Ultrafiltration LC-ESI-MSn screening of 5-lipoxygenase inhibitors from selected Chinese medicinal herbs Saposhnikovia divaricata, Smilax glabra, Pueraria lobata and Carthamus tinctorius

Ultrafiltration liquid chromatography coupled to electrospray ionization tandem mass spectrometry (ultrafiltration LC-ESI-MSn) was used to screen 5-lipoxygenase (5-LOX) inhibitors from selected Chinese medicinal herbs Saposhnikovia divaricata (Turcz.) Schischk, Smilax glabra Roxb., Pueraria lobata a...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Anqi Zhao [verfasserIn] Li Li [verfasserIn] Bo Li [verfasserIn] Meizhu Zheng [verfasserIn] Rong Tsao [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	S. divaricata S. glabra P. lobata C. tinctorius 5-LOX inhibitor Ultrafiltration LC-ESI-MS

Übergeordnetes Werk:	In: Journal of Functional Foods - Elsevier, 2021, 24(2016), Seite 244-253
Übergeordnetes Werk:	volume:24 ; year:2016 ; pages:244-253

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.jff.2016.04.011

Katalog-ID:	DOAJ073547824

Internformat


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245	1	0	\|a Ultrafiltration LC-ESI-MSn screening of 5-lipoxygenase inhibitors from selected Chinese medicinal herbs Saposhnikovia divaricata, Smilax glabra, Pueraria lobata and Carthamus tinctorius
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520			\|a Ultrafiltration liquid chromatography coupled to electrospray ionization tandem mass spectrometry (ultrafiltration LC-ESI-MSn) was used to screen 5-lipoxygenase (5-LOX) inhibitors from selected Chinese medicinal herbs Saposhnikovia divaricata (Turcz.) Schischk, Smilax glabra Roxb., Pueraria lobata and Carthamus tinctorius L. for the first time. The phytochemical compositions of the four medicinal herbs were analysed and the major components identified. The potency of the 5-LOX inhibitors identified in ultrafiltration LC-ESI-MSn was compared to the IC50's obtained from in vitro enzyme inhibition assay. As a result, sec-O-glucosylhamaudol, resveratrol, daidzin and anhydrosafflor yellow B had the highest binding ability to 5-LOX, and were the main contributors to the 5-LOX inhibitory activities of S. divaricata, S. glabra, P. lobata and C. tinctorius extracts, respectively. These strong 5-LOX inhibitors were not necessarily the major components. The high inhibitory activity of resveratrol and daidzin indicates foods such as grapes and soybean may be beneficial to 5-LOX mediated diseases.
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912			\|a GBV_ILN_2006
912			\|a GBV_ILN_2007
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matchkey_str	article:22149414:2016----::lrflrtoleissreigflpxgnsihbtrfoslcecieeeiiahrsaohioidvrctsiag
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publishDate	2016
allfields	10.1016/j.jff.2016.04.011 doi (DE-627)DOAJ073547824 (DE-599)DOAJ4231fe769e18489db2b9a55e245aa71e DE-627 ger DE-627 rakwb eng TX341-641 Anqi Zhao verfasserin aut Ultrafiltration LC-ESI-MSn screening of 5-lipoxygenase inhibitors from selected Chinese medicinal herbs Saposhnikovia divaricata, Smilax glabra, Pueraria lobata and Carthamus tinctorius 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Ultrafiltration liquid chromatography coupled to electrospray ionization tandem mass spectrometry (ultrafiltration LC-ESI-MSn) was used to screen 5-lipoxygenase (5-LOX) inhibitors from selected Chinese medicinal herbs Saposhnikovia divaricata (Turcz.) Schischk, Smilax glabra Roxb., Pueraria lobata and Carthamus tinctorius L. for the first time. The phytochemical compositions of the four medicinal herbs were analysed and the major components identified. The potency of the 5-LOX inhibitors identified in ultrafiltration LC-ESI-MSn was compared to the IC50's obtained from in vitro enzyme inhibition assay. As a result, sec-O-glucosylhamaudol, resveratrol, daidzin and anhydrosafflor yellow B had the highest binding ability to 5-LOX, and were the main contributors to the 5-LOX inhibitory activities of S. divaricata, S. glabra, P. lobata and C. tinctorius extracts, respectively. These strong 5-LOX inhibitors were not necessarily the major components. The high inhibitory activity of resveratrol and daidzin indicates foods such as grapes and soybean may be beneficial to 5-LOX mediated diseases. S. divaricata S. glabra P. lobata C. tinctorius 5-LOX inhibitor Ultrafiltration LC-ESI-MS Nutrition. Foods and food supply Li Li verfasserin aut Bo Li verfasserin aut Meizhu Zheng verfasserin aut Rong Tsao verfasserin aut In Journal of Functional Foods Elsevier, 2021 24(2016), Seite 244-253 (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:24 year:2016 pages:244-253 https://doi.org/10.1016/j.jff.2016.04.011 kostenfrei https://doaj.org/article/4231fe769e18489db2b9a55e245aa71e kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464616300664 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_165 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 24 2016 244-253
spelling	10.1016/j.jff.2016.04.011 doi (DE-627)DOAJ073547824 (DE-599)DOAJ4231fe769e18489db2b9a55e245aa71e DE-627 ger DE-627 rakwb eng TX341-641 Anqi Zhao verfasserin aut Ultrafiltration LC-ESI-MSn screening of 5-lipoxygenase inhibitors from selected Chinese medicinal herbs Saposhnikovia divaricata, Smilax glabra, Pueraria lobata and Carthamus tinctorius 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Ultrafiltration liquid chromatography coupled to electrospray ionization tandem mass spectrometry (ultrafiltration LC-ESI-MSn) was used to screen 5-lipoxygenase (5-LOX) inhibitors from selected Chinese medicinal herbs Saposhnikovia divaricata (Turcz.) Schischk, Smilax glabra Roxb., Pueraria lobata and Carthamus tinctorius L. for the first time. The phytochemical compositions of the four medicinal herbs were analysed and the major components identified. The potency of the 5-LOX inhibitors identified in ultrafiltration LC-ESI-MSn was compared to the IC50's obtained from in vitro enzyme inhibition assay. As a result, sec-O-glucosylhamaudol, resveratrol, daidzin and anhydrosafflor yellow B had the highest binding ability to 5-LOX, and were the main contributors to the 5-LOX inhibitory activities of S. divaricata, S. glabra, P. lobata and C. tinctorius extracts, respectively. These strong 5-LOX inhibitors were not necessarily the major components. The high inhibitory activity of resveratrol and daidzin indicates foods such as grapes and soybean may be beneficial to 5-LOX mediated diseases. S. divaricata S. glabra P. lobata C. tinctorius 5-LOX inhibitor Ultrafiltration LC-ESI-MS Nutrition. Foods and food supply Li Li verfasserin aut Bo Li verfasserin aut Meizhu Zheng verfasserin aut Rong Tsao verfasserin aut In Journal of Functional Foods Elsevier, 2021 24(2016), Seite 244-253 (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:24 year:2016 pages:244-253 https://doi.org/10.1016/j.jff.2016.04.011 kostenfrei https://doaj.org/article/4231fe769e18489db2b9a55e245aa71e kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464616300664 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_165 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 24 2016 244-253
allfields_unstemmed	10.1016/j.jff.2016.04.011 doi (DE-627)DOAJ073547824 (DE-599)DOAJ4231fe769e18489db2b9a55e245aa71e DE-627 ger DE-627 rakwb eng TX341-641 Anqi Zhao verfasserin aut Ultrafiltration LC-ESI-MSn screening of 5-lipoxygenase inhibitors from selected Chinese medicinal herbs Saposhnikovia divaricata, Smilax glabra, Pueraria lobata and Carthamus tinctorius 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Ultrafiltration liquid chromatography coupled to electrospray ionization tandem mass spectrometry (ultrafiltration LC-ESI-MSn) was used to screen 5-lipoxygenase (5-LOX) inhibitors from selected Chinese medicinal herbs Saposhnikovia divaricata (Turcz.) Schischk, Smilax glabra Roxb., Pueraria lobata and Carthamus tinctorius L. for the first time. The phytochemical compositions of the four medicinal herbs were analysed and the major components identified. The potency of the 5-LOX inhibitors identified in ultrafiltration LC-ESI-MSn was compared to the IC50's obtained from in vitro enzyme inhibition assay. As a result, sec-O-glucosylhamaudol, resveratrol, daidzin and anhydrosafflor yellow B had the highest binding ability to 5-LOX, and were the main contributors to the 5-LOX inhibitory activities of S. divaricata, S. glabra, P. lobata and C. tinctorius extracts, respectively. These strong 5-LOX inhibitors were not necessarily the major components. The high inhibitory activity of resveratrol and daidzin indicates foods such as grapes and soybean may be beneficial to 5-LOX mediated diseases. S. divaricata S. glabra P. lobata C. tinctorius 5-LOX inhibitor Ultrafiltration LC-ESI-MS Nutrition. Foods and food supply Li Li verfasserin aut Bo Li verfasserin aut Meizhu Zheng verfasserin aut Rong Tsao verfasserin aut In Journal of Functional Foods Elsevier, 2021 24(2016), Seite 244-253 (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:24 year:2016 pages:244-253 https://doi.org/10.1016/j.jff.2016.04.011 kostenfrei https://doaj.org/article/4231fe769e18489db2b9a55e245aa71e kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464616300664 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_165 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 24 2016 244-253
allfieldsGer	10.1016/j.jff.2016.04.011 doi (DE-627)DOAJ073547824 (DE-599)DOAJ4231fe769e18489db2b9a55e245aa71e DE-627 ger DE-627 rakwb eng TX341-641 Anqi Zhao verfasserin aut Ultrafiltration LC-ESI-MSn screening of 5-lipoxygenase inhibitors from selected Chinese medicinal herbs Saposhnikovia divaricata, Smilax glabra, Pueraria lobata and Carthamus tinctorius 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Ultrafiltration liquid chromatography coupled to electrospray ionization tandem mass spectrometry (ultrafiltration LC-ESI-MSn) was used to screen 5-lipoxygenase (5-LOX) inhibitors from selected Chinese medicinal herbs Saposhnikovia divaricata (Turcz.) Schischk, Smilax glabra Roxb., Pueraria lobata and Carthamus tinctorius L. for the first time. The phytochemical compositions of the four medicinal herbs were analysed and the major components identified. The potency of the 5-LOX inhibitors identified in ultrafiltration LC-ESI-MSn was compared to the IC50's obtained from in vitro enzyme inhibition assay. As a result, sec-O-glucosylhamaudol, resveratrol, daidzin and anhydrosafflor yellow B had the highest binding ability to 5-LOX, and were the main contributors to the 5-LOX inhibitory activities of S. divaricata, S. glabra, P. lobata and C. tinctorius extracts, respectively. These strong 5-LOX inhibitors were not necessarily the major components. The high inhibitory activity of resveratrol and daidzin indicates foods such as grapes and soybean may be beneficial to 5-LOX mediated diseases. S. divaricata S. glabra P. lobata C. tinctorius 5-LOX inhibitor Ultrafiltration LC-ESI-MS Nutrition. Foods and food supply Li Li verfasserin aut Bo Li verfasserin aut Meizhu Zheng verfasserin aut Rong Tsao verfasserin aut In Journal of Functional Foods Elsevier, 2021 24(2016), Seite 244-253 (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:24 year:2016 pages:244-253 https://doi.org/10.1016/j.jff.2016.04.011 kostenfrei https://doaj.org/article/4231fe769e18489db2b9a55e245aa71e kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464616300664 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_165 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 24 2016 244-253
allfieldsSound	10.1016/j.jff.2016.04.011 doi (DE-627)DOAJ073547824 (DE-599)DOAJ4231fe769e18489db2b9a55e245aa71e DE-627 ger DE-627 rakwb eng TX341-641 Anqi Zhao verfasserin aut Ultrafiltration LC-ESI-MSn screening of 5-lipoxygenase inhibitors from selected Chinese medicinal herbs Saposhnikovia divaricata, Smilax glabra, Pueraria lobata and Carthamus tinctorius 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Ultrafiltration liquid chromatography coupled to electrospray ionization tandem mass spectrometry (ultrafiltration LC-ESI-MSn) was used to screen 5-lipoxygenase (5-LOX) inhibitors from selected Chinese medicinal herbs Saposhnikovia divaricata (Turcz.) Schischk, Smilax glabra Roxb., Pueraria lobata and Carthamus tinctorius L. for the first time. The phytochemical compositions of the four medicinal herbs were analysed and the major components identified. The potency of the 5-LOX inhibitors identified in ultrafiltration LC-ESI-MSn was compared to the IC50's obtained from in vitro enzyme inhibition assay. As a result, sec-O-glucosylhamaudol, resveratrol, daidzin and anhydrosafflor yellow B had the highest binding ability to 5-LOX, and were the main contributors to the 5-LOX inhibitory activities of S. divaricata, S. glabra, P. lobata and C. tinctorius extracts, respectively. These strong 5-LOX inhibitors were not necessarily the major components. The high inhibitory activity of resveratrol and daidzin indicates foods such as grapes and soybean may be beneficial to 5-LOX mediated diseases. S. divaricata S. glabra P. lobata C. tinctorius 5-LOX inhibitor Ultrafiltration LC-ESI-MS Nutrition. Foods and food supply Li Li verfasserin aut Bo Li verfasserin aut Meizhu Zheng verfasserin aut Rong Tsao verfasserin aut In Journal of Functional Foods Elsevier, 2021 24(2016), Seite 244-253 (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:24 year:2016 pages:244-253 https://doi.org/10.1016/j.jff.2016.04.011 kostenfrei https://doaj.org/article/4231fe769e18489db2b9a55e245aa71e kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464616300664 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_165 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 24 2016 244-253
language	English
source	In Journal of Functional Foods 24(2016), Seite 244-253 volume:24 year:2016 pages:244-253
sourceStr	In Journal of Functional Foods 24(2016), Seite 244-253 volume:24 year:2016 pages:244-253
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	S. divaricata S. glabra P. lobata C. tinctorius 5-LOX inhibitor Ultrafiltration LC-ESI-MS Nutrition. Foods and food supply
isfreeaccess_bool	true
container_title	Journal of Functional Foods
authorswithroles_txt_mv	Anqi Zhao @@aut@@ Li Li @@aut@@ Bo Li @@aut@@ Meizhu Zheng @@aut@@ Rong Tsao @@aut@@
publishDateDaySort_date	2016-01-01T00:00:00Z
hierarchy_top_id	587138432
id	DOAJ073547824
language_de	englisch
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Schischk, Smilax glabra Roxb., Pueraria lobata and Carthamus tinctorius L. for the first time. The phytochemical compositions of the four medicinal herbs were analysed and the major components identified. The potency of the 5-LOX inhibitors identified in ultrafiltration LC-ESI-MSn was compared to the IC50's obtained from in vitro enzyme inhibition assay. As a result, sec-O-glucosylhamaudol, resveratrol, daidzin and anhydrosafflor yellow B had the highest binding ability to 5-LOX, and were the main contributors to the 5-LOX inhibitory activities of S. divaricata, S. glabra, P. lobata and C. tinctorius extracts, respectively. These strong 5-LOX inhibitors were not necessarily the major components. 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callnumber-first	T - Technology
author	Anqi Zhao
spellingShingle	Anqi Zhao misc TX341-641 misc S. divaricata misc S. glabra misc P. lobata misc C. tinctorius misc 5-LOX inhibitor misc Ultrafiltration LC-ESI-MS misc Nutrition. Foods and food supply Ultrafiltration LC-ESI-MSn screening of 5-lipoxygenase inhibitors from selected Chinese medicinal herbs Saposhnikovia divaricata, Smilax glabra, Pueraria lobata and Carthamus tinctorius
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topic_title	TX341-641 Ultrafiltration LC-ESI-MSn screening of 5-lipoxygenase inhibitors from selected Chinese medicinal herbs Saposhnikovia divaricata, Smilax glabra, Pueraria lobata and Carthamus tinctorius S. divaricata S. glabra P. lobata C. tinctorius 5-LOX inhibitor Ultrafiltration LC-ESI-MS
topic	misc TX341-641 misc S. divaricata misc S. glabra misc P. lobata misc C. tinctorius misc 5-LOX inhibitor misc Ultrafiltration LC-ESI-MS misc Nutrition. Foods and food supply
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title	Ultrafiltration LC-ESI-MSn screening of 5-lipoxygenase inhibitors from selected Chinese medicinal herbs Saposhnikovia divaricata, Smilax glabra, Pueraria lobata and Carthamus tinctorius
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title_full	Ultrafiltration LC-ESI-MSn screening of 5-lipoxygenase inhibitors from selected Chinese medicinal herbs Saposhnikovia divaricata, Smilax glabra, Pueraria lobata and Carthamus tinctorius
author_sort	Anqi Zhao
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title_sort	ultrafiltration lc-esi-msn screening of 5-lipoxygenase inhibitors from selected chinese medicinal herbs saposhnikovia divaricata, smilax glabra, pueraria lobata and carthamus tinctorius
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title_auth	Ultrafiltration LC-ESI-MSn screening of 5-lipoxygenase inhibitors from selected Chinese medicinal herbs Saposhnikovia divaricata, Smilax glabra, Pueraria lobata and Carthamus tinctorius
abstract	Ultrafiltration liquid chromatography coupled to electrospray ionization tandem mass spectrometry (ultrafiltration LC-ESI-MSn) was used to screen 5-lipoxygenase (5-LOX) inhibitors from selected Chinese medicinal herbs Saposhnikovia divaricata (Turcz.) Schischk, Smilax glabra Roxb., Pueraria lobata and Carthamus tinctorius L. for the first time. The phytochemical compositions of the four medicinal herbs were analysed and the major components identified. The potency of the 5-LOX inhibitors identified in ultrafiltration LC-ESI-MSn was compared to the IC50's obtained from in vitro enzyme inhibition assay. As a result, sec-O-glucosylhamaudol, resveratrol, daidzin and anhydrosafflor yellow B had the highest binding ability to 5-LOX, and were the main contributors to the 5-LOX inhibitory activities of S. divaricata, S. glabra, P. lobata and C. tinctorius extracts, respectively. These strong 5-LOX inhibitors were not necessarily the major components. The high inhibitory activity of resveratrol and daidzin indicates foods such as grapes and soybean may be beneficial to 5-LOX mediated diseases.
abstractGer	Ultrafiltration liquid chromatography coupled to electrospray ionization tandem mass spectrometry (ultrafiltration LC-ESI-MSn) was used to screen 5-lipoxygenase (5-LOX) inhibitors from selected Chinese medicinal herbs Saposhnikovia divaricata (Turcz.) Schischk, Smilax glabra Roxb., Pueraria lobata and Carthamus tinctorius L. for the first time. The phytochemical compositions of the four medicinal herbs were analysed and the major components identified. The potency of the 5-LOX inhibitors identified in ultrafiltration LC-ESI-MSn was compared to the IC50's obtained from in vitro enzyme inhibition assay. As a result, sec-O-glucosylhamaudol, resveratrol, daidzin and anhydrosafflor yellow B had the highest binding ability to 5-LOX, and were the main contributors to the 5-LOX inhibitory activities of S. divaricata, S. glabra, P. lobata and C. tinctorius extracts, respectively. These strong 5-LOX inhibitors were not necessarily the major components. The high inhibitory activity of resveratrol and daidzin indicates foods such as grapes and soybean may be beneficial to 5-LOX mediated diseases.
abstract_unstemmed	Ultrafiltration liquid chromatography coupled to electrospray ionization tandem mass spectrometry (ultrafiltration LC-ESI-MSn) was used to screen 5-lipoxygenase (5-LOX) inhibitors from selected Chinese medicinal herbs Saposhnikovia divaricata (Turcz.) Schischk, Smilax glabra Roxb., Pueraria lobata and Carthamus tinctorius L. for the first time. The phytochemical compositions of the four medicinal herbs were analysed and the major components identified. The potency of the 5-LOX inhibitors identified in ultrafiltration LC-ESI-MSn was compared to the IC50's obtained from in vitro enzyme inhibition assay. As a result, sec-O-glucosylhamaudol, resveratrol, daidzin and anhydrosafflor yellow B had the highest binding ability to 5-LOX, and were the main contributors to the 5-LOX inhibitory activities of S. divaricata, S. glabra, P. lobata and C. tinctorius extracts, respectively. These strong 5-LOX inhibitors were not necessarily the major components. The high inhibitory activity of resveratrol and daidzin indicates foods such as grapes and soybean may be beneficial to 5-LOX mediated diseases.
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title_short	Ultrafiltration LC-ESI-MSn screening of 5-lipoxygenase inhibitors from selected Chinese medicinal herbs Saposhnikovia divaricata, Smilax glabra, Pueraria lobata and Carthamus tinctorius
url	https://doi.org/10.1016/j.jff.2016.04.011 https://doaj.org/article/4231fe769e18489db2b9a55e245aa71e http://www.sciencedirect.com/science/article/pii/S1756464616300664 https://doaj.org/toc/1756-4646
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doi_str	10.1016/j.jff.2016.04.011
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up_date	2024-07-03T18:18:36.318Z
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fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ073547824</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230309115647.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230228s2016 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.jff.2016.04.011</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ073547824</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ4231fe769e18489db2b9a55e245aa71e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">TX341-641</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Anqi Zhao</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Ultrafiltration LC-ESI-MSn screening of 5-lipoxygenase inhibitors from selected Chinese medicinal herbs Saposhnikovia divaricata, Smilax glabra, Pueraria lobata and Carthamus tinctorius</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2016</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Ultrafiltration liquid chromatography coupled to electrospray ionization tandem mass spectrometry (ultrafiltration LC-ESI-MSn) was used to screen 5-lipoxygenase (5-LOX) inhibitors from selected Chinese medicinal herbs Saposhnikovia divaricata (Turcz.) Schischk, Smilax glabra Roxb., Pueraria lobata and Carthamus tinctorius L. for the first time. The phytochemical compositions of the four medicinal herbs were analysed and the major components identified. The potency of the 5-LOX inhibitors identified in ultrafiltration LC-ESI-MSn was compared to the IC50's obtained from in vitro enzyme inhibition assay. As a result, sec-O-glucosylhamaudol, resveratrol, daidzin and anhydrosafflor yellow B had the highest binding ability to 5-LOX, and were the main contributors to the 5-LOX inhibitory activities of S. divaricata, S. glabra, P. lobata and C. tinctorius extracts, respectively. These strong 5-LOX inhibitors were not necessarily the major components. 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Ultrafiltration LC-ESI-MSn screening of 5-lipoxygenase inhibitors from selected Chinese medicinal herbs Saposhnikovia divaricata, Smilax glabra, Pueraria lobata and Carthamus tinctorius

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