the tumor site is present. In addition, different pathological types and metastatic status of lung cancer can lead to differences in microbiota. Mechanistic studies have found that the lung microbiota may influence lung cancer development by affecting the immune response. Clinical studies on lung microbiota and immunotherapy are still in the preliminary stage. More relevant studies are needed in the future to provide high-quality evidence to further understand the oncogenic mechanisms of lung microbiota and provide new ideas for clinical treatment. This paper briefly reviews the progress of lung microbiota research in terms of its relevance to lung cancer, possible molecular mechanisms and applications in clinical treatment, and provides an outlook for future research.
abstract_unstemmed	The microbiota plays an important role in the biological functions of the human body and is associated with various disease states such as inflammation (gastritis, hepatitis) and cancer (stomach, cervical, liver). The Human Microbiome Project painted a panorama of human microorganisms in its first phase, incorporating body parts such as the nasal cavity, oral cavity, intestine, vagina and skin, while the lungs were considered a sterile environment. However, studies in recent years have confirmed the presence of a rich microbial community in the lung, and the association of this lung microbiota with lung disease has become a hot topic of research. Current research has found that patients with lung cancer have a specific microbiota compared to healthy individuals or patients with lung disease. Even in patients with lung cancer, a lung microbiota specific to the tumor site is present. In addition, different pathological types and metastatic status of lung cancer can lead to differences in microbiota. Mechanistic studies have found that the lung microbiota may influence lung cancer development by affecting the immune response. Clinical studies on lung microbiota and immunotherapy are still in the preliminary stage. More relevant studies are needed in the future to provide high-quality evidence to further understand the oncogenic mechanisms of lung microbiota and provide new ideas for clinical treatment. This paper briefly reviews the progress of lung microbiota research in terms of its relevance to lung cancer, possible molecular mechanisms and applications in clinical treatment, and provides an outlook for future research.
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title_short	Progress of Research on the Relationship between Lung Microbiome and Lung Cancer
url	https://doi.org/10.3779/j.issn.1009-3419.2021.102.53 https://doaj.org/article/abce666d30594647a1a012ec2682b458 http://dx.doi.org/10.3779/j.issn.1009-3419.2021.102.53 https://doaj.org/toc/1009-3419 https://doaj.org/toc/1999-6187
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Progress of Research on the Relationship between Lung Microbiome and Lung Cancer

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