Bacillus cereus Biovar Anthracis Causing Anthrax in Sub-Saharan Africa-Chromosomal Monophyly and Broad Geographic Distribution.

Through full genome analyses of four atypical Bacillus cereus isolates, designated B. cereus biovar anthracis, we describe a distinct clade within the B. cereus group that presents with anthrax-like disease, carrying virulence plasmids similar to those of classic Bacillus anthracis. We have isolated...
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Autor*in:	Kym S Antonation [verfasserIn] Kim Grützmacher [verfasserIn] Susann Dupke [verfasserIn] Philip Mabon [verfasserIn] Fee Zimmermann [verfasserIn] Felix Lankester [verfasserIn] Tianna Peller [verfasserIn] Anna Feistner [verfasserIn] Angelique Todd [verfasserIn] Ilka Herbinger [verfasserIn] Hélène M de Nys [verfasserIn] Jean-Jacques Muyembe-Tamfun [verfasserIn] Stomy Karhemere [verfasserIn] Roman M Wittig [verfasserIn] Emmanuel Couacy-Hymann [verfasserIn] Roland Grunow [verfasserIn] Sébastien Calvignac-Spencer [verfasserIn] Cindi R Corbett [verfasserIn] Silke R Klee [verfasserIn] Fabian H Leendertz [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Übergeordnetes Werk:	In: PLoS Neglected Tropical Diseases - Public Library of Science (PLoS), 2008, 10(2016), 9, p e0004923
Übergeordnetes Werk:	volume:10 ; year:2016 ; number:9, p e0004923

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1371/journal.pntd.0004923

Katalog-ID:	DOAJ073642126

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520			\|a Through full genome analyses of four atypical Bacillus cereus isolates, designated B. cereus biovar anthracis, we describe a distinct clade within the B. cereus group that presents with anthrax-like disease, carrying virulence plasmids similar to those of classic Bacillus anthracis. We have isolated members of this clade from different mammals (wild chimpanzees, gorillas, an elephant and goats) in West and Central Africa (Côte d'Ivoire, Cameroon, Central African Republic and Democratic Republic of Congo). The isolates shared several phenotypic features of both B. anthracis and B. cereus, but differed amongst each other in motility and their resistance or sensitivity to penicillin. They all possessed the same mutation in the regulator gene plcR, different from the one found in B. anthracis, and in addition, carry genes which enable them to produce a second capsule composed of hyaluronic acid. Our findings show the existence of a discrete clade of the B. cereus group capable of causing anthrax-like disease, found in areas of high biodiversity, which are possibly also the origin of the worldwide distributed B. anthracis. Establishing the impact of these pathogenic bacteria on threatened wildlife species will require systematic investigation. Furthermore, the consumption of wildlife found dead by the local population and presence in a domestic animal reveal potential sources of exposure to humans.
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allfieldsGer	10.1371/journal.pntd.0004923 doi (DE-627)DOAJ073642126 (DE-599)DOAJ9bc0ba9a50cd4db794a5ba6495c82e41 DE-627 ger DE-627 rakwb eng RC955-962 RA1-1270 Kym S Antonation verfasserin aut Bacillus cereus Biovar Anthracis Causing Anthrax in Sub-Saharan Africa-Chromosomal Monophyly and Broad Geographic Distribution. 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Through full genome analyses of four atypical Bacillus cereus isolates, designated B. cereus biovar anthracis, we describe a distinct clade within the B. cereus group that presents with anthrax-like disease, carrying virulence plasmids similar to those of classic Bacillus anthracis. We have isolated members of this clade from different mammals (wild chimpanzees, gorillas, an elephant and goats) in West and Central Africa (Côte d'Ivoire, Cameroon, Central African Republic and Democratic Republic of Congo). The isolates shared several phenotypic features of both B. anthracis and B. cereus, but differed amongst each other in motility and their resistance or sensitivity to penicillin. They all possessed the same mutation in the regulator gene plcR, different from the one found in B. anthracis, and in addition, carry genes which enable them to produce a second capsule composed of hyaluronic acid. Our findings show the existence of a discrete clade of the B. cereus group capable of causing anthrax-like disease, found in areas of high biodiversity, which are possibly also the origin of the worldwide distributed B. anthracis. Establishing the impact of these pathogenic bacteria on threatened wildlife species will require systematic investigation. Furthermore, the consumption of wildlife found dead by the local population and presence in a domestic animal reveal potential sources of exposure to humans. Arctic medicine. Tropical medicine Public aspects of medicine Kim Grützmacher verfasserin aut Susann Dupke verfasserin aut Philip Mabon verfasserin aut Fee Zimmermann verfasserin aut Felix Lankester verfasserin aut Tianna Peller verfasserin aut Anna Feistner verfasserin aut Angelique Todd verfasserin aut Ilka Herbinger verfasserin aut Hélène M de Nys verfasserin aut Jean-Jacques Muyembe-Tamfun verfasserin aut Stomy Karhemere verfasserin aut Roman M Wittig verfasserin aut Emmanuel Couacy-Hymann verfasserin aut Roland Grunow verfasserin aut Sébastien Calvignac-Spencer verfasserin aut Cindi R Corbett verfasserin aut Silke R Klee verfasserin aut Fabian H Leendertz verfasserin aut In PLoS Neglected Tropical Diseases Public Library of Science (PLoS), 2008 10(2016), 9, p e0004923 (DE-627)568915356 (DE-600)2429704-5 19352735 nnns volume:10 year:2016 number:9, p e0004923 https://doi.org/10.1371/journal.pntd.0004923 kostenfrei https://doaj.org/article/9bc0ba9a50cd4db794a5ba6495c82e41 kostenfrei http://europepmc.org/articles/PMC5015827?pdf=render kostenfrei https://doaj.org/toc/1935-2727 Journal toc kostenfrei https://doaj.org/toc/1935-2735 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2016 9, p e0004923
allfieldsSound	10.1371/journal.pntd.0004923 doi (DE-627)DOAJ073642126 (DE-599)DOAJ9bc0ba9a50cd4db794a5ba6495c82e41 DE-627 ger DE-627 rakwb eng RC955-962 RA1-1270 Kym S Antonation verfasserin aut Bacillus cereus Biovar Anthracis Causing Anthrax in Sub-Saharan Africa-Chromosomal Monophyly and Broad Geographic Distribution. 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Through full genome analyses of four atypical Bacillus cereus isolates, designated B. cereus biovar anthracis, we describe a distinct clade within the B. cereus group that presents with anthrax-like disease, carrying virulence plasmids similar to those of classic Bacillus anthracis. We have isolated members of this clade from different mammals (wild chimpanzees, gorillas, an elephant and goats) in West and Central Africa (Côte d'Ivoire, Cameroon, Central African Republic and Democratic Republic of Congo). The isolates shared several phenotypic features of both B. anthracis and B. cereus, but differed amongst each other in motility and their resistance or sensitivity to penicillin. They all possessed the same mutation in the regulator gene plcR, different from the one found in B. anthracis, and in addition, carry genes which enable them to produce a second capsule composed of hyaluronic acid. Our findings show the existence of a discrete clade of the B. cereus group capable of causing anthrax-like disease, found in areas of high biodiversity, which are possibly also the origin of the worldwide distributed B. anthracis. Establishing the impact of these pathogenic bacteria on threatened wildlife species will require systematic investigation. Furthermore, the consumption of wildlife found dead by the local population and presence in a domestic animal reveal potential sources of exposure to humans. Arctic medicine. Tropical medicine Public aspects of medicine Kim Grützmacher verfasserin aut Susann Dupke verfasserin aut Philip Mabon verfasserin aut Fee Zimmermann verfasserin aut Felix Lankester verfasserin aut Tianna Peller verfasserin aut Anna Feistner verfasserin aut Angelique Todd verfasserin aut Ilka Herbinger verfasserin aut Hélène M de Nys verfasserin aut Jean-Jacques Muyembe-Tamfun verfasserin aut Stomy Karhemere verfasserin aut Roman M Wittig verfasserin aut Emmanuel Couacy-Hymann verfasserin aut Roland Grunow verfasserin aut Sébastien Calvignac-Spencer verfasserin aut Cindi R Corbett verfasserin aut Silke R Klee verfasserin aut Fabian H Leendertz verfasserin aut In PLoS Neglected Tropical Diseases Public Library of Science (PLoS), 2008 10(2016), 9, p e0004923 (DE-627)568915356 (DE-600)2429704-5 19352735 nnns volume:10 year:2016 number:9, p e0004923 https://doi.org/10.1371/journal.pntd.0004923 kostenfrei https://doaj.org/article/9bc0ba9a50cd4db794a5ba6495c82e41 kostenfrei http://europepmc.org/articles/PMC5015827?pdf=render kostenfrei https://doaj.org/toc/1935-2727 Journal toc kostenfrei https://doaj.org/toc/1935-2735 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2016 9, p e0004923
language	English
source	In PLoS Neglected Tropical Diseases 10(2016), 9, p e0004923 volume:10 year:2016 number:9, p e0004923
sourceStr	In PLoS Neglected Tropical Diseases 10(2016), 9, p e0004923 volume:10 year:2016 number:9, p e0004923
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Arctic medicine. Tropical medicine Public aspects of medicine
isfreeaccess_bool	true
container_title	PLoS Neglected Tropical Diseases
authorswithroles_txt_mv	Kym S Antonation @@aut@@ Kim Grützmacher @@aut@@ Susann Dupke @@aut@@ Philip Mabon @@aut@@ Fee Zimmermann @@aut@@ Felix Lankester @@aut@@ Tianna Peller @@aut@@ Anna Feistner @@aut@@ Angelique Todd @@aut@@ Ilka Herbinger @@aut@@ Hélène M de Nys @@aut@@ Jean-Jacques Muyembe-Tamfun @@aut@@ Stomy Karhemere @@aut@@ Roman M Wittig @@aut@@ Emmanuel Couacy-Hymann @@aut@@ Roland Grunow @@aut@@ Sébastien Calvignac-Spencer @@aut@@ Cindi R Corbett @@aut@@ Silke R Klee @@aut@@ Fabian H Leendertz @@aut@@
publishDateDaySort_date	2016-01-01T00:00:00Z
hierarchy_top_id	568915356
id	DOAJ073642126
language_de	englisch
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topic_title	RC955-962 RA1-1270 Bacillus cereus Biovar Anthracis Causing Anthrax in Sub-Saharan Africa-Chromosomal Monophyly and Broad Geographic Distribution
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title	Bacillus cereus Biovar Anthracis Causing Anthrax in Sub-Saharan Africa-Chromosomal Monophyly and Broad Geographic Distribution.
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title_sort	bacillus cereus biovar anthracis causing anthrax in sub-saharan africa-chromosomal monophyly and broad geographic distribution
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title_auth	Bacillus cereus Biovar Anthracis Causing Anthrax in Sub-Saharan Africa-Chromosomal Monophyly and Broad Geographic Distribution.
abstract	Through full genome analyses of four atypical Bacillus cereus isolates, designated B. cereus biovar anthracis, we describe a distinct clade within the B. cereus group that presents with anthrax-like disease, carrying virulence plasmids similar to those of classic Bacillus anthracis. We have isolated members of this clade from different mammals (wild chimpanzees, gorillas, an elephant and goats) in West and Central Africa (Côte d'Ivoire, Cameroon, Central African Republic and Democratic Republic of Congo). The isolates shared several phenotypic features of both B. anthracis and B. cereus, but differed amongst each other in motility and their resistance or sensitivity to penicillin. They all possessed the same mutation in the regulator gene plcR, different from the one found in B. anthracis, and in addition, carry genes which enable them to produce a second capsule composed of hyaluronic acid. Our findings show the existence of a discrete clade of the B. cereus group capable of causing anthrax-like disease, found in areas of high biodiversity, which are possibly also the origin of the worldwide distributed B. anthracis. Establishing the impact of these pathogenic bacteria on threatened wildlife species will require systematic investigation. Furthermore, the consumption of wildlife found dead by the local population and presence in a domestic animal reveal potential sources of exposure to humans.
abstractGer	Through full genome analyses of four atypical Bacillus cereus isolates, designated B. cereus biovar anthracis, we describe a distinct clade within the B. cereus group that presents with anthrax-like disease, carrying virulence plasmids similar to those of classic Bacillus anthracis. We have isolated members of this clade from different mammals (wild chimpanzees, gorillas, an elephant and goats) in West and Central Africa (Côte d'Ivoire, Cameroon, Central African Republic and Democratic Republic of Congo). The isolates shared several phenotypic features of both B. anthracis and B. cereus, but differed amongst each other in motility and their resistance or sensitivity to penicillin. They all possessed the same mutation in the regulator gene plcR, different from the one found in B. anthracis, and in addition, carry genes which enable them to produce a second capsule composed of hyaluronic acid. Our findings show the existence of a discrete clade of the B. cereus group capable of causing anthrax-like disease, found in areas of high biodiversity, which are possibly also the origin of the worldwide distributed B. anthracis. Establishing the impact of these pathogenic bacteria on threatened wildlife species will require systematic investigation. Furthermore, the consumption of wildlife found dead by the local population and presence in a domestic animal reveal potential sources of exposure to humans.
abstract_unstemmed	Through full genome analyses of four atypical Bacillus cereus isolates, designated B. cereus biovar anthracis, we describe a distinct clade within the B. cereus group that presents with anthrax-like disease, carrying virulence plasmids similar to those of classic Bacillus anthracis. We have isolated members of this clade from different mammals (wild chimpanzees, gorillas, an elephant and goats) in West and Central Africa (Côte d'Ivoire, Cameroon, Central African Republic and Democratic Republic of Congo). The isolates shared several phenotypic features of both B. anthracis and B. cereus, but differed amongst each other in motility and their resistance or sensitivity to penicillin. They all possessed the same mutation in the regulator gene plcR, different from the one found in B. anthracis, and in addition, carry genes which enable them to produce a second capsule composed of hyaluronic acid. Our findings show the existence of a discrete clade of the B. cereus group capable of causing anthrax-like disease, found in areas of high biodiversity, which are possibly also the origin of the worldwide distributed B. anthracis. Establishing the impact of these pathogenic bacteria on threatened wildlife species will require systematic investigation. Furthermore, the consumption of wildlife found dead by the local population and presence in a domestic animal reveal potential sources of exposure to humans.
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title_short	Bacillus cereus Biovar Anthracis Causing Anthrax in Sub-Saharan Africa-Chromosomal Monophyly and Broad Geographic Distribution.
url	https://doi.org/10.1371/journal.pntd.0004923 https://doaj.org/article/9bc0ba9a50cd4db794a5ba6495c82e41 http://europepmc.org/articles/PMC5015827?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735
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We have isolated members of this clade from different mammals (wild chimpanzees, gorillas, an elephant and goats) in West and Central Africa (Côte d'Ivoire, Cameroon, Central African Republic and Democratic Republic of Congo). The isolates shared several phenotypic features of both B. anthracis and B. cereus, but differed amongst each other in motility and their resistance or sensitivity to penicillin. They all possessed the same mutation in the regulator gene plcR, different from the one found in B. anthracis, and in addition, carry genes which enable them to produce a second capsule composed of hyaluronic acid. Our findings show the existence of a discrete clade of the B. cereus group capable of causing anthrax-like disease, found in areas of high biodiversity, which are possibly also the origin of the worldwide distributed B. anthracis. Establishing the impact of these pathogenic bacteria on threatened wildlife species will require systematic investigation. 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Bacillus cereus Biovar Anthracis Causing Anthrax in Sub-Saharan Africa-Chromosomal Monophyly and Broad Geographic Distribution.

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