A patient with primary biliary cholangitis, autoimmune hepatitis, and primary sclerosing cholangitis variant syndrome

Overlap between autoimmune hepatitis (AIH) and either primary biliary cholangitis (PBC) or primary sclerosing cholangitis (PSC) is not rare and has extensively been reported. We herein report the first well documented case of triple overlap. A 68-year-old male patient presented with asymptomatic PBC...
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Gespeichert in:

Autor*in:	Benedetta Terziroli Beretta-Piccoli [verfasserIn] Luca Mazzucchelli [verfasserIn] Chiara Taiana [verfasserIn] Giuseppe Mossi [verfasserIn] Corrado Usai [verfasserIn] Diego Vergani [verfasserIn] Giorgina Mieli-Vergani [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	Primary biliary cholangitis Autoimmune hepatitis Primary sclerosing cholangitis Variant syndrome Normal serum alkaline phosphatase level

Übergeordnetes Werk:	In: Journal of Translational Autoimmunity - Elsevier, 2020, 3(2020), Seite 100033-
Übergeordnetes Werk:	volume:3 ; year:2020 ; pages:100033-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.jtauto.2019.100033

Katalog-ID:	DOAJ073518018

Internformat


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520			\|a Overlap between autoimmune hepatitis (AIH) and either primary biliary cholangitis (PBC) or primary sclerosing cholangitis (PSC) is not rare and has extensively been reported. We herein report the first well documented case of triple overlap. A 68-year-old male patient presented with asymptomatic PBC including normal alkaline phosphatase serum level, developed AIH five years later, associated with magnetic resonance cholangiopancreatography biliary changes typical for PSC. Despite treatment with ursodeoxycholic acid and mycophenolate mofetil, owing to prednisone and azathioprine intolerance, he continued to have interface hepatitis and developed increasing fibrosis at follow-up liver biopsy. Our case report raises awareness for this rare and difficult to diagnose and treat clinical phenotype.
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author_variant	b t b p btbp l m lm c t ct g m gm c u cu d v dv g m v gmv
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publishDate	2020
allfields	10.1016/j.jtauto.2019.100033 doi (DE-627)DOAJ073518018 (DE-599)DOAJd1b9a36475704dffa0bf2648a293b2c6 DE-627 ger DE-627 rakwb eng RC581-607 Benedetta Terziroli Beretta-Piccoli verfasserin aut A patient with primary biliary cholangitis, autoimmune hepatitis, and primary sclerosing cholangitis variant syndrome 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Overlap between autoimmune hepatitis (AIH) and either primary biliary cholangitis (PBC) or primary sclerosing cholangitis (PSC) is not rare and has extensively been reported. We herein report the first well documented case of triple overlap. A 68-year-old male patient presented with asymptomatic PBC including normal alkaline phosphatase serum level, developed AIH five years later, associated with magnetic resonance cholangiopancreatography biliary changes typical for PSC. Despite treatment with ursodeoxycholic acid and mycophenolate mofetil, owing to prednisone and azathioprine intolerance, he continued to have interface hepatitis and developed increasing fibrosis at follow-up liver biopsy. Our case report raises awareness for this rare and difficult to diagnose and treat clinical phenotype. Primary biliary cholangitis Autoimmune hepatitis Primary sclerosing cholangitis Variant syndrome Normal serum alkaline phosphatase level Immunologic diseases. Allergy Luca Mazzucchelli verfasserin aut Chiara Taiana verfasserin aut Giuseppe Mossi verfasserin aut Corrado Usai verfasserin aut Diego Vergani verfasserin aut Giorgina Mieli-Vergani verfasserin aut In Journal of Translational Autoimmunity Elsevier, 2020 3(2020), Seite 100033- (DE-627)1691028606 25899090 nnns volume:3 year:2020 pages:100033- https://doi.org/10.1016/j.jtauto.2019.100033 kostenfrei https://doaj.org/article/d1b9a36475704dffa0bf2648a293b2c6 kostenfrei http://www.sciencedirect.com/science/article/pii/S2589909019300334 kostenfrei https://doaj.org/toc/2589-9090 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 3 2020 100033-
spelling	10.1016/j.jtauto.2019.100033 doi (DE-627)DOAJ073518018 (DE-599)DOAJd1b9a36475704dffa0bf2648a293b2c6 DE-627 ger DE-627 rakwb eng RC581-607 Benedetta Terziroli Beretta-Piccoli verfasserin aut A patient with primary biliary cholangitis, autoimmune hepatitis, and primary sclerosing cholangitis variant syndrome 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Overlap between autoimmune hepatitis (AIH) and either primary biliary cholangitis (PBC) or primary sclerosing cholangitis (PSC) is not rare and has extensively been reported. We herein report the first well documented case of triple overlap. A 68-year-old male patient presented with asymptomatic PBC including normal alkaline phosphatase serum level, developed AIH five years later, associated with magnetic resonance cholangiopancreatography biliary changes typical for PSC. Despite treatment with ursodeoxycholic acid and mycophenolate mofetil, owing to prednisone and azathioprine intolerance, he continued to have interface hepatitis and developed increasing fibrosis at follow-up liver biopsy. Our case report raises awareness for this rare and difficult to diagnose and treat clinical phenotype. Primary biliary cholangitis Autoimmune hepatitis Primary sclerosing cholangitis Variant syndrome Normal serum alkaline phosphatase level Immunologic diseases. Allergy Luca Mazzucchelli verfasserin aut Chiara Taiana verfasserin aut Giuseppe Mossi verfasserin aut Corrado Usai verfasserin aut Diego Vergani verfasserin aut Giorgina Mieli-Vergani verfasserin aut In Journal of Translational Autoimmunity Elsevier, 2020 3(2020), Seite 100033- (DE-627)1691028606 25899090 nnns volume:3 year:2020 pages:100033- https://doi.org/10.1016/j.jtauto.2019.100033 kostenfrei https://doaj.org/article/d1b9a36475704dffa0bf2648a293b2c6 kostenfrei http://www.sciencedirect.com/science/article/pii/S2589909019300334 kostenfrei https://doaj.org/toc/2589-9090 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 3 2020 100033-
allfields_unstemmed	10.1016/j.jtauto.2019.100033 doi (DE-627)DOAJ073518018 (DE-599)DOAJd1b9a36475704dffa0bf2648a293b2c6 DE-627 ger DE-627 rakwb eng RC581-607 Benedetta Terziroli Beretta-Piccoli verfasserin aut A patient with primary biliary cholangitis, autoimmune hepatitis, and primary sclerosing cholangitis variant syndrome 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Overlap between autoimmune hepatitis (AIH) and either primary biliary cholangitis (PBC) or primary sclerosing cholangitis (PSC) is not rare and has extensively been reported. We herein report the first well documented case of triple overlap. A 68-year-old male patient presented with asymptomatic PBC including normal alkaline phosphatase serum level, developed AIH five years later, associated with magnetic resonance cholangiopancreatography biliary changes typical for PSC. Despite treatment with ursodeoxycholic acid and mycophenolate mofetil, owing to prednisone and azathioprine intolerance, he continued to have interface hepatitis and developed increasing fibrosis at follow-up liver biopsy. Our case report raises awareness for this rare and difficult to diagnose and treat clinical phenotype. Primary biliary cholangitis Autoimmune hepatitis Primary sclerosing cholangitis Variant syndrome Normal serum alkaline phosphatase level Immunologic diseases. Allergy Luca Mazzucchelli verfasserin aut Chiara Taiana verfasserin aut Giuseppe Mossi verfasserin aut Corrado Usai verfasserin aut Diego Vergani verfasserin aut Giorgina Mieli-Vergani verfasserin aut In Journal of Translational Autoimmunity Elsevier, 2020 3(2020), Seite 100033- (DE-627)1691028606 25899090 nnns volume:3 year:2020 pages:100033- https://doi.org/10.1016/j.jtauto.2019.100033 kostenfrei https://doaj.org/article/d1b9a36475704dffa0bf2648a293b2c6 kostenfrei http://www.sciencedirect.com/science/article/pii/S2589909019300334 kostenfrei https://doaj.org/toc/2589-9090 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 3 2020 100033-
allfieldsGer	10.1016/j.jtauto.2019.100033 doi (DE-627)DOAJ073518018 (DE-599)DOAJd1b9a36475704dffa0bf2648a293b2c6 DE-627 ger DE-627 rakwb eng RC581-607 Benedetta Terziroli Beretta-Piccoli verfasserin aut A patient with primary biliary cholangitis, autoimmune hepatitis, and primary sclerosing cholangitis variant syndrome 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Overlap between autoimmune hepatitis (AIH) and either primary biliary cholangitis (PBC) or primary sclerosing cholangitis (PSC) is not rare and has extensively been reported. We herein report the first well documented case of triple overlap. A 68-year-old male patient presented with asymptomatic PBC including normal alkaline phosphatase serum level, developed AIH five years later, associated with magnetic resonance cholangiopancreatography biliary changes typical for PSC. Despite treatment with ursodeoxycholic acid and mycophenolate mofetil, owing to prednisone and azathioprine intolerance, he continued to have interface hepatitis and developed increasing fibrosis at follow-up liver biopsy. Our case report raises awareness for this rare and difficult to diagnose and treat clinical phenotype. Primary biliary cholangitis Autoimmune hepatitis Primary sclerosing cholangitis Variant syndrome Normal serum alkaline phosphatase level Immunologic diseases. Allergy Luca Mazzucchelli verfasserin aut Chiara Taiana verfasserin aut Giuseppe Mossi verfasserin aut Corrado Usai verfasserin aut Diego Vergani verfasserin aut Giorgina Mieli-Vergani verfasserin aut In Journal of Translational Autoimmunity Elsevier, 2020 3(2020), Seite 100033- (DE-627)1691028606 25899090 nnns volume:3 year:2020 pages:100033- https://doi.org/10.1016/j.jtauto.2019.100033 kostenfrei https://doaj.org/article/d1b9a36475704dffa0bf2648a293b2c6 kostenfrei http://www.sciencedirect.com/science/article/pii/S2589909019300334 kostenfrei https://doaj.org/toc/2589-9090 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 3 2020 100033-
allfieldsSound	10.1016/j.jtauto.2019.100033 doi (DE-627)DOAJ073518018 (DE-599)DOAJd1b9a36475704dffa0bf2648a293b2c6 DE-627 ger DE-627 rakwb eng RC581-607 Benedetta Terziroli Beretta-Piccoli verfasserin aut A patient with primary biliary cholangitis, autoimmune hepatitis, and primary sclerosing cholangitis variant syndrome 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Overlap between autoimmune hepatitis (AIH) and either primary biliary cholangitis (PBC) or primary sclerosing cholangitis (PSC) is not rare and has extensively been reported. We herein report the first well documented case of triple overlap. A 68-year-old male patient presented with asymptomatic PBC including normal alkaline phosphatase serum level, developed AIH five years later, associated with magnetic resonance cholangiopancreatography biliary changes typical for PSC. Despite treatment with ursodeoxycholic acid and mycophenolate mofetil, owing to prednisone and azathioprine intolerance, he continued to have interface hepatitis and developed increasing fibrosis at follow-up liver biopsy. Our case report raises awareness for this rare and difficult to diagnose and treat clinical phenotype. Primary biliary cholangitis Autoimmune hepatitis Primary sclerosing cholangitis Variant syndrome Normal serum alkaline phosphatase level Immunologic diseases. Allergy Luca Mazzucchelli verfasserin aut Chiara Taiana verfasserin aut Giuseppe Mossi verfasserin aut Corrado Usai verfasserin aut Diego Vergani verfasserin aut Giorgina Mieli-Vergani verfasserin aut In Journal of Translational Autoimmunity Elsevier, 2020 3(2020), Seite 100033- (DE-627)1691028606 25899090 nnns volume:3 year:2020 pages:100033- https://doi.org/10.1016/j.jtauto.2019.100033 kostenfrei https://doaj.org/article/d1b9a36475704dffa0bf2648a293b2c6 kostenfrei http://www.sciencedirect.com/science/article/pii/S2589909019300334 kostenfrei https://doaj.org/toc/2589-9090 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 3 2020 100033-
language	English
source	In Journal of Translational Autoimmunity 3(2020), Seite 100033- volume:3 year:2020 pages:100033-
sourceStr	In Journal of Translational Autoimmunity 3(2020), Seite 100033- volume:3 year:2020 pages:100033-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Primary biliary cholangitis Autoimmune hepatitis Primary sclerosing cholangitis Variant syndrome Normal serum alkaline phosphatase level Immunologic diseases. Allergy
isfreeaccess_bool	true
container_title	Journal of Translational Autoimmunity
authorswithroles_txt_mv	Benedetta Terziroli Beretta-Piccoli @@aut@@ Luca Mazzucchelli @@aut@@ Chiara Taiana @@aut@@ Giuseppe Mossi @@aut@@ Corrado Usai @@aut@@ Diego Vergani @@aut@@ Giorgina Mieli-Vergani @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	1691028606
id	DOAJ073518018
language_de	englisch
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callnumber-first	R - Medicine
author	Benedetta Terziroli Beretta-Piccoli
spellingShingle	Benedetta Terziroli Beretta-Piccoli misc RC581-607 misc Primary biliary cholangitis misc Autoimmune hepatitis misc Primary sclerosing cholangitis misc Variant syndrome misc Normal serum alkaline phosphatase level misc Immunologic diseases. Allergy A patient with primary biliary cholangitis, autoimmune hepatitis, and primary sclerosing cholangitis variant syndrome
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topic_title	RC581-607 A patient with primary biliary cholangitis, autoimmune hepatitis, and primary sclerosing cholangitis variant syndrome Primary biliary cholangitis Autoimmune hepatitis Primary sclerosing cholangitis Variant syndrome Normal serum alkaline phosphatase level
topic	misc RC581-607 misc Primary biliary cholangitis misc Autoimmune hepatitis misc Primary sclerosing cholangitis misc Variant syndrome misc Normal serum alkaline phosphatase level misc Immunologic diseases. Allergy
topic_unstemmed	misc RC581-607 misc Primary biliary cholangitis misc Autoimmune hepatitis misc Primary sclerosing cholangitis misc Variant syndrome misc Normal serum alkaline phosphatase level misc Immunologic diseases. Allergy
topic_browse	misc RC581-607 misc Primary biliary cholangitis misc Autoimmune hepatitis misc Primary sclerosing cholangitis misc Variant syndrome misc Normal serum alkaline phosphatase level misc Immunologic diseases. Allergy
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title	A patient with primary biliary cholangitis, autoimmune hepatitis, and primary sclerosing cholangitis variant syndrome
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title_full	A patient with primary biliary cholangitis, autoimmune hepatitis, and primary sclerosing cholangitis variant syndrome
author_sort	Benedetta Terziroli Beretta-Piccoli
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author_browse	Benedetta Terziroli Beretta-Piccoli Luca Mazzucchelli Chiara Taiana Giuseppe Mossi Corrado Usai Diego Vergani Giorgina Mieli-Vergani
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author-letter	Benedetta Terziroli Beretta-Piccoli
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title_sort	patient with primary biliary cholangitis, autoimmune hepatitis, and primary sclerosing cholangitis variant syndrome
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title_auth	A patient with primary biliary cholangitis, autoimmune hepatitis, and primary sclerosing cholangitis variant syndrome
abstract	Overlap between autoimmune hepatitis (AIH) and either primary biliary cholangitis (PBC) or primary sclerosing cholangitis (PSC) is not rare and has extensively been reported. We herein report the first well documented case of triple overlap. A 68-year-old male patient presented with asymptomatic PBC including normal alkaline phosphatase serum level, developed AIH five years later, associated with magnetic resonance cholangiopancreatography biliary changes typical for PSC. Despite treatment with ursodeoxycholic acid and mycophenolate mofetil, owing to prednisone and azathioprine intolerance, he continued to have interface hepatitis and developed increasing fibrosis at follow-up liver biopsy. Our case report raises awareness for this rare and difficult to diagnose and treat clinical phenotype.
abstractGer	Overlap between autoimmune hepatitis (AIH) and either primary biliary cholangitis (PBC) or primary sclerosing cholangitis (PSC) is not rare and has extensively been reported. We herein report the first well documented case of triple overlap. A 68-year-old male patient presented with asymptomatic PBC including normal alkaline phosphatase serum level, developed AIH five years later, associated with magnetic resonance cholangiopancreatography biliary changes typical for PSC. Despite treatment with ursodeoxycholic acid and mycophenolate mofetil, owing to prednisone and azathioprine intolerance, he continued to have interface hepatitis and developed increasing fibrosis at follow-up liver biopsy. Our case report raises awareness for this rare and difficult to diagnose and treat clinical phenotype.
abstract_unstemmed	Overlap between autoimmune hepatitis (AIH) and either primary biliary cholangitis (PBC) or primary sclerosing cholangitis (PSC) is not rare and has extensively been reported. We herein report the first well documented case of triple overlap. A 68-year-old male patient presented with asymptomatic PBC including normal alkaline phosphatase serum level, developed AIH five years later, associated with magnetic resonance cholangiopancreatography biliary changes typical for PSC. Despite treatment with ursodeoxycholic acid and mycophenolate mofetil, owing to prednisone and azathioprine intolerance, he continued to have interface hepatitis and developed increasing fibrosis at follow-up liver biopsy. Our case report raises awareness for this rare and difficult to diagnose and treat clinical phenotype.
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title_short	A patient with primary biliary cholangitis, autoimmune hepatitis, and primary sclerosing cholangitis variant syndrome
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up_date	2024-07-03T18:08:04.983Z
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A patient with primary biliary cholangitis, autoimmune hepatitis, and primary sclerosing cholangitis variant syndrome

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