Knockdown of lncRNA H19 suppresses endometriosis in vivo
The long noncoding RNA (lncRNA) H19 is involved in the pathogenesis of endometriosis by modulating the proliferation and invasion of ectopic endometrial cells in vitro, but related in vivo studies are rare. This study aimed to investigate the role of lncRNA H19 in a nude mouse model of endometriosis...
Ausführliche Beschreibung
Autor*in: |
Songping Liu [verfasserIn] Weijuan Xin [verfasserIn] Qi Lu [verfasserIn] Xiaoyan Tang [verfasserIn] Fengqin Wang [verfasserIn] Wei Shao [verfasserIn] Yajiao Zhang [verfasserIn] Junjun Qiu [verfasserIn] Keqin Hua [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2021 |
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Übergeordnetes Werk: |
In: Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica, 2004, 54(2021), 4 |
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Übergeordnetes Werk: |
volume:54 ; year:2021 ; number:4 |
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Link aufrufen |
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DOI / URN: |
10.1590/1414-431x202010117 |
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Katalog-ID: |
DOAJ073614327 |
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520 | |a The long noncoding RNA (lncRNA) H19 is involved in the pathogenesis of endometriosis by modulating the proliferation and invasion of ectopic endometrial cells in vitro, but related in vivo studies are rare. This study aimed to investigate the role of lncRNA H19 in a nude mouse model of endometriosis. Ectopic endometrial stromal cells (ecESCs) were isolated from ectopic endometrium of patients with endometriosis and infected with lentiviruses expressing short hairpin RNA (shRNA) negative control (LV-NC-shRNA) or lncRNA-H19 shRNA (LV-H19-shRNA). The ecESCs infected with LV-NC-shRNA and LV-H19-shRNA were subcutaneously implanted into forty 6- to 8-week-old female nude mice. The size and weight of the endometriotic implants were measured at 1, 2, 3, and 4 weeks after implantation and compared, and lncRNA H19 levels in endometriotic implants were evaluated using real-time polymerase chain reaction (RT-PCR). All nude mice survived the experimental period, and no significant differences in body weight were observed between the experimental group and the control group. All nude mice developed histologically confirmed subcutaneous endometriotic lesions with glandular structures and stroma after 1 week of implantation. The subcutaneous lesions in the LV-NC-shRNA group after 1, 2, 3, and 4 weeks of implantation were larger than those in the LV-H19-shRNA group, and lncRNA H19 levels in subcutaneous lesions in the LV-NC-shRNA group were significantly higher than those in the LV-H19-shRNA group. Knockdown of lncRNA H19 suppresses endometriosis in vivo. Further study is required to explore the underlying mechanism in the future. | ||
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10.1590/1414-431x202010117 doi (DE-627)DOAJ073614327 (DE-599)DOAJc57e4945084e44abb4ea186ea000ec5a DE-627 ger DE-627 rakwb eng R5-920 QH301-705.5 Songping Liu verfasserin aut Knockdown of lncRNA H19 suppresses endometriosis in vivo 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The long noncoding RNA (lncRNA) H19 is involved in the pathogenesis of endometriosis by modulating the proliferation and invasion of ectopic endometrial cells in vitro, but related in vivo studies are rare. This study aimed to investigate the role of lncRNA H19 in a nude mouse model of endometriosis. Ectopic endometrial stromal cells (ecESCs) were isolated from ectopic endometrium of patients with endometriosis and infected with lentiviruses expressing short hairpin RNA (shRNA) negative control (LV-NC-shRNA) or lncRNA-H19 shRNA (LV-H19-shRNA). The ecESCs infected with LV-NC-shRNA and LV-H19-shRNA were subcutaneously implanted into forty 6- to 8-week-old female nude mice. The size and weight of the endometriotic implants were measured at 1, 2, 3, and 4 weeks after implantation and compared, and lncRNA H19 levels in endometriotic implants were evaluated using real-time polymerase chain reaction (RT-PCR). All nude mice survived the experimental period, and no significant differences in body weight were observed between the experimental group and the control group. All nude mice developed histologically confirmed subcutaneous endometriotic lesions with glandular structures and stroma after 1 week of implantation. The subcutaneous lesions in the LV-NC-shRNA group after 1, 2, 3, and 4 weeks of implantation were larger than those in the LV-H19-shRNA group, and lncRNA H19 levels in subcutaneous lesions in the LV-NC-shRNA group were significantly higher than those in the LV-H19-shRNA group. Knockdown of lncRNA H19 suppresses endometriosis in vivo. Further study is required to explore the underlying mechanism in the future. Endometriosis lncRNA H19 Gene knockdown Animal experiments Medicine (General) Biology (General) Weijuan Xin verfasserin aut Qi Lu verfasserin aut Xiaoyan Tang verfasserin aut Fengqin Wang verfasserin aut Wei Shao verfasserin aut Yajiao Zhang verfasserin aut Junjun Qiu verfasserin aut Keqin Hua verfasserin aut In Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica, 2004 54(2021), 4 (DE-627)324613407 (DE-600)2028749-5 1414431X nnns volume:54 year:2021 number:4 https://doi.org/10.1590/1414-431x202010117 kostenfrei https://doaj.org/article/c57e4945084e44abb4ea186ea000ec5a kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2021000400610&tlng=en kostenfrei http://www.scielo.br/pdf/bjmbr/v54n4/1414-431X-bjmbr-54-4-e10117.pdf kostenfrei https://doaj.org/toc/1414-431X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 54 2021 4 |
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10.1590/1414-431x202010117 doi (DE-627)DOAJ073614327 (DE-599)DOAJc57e4945084e44abb4ea186ea000ec5a DE-627 ger DE-627 rakwb eng R5-920 QH301-705.5 Songping Liu verfasserin aut Knockdown of lncRNA H19 suppresses endometriosis in vivo 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The long noncoding RNA (lncRNA) H19 is involved in the pathogenesis of endometriosis by modulating the proliferation and invasion of ectopic endometrial cells in vitro, but related in vivo studies are rare. This study aimed to investigate the role of lncRNA H19 in a nude mouse model of endometriosis. Ectopic endometrial stromal cells (ecESCs) were isolated from ectopic endometrium of patients with endometriosis and infected with lentiviruses expressing short hairpin RNA (shRNA) negative control (LV-NC-shRNA) or lncRNA-H19 shRNA (LV-H19-shRNA). The ecESCs infected with LV-NC-shRNA and LV-H19-shRNA were subcutaneously implanted into forty 6- to 8-week-old female nude mice. The size and weight of the endometriotic implants were measured at 1, 2, 3, and 4 weeks after implantation and compared, and lncRNA H19 levels in endometriotic implants were evaluated using real-time polymerase chain reaction (RT-PCR). All nude mice survived the experimental period, and no significant differences in body weight were observed between the experimental group and the control group. All nude mice developed histologically confirmed subcutaneous endometriotic lesions with glandular structures and stroma after 1 week of implantation. The subcutaneous lesions in the LV-NC-shRNA group after 1, 2, 3, and 4 weeks of implantation were larger than those in the LV-H19-shRNA group, and lncRNA H19 levels in subcutaneous lesions in the LV-NC-shRNA group were significantly higher than those in the LV-H19-shRNA group. Knockdown of lncRNA H19 suppresses endometriosis in vivo. Further study is required to explore the underlying mechanism in the future. Endometriosis lncRNA H19 Gene knockdown Animal experiments Medicine (General) Biology (General) Weijuan Xin verfasserin aut Qi Lu verfasserin aut Xiaoyan Tang verfasserin aut Fengqin Wang verfasserin aut Wei Shao verfasserin aut Yajiao Zhang verfasserin aut Junjun Qiu verfasserin aut Keqin Hua verfasserin aut In Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica, 2004 54(2021), 4 (DE-627)324613407 (DE-600)2028749-5 1414431X nnns volume:54 year:2021 number:4 https://doi.org/10.1590/1414-431x202010117 kostenfrei https://doaj.org/article/c57e4945084e44abb4ea186ea000ec5a kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2021000400610&tlng=en kostenfrei http://www.scielo.br/pdf/bjmbr/v54n4/1414-431X-bjmbr-54-4-e10117.pdf kostenfrei https://doaj.org/toc/1414-431X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 54 2021 4 |
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10.1590/1414-431x202010117 doi (DE-627)DOAJ073614327 (DE-599)DOAJc57e4945084e44abb4ea186ea000ec5a DE-627 ger DE-627 rakwb eng R5-920 QH301-705.5 Songping Liu verfasserin aut Knockdown of lncRNA H19 suppresses endometriosis in vivo 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The long noncoding RNA (lncRNA) H19 is involved in the pathogenesis of endometriosis by modulating the proliferation and invasion of ectopic endometrial cells in vitro, but related in vivo studies are rare. This study aimed to investigate the role of lncRNA H19 in a nude mouse model of endometriosis. Ectopic endometrial stromal cells (ecESCs) were isolated from ectopic endometrium of patients with endometriosis and infected with lentiviruses expressing short hairpin RNA (shRNA) negative control (LV-NC-shRNA) or lncRNA-H19 shRNA (LV-H19-shRNA). The ecESCs infected with LV-NC-shRNA and LV-H19-shRNA were subcutaneously implanted into forty 6- to 8-week-old female nude mice. The size and weight of the endometriotic implants were measured at 1, 2, 3, and 4 weeks after implantation and compared, and lncRNA H19 levels in endometriotic implants were evaluated using real-time polymerase chain reaction (RT-PCR). All nude mice survived the experimental period, and no significant differences in body weight were observed between the experimental group and the control group. All nude mice developed histologically confirmed subcutaneous endometriotic lesions with glandular structures and stroma after 1 week of implantation. The subcutaneous lesions in the LV-NC-shRNA group after 1, 2, 3, and 4 weeks of implantation were larger than those in the LV-H19-shRNA group, and lncRNA H19 levels in subcutaneous lesions in the LV-NC-shRNA group were significantly higher than those in the LV-H19-shRNA group. Knockdown of lncRNA H19 suppresses endometriosis in vivo. Further study is required to explore the underlying mechanism in the future. Endometriosis lncRNA H19 Gene knockdown Animal experiments Medicine (General) Biology (General) Weijuan Xin verfasserin aut Qi Lu verfasserin aut Xiaoyan Tang verfasserin aut Fengqin Wang verfasserin aut Wei Shao verfasserin aut Yajiao Zhang verfasserin aut Junjun Qiu verfasserin aut Keqin Hua verfasserin aut In Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica, 2004 54(2021), 4 (DE-627)324613407 (DE-600)2028749-5 1414431X nnns volume:54 year:2021 number:4 https://doi.org/10.1590/1414-431x202010117 kostenfrei https://doaj.org/article/c57e4945084e44abb4ea186ea000ec5a kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2021000400610&tlng=en kostenfrei http://www.scielo.br/pdf/bjmbr/v54n4/1414-431X-bjmbr-54-4-e10117.pdf kostenfrei https://doaj.org/toc/1414-431X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 54 2021 4 |
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10.1590/1414-431x202010117 doi (DE-627)DOAJ073614327 (DE-599)DOAJc57e4945084e44abb4ea186ea000ec5a DE-627 ger DE-627 rakwb eng R5-920 QH301-705.5 Songping Liu verfasserin aut Knockdown of lncRNA H19 suppresses endometriosis in vivo 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The long noncoding RNA (lncRNA) H19 is involved in the pathogenesis of endometriosis by modulating the proliferation and invasion of ectopic endometrial cells in vitro, but related in vivo studies are rare. This study aimed to investigate the role of lncRNA H19 in a nude mouse model of endometriosis. Ectopic endometrial stromal cells (ecESCs) were isolated from ectopic endometrium of patients with endometriosis and infected with lentiviruses expressing short hairpin RNA (shRNA) negative control (LV-NC-shRNA) or lncRNA-H19 shRNA (LV-H19-shRNA). The ecESCs infected with LV-NC-shRNA and LV-H19-shRNA were subcutaneously implanted into forty 6- to 8-week-old female nude mice. The size and weight of the endometriotic implants were measured at 1, 2, 3, and 4 weeks after implantation and compared, and lncRNA H19 levels in endometriotic implants were evaluated using real-time polymerase chain reaction (RT-PCR). All nude mice survived the experimental period, and no significant differences in body weight were observed between the experimental group and the control group. All nude mice developed histologically confirmed subcutaneous endometriotic lesions with glandular structures and stroma after 1 week of implantation. The subcutaneous lesions in the LV-NC-shRNA group after 1, 2, 3, and 4 weeks of implantation were larger than those in the LV-H19-shRNA group, and lncRNA H19 levels in subcutaneous lesions in the LV-NC-shRNA group were significantly higher than those in the LV-H19-shRNA group. Knockdown of lncRNA H19 suppresses endometriosis in vivo. Further study is required to explore the underlying mechanism in the future. Endometriosis lncRNA H19 Gene knockdown Animal experiments Medicine (General) Biology (General) Weijuan Xin verfasserin aut Qi Lu verfasserin aut Xiaoyan Tang verfasserin aut Fengqin Wang verfasserin aut Wei Shao verfasserin aut Yajiao Zhang verfasserin aut Junjun Qiu verfasserin aut Keqin Hua verfasserin aut In Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica, 2004 54(2021), 4 (DE-627)324613407 (DE-600)2028749-5 1414431X nnns volume:54 year:2021 number:4 https://doi.org/10.1590/1414-431x202010117 kostenfrei https://doaj.org/article/c57e4945084e44abb4ea186ea000ec5a kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2021000400610&tlng=en kostenfrei http://www.scielo.br/pdf/bjmbr/v54n4/1414-431X-bjmbr-54-4-e10117.pdf kostenfrei https://doaj.org/toc/1414-431X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 54 2021 4 |
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Knockdown of lncRNA H19 suppresses endometriosis in vivo |
abstract |
The long noncoding RNA (lncRNA) H19 is involved in the pathogenesis of endometriosis by modulating the proliferation and invasion of ectopic endometrial cells in vitro, but related in vivo studies are rare. This study aimed to investigate the role of lncRNA H19 in a nude mouse model of endometriosis. Ectopic endometrial stromal cells (ecESCs) were isolated from ectopic endometrium of patients with endometriosis and infected with lentiviruses expressing short hairpin RNA (shRNA) negative control (LV-NC-shRNA) or lncRNA-H19 shRNA (LV-H19-shRNA). The ecESCs infected with LV-NC-shRNA and LV-H19-shRNA were subcutaneously implanted into forty 6- to 8-week-old female nude mice. The size and weight of the endometriotic implants were measured at 1, 2, 3, and 4 weeks after implantation and compared, and lncRNA H19 levels in endometriotic implants were evaluated using real-time polymerase chain reaction (RT-PCR). All nude mice survived the experimental period, and no significant differences in body weight were observed between the experimental group and the control group. All nude mice developed histologically confirmed subcutaneous endometriotic lesions with glandular structures and stroma after 1 week of implantation. The subcutaneous lesions in the LV-NC-shRNA group after 1, 2, 3, and 4 weeks of implantation were larger than those in the LV-H19-shRNA group, and lncRNA H19 levels in subcutaneous lesions in the LV-NC-shRNA group were significantly higher than those in the LV-H19-shRNA group. Knockdown of lncRNA H19 suppresses endometriosis in vivo. Further study is required to explore the underlying mechanism in the future. |
abstractGer |
The long noncoding RNA (lncRNA) H19 is involved in the pathogenesis of endometriosis by modulating the proliferation and invasion of ectopic endometrial cells in vitro, but related in vivo studies are rare. This study aimed to investigate the role of lncRNA H19 in a nude mouse model of endometriosis. Ectopic endometrial stromal cells (ecESCs) were isolated from ectopic endometrium of patients with endometriosis and infected with lentiviruses expressing short hairpin RNA (shRNA) negative control (LV-NC-shRNA) or lncRNA-H19 shRNA (LV-H19-shRNA). The ecESCs infected with LV-NC-shRNA and LV-H19-shRNA were subcutaneously implanted into forty 6- to 8-week-old female nude mice. The size and weight of the endometriotic implants were measured at 1, 2, 3, and 4 weeks after implantation and compared, and lncRNA H19 levels in endometriotic implants were evaluated using real-time polymerase chain reaction (RT-PCR). All nude mice survived the experimental period, and no significant differences in body weight were observed between the experimental group and the control group. All nude mice developed histologically confirmed subcutaneous endometriotic lesions with glandular structures and stroma after 1 week of implantation. The subcutaneous lesions in the LV-NC-shRNA group after 1, 2, 3, and 4 weeks of implantation were larger than those in the LV-H19-shRNA group, and lncRNA H19 levels in subcutaneous lesions in the LV-NC-shRNA group were significantly higher than those in the LV-H19-shRNA group. Knockdown of lncRNA H19 suppresses endometriosis in vivo. Further study is required to explore the underlying mechanism in the future. |
abstract_unstemmed |
The long noncoding RNA (lncRNA) H19 is involved in the pathogenesis of endometriosis by modulating the proliferation and invasion of ectopic endometrial cells in vitro, but related in vivo studies are rare. This study aimed to investigate the role of lncRNA H19 in a nude mouse model of endometriosis. Ectopic endometrial stromal cells (ecESCs) were isolated from ectopic endometrium of patients with endometriosis and infected with lentiviruses expressing short hairpin RNA (shRNA) negative control (LV-NC-shRNA) or lncRNA-H19 shRNA (LV-H19-shRNA). The ecESCs infected with LV-NC-shRNA and LV-H19-shRNA were subcutaneously implanted into forty 6- to 8-week-old female nude mice. The size and weight of the endometriotic implants were measured at 1, 2, 3, and 4 weeks after implantation and compared, and lncRNA H19 levels in endometriotic implants were evaluated using real-time polymerase chain reaction (RT-PCR). All nude mice survived the experimental period, and no significant differences in body weight were observed between the experimental group and the control group. All nude mice developed histologically confirmed subcutaneous endometriotic lesions with glandular structures and stroma after 1 week of implantation. The subcutaneous lesions in the LV-NC-shRNA group after 1, 2, 3, and 4 weeks of implantation were larger than those in the LV-H19-shRNA group, and lncRNA H19 levels in subcutaneous lesions in the LV-NC-shRNA group were significantly higher than those in the LV-H19-shRNA group. Knockdown of lncRNA H19 suppresses endometriosis in vivo. Further study is required to explore the underlying mechanism in the future. |
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title_short |
Knockdown of lncRNA H19 suppresses endometriosis in vivo |
url |
https://doi.org/10.1590/1414-431x202010117 https://doaj.org/article/c57e4945084e44abb4ea186ea000ec5a http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2021000400610&tlng=en http://www.scielo.br/pdf/bjmbr/v54n4/1414-431X-bjmbr-54-4-e10117.pdf https://doaj.org/toc/1414-431X |
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author2 |
Weijuan Xin Qi Lu Xiaoyan Tang Fengqin Wang Wei Shao Yajiao Zhang Junjun Qiu Keqin Hua |
author2Str |
Weijuan Xin Qi Lu Xiaoyan Tang Fengqin Wang Wei Shao Yajiao Zhang Junjun Qiu Keqin Hua |
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10.1590/1414-431x202010117 |
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up_date |
2024-07-03T18:40:22.743Z |
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