Maintained partial protection against Streptococcus pneumoniae despite B‐cell depletion in mice vaccinated with a pneumococcal glycoconjugate vaccine
Abstract Objectives Anti‐CD20 monoclonal antibody therapy rapidly depletes < 95% of CD20+ B cells from the circulation. B‐cell depletion is an effective treatment for autoimmune disease and B‐cell malignancies but also increases the risk of respiratory tract infections. This effect on adaptive im...
Ausführliche Beschreibung
Autor*in: |
Giuseppe Ercoli [verfasserIn] Elisa Ramos‐Sevillano [verfasserIn] Emma Pearce [verfasserIn] Sara Ragab [verfasserIn] David Goldblatt [verfasserIn] Gisbert Weckbecker [verfasserIn] Jeremy S Brown [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2022 |
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Übergeordnetes Werk: |
In: Clinical & Translational Immunology - Wiley, 2015, 11(2022), 1, Seite n/a-n/a |
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Übergeordnetes Werk: |
volume:11 ; year:2022 ; number:1 ; pages:n/a-n/a |
Links: |
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DOI / URN: |
10.1002/cti2.1366 |
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Katalog-ID: |
DOAJ073588334 |
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245 | 1 | 0 | |a Maintained partial protection against Streptococcus pneumoniae despite B‐cell depletion in mice vaccinated with a pneumococcal glycoconjugate vaccine |
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520 | |a Abstract Objectives Anti‐CD20 monoclonal antibody therapy rapidly depletes < 95% of CD20+ B cells from the circulation. B‐cell depletion is an effective treatment for autoimmune disease and B‐cell malignancies but also increases the risk of respiratory tract infections. This effect on adaptive immunity could be countered by vaccination. We have used mouse models to investigate the effects of B‐cell depletion on pneumococcal vaccination, including protection against infection and timing of vaccination in relation to B‐cell depletion. Methods C57BL/6 female mice were B‐cell depleted using anti‐CD20 antibody and immunized with two doses of Prevnar‐13 vaccine either before or after anti‐CD20 treatment. B‐cell repertoire and Streptococcus pneumoniae–specific IgG levels were measured using whole‐cell ELISA and flow cytometry antibody‐binding assay. Protection induced by vaccination was assessed by challenging the mice using a S. pneumoniae pneumonia model. Results Antibody responses to S. pneumoniae were largely preserved in mice B‐cell depleted after vaccination resulting in full protection against pneumococcal infections. In contrast, mice vaccinated with Prevnar‐13 while B cells were depleted (with < 90% reduction in B‐cell numbers) had decreased circulating anti–S. pneumoniae IgG and IgM levels (measured using ELISA and flow cytometry antibody binding assays). However, some antibody responses were maintained, and, although vaccine‐induced protection against S. pneumoniae infection was impaired, septicaemia was still prevented in 50% of challenged mice. Conclusions This study showed that although vaccine efficacy during periods of profound B‐cell depletion was impaired some protective efficacy was preserved, suggesting that vaccination remains beneficial. | ||
650 | 4 | |a B‐cell depletion | |
650 | 4 | |a CD20 | |
650 | 4 | |a immunity | |
650 | 4 | |a Streptococcus pneumoniae | |
650 | 4 | |a vaccination | |
653 | 0 | |a Immunologic diseases. Allergy | |
700 | 0 | |a Elisa Ramos‐Sevillano |e verfasserin |4 aut | |
700 | 0 | |a Emma Pearce |e verfasserin |4 aut | |
700 | 0 | |a Sara Ragab |e verfasserin |4 aut | |
700 | 0 | |a David Goldblatt |e verfasserin |4 aut | |
700 | 0 | |a Gisbert Weckbecker |e verfasserin |4 aut | |
700 | 0 | |a Jeremy S Brown |e verfasserin |4 aut | |
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10.1002/cti2.1366 doi (DE-627)DOAJ073588334 (DE-599)DOAJ44361b1c8e4d434ab9c3e34bd97c6843 DE-627 ger DE-627 rakwb eng RC581-607 Giuseppe Ercoli verfasserin aut Maintained partial protection against Streptococcus pneumoniae despite B‐cell depletion in mice vaccinated with a pneumococcal glycoconjugate vaccine 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Objectives Anti‐CD20 monoclonal antibody therapy rapidly depletes < 95% of CD20+ B cells from the circulation. B‐cell depletion is an effective treatment for autoimmune disease and B‐cell malignancies but also increases the risk of respiratory tract infections. This effect on adaptive immunity could be countered by vaccination. We have used mouse models to investigate the effects of B‐cell depletion on pneumococcal vaccination, including protection against infection and timing of vaccination in relation to B‐cell depletion. Methods C57BL/6 female mice were B‐cell depleted using anti‐CD20 antibody and immunized with two doses of Prevnar‐13 vaccine either before or after anti‐CD20 treatment. B‐cell repertoire and Streptococcus pneumoniae–specific IgG levels were measured using whole‐cell ELISA and flow cytometry antibody‐binding assay. Protection induced by vaccination was assessed by challenging the mice using a S. pneumoniae pneumonia model. Results Antibody responses to S. pneumoniae were largely preserved in mice B‐cell depleted after vaccination resulting in full protection against pneumococcal infections. In contrast, mice vaccinated with Prevnar‐13 while B cells were depleted (with < 90% reduction in B‐cell numbers) had decreased circulating anti–S. pneumoniae IgG and IgM levels (measured using ELISA and flow cytometry antibody binding assays). However, some antibody responses were maintained, and, although vaccine‐induced protection against S. pneumoniae infection was impaired, septicaemia was still prevented in 50% of challenged mice. Conclusions This study showed that although vaccine efficacy during periods of profound B‐cell depletion was impaired some protective efficacy was preserved, suggesting that vaccination remains beneficial. B‐cell depletion CD20 immunity Streptococcus pneumoniae vaccination Immunologic diseases. Allergy Elisa Ramos‐Sevillano verfasserin aut Emma Pearce verfasserin aut Sara Ragab verfasserin aut David Goldblatt verfasserin aut Gisbert Weckbecker verfasserin aut Jeremy S Brown verfasserin aut In Clinical & Translational Immunology Wiley, 2015 11(2022), 1, Seite n/a-n/a (DE-627)731890310 (DE-600)2694482-0 20500068 nnns volume:11 year:2022 number:1 pages:n/a-n/a https://doi.org/10.1002/cti2.1366 kostenfrei https://doaj.org/article/44361b1c8e4d434ab9c3e34bd97c6843 kostenfrei https://doi.org/10.1002/cti2.1366 kostenfrei https://doaj.org/toc/2050-0068 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 1 n/a-n/a |
spelling |
10.1002/cti2.1366 doi (DE-627)DOAJ073588334 (DE-599)DOAJ44361b1c8e4d434ab9c3e34bd97c6843 DE-627 ger DE-627 rakwb eng RC581-607 Giuseppe Ercoli verfasserin aut Maintained partial protection against Streptococcus pneumoniae despite B‐cell depletion in mice vaccinated with a pneumococcal glycoconjugate vaccine 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Objectives Anti‐CD20 monoclonal antibody therapy rapidly depletes < 95% of CD20+ B cells from the circulation. B‐cell depletion is an effective treatment for autoimmune disease and B‐cell malignancies but also increases the risk of respiratory tract infections. This effect on adaptive immunity could be countered by vaccination. We have used mouse models to investigate the effects of B‐cell depletion on pneumococcal vaccination, including protection against infection and timing of vaccination in relation to B‐cell depletion. Methods C57BL/6 female mice were B‐cell depleted using anti‐CD20 antibody and immunized with two doses of Prevnar‐13 vaccine either before or after anti‐CD20 treatment. B‐cell repertoire and Streptococcus pneumoniae–specific IgG levels were measured using whole‐cell ELISA and flow cytometry antibody‐binding assay. Protection induced by vaccination was assessed by challenging the mice using a S. pneumoniae pneumonia model. Results Antibody responses to S. pneumoniae were largely preserved in mice B‐cell depleted after vaccination resulting in full protection against pneumococcal infections. In contrast, mice vaccinated with Prevnar‐13 while B cells were depleted (with < 90% reduction in B‐cell numbers) had decreased circulating anti–S. pneumoniae IgG and IgM levels (measured using ELISA and flow cytometry antibody binding assays). However, some antibody responses were maintained, and, although vaccine‐induced protection against S. pneumoniae infection was impaired, septicaemia was still prevented in 50% of challenged mice. Conclusions This study showed that although vaccine efficacy during periods of profound B‐cell depletion was impaired some protective efficacy was preserved, suggesting that vaccination remains beneficial. B‐cell depletion CD20 immunity Streptococcus pneumoniae vaccination Immunologic diseases. Allergy Elisa Ramos‐Sevillano verfasserin aut Emma Pearce verfasserin aut Sara Ragab verfasserin aut David Goldblatt verfasserin aut Gisbert Weckbecker verfasserin aut Jeremy S Brown verfasserin aut In Clinical & Translational Immunology Wiley, 2015 11(2022), 1, Seite n/a-n/a (DE-627)731890310 (DE-600)2694482-0 20500068 nnns volume:11 year:2022 number:1 pages:n/a-n/a https://doi.org/10.1002/cti2.1366 kostenfrei https://doaj.org/article/44361b1c8e4d434ab9c3e34bd97c6843 kostenfrei https://doi.org/10.1002/cti2.1366 kostenfrei https://doaj.org/toc/2050-0068 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 1 n/a-n/a |
allfields_unstemmed |
10.1002/cti2.1366 doi (DE-627)DOAJ073588334 (DE-599)DOAJ44361b1c8e4d434ab9c3e34bd97c6843 DE-627 ger DE-627 rakwb eng RC581-607 Giuseppe Ercoli verfasserin aut Maintained partial protection against Streptococcus pneumoniae despite B‐cell depletion in mice vaccinated with a pneumococcal glycoconjugate vaccine 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Objectives Anti‐CD20 monoclonal antibody therapy rapidly depletes < 95% of CD20+ B cells from the circulation. B‐cell depletion is an effective treatment for autoimmune disease and B‐cell malignancies but also increases the risk of respiratory tract infections. This effect on adaptive immunity could be countered by vaccination. We have used mouse models to investigate the effects of B‐cell depletion on pneumococcal vaccination, including protection against infection and timing of vaccination in relation to B‐cell depletion. Methods C57BL/6 female mice were B‐cell depleted using anti‐CD20 antibody and immunized with two doses of Prevnar‐13 vaccine either before or after anti‐CD20 treatment. B‐cell repertoire and Streptococcus pneumoniae–specific IgG levels were measured using whole‐cell ELISA and flow cytometry antibody‐binding assay. Protection induced by vaccination was assessed by challenging the mice using a S. pneumoniae pneumonia model. Results Antibody responses to S. pneumoniae were largely preserved in mice B‐cell depleted after vaccination resulting in full protection against pneumococcal infections. In contrast, mice vaccinated with Prevnar‐13 while B cells were depleted (with < 90% reduction in B‐cell numbers) had decreased circulating anti–S. pneumoniae IgG and IgM levels (measured using ELISA and flow cytometry antibody binding assays). However, some antibody responses were maintained, and, although vaccine‐induced protection against S. pneumoniae infection was impaired, septicaemia was still prevented in 50% of challenged mice. Conclusions This study showed that although vaccine efficacy during periods of profound B‐cell depletion was impaired some protective efficacy was preserved, suggesting that vaccination remains beneficial. B‐cell depletion CD20 immunity Streptococcus pneumoniae vaccination Immunologic diseases. Allergy Elisa Ramos‐Sevillano verfasserin aut Emma Pearce verfasserin aut Sara Ragab verfasserin aut David Goldblatt verfasserin aut Gisbert Weckbecker verfasserin aut Jeremy S Brown verfasserin aut In Clinical & Translational Immunology Wiley, 2015 11(2022), 1, Seite n/a-n/a (DE-627)731890310 (DE-600)2694482-0 20500068 nnns volume:11 year:2022 number:1 pages:n/a-n/a https://doi.org/10.1002/cti2.1366 kostenfrei https://doaj.org/article/44361b1c8e4d434ab9c3e34bd97c6843 kostenfrei https://doi.org/10.1002/cti2.1366 kostenfrei https://doaj.org/toc/2050-0068 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 1 n/a-n/a |
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10.1002/cti2.1366 doi (DE-627)DOAJ073588334 (DE-599)DOAJ44361b1c8e4d434ab9c3e34bd97c6843 DE-627 ger DE-627 rakwb eng RC581-607 Giuseppe Ercoli verfasserin aut Maintained partial protection against Streptococcus pneumoniae despite B‐cell depletion in mice vaccinated with a pneumococcal glycoconjugate vaccine 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Objectives Anti‐CD20 monoclonal antibody therapy rapidly depletes < 95% of CD20+ B cells from the circulation. B‐cell depletion is an effective treatment for autoimmune disease and B‐cell malignancies but also increases the risk of respiratory tract infections. This effect on adaptive immunity could be countered by vaccination. We have used mouse models to investigate the effects of B‐cell depletion on pneumococcal vaccination, including protection against infection and timing of vaccination in relation to B‐cell depletion. Methods C57BL/6 female mice were B‐cell depleted using anti‐CD20 antibody and immunized with two doses of Prevnar‐13 vaccine either before or after anti‐CD20 treatment. B‐cell repertoire and Streptococcus pneumoniae–specific IgG levels were measured using whole‐cell ELISA and flow cytometry antibody‐binding assay. Protection induced by vaccination was assessed by challenging the mice using a S. pneumoniae pneumonia model. Results Antibody responses to S. pneumoniae were largely preserved in mice B‐cell depleted after vaccination resulting in full protection against pneumococcal infections. In contrast, mice vaccinated with Prevnar‐13 while B cells were depleted (with < 90% reduction in B‐cell numbers) had decreased circulating anti–S. pneumoniae IgG and IgM levels (measured using ELISA and flow cytometry antibody binding assays). However, some antibody responses were maintained, and, although vaccine‐induced protection against S. pneumoniae infection was impaired, septicaemia was still prevented in 50% of challenged mice. Conclusions This study showed that although vaccine efficacy during periods of profound B‐cell depletion was impaired some protective efficacy was preserved, suggesting that vaccination remains beneficial. B‐cell depletion CD20 immunity Streptococcus pneumoniae vaccination Immunologic diseases. Allergy Elisa Ramos‐Sevillano verfasserin aut Emma Pearce verfasserin aut Sara Ragab verfasserin aut David Goldblatt verfasserin aut Gisbert Weckbecker verfasserin aut Jeremy S Brown verfasserin aut In Clinical & Translational Immunology Wiley, 2015 11(2022), 1, Seite n/a-n/a (DE-627)731890310 (DE-600)2694482-0 20500068 nnns volume:11 year:2022 number:1 pages:n/a-n/a https://doi.org/10.1002/cti2.1366 kostenfrei https://doaj.org/article/44361b1c8e4d434ab9c3e34bd97c6843 kostenfrei https://doi.org/10.1002/cti2.1366 kostenfrei https://doaj.org/toc/2050-0068 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 1 n/a-n/a |
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10.1002/cti2.1366 doi (DE-627)DOAJ073588334 (DE-599)DOAJ44361b1c8e4d434ab9c3e34bd97c6843 DE-627 ger DE-627 rakwb eng RC581-607 Giuseppe Ercoli verfasserin aut Maintained partial protection against Streptococcus pneumoniae despite B‐cell depletion in mice vaccinated with a pneumococcal glycoconjugate vaccine 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Objectives Anti‐CD20 monoclonal antibody therapy rapidly depletes < 95% of CD20+ B cells from the circulation. B‐cell depletion is an effective treatment for autoimmune disease and B‐cell malignancies but also increases the risk of respiratory tract infections. This effect on adaptive immunity could be countered by vaccination. We have used mouse models to investigate the effects of B‐cell depletion on pneumococcal vaccination, including protection against infection and timing of vaccination in relation to B‐cell depletion. Methods C57BL/6 female mice were B‐cell depleted using anti‐CD20 antibody and immunized with two doses of Prevnar‐13 vaccine either before or after anti‐CD20 treatment. B‐cell repertoire and Streptococcus pneumoniae–specific IgG levels were measured using whole‐cell ELISA and flow cytometry antibody‐binding assay. Protection induced by vaccination was assessed by challenging the mice using a S. pneumoniae pneumonia model. Results Antibody responses to S. pneumoniae were largely preserved in mice B‐cell depleted after vaccination resulting in full protection against pneumococcal infections. In contrast, mice vaccinated with Prevnar‐13 while B cells were depleted (with < 90% reduction in B‐cell numbers) had decreased circulating anti–S. pneumoniae IgG and IgM levels (measured using ELISA and flow cytometry antibody binding assays). However, some antibody responses were maintained, and, although vaccine‐induced protection against S. pneumoniae infection was impaired, septicaemia was still prevented in 50% of challenged mice. Conclusions This study showed that although vaccine efficacy during periods of profound B‐cell depletion was impaired some protective efficacy was preserved, suggesting that vaccination remains beneficial. B‐cell depletion CD20 immunity Streptococcus pneumoniae vaccination Immunologic diseases. Allergy Elisa Ramos‐Sevillano verfasserin aut Emma Pearce verfasserin aut Sara Ragab verfasserin aut David Goldblatt verfasserin aut Gisbert Weckbecker verfasserin aut Jeremy S Brown verfasserin aut In Clinical & Translational Immunology Wiley, 2015 11(2022), 1, Seite n/a-n/a (DE-627)731890310 (DE-600)2694482-0 20500068 nnns volume:11 year:2022 number:1 pages:n/a-n/a https://doi.org/10.1002/cti2.1366 kostenfrei https://doaj.org/article/44361b1c8e4d434ab9c3e34bd97c6843 kostenfrei https://doi.org/10.1002/cti2.1366 kostenfrei https://doaj.org/toc/2050-0068 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 1 n/a-n/a |
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Giuseppe Ercoli @@aut@@ Elisa Ramos‐Sevillano @@aut@@ Emma Pearce @@aut@@ Sara Ragab @@aut@@ David Goldblatt @@aut@@ Gisbert Weckbecker @@aut@@ Jeremy S Brown @@aut@@ |
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Results Antibody responses to S. pneumoniae were largely preserved in mice B‐cell depleted after vaccination resulting in full protection against pneumococcal infections. In contrast, mice vaccinated with Prevnar‐13 while B cells were depleted (with < 90% reduction in B‐cell numbers) had decreased circulating anti–S. pneumoniae IgG and IgM levels (measured using ELISA and flow cytometry antibody binding assays). However, some antibody responses were maintained, and, although vaccine‐induced protection against S. pneumoniae infection was impaired, septicaemia was still prevented in 50% of challenged mice. 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Giuseppe Ercoli |
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Giuseppe Ercoli misc RC581-607 misc B‐cell depletion misc CD20 misc immunity misc Streptococcus pneumoniae misc vaccination misc Immunologic diseases. Allergy Maintained partial protection against Streptococcus pneumoniae despite B‐cell depletion in mice vaccinated with a pneumococcal glycoconjugate vaccine |
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RC581-607 Maintained partial protection against Streptococcus pneumoniae despite B‐cell depletion in mice vaccinated with a pneumococcal glycoconjugate vaccine B‐cell depletion CD20 immunity Streptococcus pneumoniae vaccination |
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misc RC581-607 misc B‐cell depletion misc CD20 misc immunity misc Streptococcus pneumoniae misc vaccination misc Immunologic diseases. Allergy |
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Maintained partial protection against Streptococcus pneumoniae despite B‐cell depletion in mice vaccinated with a pneumococcal glycoconjugate vaccine |
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Maintained partial protection against Streptococcus pneumoniae despite B‐cell depletion in mice vaccinated with a pneumococcal glycoconjugate vaccine |
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maintained partial protection against streptococcus pneumoniae despite b‐cell depletion in mice vaccinated with a pneumococcal glycoconjugate vaccine |
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Maintained partial protection against Streptococcus pneumoniae despite B‐cell depletion in mice vaccinated with a pneumococcal glycoconjugate vaccine |
abstract |
Abstract Objectives Anti‐CD20 monoclonal antibody therapy rapidly depletes < 95% of CD20+ B cells from the circulation. B‐cell depletion is an effective treatment for autoimmune disease and B‐cell malignancies but also increases the risk of respiratory tract infections. This effect on adaptive immunity could be countered by vaccination. We have used mouse models to investigate the effects of B‐cell depletion on pneumococcal vaccination, including protection against infection and timing of vaccination in relation to B‐cell depletion. Methods C57BL/6 female mice were B‐cell depleted using anti‐CD20 antibody and immunized with two doses of Prevnar‐13 vaccine either before or after anti‐CD20 treatment. B‐cell repertoire and Streptococcus pneumoniae–specific IgG levels were measured using whole‐cell ELISA and flow cytometry antibody‐binding assay. Protection induced by vaccination was assessed by challenging the mice using a S. pneumoniae pneumonia model. Results Antibody responses to S. pneumoniae were largely preserved in mice B‐cell depleted after vaccination resulting in full protection against pneumococcal infections. In contrast, mice vaccinated with Prevnar‐13 while B cells were depleted (with < 90% reduction in B‐cell numbers) had decreased circulating anti–S. pneumoniae IgG and IgM levels (measured using ELISA and flow cytometry antibody binding assays). However, some antibody responses were maintained, and, although vaccine‐induced protection against S. pneumoniae infection was impaired, septicaemia was still prevented in 50% of challenged mice. Conclusions This study showed that although vaccine efficacy during periods of profound B‐cell depletion was impaired some protective efficacy was preserved, suggesting that vaccination remains beneficial. |
abstractGer |
Abstract Objectives Anti‐CD20 monoclonal antibody therapy rapidly depletes < 95% of CD20+ B cells from the circulation. B‐cell depletion is an effective treatment for autoimmune disease and B‐cell malignancies but also increases the risk of respiratory tract infections. This effect on adaptive immunity could be countered by vaccination. We have used mouse models to investigate the effects of B‐cell depletion on pneumococcal vaccination, including protection against infection and timing of vaccination in relation to B‐cell depletion. Methods C57BL/6 female mice were B‐cell depleted using anti‐CD20 antibody and immunized with two doses of Prevnar‐13 vaccine either before or after anti‐CD20 treatment. B‐cell repertoire and Streptococcus pneumoniae–specific IgG levels were measured using whole‐cell ELISA and flow cytometry antibody‐binding assay. Protection induced by vaccination was assessed by challenging the mice using a S. pneumoniae pneumonia model. Results Antibody responses to S. pneumoniae were largely preserved in mice B‐cell depleted after vaccination resulting in full protection against pneumococcal infections. In contrast, mice vaccinated with Prevnar‐13 while B cells were depleted (with < 90% reduction in B‐cell numbers) had decreased circulating anti–S. pneumoniae IgG and IgM levels (measured using ELISA and flow cytometry antibody binding assays). However, some antibody responses were maintained, and, although vaccine‐induced protection against S. pneumoniae infection was impaired, septicaemia was still prevented in 50% of challenged mice. Conclusions This study showed that although vaccine efficacy during periods of profound B‐cell depletion was impaired some protective efficacy was preserved, suggesting that vaccination remains beneficial. |
abstract_unstemmed |
Abstract Objectives Anti‐CD20 monoclonal antibody therapy rapidly depletes < 95% of CD20+ B cells from the circulation. B‐cell depletion is an effective treatment for autoimmune disease and B‐cell malignancies but also increases the risk of respiratory tract infections. This effect on adaptive immunity could be countered by vaccination. We have used mouse models to investigate the effects of B‐cell depletion on pneumococcal vaccination, including protection against infection and timing of vaccination in relation to B‐cell depletion. Methods C57BL/6 female mice were B‐cell depleted using anti‐CD20 antibody and immunized with two doses of Prevnar‐13 vaccine either before or after anti‐CD20 treatment. B‐cell repertoire and Streptococcus pneumoniae–specific IgG levels were measured using whole‐cell ELISA and flow cytometry antibody‐binding assay. Protection induced by vaccination was assessed by challenging the mice using a S. pneumoniae pneumonia model. Results Antibody responses to S. pneumoniae were largely preserved in mice B‐cell depleted after vaccination resulting in full protection against pneumococcal infections. In contrast, mice vaccinated with Prevnar‐13 while B cells were depleted (with < 90% reduction in B‐cell numbers) had decreased circulating anti–S. pneumoniae IgG and IgM levels (measured using ELISA and flow cytometry antibody binding assays). However, some antibody responses were maintained, and, although vaccine‐induced protection against S. pneumoniae infection was impaired, septicaemia was still prevented in 50% of challenged mice. Conclusions This study showed that although vaccine efficacy during periods of profound B‐cell depletion was impaired some protective efficacy was preserved, suggesting that vaccination remains beneficial. |
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Maintained partial protection against Streptococcus pneumoniae despite B‐cell depletion in mice vaccinated with a pneumococcal glycoconjugate vaccine |
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https://doi.org/10.1002/cti2.1366 https://doaj.org/article/44361b1c8e4d434ab9c3e34bd97c6843 https://doaj.org/toc/2050-0068 |
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Elisa Ramos‐Sevillano Emma Pearce Sara Ragab David Goldblatt Gisbert Weckbecker Jeremy S Brown |
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