Xanthoma Disseminatum Presenting with Hoarseness

Introduction: Xanthoma disseminatum (XD) is a rare, benign, non-Langerhans cell histiocytic disorder with unknown etio-pathology. It manifests with multiple, grouped, red-brown to yellow papules and nodules involving the skin, mucous membranes, and internal organs with a predilection for flexures an...
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Autor*in:	Biswanath Behera [verfasserIn] Munisamy Malathi [verfasserIn] Devinder-Mohan Thappa [verfasserIn] Hemanth Vamanshankar [verfasserIn] Pradipta-Kumar Parida [verfasserIn] Debasis Gochhait [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	Hoarseness Vocal cord Xanthoma

Übergeordnetes Werk:	In: Iranian Journal of Otorhinolaryngology - Mashhad University of Medical Sciences, 2013, 29(2017), 6, Seite 365-368
Übergeordnetes Werk:	volume:29 ; year:2017 ; number:6 ; pages:365-368

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.22038/ijorl.2017.16705.1574

Katalog-ID:	DOAJ073543977

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spelling	10.22038/ijorl.2017.16705.1574 doi (DE-627)DOAJ073543977 (DE-599)DOAJda204f3ea8d844b2929ee2d6ea41ab87 DE-627 ger DE-627 rakwb eng RF1-547 Biswanath Behera verfasserin aut Xanthoma Disseminatum Presenting with Hoarseness 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Xanthoma disseminatum (XD) is a rare, benign, non-Langerhans cell histiocytic disorder with unknown etio-pathology. It manifests with multiple, grouped, red-brown to yellow papules and nodules involving the skin, mucous membranes, and internal organs with a predilection for flexures and the face. Case Report: We report a patient who presented with disseminated xanthomatous papules and nodules involving the face, neck, trunk, axilla, groin, and oral cavity, along with hoarseness of voice. Video laryngoscopy revealed multiple yellowish nodules over the base of the tongue, vallecula, laryngeal surface of the epiglottis, ary-epiglottic folds, interarytenoid region, and subglottic region. Histopathology was suggestive of xanthoma disseminatum and the patient was treated with tablet acitretin 25mg daily for three months without any response. Following this, the patient was prescribed tablet thalidomide 100 mg daily without any significant improvement at the end of two months. Conclusion: Xanthoma disseminatum is a very rare form of non-Langerhans cell histiocytosis that classically presents with cutaneous xanthomas, mucosal xanthomas, and diabetes insipidus. Hoarseness of voice due to lesions involving the larynx is a rare symptom. Because the disease has punctated, numerous relapses and causes morbidity to the patient, its multisystem manifestations have to be known. Therefore, xanthoma disseminatum has to be kept in mind as a differential diagnosis for hoarseness of voice. Hoarseness Vocal cord Xanthoma Otorhinolaryngology Munisamy Malathi verfasserin aut Devinder-Mohan Thappa verfasserin aut Hemanth Vamanshankar verfasserin aut Pradipta-Kumar Parida verfasserin aut Debasis Gochhait verfasserin aut In Iranian Journal of Otorhinolaryngology Mashhad University of Medical Sciences, 2013 29(2017), 6, Seite 365-368 (DE-627)169604944X 2251726X nnns volume:29 year:2017 number:6 pages:365-368 https://doi.org/10.22038/ijorl.2017.16705.1574 kostenfrei https://doaj.org/article/da204f3ea8d844b2929ee2d6ea41ab87 kostenfrei http://ijorl.mums.ac.ir/article_9581_ab61d6d73e276d7bcb844a0f1ddfc527.pdf kostenfrei https://doaj.org/toc/2251-7251 Journal toc kostenfrei https://doaj.org/toc/2251-726X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 29 2017 6 365-368
allfields_unstemmed	10.22038/ijorl.2017.16705.1574 doi (DE-627)DOAJ073543977 (DE-599)DOAJda204f3ea8d844b2929ee2d6ea41ab87 DE-627 ger DE-627 rakwb eng RF1-547 Biswanath Behera verfasserin aut Xanthoma Disseminatum Presenting with Hoarseness 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Xanthoma disseminatum (XD) is a rare, benign, non-Langerhans cell histiocytic disorder with unknown etio-pathology. It manifests with multiple, grouped, red-brown to yellow papules and nodules involving the skin, mucous membranes, and internal organs with a predilection for flexures and the face. Case Report: We report a patient who presented with disseminated xanthomatous papules and nodules involving the face, neck, trunk, axilla, groin, and oral cavity, along with hoarseness of voice. Video laryngoscopy revealed multiple yellowish nodules over the base of the tongue, vallecula, laryngeal surface of the epiglottis, ary-epiglottic folds, interarytenoid region, and subglottic region. Histopathology was suggestive of xanthoma disseminatum and the patient was treated with tablet acitretin 25mg daily for three months without any response. Following this, the patient was prescribed tablet thalidomide 100 mg daily without any significant improvement at the end of two months. Conclusion: Xanthoma disseminatum is a very rare form of non-Langerhans cell histiocytosis that classically presents with cutaneous xanthomas, mucosal xanthomas, and diabetes insipidus. Hoarseness of voice due to lesions involving the larynx is a rare symptom. Because the disease has punctated, numerous relapses and causes morbidity to the patient, its multisystem manifestations have to be known. Therefore, xanthoma disseminatum has to be kept in mind as a differential diagnosis for hoarseness of voice. Hoarseness Vocal cord Xanthoma Otorhinolaryngology Munisamy Malathi verfasserin aut Devinder-Mohan Thappa verfasserin aut Hemanth Vamanshankar verfasserin aut Pradipta-Kumar Parida verfasserin aut Debasis Gochhait verfasserin aut In Iranian Journal of Otorhinolaryngology Mashhad University of Medical Sciences, 2013 29(2017), 6, Seite 365-368 (DE-627)169604944X 2251726X nnns volume:29 year:2017 number:6 pages:365-368 https://doi.org/10.22038/ijorl.2017.16705.1574 kostenfrei https://doaj.org/article/da204f3ea8d844b2929ee2d6ea41ab87 kostenfrei http://ijorl.mums.ac.ir/article_9581_ab61d6d73e276d7bcb844a0f1ddfc527.pdf kostenfrei https://doaj.org/toc/2251-7251 Journal toc kostenfrei https://doaj.org/toc/2251-726X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 29 2017 6 365-368
allfieldsGer	10.22038/ijorl.2017.16705.1574 doi (DE-627)DOAJ073543977 (DE-599)DOAJda204f3ea8d844b2929ee2d6ea41ab87 DE-627 ger DE-627 rakwb eng RF1-547 Biswanath Behera verfasserin aut Xanthoma Disseminatum Presenting with Hoarseness 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Xanthoma disseminatum (XD) is a rare, benign, non-Langerhans cell histiocytic disorder with unknown etio-pathology. It manifests with multiple, grouped, red-brown to yellow papules and nodules involving the skin, mucous membranes, and internal organs with a predilection for flexures and the face. Case Report: We report a patient who presented with disseminated xanthomatous papules and nodules involving the face, neck, trunk, axilla, groin, and oral cavity, along with hoarseness of voice. Video laryngoscopy revealed multiple yellowish nodules over the base of the tongue, vallecula, laryngeal surface of the epiglottis, ary-epiglottic folds, interarytenoid region, and subglottic region. Histopathology was suggestive of xanthoma disseminatum and the patient was treated with tablet acitretin 25mg daily for three months without any response. Following this, the patient was prescribed tablet thalidomide 100 mg daily without any significant improvement at the end of two months. Conclusion: Xanthoma disseminatum is a very rare form of non-Langerhans cell histiocytosis that classically presents with cutaneous xanthomas, mucosal xanthomas, and diabetes insipidus. Hoarseness of voice due to lesions involving the larynx is a rare symptom. Because the disease has punctated, numerous relapses and causes morbidity to the patient, its multisystem manifestations have to be known. Therefore, xanthoma disseminatum has to be kept in mind as a differential diagnosis for hoarseness of voice. Hoarseness Vocal cord Xanthoma Otorhinolaryngology Munisamy Malathi verfasserin aut Devinder-Mohan Thappa verfasserin aut Hemanth Vamanshankar verfasserin aut Pradipta-Kumar Parida verfasserin aut Debasis Gochhait verfasserin aut In Iranian Journal of Otorhinolaryngology Mashhad University of Medical Sciences, 2013 29(2017), 6, Seite 365-368 (DE-627)169604944X 2251726X nnns volume:29 year:2017 number:6 pages:365-368 https://doi.org/10.22038/ijorl.2017.16705.1574 kostenfrei https://doaj.org/article/da204f3ea8d844b2929ee2d6ea41ab87 kostenfrei http://ijorl.mums.ac.ir/article_9581_ab61d6d73e276d7bcb844a0f1ddfc527.pdf kostenfrei https://doaj.org/toc/2251-7251 Journal toc kostenfrei https://doaj.org/toc/2251-726X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 29 2017 6 365-368
allfieldsSound	10.22038/ijorl.2017.16705.1574 doi (DE-627)DOAJ073543977 (DE-599)DOAJda204f3ea8d844b2929ee2d6ea41ab87 DE-627 ger DE-627 rakwb eng RF1-547 Biswanath Behera verfasserin aut Xanthoma Disseminatum Presenting with Hoarseness 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Xanthoma disseminatum (XD) is a rare, benign, non-Langerhans cell histiocytic disorder with unknown etio-pathology. It manifests with multiple, grouped, red-brown to yellow papules and nodules involving the skin, mucous membranes, and internal organs with a predilection for flexures and the face. Case Report: We report a patient who presented with disseminated xanthomatous papules and nodules involving the face, neck, trunk, axilla, groin, and oral cavity, along with hoarseness of voice. Video laryngoscopy revealed multiple yellowish nodules over the base of the tongue, vallecula, laryngeal surface of the epiglottis, ary-epiglottic folds, interarytenoid region, and subglottic region. Histopathology was suggestive of xanthoma disseminatum and the patient was treated with tablet acitretin 25mg daily for three months without any response. Following this, the patient was prescribed tablet thalidomide 100 mg daily without any significant improvement at the end of two months. Conclusion: Xanthoma disseminatum is a very rare form of non-Langerhans cell histiocytosis that classically presents with cutaneous xanthomas, mucosal xanthomas, and diabetes insipidus. Hoarseness of voice due to lesions involving the larynx is a rare symptom. Because the disease has punctated, numerous relapses and causes morbidity to the patient, its multisystem manifestations have to be known. Therefore, xanthoma disseminatum has to be kept in mind as a differential diagnosis for hoarseness of voice. Hoarseness Vocal cord Xanthoma Otorhinolaryngology Munisamy Malathi verfasserin aut Devinder-Mohan Thappa verfasserin aut Hemanth Vamanshankar verfasserin aut Pradipta-Kumar Parida verfasserin aut Debasis Gochhait verfasserin aut In Iranian Journal of Otorhinolaryngology Mashhad University of Medical Sciences, 2013 29(2017), 6, Seite 365-368 (DE-627)169604944X 2251726X nnns volume:29 year:2017 number:6 pages:365-368 https://doi.org/10.22038/ijorl.2017.16705.1574 kostenfrei https://doaj.org/article/da204f3ea8d844b2929ee2d6ea41ab87 kostenfrei http://ijorl.mums.ac.ir/article_9581_ab61d6d73e276d7bcb844a0f1ddfc527.pdf kostenfrei https://doaj.org/toc/2251-7251 Journal toc kostenfrei https://doaj.org/toc/2251-726X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 29 2017 6 365-368
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author	Biswanath Behera
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topic_title	RF1-547 Xanthoma Disseminatum Presenting with Hoarseness Hoarseness Vocal cord Xanthoma
topic	misc RF1-547 misc Hoarseness misc Vocal cord misc Xanthoma misc Otorhinolaryngology
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title	Xanthoma Disseminatum Presenting with Hoarseness
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title_full	Xanthoma Disseminatum Presenting with Hoarseness
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title_sort	xanthoma disseminatum presenting with hoarseness
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title_auth	Xanthoma Disseminatum Presenting with Hoarseness
abstract	Introduction: Xanthoma disseminatum (XD) is a rare, benign, non-Langerhans cell histiocytic disorder with unknown etio-pathology. It manifests with multiple, grouped, red-brown to yellow papules and nodules involving the skin, mucous membranes, and internal organs with a predilection for flexures and the face. Case Report: We report a patient who presented with disseminated xanthomatous papules and nodules involving the face, neck, trunk, axilla, groin, and oral cavity, along with hoarseness of voice. Video laryngoscopy revealed multiple yellowish nodules over the base of the tongue, vallecula, laryngeal surface of the epiglottis, ary-epiglottic folds, interarytenoid region, and subglottic region. Histopathology was suggestive of xanthoma disseminatum and the patient was treated with tablet acitretin 25mg daily for three months without any response. Following this, the patient was prescribed tablet thalidomide 100 mg daily without any significant improvement at the end of two months. Conclusion: Xanthoma disseminatum is a very rare form of non-Langerhans cell histiocytosis that classically presents with cutaneous xanthomas, mucosal xanthomas, and diabetes insipidus. Hoarseness of voice due to lesions involving the larynx is a rare symptom. Because the disease has punctated, numerous relapses and causes morbidity to the patient, its multisystem manifestations have to be known. Therefore, xanthoma disseminatum has to be kept in mind as a differential diagnosis for hoarseness of voice.
abstractGer	Introduction: Xanthoma disseminatum (XD) is a rare, benign, non-Langerhans cell histiocytic disorder with unknown etio-pathology. It manifests with multiple, grouped, red-brown to yellow papules and nodules involving the skin, mucous membranes, and internal organs with a predilection for flexures and the face. Case Report: We report a patient who presented with disseminated xanthomatous papules and nodules involving the face, neck, trunk, axilla, groin, and oral cavity, along with hoarseness of voice. Video laryngoscopy revealed multiple yellowish nodules over the base of the tongue, vallecula, laryngeal surface of the epiglottis, ary-epiglottic folds, interarytenoid region, and subglottic region. Histopathology was suggestive of xanthoma disseminatum and the patient was treated with tablet acitretin 25mg daily for three months without any response. Following this, the patient was prescribed tablet thalidomide 100 mg daily without any significant improvement at the end of two months. Conclusion: Xanthoma disseminatum is a very rare form of non-Langerhans cell histiocytosis that classically presents with cutaneous xanthomas, mucosal xanthomas, and diabetes insipidus. Hoarseness of voice due to lesions involving the larynx is a rare symptom. Because the disease has punctated, numerous relapses and causes morbidity to the patient, its multisystem manifestations have to be known. Therefore, xanthoma disseminatum has to be kept in mind as a differential diagnosis for hoarseness of voice.
abstract_unstemmed	Introduction: Xanthoma disseminatum (XD) is a rare, benign, non-Langerhans cell histiocytic disorder with unknown etio-pathology. It manifests with multiple, grouped, red-brown to yellow papules and nodules involving the skin, mucous membranes, and internal organs with a predilection for flexures and the face. Case Report: We report a patient who presented with disseminated xanthomatous papules and nodules involving the face, neck, trunk, axilla, groin, and oral cavity, along with hoarseness of voice. Video laryngoscopy revealed multiple yellowish nodules over the base of the tongue, vallecula, laryngeal surface of the epiglottis, ary-epiglottic folds, interarytenoid region, and subglottic region. Histopathology was suggestive of xanthoma disseminatum and the patient was treated with tablet acitretin 25mg daily for three months without any response. Following this, the patient was prescribed tablet thalidomide 100 mg daily without any significant improvement at the end of two months. Conclusion: Xanthoma disseminatum is a very rare form of non-Langerhans cell histiocytosis that classically presents with cutaneous xanthomas, mucosal xanthomas, and diabetes insipidus. Hoarseness of voice due to lesions involving the larynx is a rare symptom. Because the disease has punctated, numerous relapses and causes morbidity to the patient, its multisystem manifestations have to be known. Therefore, xanthoma disseminatum has to be kept in mind as a differential diagnosis for hoarseness of voice.
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url	https://doi.org/10.22038/ijorl.2017.16705.1574 https://doaj.org/article/da204f3ea8d844b2929ee2d6ea41ab87 http://ijorl.mums.ac.ir/article_9581_ab61d6d73e276d7bcb844a0f1ddfc527.pdf https://doaj.org/toc/2251-7251 https://doaj.org/toc/2251-726X
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Conclusion: Xanthoma disseminatum is a very rare form of non-Langerhans cell histiocytosis that classically presents with cutaneous xanthomas, mucosal xanthomas, and diabetes insipidus. Hoarseness of voice due to lesions involving the larynx is a rare symptom. Because the disease has punctated, numerous relapses and causes morbidity to the patient, its multisystem manifestations have to be known. 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Xanthoma Disseminatum Presenting with Hoarseness

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