Anti-inflammatory effects of tyrosol in streptozotocin-induced diabetic Wistar rats

The anti-inflammatory effect of tyrosol (4-(2-hydroxyethyl)), a phenolic compound in olive oil (20 mg/kg body weight), in streptozotocin (STZ)-induced diabetic rat was evaluated. Diabetic rats showed significant (P < 0.05) increase in plasma glucose and lipid peroxidation products and significant...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Ramasamy Chandramohan [verfasserIn] Leelavinothan Pari [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	Hyperglycaemia Inflammation Oxidative stress Streptozotocin Tyrosol Wistar rat

Übergeordnetes Werk:	In: Journal of Functional Foods - Elsevier, 2021, 27(2016), Seite 17-28
Übergeordnetes Werk:	volume:27 ; year:2016 ; pages:17-28

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.jff.2016.08.043

Katalog-ID:	DOAJ073553174

Internformat


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520			\|a The anti-inflammatory effect of tyrosol (4-(2-hydroxyethyl)), a phenolic compound in olive oil (20 mg/kg body weight), in streptozotocin (STZ)-induced diabetic rat was evaluated. Diabetic rats showed significant (P < 0.05) increase in plasma glucose and lipid peroxidation products and significant (P < 0.05) decrease in plasma insulin and enzymatic and non-enzymatic antioxidants in the liver and pancreas. The levels of inflammatory marker, C-reactive protein in plasma and protein expressions of nuclear factor-kappa B p65, tumour necrosis factor-alpha and interleukin-6 in the liver and pancreas were significantly (P < 0.05) increased in STZ-induced diabetic rats. Conversely, daily oral treatment with tyrosol for 45 days significantly (P < 0.05) restored all the above mentioned parameters to near normal levels. The immunohistochemical studies confirm the anti-inflammatory effects of tyrosol. Tyrosol exerts anti-inflammatory effects on the liver and pancreas of STZ-induced diabetic rats via its antioxidant activity, hence it may play an important role in the management of diabetes mellitus.
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author_variant	r c rc l p lp
matchkey_str	article:22149414:2016----::ninlmaoyfetotrslntetztcnnue
hierarchy_sort_str	2016
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publishDate	2016
allfields	10.1016/j.jff.2016.08.043 doi (DE-627)DOAJ073553174 (DE-599)DOAJ5627bc56da304fd7b9ef8ba68443a2f7 DE-627 ger DE-627 rakwb eng TX341-641 Ramasamy Chandramohan verfasserin aut Anti-inflammatory effects of tyrosol in streptozotocin-induced diabetic Wistar rats 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The anti-inflammatory effect of tyrosol (4-(2-hydroxyethyl)), a phenolic compound in olive oil (20 mg/kg body weight), in streptozotocin (STZ)-induced diabetic rat was evaluated. Diabetic rats showed significant (P < 0.05) increase in plasma glucose and lipid peroxidation products and significant (P < 0.05) decrease in plasma insulin and enzymatic and non-enzymatic antioxidants in the liver and pancreas. The levels of inflammatory marker, C-reactive protein in plasma and protein expressions of nuclear factor-kappa B p65, tumour necrosis factor-alpha and interleukin-6 in the liver and pancreas were significantly (P < 0.05) increased in STZ-induced diabetic rats. Conversely, daily oral treatment with tyrosol for 45 days significantly (P < 0.05) restored all the above mentioned parameters to near normal levels. The immunohistochemical studies confirm the anti-inflammatory effects of tyrosol. Tyrosol exerts anti-inflammatory effects on the liver and pancreas of STZ-induced diabetic rats via its antioxidant activity, hence it may play an important role in the management of diabetes mellitus. Hyperglycaemia Inflammation Oxidative stress Streptozotocin Tyrosol Wistar rat Nutrition. Foods and food supply Leelavinothan Pari verfasserin aut In Journal of Functional Foods Elsevier, 2021 27(2016), Seite 17-28 (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:27 year:2016 pages:17-28 https://doi.org/10.1016/j.jff.2016.08.043 kostenfrei https://doaj.org/article/5627bc56da304fd7b9ef8ba68443a2f7 kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464616302572 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_165 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 27 2016 17-28
spelling	10.1016/j.jff.2016.08.043 doi (DE-627)DOAJ073553174 (DE-599)DOAJ5627bc56da304fd7b9ef8ba68443a2f7 DE-627 ger DE-627 rakwb eng TX341-641 Ramasamy Chandramohan verfasserin aut Anti-inflammatory effects of tyrosol in streptozotocin-induced diabetic Wistar rats 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The anti-inflammatory effect of tyrosol (4-(2-hydroxyethyl)), a phenolic compound in olive oil (20 mg/kg body weight), in streptozotocin (STZ)-induced diabetic rat was evaluated. Diabetic rats showed significant (P < 0.05) increase in plasma glucose and lipid peroxidation products and significant (P < 0.05) decrease in plasma insulin and enzymatic and non-enzymatic antioxidants in the liver and pancreas. The levels of inflammatory marker, C-reactive protein in plasma and protein expressions of nuclear factor-kappa B p65, tumour necrosis factor-alpha and interleukin-6 in the liver and pancreas were significantly (P < 0.05) increased in STZ-induced diabetic rats. Conversely, daily oral treatment with tyrosol for 45 days significantly (P < 0.05) restored all the above mentioned parameters to near normal levels. The immunohistochemical studies confirm the anti-inflammatory effects of tyrosol. Tyrosol exerts anti-inflammatory effects on the liver and pancreas of STZ-induced diabetic rats via its antioxidant activity, hence it may play an important role in the management of diabetes mellitus. Hyperglycaemia Inflammation Oxidative stress Streptozotocin Tyrosol Wistar rat Nutrition. Foods and food supply Leelavinothan Pari verfasserin aut In Journal of Functional Foods Elsevier, 2021 27(2016), Seite 17-28 (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:27 year:2016 pages:17-28 https://doi.org/10.1016/j.jff.2016.08.043 kostenfrei https://doaj.org/article/5627bc56da304fd7b9ef8ba68443a2f7 kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464616302572 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_165 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 27 2016 17-28
allfields_unstemmed	10.1016/j.jff.2016.08.043 doi (DE-627)DOAJ073553174 (DE-599)DOAJ5627bc56da304fd7b9ef8ba68443a2f7 DE-627 ger DE-627 rakwb eng TX341-641 Ramasamy Chandramohan verfasserin aut Anti-inflammatory effects of tyrosol in streptozotocin-induced diabetic Wistar rats 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The anti-inflammatory effect of tyrosol (4-(2-hydroxyethyl)), a phenolic compound in olive oil (20 mg/kg body weight), in streptozotocin (STZ)-induced diabetic rat was evaluated. Diabetic rats showed significant (P < 0.05) increase in plasma glucose and lipid peroxidation products and significant (P < 0.05) decrease in plasma insulin and enzymatic and non-enzymatic antioxidants in the liver and pancreas. The levels of inflammatory marker, C-reactive protein in plasma and protein expressions of nuclear factor-kappa B p65, tumour necrosis factor-alpha and interleukin-6 in the liver and pancreas were significantly (P < 0.05) increased in STZ-induced diabetic rats. Conversely, daily oral treatment with tyrosol for 45 days significantly (P < 0.05) restored all the above mentioned parameters to near normal levels. The immunohistochemical studies confirm the anti-inflammatory effects of tyrosol. Tyrosol exerts anti-inflammatory effects on the liver and pancreas of STZ-induced diabetic rats via its antioxidant activity, hence it may play an important role in the management of diabetes mellitus. Hyperglycaemia Inflammation Oxidative stress Streptozotocin Tyrosol Wistar rat Nutrition. Foods and food supply Leelavinothan Pari verfasserin aut In Journal of Functional Foods Elsevier, 2021 27(2016), Seite 17-28 (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:27 year:2016 pages:17-28 https://doi.org/10.1016/j.jff.2016.08.043 kostenfrei https://doaj.org/article/5627bc56da304fd7b9ef8ba68443a2f7 kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464616302572 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_165 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 27 2016 17-28
allfieldsGer	10.1016/j.jff.2016.08.043 doi (DE-627)DOAJ073553174 (DE-599)DOAJ5627bc56da304fd7b9ef8ba68443a2f7 DE-627 ger DE-627 rakwb eng TX341-641 Ramasamy Chandramohan verfasserin aut Anti-inflammatory effects of tyrosol in streptozotocin-induced diabetic Wistar rats 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The anti-inflammatory effect of tyrosol (4-(2-hydroxyethyl)), a phenolic compound in olive oil (20 mg/kg body weight), in streptozotocin (STZ)-induced diabetic rat was evaluated. Diabetic rats showed significant (P < 0.05) increase in plasma glucose and lipid peroxidation products and significant (P < 0.05) decrease in plasma insulin and enzymatic and non-enzymatic antioxidants in the liver and pancreas. The levels of inflammatory marker, C-reactive protein in plasma and protein expressions of nuclear factor-kappa B p65, tumour necrosis factor-alpha and interleukin-6 in the liver and pancreas were significantly (P < 0.05) increased in STZ-induced diabetic rats. Conversely, daily oral treatment with tyrosol for 45 days significantly (P < 0.05) restored all the above mentioned parameters to near normal levels. The immunohistochemical studies confirm the anti-inflammatory effects of tyrosol. Tyrosol exerts anti-inflammatory effects on the liver and pancreas of STZ-induced diabetic rats via its antioxidant activity, hence it may play an important role in the management of diabetes mellitus. Hyperglycaemia Inflammation Oxidative stress Streptozotocin Tyrosol Wistar rat Nutrition. Foods and food supply Leelavinothan Pari verfasserin aut In Journal of Functional Foods Elsevier, 2021 27(2016), Seite 17-28 (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:27 year:2016 pages:17-28 https://doi.org/10.1016/j.jff.2016.08.043 kostenfrei https://doaj.org/article/5627bc56da304fd7b9ef8ba68443a2f7 kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464616302572 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_165 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 27 2016 17-28
allfieldsSound	10.1016/j.jff.2016.08.043 doi (DE-627)DOAJ073553174 (DE-599)DOAJ5627bc56da304fd7b9ef8ba68443a2f7 DE-627 ger DE-627 rakwb eng TX341-641 Ramasamy Chandramohan verfasserin aut Anti-inflammatory effects of tyrosol in streptozotocin-induced diabetic Wistar rats 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The anti-inflammatory effect of tyrosol (4-(2-hydroxyethyl)), a phenolic compound in olive oil (20 mg/kg body weight), in streptozotocin (STZ)-induced diabetic rat was evaluated. Diabetic rats showed significant (P < 0.05) increase in plasma glucose and lipid peroxidation products and significant (P < 0.05) decrease in plasma insulin and enzymatic and non-enzymatic antioxidants in the liver and pancreas. The levels of inflammatory marker, C-reactive protein in plasma and protein expressions of nuclear factor-kappa B p65, tumour necrosis factor-alpha and interleukin-6 in the liver and pancreas were significantly (P < 0.05) increased in STZ-induced diabetic rats. Conversely, daily oral treatment with tyrosol for 45 days significantly (P < 0.05) restored all the above mentioned parameters to near normal levels. The immunohistochemical studies confirm the anti-inflammatory effects of tyrosol. Tyrosol exerts anti-inflammatory effects on the liver and pancreas of STZ-induced diabetic rats via its antioxidant activity, hence it may play an important role in the management of diabetes mellitus. Hyperglycaemia Inflammation Oxidative stress Streptozotocin Tyrosol Wistar rat Nutrition. Foods and food supply Leelavinothan Pari verfasserin aut In Journal of Functional Foods Elsevier, 2021 27(2016), Seite 17-28 (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:27 year:2016 pages:17-28 https://doi.org/10.1016/j.jff.2016.08.043 kostenfrei https://doaj.org/article/5627bc56da304fd7b9ef8ba68443a2f7 kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464616302572 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_165 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 27 2016 17-28
language	English
source	In Journal of Functional Foods 27(2016), Seite 17-28 volume:27 year:2016 pages:17-28
sourceStr	In Journal of Functional Foods 27(2016), Seite 17-28 volume:27 year:2016 pages:17-28
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Hyperglycaemia Inflammation Oxidative stress Streptozotocin Tyrosol Wistar rat Nutrition. Foods and food supply
isfreeaccess_bool	true
container_title	Journal of Functional Foods
authorswithroles_txt_mv	Ramasamy Chandramohan @@aut@@ Leelavinothan Pari @@aut@@
publishDateDaySort_date	2016-01-01T00:00:00Z
hierarchy_top_id	587138432
id	DOAJ073553174
language_de	englisch
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callnumber-first	T - Technology
author	Ramasamy Chandramohan
spellingShingle	Ramasamy Chandramohan misc TX341-641 misc Hyperglycaemia misc Inflammation misc Oxidative stress misc Streptozotocin misc Tyrosol misc Wistar rat misc Nutrition. Foods and food supply Anti-inflammatory effects of tyrosol in streptozotocin-induced diabetic Wistar rats
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topic_title	TX341-641 Anti-inflammatory effects of tyrosol in streptozotocin-induced diabetic Wistar rats Hyperglycaemia Inflammation Oxidative stress Streptozotocin Tyrosol Wistar rat
topic	misc TX341-641 misc Hyperglycaemia misc Inflammation misc Oxidative stress misc Streptozotocin misc Tyrosol misc Wistar rat misc Nutrition. Foods and food supply
topic_unstemmed	misc TX341-641 misc Hyperglycaemia misc Inflammation misc Oxidative stress misc Streptozotocin misc Tyrosol misc Wistar rat misc Nutrition. Foods and food supply
topic_browse	misc TX341-641 misc Hyperglycaemia misc Inflammation misc Oxidative stress misc Streptozotocin misc Tyrosol misc Wistar rat misc Nutrition. Foods and food supply
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title	Anti-inflammatory effects of tyrosol in streptozotocin-induced diabetic Wistar rats
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title_full	Anti-inflammatory effects of tyrosol in streptozotocin-induced diabetic Wistar rats
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title_sort	anti-inflammatory effects of tyrosol in streptozotocin-induced diabetic wistar rats
callnumber	TX341-641
title_auth	Anti-inflammatory effects of tyrosol in streptozotocin-induced diabetic Wistar rats
abstract	The anti-inflammatory effect of tyrosol (4-(2-hydroxyethyl)), a phenolic compound in olive oil (20 mg/kg body weight), in streptozotocin (STZ)-induced diabetic rat was evaluated. Diabetic rats showed significant (P < 0.05) increase in plasma glucose and lipid peroxidation products and significant (P < 0.05) decrease in plasma insulin and enzymatic and non-enzymatic antioxidants in the liver and pancreas. The levels of inflammatory marker, C-reactive protein in plasma and protein expressions of nuclear factor-kappa B p65, tumour necrosis factor-alpha and interleukin-6 in the liver and pancreas were significantly (P < 0.05) increased in STZ-induced diabetic rats. Conversely, daily oral treatment with tyrosol for 45 days significantly (P < 0.05) restored all the above mentioned parameters to near normal levels. The immunohistochemical studies confirm the anti-inflammatory effects of tyrosol. Tyrosol exerts anti-inflammatory effects on the liver and pancreas of STZ-induced diabetic rats via its antioxidant activity, hence it may play an important role in the management of diabetes mellitus.
abstractGer	The anti-inflammatory effect of tyrosol (4-(2-hydroxyethyl)), a phenolic compound in olive oil (20 mg/kg body weight), in streptozotocin (STZ)-induced diabetic rat was evaluated. Diabetic rats showed significant (P < 0.05) increase in plasma glucose and lipid peroxidation products and significant (P < 0.05) decrease in plasma insulin and enzymatic and non-enzymatic antioxidants in the liver and pancreas. The levels of inflammatory marker, C-reactive protein in plasma and protein expressions of nuclear factor-kappa B p65, tumour necrosis factor-alpha and interleukin-6 in the liver and pancreas were significantly (P < 0.05) increased in STZ-induced diabetic rats. Conversely, daily oral treatment with tyrosol for 45 days significantly (P < 0.05) restored all the above mentioned parameters to near normal levels. The immunohistochemical studies confirm the anti-inflammatory effects of tyrosol. Tyrosol exerts anti-inflammatory effects on the liver and pancreas of STZ-induced diabetic rats via its antioxidant activity, hence it may play an important role in the management of diabetes mellitus.
abstract_unstemmed	The anti-inflammatory effect of tyrosol (4-(2-hydroxyethyl)), a phenolic compound in olive oil (20 mg/kg body weight), in streptozotocin (STZ)-induced diabetic rat was evaluated. Diabetic rats showed significant (P < 0.05) increase in plasma glucose and lipid peroxidation products and significant (P < 0.05) decrease in plasma insulin and enzymatic and non-enzymatic antioxidants in the liver and pancreas. The levels of inflammatory marker, C-reactive protein in plasma and protein expressions of nuclear factor-kappa B p65, tumour necrosis factor-alpha and interleukin-6 in the liver and pancreas were significantly (P < 0.05) increased in STZ-induced diabetic rats. Conversely, daily oral treatment with tyrosol for 45 days significantly (P < 0.05) restored all the above mentioned parameters to near normal levels. The immunohistochemical studies confirm the anti-inflammatory effects of tyrosol. Tyrosol exerts anti-inflammatory effects on the liver and pancreas of STZ-induced diabetic rats via its antioxidant activity, hence it may play an important role in the management of diabetes mellitus.
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title_short	Anti-inflammatory effects of tyrosol in streptozotocin-induced diabetic Wistar rats
url	https://doi.org/10.1016/j.jff.2016.08.043 https://doaj.org/article/5627bc56da304fd7b9ef8ba68443a2f7 http://www.sciencedirect.com/science/article/pii/S1756464616302572 https://doaj.org/toc/1756-4646
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Diabetic rats showed significant (P < 0.05) increase in plasma glucose and lipid peroxidation products and significant (P < 0.05) decrease in plasma insulin and enzymatic and non-enzymatic antioxidants in the liver and pancreas. The levels of inflammatory marker, C-reactive protein in plasma and protein expressions of nuclear factor-kappa B p65, tumour necrosis factor-alpha and interleukin-6 in the liver and pancreas were significantly (P < 0.05) increased in STZ-induced diabetic rats. Conversely, daily oral treatment with tyrosol for 45 days significantly (P < 0.05) restored all the above mentioned parameters to near normal levels. The immunohistochemical studies confirm the anti-inflammatory effects of tyrosol. 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Anti-inflammatory effects of tyrosol in streptozotocin-induced diabetic Wistar rats

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