To Study the Association between AcrAB and Qep A Efflux Pumps and Ciprofloxacin Resistance among Escherichia Coli and Klebsiella Pneumoniae Clinical Strains
Abstract Background: The efflux pumps are one of the main mechanisms of resistance to antibiotics in E. coli and K. pneumoniae strains. The aim of this study is to study the association between genes coding efflux pumps AcrAB and Qep A and ciprofloxacin resistance among E. coli and K. pneumoniae cli...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Mohsen Heidary [verfasserIn] Aghil Bahramian [verfasserIn] Hossein Goudarzi [verfasserIn] Gita Eslami [verfasserIn] Ali Hashemi [verfasserIn] Saeed Khoshnood [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Persisch |
| Erschienen: |
2016 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk - Arak Medical University, 2017, 19(2016), 4, Seite 10 |
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| Übergeordnetes Werk: |
volume:19 ; year:2016 ; number:4 ; pages:10 |
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DOAJ073654892 |
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| 520 | |a Abstract Background: The efflux pumps are one of the main mechanisms of resistance to antibiotics in E. coli and K. pneumoniae strains. The aim of this study is to study the association between genes coding efflux pumps AcrAB and Qep A and ciprofloxacin resistance among E. coli and K. pneumoniae clinical strains Materials and Methods: This study was done on 100 strains of E. coli isolated from Taleghani and Labbafinejad Hospitals and 100 strains of K. pneumoniae isolated from Taleghani and Mofid Children Hospitals. Antimicrobial susceptibility tests were performed by disk diffusion method based on CLSI guidelines. Identification of genes encoding efflux pumps Acr AB and Qep A was done by PCR technique. Results: In this study, fosfomycin and imipenem had the best effect against E. coli clinical isolates and fosfomycin and tigecycline had the best effect against K. pneumoniae clinical isolates. PCR assay demonstrated that the prevalence of AcrA, AcrB and QepA genes among E. coli isolates were 92%, 84% and 0%, respectively and among K. pneumoniae isolates were 94%, 87% and 4%, respectively. Conclusion: The prevalence of genes encoding efflux pumps in E. coli and K. pneumoniae clinical strains, which causes resistance to fluoroquinolones, is cause for concern. Therefore, controlling infection and preventing the spread of drug-resistant bacteria needs to manage medication carefully and identify resistant isolates. | ||
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(DE-627)DOAJ073654892 (DE-599)DOAJfc927e98d01c47788a21cbf57756bcb9 DE-627 ger DE-627 rakwb per R5-920 Mohsen Heidary verfasserin aut To Study the Association between AcrAB and Qep A Efflux Pumps and Ciprofloxacin Resistance among Escherichia Coli and Klebsiella Pneumoniae Clinical Strains 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: The efflux pumps are one of the main mechanisms of resistance to antibiotics in E. coli and K. pneumoniae strains. The aim of this study is to study the association between genes coding efflux pumps AcrAB and Qep A and ciprofloxacin resistance among E. coli and K. pneumoniae clinical strains Materials and Methods: This study was done on 100 strains of E. coli isolated from Taleghani and Labbafinejad Hospitals and 100 strains of K. pneumoniae isolated from Taleghani and Mofid Children Hospitals. Antimicrobial susceptibility tests were performed by disk diffusion method based on CLSI guidelines. Identification of genes encoding efflux pumps Acr AB and Qep A was done by PCR technique. Results: In this study, fosfomycin and imipenem had the best effect against E. coli clinical isolates and fosfomycin and tigecycline had the best effect against K. pneumoniae clinical isolates. PCR assay demonstrated that the prevalence of AcrA, AcrB and QepA genes among E. coli isolates were 92%, 84% and 0%, respectively and among K. pneumoniae isolates were 94%, 87% and 4%, respectively. Conclusion: The prevalence of genes encoding efflux pumps in E. coli and K. pneumoniae clinical strains, which causes resistance to fluoroquinolones, is cause for concern. Therefore, controlling infection and preventing the spread of drug-resistant bacteria needs to manage medication carefully and identify resistant isolates. Klebsiella pneumoniae Efflux pump Fluoroquinolone Antibiotic sensitivity Medicine R Medicine (General) Aghil Bahramian verfasserin aut Hossein Goudarzi verfasserin aut Gita Eslami verfasserin aut Ali Hashemi verfasserin aut Saeed Khoshnood verfasserin aut In Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk Arak Medical University, 2017 19(2016), 4, Seite 10 (DE-627)669055263 (DE-600)2629479-5 2008644X nnns volume:19 year:2016 number:4 pages:10 https://doaj.org/article/fc927e98d01c47788a21cbf57756bcb9 kostenfrei http://amuj.arakmu.ac.ir/article-1-4155-en.pdf kostenfrei https://doaj.org/toc/1735-5338 Journal toc kostenfrei https://doaj.org/toc/2008-644X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 19 2016 4 10 |
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(DE-627)DOAJ073654892 (DE-599)DOAJfc927e98d01c47788a21cbf57756bcb9 DE-627 ger DE-627 rakwb per R5-920 Mohsen Heidary verfasserin aut To Study the Association between AcrAB and Qep A Efflux Pumps and Ciprofloxacin Resistance among Escherichia Coli and Klebsiella Pneumoniae Clinical Strains 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: The efflux pumps are one of the main mechanisms of resistance to antibiotics in E. coli and K. pneumoniae strains. The aim of this study is to study the association between genes coding efflux pumps AcrAB and Qep A and ciprofloxacin resistance among E. coli and K. pneumoniae clinical strains Materials and Methods: This study was done on 100 strains of E. coli isolated from Taleghani and Labbafinejad Hospitals and 100 strains of K. pneumoniae isolated from Taleghani and Mofid Children Hospitals. Antimicrobial susceptibility tests were performed by disk diffusion method based on CLSI guidelines. Identification of genes encoding efflux pumps Acr AB and Qep A was done by PCR technique. Results: In this study, fosfomycin and imipenem had the best effect against E. coli clinical isolates and fosfomycin and tigecycline had the best effect against K. pneumoniae clinical isolates. PCR assay demonstrated that the prevalence of AcrA, AcrB and QepA genes among E. coli isolates were 92%, 84% and 0%, respectively and among K. pneumoniae isolates were 94%, 87% and 4%, respectively. Conclusion: The prevalence of genes encoding efflux pumps in E. coli and K. pneumoniae clinical strains, which causes resistance to fluoroquinolones, is cause for concern. Therefore, controlling infection and preventing the spread of drug-resistant bacteria needs to manage medication carefully and identify resistant isolates. Klebsiella pneumoniae Efflux pump Fluoroquinolone Antibiotic sensitivity Medicine R Medicine (General) Aghil Bahramian verfasserin aut Hossein Goudarzi verfasserin aut Gita Eslami verfasserin aut Ali Hashemi verfasserin aut Saeed Khoshnood verfasserin aut In Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk Arak Medical University, 2017 19(2016), 4, Seite 10 (DE-627)669055263 (DE-600)2629479-5 2008644X nnns volume:19 year:2016 number:4 pages:10 https://doaj.org/article/fc927e98d01c47788a21cbf57756bcb9 kostenfrei http://amuj.arakmu.ac.ir/article-1-4155-en.pdf kostenfrei https://doaj.org/toc/1735-5338 Journal toc kostenfrei https://doaj.org/toc/2008-644X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 19 2016 4 10 |
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(DE-627)DOAJ073654892 (DE-599)DOAJfc927e98d01c47788a21cbf57756bcb9 DE-627 ger DE-627 rakwb per R5-920 Mohsen Heidary verfasserin aut To Study the Association between AcrAB and Qep A Efflux Pumps and Ciprofloxacin Resistance among Escherichia Coli and Klebsiella Pneumoniae Clinical Strains 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: The efflux pumps are one of the main mechanisms of resistance to antibiotics in E. coli and K. pneumoniae strains. The aim of this study is to study the association between genes coding efflux pumps AcrAB and Qep A and ciprofloxacin resistance among E. coli and K. pneumoniae clinical strains Materials and Methods: This study was done on 100 strains of E. coli isolated from Taleghani and Labbafinejad Hospitals and 100 strains of K. pneumoniae isolated from Taleghani and Mofid Children Hospitals. Antimicrobial susceptibility tests were performed by disk diffusion method based on CLSI guidelines. Identification of genes encoding efflux pumps Acr AB and Qep A was done by PCR technique. Results: In this study, fosfomycin and imipenem had the best effect against E. coli clinical isolates and fosfomycin and tigecycline had the best effect against K. pneumoniae clinical isolates. PCR assay demonstrated that the prevalence of AcrA, AcrB and QepA genes among E. coli isolates were 92%, 84% and 0%, respectively and among K. pneumoniae isolates were 94%, 87% and 4%, respectively. Conclusion: The prevalence of genes encoding efflux pumps in E. coli and K. pneumoniae clinical strains, which causes resistance to fluoroquinolones, is cause for concern. Therefore, controlling infection and preventing the spread of drug-resistant bacteria needs to manage medication carefully and identify resistant isolates. Klebsiella pneumoniae Efflux pump Fluoroquinolone Antibiotic sensitivity Medicine R Medicine (General) Aghil Bahramian verfasserin aut Hossein Goudarzi verfasserin aut Gita Eslami verfasserin aut Ali Hashemi verfasserin aut Saeed Khoshnood verfasserin aut In Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk Arak Medical University, 2017 19(2016), 4, Seite 10 (DE-627)669055263 (DE-600)2629479-5 2008644X nnns volume:19 year:2016 number:4 pages:10 https://doaj.org/article/fc927e98d01c47788a21cbf57756bcb9 kostenfrei http://amuj.arakmu.ac.ir/article-1-4155-en.pdf kostenfrei https://doaj.org/toc/1735-5338 Journal toc kostenfrei https://doaj.org/toc/2008-644X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 19 2016 4 10 |
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(DE-627)DOAJ073654892 (DE-599)DOAJfc927e98d01c47788a21cbf57756bcb9 DE-627 ger DE-627 rakwb per R5-920 Mohsen Heidary verfasserin aut To Study the Association between AcrAB and Qep A Efflux Pumps and Ciprofloxacin Resistance among Escherichia Coli and Klebsiella Pneumoniae Clinical Strains 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: The efflux pumps are one of the main mechanisms of resistance to antibiotics in E. coli and K. pneumoniae strains. The aim of this study is to study the association between genes coding efflux pumps AcrAB and Qep A and ciprofloxacin resistance among E. coli and K. pneumoniae clinical strains Materials and Methods: This study was done on 100 strains of E. coli isolated from Taleghani and Labbafinejad Hospitals and 100 strains of K. pneumoniae isolated from Taleghani and Mofid Children Hospitals. Antimicrobial susceptibility tests were performed by disk diffusion method based on CLSI guidelines. Identification of genes encoding efflux pumps Acr AB and Qep A was done by PCR technique. Results: In this study, fosfomycin and imipenem had the best effect against E. coli clinical isolates and fosfomycin and tigecycline had the best effect against K. pneumoniae clinical isolates. PCR assay demonstrated that the prevalence of AcrA, AcrB and QepA genes among E. coli isolates were 92%, 84% and 0%, respectively and among K. pneumoniae isolates were 94%, 87% and 4%, respectively. Conclusion: The prevalence of genes encoding efflux pumps in E. coli and K. pneumoniae clinical strains, which causes resistance to fluoroquinolones, is cause for concern. Therefore, controlling infection and preventing the spread of drug-resistant bacteria needs to manage medication carefully and identify resistant isolates. Klebsiella pneumoniae Efflux pump Fluoroquinolone Antibiotic sensitivity Medicine R Medicine (General) Aghil Bahramian verfasserin aut Hossein Goudarzi verfasserin aut Gita Eslami verfasserin aut Ali Hashemi verfasserin aut Saeed Khoshnood verfasserin aut In Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk Arak Medical University, 2017 19(2016), 4, Seite 10 (DE-627)669055263 (DE-600)2629479-5 2008644X nnns volume:19 year:2016 number:4 pages:10 https://doaj.org/article/fc927e98d01c47788a21cbf57756bcb9 kostenfrei http://amuj.arakmu.ac.ir/article-1-4155-en.pdf kostenfrei https://doaj.org/toc/1735-5338 Journal toc kostenfrei https://doaj.org/toc/2008-644X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 19 2016 4 10 |
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(DE-627)DOAJ073654892 (DE-599)DOAJfc927e98d01c47788a21cbf57756bcb9 DE-627 ger DE-627 rakwb per R5-920 Mohsen Heidary verfasserin aut To Study the Association between AcrAB and Qep A Efflux Pumps and Ciprofloxacin Resistance among Escherichia Coli and Klebsiella Pneumoniae Clinical Strains 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: The efflux pumps are one of the main mechanisms of resistance to antibiotics in E. coli and K. pneumoniae strains. The aim of this study is to study the association between genes coding efflux pumps AcrAB and Qep A and ciprofloxacin resistance among E. coli and K. pneumoniae clinical strains Materials and Methods: This study was done on 100 strains of E. coli isolated from Taleghani and Labbafinejad Hospitals and 100 strains of K. pneumoniae isolated from Taleghani and Mofid Children Hospitals. Antimicrobial susceptibility tests were performed by disk diffusion method based on CLSI guidelines. Identification of genes encoding efflux pumps Acr AB and Qep A was done by PCR technique. Results: In this study, fosfomycin and imipenem had the best effect against E. coli clinical isolates and fosfomycin and tigecycline had the best effect against K. pneumoniae clinical isolates. PCR assay demonstrated that the prevalence of AcrA, AcrB and QepA genes among E. coli isolates were 92%, 84% and 0%, respectively and among K. pneumoniae isolates were 94%, 87% and 4%, respectively. Conclusion: The prevalence of genes encoding efflux pumps in E. coli and K. pneumoniae clinical strains, which causes resistance to fluoroquinolones, is cause for concern. Therefore, controlling infection and preventing the spread of drug-resistant bacteria needs to manage medication carefully and identify resistant isolates. Klebsiella pneumoniae Efflux pump Fluoroquinolone Antibiotic sensitivity Medicine R Medicine (General) Aghil Bahramian verfasserin aut Hossein Goudarzi verfasserin aut Gita Eslami verfasserin aut Ali Hashemi verfasserin aut Saeed Khoshnood verfasserin aut In Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk Arak Medical University, 2017 19(2016), 4, Seite 10 (DE-627)669055263 (DE-600)2629479-5 2008644X nnns volume:19 year:2016 number:4 pages:10 https://doaj.org/article/fc927e98d01c47788a21cbf57756bcb9 kostenfrei http://amuj.arakmu.ac.ir/article-1-4155-en.pdf kostenfrei https://doaj.org/toc/1735-5338 Journal toc kostenfrei https://doaj.org/toc/2008-644X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 19 2016 4 10 |
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R5-920 To Study the Association between AcrAB and Qep A Efflux Pumps and Ciprofloxacin Resistance among Escherichia Coli and Klebsiella Pneumoniae Clinical Strains Klebsiella pneumoniae Efflux pump Fluoroquinolone Antibiotic sensitivity |
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To Study the Association between AcrAB and Qep A Efflux Pumps and Ciprofloxacin Resistance among Escherichia Coli and Klebsiella Pneumoniae Clinical Strains |
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To Study the Association between AcrAB and Qep A Efflux Pumps and Ciprofloxacin Resistance among Escherichia Coli and Klebsiella Pneumoniae Clinical Strains |
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Mohsen Heidary |
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Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk |
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Mohsen Heidary Aghil Bahramian Hossein Goudarzi Gita Eslami Ali Hashemi Saeed Khoshnood |
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study the association between acrab and qep a efflux pumps and ciprofloxacin resistance among escherichia coli and klebsiella pneumoniae clinical strains |
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R5-920 |
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To Study the Association between AcrAB and Qep A Efflux Pumps and Ciprofloxacin Resistance among Escherichia Coli and Klebsiella Pneumoniae Clinical Strains |
| abstract |
Abstract Background: The efflux pumps are one of the main mechanisms of resistance to antibiotics in E. coli and K. pneumoniae strains. The aim of this study is to study the association between genes coding efflux pumps AcrAB and Qep A and ciprofloxacin resistance among E. coli and K. pneumoniae clinical strains Materials and Methods: This study was done on 100 strains of E. coli isolated from Taleghani and Labbafinejad Hospitals and 100 strains of K. pneumoniae isolated from Taleghani and Mofid Children Hospitals. Antimicrobial susceptibility tests were performed by disk diffusion method based on CLSI guidelines. Identification of genes encoding efflux pumps Acr AB and Qep A was done by PCR technique. Results: In this study, fosfomycin and imipenem had the best effect against E. coli clinical isolates and fosfomycin and tigecycline had the best effect against K. pneumoniae clinical isolates. PCR assay demonstrated that the prevalence of AcrA, AcrB and QepA genes among E. coli isolates were 92%, 84% and 0%, respectively and among K. pneumoniae isolates were 94%, 87% and 4%, respectively. Conclusion: The prevalence of genes encoding efflux pumps in E. coli and K. pneumoniae clinical strains, which causes resistance to fluoroquinolones, is cause for concern. Therefore, controlling infection and preventing the spread of drug-resistant bacteria needs to manage medication carefully and identify resistant isolates. |
| abstractGer |
Abstract Background: The efflux pumps are one of the main mechanisms of resistance to antibiotics in E. coli and K. pneumoniae strains. The aim of this study is to study the association between genes coding efflux pumps AcrAB and Qep A and ciprofloxacin resistance among E. coli and K. pneumoniae clinical strains Materials and Methods: This study was done on 100 strains of E. coli isolated from Taleghani and Labbafinejad Hospitals and 100 strains of K. pneumoniae isolated from Taleghani and Mofid Children Hospitals. Antimicrobial susceptibility tests were performed by disk diffusion method based on CLSI guidelines. Identification of genes encoding efflux pumps Acr AB and Qep A was done by PCR technique. Results: In this study, fosfomycin and imipenem had the best effect against E. coli clinical isolates and fosfomycin and tigecycline had the best effect against K. pneumoniae clinical isolates. PCR assay demonstrated that the prevalence of AcrA, AcrB and QepA genes among E. coli isolates were 92%, 84% and 0%, respectively and among K. pneumoniae isolates were 94%, 87% and 4%, respectively. Conclusion: The prevalence of genes encoding efflux pumps in E. coli and K. pneumoniae clinical strains, which causes resistance to fluoroquinolones, is cause for concern. Therefore, controlling infection and preventing the spread of drug-resistant bacteria needs to manage medication carefully and identify resistant isolates. |
| abstract_unstemmed |
Abstract Background: The efflux pumps are one of the main mechanisms of resistance to antibiotics in E. coli and K. pneumoniae strains. The aim of this study is to study the association between genes coding efflux pumps AcrAB and Qep A and ciprofloxacin resistance among E. coli and K. pneumoniae clinical strains Materials and Methods: This study was done on 100 strains of E. coli isolated from Taleghani and Labbafinejad Hospitals and 100 strains of K. pneumoniae isolated from Taleghani and Mofid Children Hospitals. Antimicrobial susceptibility tests were performed by disk diffusion method based on CLSI guidelines. Identification of genes encoding efflux pumps Acr AB and Qep A was done by PCR technique. Results: In this study, fosfomycin and imipenem had the best effect against E. coli clinical isolates and fosfomycin and tigecycline had the best effect against K. pneumoniae clinical isolates. PCR assay demonstrated that the prevalence of AcrA, AcrB and QepA genes among E. coli isolates were 92%, 84% and 0%, respectively and among K. pneumoniae isolates were 94%, 87% and 4%, respectively. Conclusion: The prevalence of genes encoding efflux pumps in E. coli and K. pneumoniae clinical strains, which causes resistance to fluoroquinolones, is cause for concern. Therefore, controlling infection and preventing the spread of drug-resistant bacteria needs to manage medication carefully and identify resistant isolates. |
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To Study the Association between AcrAB and Qep A Efflux Pumps and Ciprofloxacin Resistance among Escherichia Coli and Klebsiella Pneumoniae Clinical Strains |
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