HPA-axis genes as potential risk variants for neurocognitive decline in trauma-exposed, HIV-positive females

Sean Jacobs, Karis Moxley, Jacqueline S Womersley, Georgina Spies, Sian MJ Hemmings, Soraya Seedat Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa Purpose: Previous studies have independently provided evidence for the effects of HIV infection, hypothalamic–pituitary–adrenal (HPA) axis dysfunction and early life trauma on neurocognitive impairment (NCI). This study examined the interaction between single-nucleotide polymorphisms (SNPs) of two HPA axis genes, corticotrophin-releasing hormone receptor 1 (CRHR1; rs110402, rs242924, rs7209436, and rs4792888) and corticotrophin-releasing hormone-binding protein (CRHBP; rs32897, rs10062367, and rs1053989), childhood trauma, and HIV-associated NCI. Patients and methods: The sample comprised 128 HIV-positive Xhosa females of whom 88 (69%) had a history of childhood trauma. NCI was assessed using a battery of 17 measures sensitive to the effects of HIV, and the history of childhood trauma was assessed using the validated retrospective Childhood Trauma Questionnaire-Short Form. Generalized linear regression models were used to compare allelic distribution by trauma status and global NCI. The association between genotype, childhood trauma, and cognitive scores was also evaluated using generalized linear regression models, assuming additive models for the SNPs, and ANOVA. Results: Of the seven polymorphisms assessed, only the rs10062367 variant of CRHBP was significantly associated with global NCI (P=0.034), independent of childhood trauma. This polymorphism was not significantly associated with z-scores on any specific cognitive domain. The interaction of childhood trauma and variants of CRHR1 was associated with poorer learning (rs110402) and/or recall (rs110402 and rs4792888). Conclusion: These findings suggest that CRHBP rs10062367 A allele is a possible risk variant for NCI in HIV, independent of childhood trauma. Furthermore, results show that the interaction of childhood trauma with variants of CRHR1, rs110402 and rs4792888, confer added vulnerability to NCI in HIV-infected individuals in cognitive domains that are known to be impacted by HIV. While these findings need independent replication in larger samples, it adds CRHBP and CRHR1 to the list of known genes linked to HIV- and childhood trauma-associated neurocognitive phenotypes. Keywords: neurocognitive impairment, HIV, childhood trauma, HPA-axis, CRHBP, CRHR1 Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Jacobs S [verfasserIn] Moxley K [verfasserIn] Womersley JS [verfasserIn] Spies G [verfasserIn] Hemmings SMJ [verfasserIn] Seedat S [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Neurocognitive impairment HIV Childhood trauma HPA-axis CRHBP CRHR1

Übergeordnetes Werk:	In: Neuropsychiatric Disease and Treatment - Dove Medical Press, 2009, (2018), Seite 2497-2504
Übergeordnetes Werk:	year:2018 ; pages:2497-2504

Links:	Link aufrufen Link aufrufen Journal toc

Katalog-ID:	DOAJ073680591

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520			\|a Sean Jacobs, Karis Moxley, Jacqueline S Womersley, Georgina Spies, Sian MJ Hemmings, Soraya Seedat Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa Purpose: Previous studies have independently provided evidence for the effects of HIV infection, hypothalamic–pituitary–adrenal (HPA) axis dysfunction and early life trauma on neurocognitive impairment (NCI). This study examined the interaction between single-nucleotide polymorphisms (SNPs) of two HPA axis genes, corticotrophin-releasing hormone receptor 1 (CRHR1; rs110402, rs242924, rs7209436, and rs4792888) and corticotrophin-releasing hormone-binding protein (CRHBP; rs32897, rs10062367, and rs1053989), childhood trauma, and HIV-associated NCI. Patients and methods: The sample comprised 128 HIV-positive Xhosa females of whom 88 (69%) had a history of childhood trauma. NCI was assessed using a battery of 17 measures sensitive to the effects of HIV, and the history of childhood trauma was assessed using the validated retrospective Childhood Trauma Questionnaire-Short Form. Generalized linear regression models were used to compare allelic distribution by trauma status and global NCI. The association between genotype, childhood trauma, and cognitive scores was also evaluated using generalized linear regression models, assuming additive models for the SNPs, and ANOVA. Results: Of the seven polymorphisms assessed, only the rs10062367 variant of CRHBP was significantly associated with global NCI (P=0.034), independent of childhood trauma. This polymorphism was not significantly associated with z-scores on any specific cognitive domain. The interaction of childhood trauma and variants of CRHR1 was associated with poorer learning (rs110402) and/or recall (rs110402 and rs4792888). Conclusion: These findings suggest that CRHBP rs10062367 A allele is a possible risk variant for NCI in HIV, independent of childhood trauma. Furthermore, results show that the interaction of childhood trauma with variants of CRHR1, rs110402 and rs4792888, confer added vulnerability to NCI in HIV-infected individuals in cognitive domains that are known to be impacted by HIV. While these findings need independent replication in larger samples, it adds CRHBP and CRHR1 to the list of known genes linked to HIV- and childhood trauma-associated neurocognitive phenotypes. Keywords: neurocognitive impairment, HIV, childhood trauma, HPA-axis, CRHBP, CRHR1
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allfields	(DE-627)DOAJ073680591 (DE-599)DOAJ8758c02d65364df3b650f39148d9e45d DE-627 ger DE-627 rakwb eng RC321-571 RC346-429 Jacobs S verfasserin aut HPA-axis genes as potential risk variants for neurocognitive decline in trauma-exposed, HIV-positive females 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Sean Jacobs, Karis Moxley, Jacqueline S Womersley, Georgina Spies, Sian MJ Hemmings, Soraya Seedat Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa Purpose: Previous studies have independently provided evidence for the effects of HIV infection, hypothalamic–pituitary–adrenal (HPA) axis dysfunction and early life trauma on neurocognitive impairment (NCI). This study examined the interaction between single-nucleotide polymorphisms (SNPs) of two HPA axis genes, corticotrophin-releasing hormone receptor 1 (CRHR1; rs110402, rs242924, rs7209436, and rs4792888) and corticotrophin-releasing hormone-binding protein (CRHBP; rs32897, rs10062367, and rs1053989), childhood trauma, and HIV-associated NCI. Patients and methods: The sample comprised 128 HIV-positive Xhosa females of whom 88 (69%) had a history of childhood trauma. NCI was assessed using a battery of 17 measures sensitive to the effects of HIV, and the history of childhood trauma was assessed using the validated retrospective Childhood Trauma Questionnaire-Short Form. Generalized linear regression models were used to compare allelic distribution by trauma status and global NCI. The association between genotype, childhood trauma, and cognitive scores was also evaluated using generalized linear regression models, assuming additive models for the SNPs, and ANOVA. Results: Of the seven polymorphisms assessed, only the rs10062367 variant of CRHBP was significantly associated with global NCI (P=0.034), independent of childhood trauma. This polymorphism was not significantly associated with z-scores on any specific cognitive domain. The interaction of childhood trauma and variants of CRHR1 was associated with poorer learning (rs110402) and/or recall (rs110402 and rs4792888). Conclusion: These findings suggest that CRHBP rs10062367 A allele is a possible risk variant for NCI in HIV, independent of childhood trauma. Furthermore, results show that the interaction of childhood trauma with variants of CRHR1, rs110402 and rs4792888, confer added vulnerability to NCI in HIV-infected individuals in cognitive domains that are known to be impacted by HIV. While these findings need independent replication in larger samples, it adds CRHBP and CRHR1 to the list of known genes linked to HIV- and childhood trauma-associated neurocognitive phenotypes. Keywords: neurocognitive impairment, HIV, childhood trauma, HPA-axis, CRHBP, CRHR1 Neurocognitive impairment HIV Childhood trauma HPA-axis CRHBP CRHR1 Neurosciences. Biological psychiatry. Neuropsychiatry Neurology. Diseases of the nervous system Moxley K verfasserin aut Womersley JS verfasserin aut Spies G verfasserin aut Hemmings SMJ verfasserin aut Seedat S verfasserin aut In Neuropsychiatric Disease and Treatment Dove Medical Press, 2009 (2018), Seite 2497-2504 (DE-627)481905693 (DE-600)2180554-4 11782021 nnns year:2018 pages:2497-2504 https://doaj.org/article/8758c02d65364df3b650f39148d9e45d kostenfrei https://www.dovepress.com/hpa-axis-genes-as-potential-risk-variants-for-neurocognitive-decline-i-peer-reviewed-article-NDT kostenfrei https://doaj.org/toc/1178-2021 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2018 2497-2504
spelling	(DE-627)DOAJ073680591 (DE-599)DOAJ8758c02d65364df3b650f39148d9e45d DE-627 ger DE-627 rakwb eng RC321-571 RC346-429 Jacobs S verfasserin aut HPA-axis genes as potential risk variants for neurocognitive decline in trauma-exposed, HIV-positive females 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Sean Jacobs, Karis Moxley, Jacqueline S Womersley, Georgina Spies, Sian MJ Hemmings, Soraya Seedat Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa Purpose: Previous studies have independently provided evidence for the effects of HIV infection, hypothalamic–pituitary–adrenal (HPA) axis dysfunction and early life trauma on neurocognitive impairment (NCI). This study examined the interaction between single-nucleotide polymorphisms (SNPs) of two HPA axis genes, corticotrophin-releasing hormone receptor 1 (CRHR1; rs110402, rs242924, rs7209436, and rs4792888) and corticotrophin-releasing hormone-binding protein (CRHBP; rs32897, rs10062367, and rs1053989), childhood trauma, and HIV-associated NCI. Patients and methods: The sample comprised 128 HIV-positive Xhosa females of whom 88 (69%) had a history of childhood trauma. NCI was assessed using a battery of 17 measures sensitive to the effects of HIV, and the history of childhood trauma was assessed using the validated retrospective Childhood Trauma Questionnaire-Short Form. Generalized linear regression models were used to compare allelic distribution by trauma status and global NCI. The association between genotype, childhood trauma, and cognitive scores was also evaluated using generalized linear regression models, assuming additive models for the SNPs, and ANOVA. Results: Of the seven polymorphisms assessed, only the rs10062367 variant of CRHBP was significantly associated with global NCI (P=0.034), independent of childhood trauma. This polymorphism was not significantly associated with z-scores on any specific cognitive domain. The interaction of childhood trauma and variants of CRHR1 was associated with poorer learning (rs110402) and/or recall (rs110402 and rs4792888). Conclusion: These findings suggest that CRHBP rs10062367 A allele is a possible risk variant for NCI in HIV, independent of childhood trauma. Furthermore, results show that the interaction of childhood trauma with variants of CRHR1, rs110402 and rs4792888, confer added vulnerability to NCI in HIV-infected individuals in cognitive domains that are known to be impacted by HIV. While these findings need independent replication in larger samples, it adds CRHBP and CRHR1 to the list of known genes linked to HIV- and childhood trauma-associated neurocognitive phenotypes. Keywords: neurocognitive impairment, HIV, childhood trauma, HPA-axis, CRHBP, CRHR1 Neurocognitive impairment HIV Childhood trauma HPA-axis CRHBP CRHR1 Neurosciences. Biological psychiatry. Neuropsychiatry Neurology. Diseases of the nervous system Moxley K verfasserin aut Womersley JS verfasserin aut Spies G verfasserin aut Hemmings SMJ verfasserin aut Seedat S verfasserin aut In Neuropsychiatric Disease and Treatment Dove Medical Press, 2009 (2018), Seite 2497-2504 (DE-627)481905693 (DE-600)2180554-4 11782021 nnns year:2018 pages:2497-2504 https://doaj.org/article/8758c02d65364df3b650f39148d9e45d kostenfrei https://www.dovepress.com/hpa-axis-genes-as-potential-risk-variants-for-neurocognitive-decline-i-peer-reviewed-article-NDT kostenfrei https://doaj.org/toc/1178-2021 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2018 2497-2504
allfields_unstemmed	(DE-627)DOAJ073680591 (DE-599)DOAJ8758c02d65364df3b650f39148d9e45d DE-627 ger DE-627 rakwb eng RC321-571 RC346-429 Jacobs S verfasserin aut HPA-axis genes as potential risk variants for neurocognitive decline in trauma-exposed, HIV-positive females 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Sean Jacobs, Karis Moxley, Jacqueline S Womersley, Georgina Spies, Sian MJ Hemmings, Soraya Seedat Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa Purpose: Previous studies have independently provided evidence for the effects of HIV infection, hypothalamic–pituitary–adrenal (HPA) axis dysfunction and early life trauma on neurocognitive impairment (NCI). This study examined the interaction between single-nucleotide polymorphisms (SNPs) of two HPA axis genes, corticotrophin-releasing hormone receptor 1 (CRHR1; rs110402, rs242924, rs7209436, and rs4792888) and corticotrophin-releasing hormone-binding protein (CRHBP; rs32897, rs10062367, and rs1053989), childhood trauma, and HIV-associated NCI. Patients and methods: The sample comprised 128 HIV-positive Xhosa females of whom 88 (69%) had a history of childhood trauma. NCI was assessed using a battery of 17 measures sensitive to the effects of HIV, and the history of childhood trauma was assessed using the validated retrospective Childhood Trauma Questionnaire-Short Form. Generalized linear regression models were used to compare allelic distribution by trauma status and global NCI. The association between genotype, childhood trauma, and cognitive scores was also evaluated using generalized linear regression models, assuming additive models for the SNPs, and ANOVA. Results: Of the seven polymorphisms assessed, only the rs10062367 variant of CRHBP was significantly associated with global NCI (P=0.034), independent of childhood trauma. This polymorphism was not significantly associated with z-scores on any specific cognitive domain. The interaction of childhood trauma and variants of CRHR1 was associated with poorer learning (rs110402) and/or recall (rs110402 and rs4792888). Conclusion: These findings suggest that CRHBP rs10062367 A allele is a possible risk variant for NCI in HIV, independent of childhood trauma. Furthermore, results show that the interaction of childhood trauma with variants of CRHR1, rs110402 and rs4792888, confer added vulnerability to NCI in HIV-infected individuals in cognitive domains that are known to be impacted by HIV. While these findings need independent replication in larger samples, it adds CRHBP and CRHR1 to the list of known genes linked to HIV- and childhood trauma-associated neurocognitive phenotypes. Keywords: neurocognitive impairment, HIV, childhood trauma, HPA-axis, CRHBP, CRHR1 Neurocognitive impairment HIV Childhood trauma HPA-axis CRHBP CRHR1 Neurosciences. Biological psychiatry. Neuropsychiatry Neurology. Diseases of the nervous system Moxley K verfasserin aut Womersley JS verfasserin aut Spies G verfasserin aut Hemmings SMJ verfasserin aut Seedat S verfasserin aut In Neuropsychiatric Disease and Treatment Dove Medical Press, 2009 (2018), Seite 2497-2504 (DE-627)481905693 (DE-600)2180554-4 11782021 nnns year:2018 pages:2497-2504 https://doaj.org/article/8758c02d65364df3b650f39148d9e45d kostenfrei https://www.dovepress.com/hpa-axis-genes-as-potential-risk-variants-for-neurocognitive-decline-i-peer-reviewed-article-NDT kostenfrei https://doaj.org/toc/1178-2021 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2018 2497-2504
allfieldsGer	(DE-627)DOAJ073680591 (DE-599)DOAJ8758c02d65364df3b650f39148d9e45d DE-627 ger DE-627 rakwb eng RC321-571 RC346-429 Jacobs S verfasserin aut HPA-axis genes as potential risk variants for neurocognitive decline in trauma-exposed, HIV-positive females 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Sean Jacobs, Karis Moxley, Jacqueline S Womersley, Georgina Spies, Sian MJ Hemmings, Soraya Seedat Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa Purpose: Previous studies have independently provided evidence for the effects of HIV infection, hypothalamic–pituitary–adrenal (HPA) axis dysfunction and early life trauma on neurocognitive impairment (NCI). This study examined the interaction between single-nucleotide polymorphisms (SNPs) of two HPA axis genes, corticotrophin-releasing hormone receptor 1 (CRHR1; rs110402, rs242924, rs7209436, and rs4792888) and corticotrophin-releasing hormone-binding protein (CRHBP; rs32897, rs10062367, and rs1053989), childhood trauma, and HIV-associated NCI. Patients and methods: The sample comprised 128 HIV-positive Xhosa females of whom 88 (69%) had a history of childhood trauma. NCI was assessed using a battery of 17 measures sensitive to the effects of HIV, and the history of childhood trauma was assessed using the validated retrospective Childhood Trauma Questionnaire-Short Form. Generalized linear regression models were used to compare allelic distribution by trauma status and global NCI. The association between genotype, childhood trauma, and cognitive scores was also evaluated using generalized linear regression models, assuming additive models for the SNPs, and ANOVA. Results: Of the seven polymorphisms assessed, only the rs10062367 variant of CRHBP was significantly associated with global NCI (P=0.034), independent of childhood trauma. This polymorphism was not significantly associated with z-scores on any specific cognitive domain. The interaction of childhood trauma and variants of CRHR1 was associated with poorer learning (rs110402) and/or recall (rs110402 and rs4792888). Conclusion: These findings suggest that CRHBP rs10062367 A allele is a possible risk variant for NCI in HIV, independent of childhood trauma. Furthermore, results show that the interaction of childhood trauma with variants of CRHR1, rs110402 and rs4792888, confer added vulnerability to NCI in HIV-infected individuals in cognitive domains that are known to be impacted by HIV. While these findings need independent replication in larger samples, it adds CRHBP and CRHR1 to the list of known genes linked to HIV- and childhood trauma-associated neurocognitive phenotypes. Keywords: neurocognitive impairment, HIV, childhood trauma, HPA-axis, CRHBP, CRHR1 Neurocognitive impairment HIV Childhood trauma HPA-axis CRHBP CRHR1 Neurosciences. Biological psychiatry. Neuropsychiatry Neurology. Diseases of the nervous system Moxley K verfasserin aut Womersley JS verfasserin aut Spies G verfasserin aut Hemmings SMJ verfasserin aut Seedat S verfasserin aut In Neuropsychiatric Disease and Treatment Dove Medical Press, 2009 (2018), Seite 2497-2504 (DE-627)481905693 (DE-600)2180554-4 11782021 nnns year:2018 pages:2497-2504 https://doaj.org/article/8758c02d65364df3b650f39148d9e45d kostenfrei https://www.dovepress.com/hpa-axis-genes-as-potential-risk-variants-for-neurocognitive-decline-i-peer-reviewed-article-NDT kostenfrei https://doaj.org/toc/1178-2021 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2018 2497-2504
allfieldsSound	(DE-627)DOAJ073680591 (DE-599)DOAJ8758c02d65364df3b650f39148d9e45d DE-627 ger DE-627 rakwb eng RC321-571 RC346-429 Jacobs S verfasserin aut HPA-axis genes as potential risk variants for neurocognitive decline in trauma-exposed, HIV-positive females 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Sean Jacobs, Karis Moxley, Jacqueline S Womersley, Georgina Spies, Sian MJ Hemmings, Soraya Seedat Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa Purpose: Previous studies have independently provided evidence for the effects of HIV infection, hypothalamic–pituitary–adrenal (HPA) axis dysfunction and early life trauma on neurocognitive impairment (NCI). This study examined the interaction between single-nucleotide polymorphisms (SNPs) of two HPA axis genes, corticotrophin-releasing hormone receptor 1 (CRHR1; rs110402, rs242924, rs7209436, and rs4792888) and corticotrophin-releasing hormone-binding protein (CRHBP; rs32897, rs10062367, and rs1053989), childhood trauma, and HIV-associated NCI. Patients and methods: The sample comprised 128 HIV-positive Xhosa females of whom 88 (69%) had a history of childhood trauma. NCI was assessed using a battery of 17 measures sensitive to the effects of HIV, and the history of childhood trauma was assessed using the validated retrospective Childhood Trauma Questionnaire-Short Form. Generalized linear regression models were used to compare allelic distribution by trauma status and global NCI. The association between genotype, childhood trauma, and cognitive scores was also evaluated using generalized linear regression models, assuming additive models for the SNPs, and ANOVA. Results: Of the seven polymorphisms assessed, only the rs10062367 variant of CRHBP was significantly associated with global NCI (P=0.034), independent of childhood trauma. This polymorphism was not significantly associated with z-scores on any specific cognitive domain. The interaction of childhood trauma and variants of CRHR1 was associated with poorer learning (rs110402) and/or recall (rs110402 and rs4792888). Conclusion: These findings suggest that CRHBP rs10062367 A allele is a possible risk variant for NCI in HIV, independent of childhood trauma. Furthermore, results show that the interaction of childhood trauma with variants of CRHR1, rs110402 and rs4792888, confer added vulnerability to NCI in HIV-infected individuals in cognitive domains that are known to be impacted by HIV. While these findings need independent replication in larger samples, it adds CRHBP and CRHR1 to the list of known genes linked to HIV- and childhood trauma-associated neurocognitive phenotypes. Keywords: neurocognitive impairment, HIV, childhood trauma, HPA-axis, CRHBP, CRHR1 Neurocognitive impairment HIV Childhood trauma HPA-axis CRHBP CRHR1 Neurosciences. Biological psychiatry. Neuropsychiatry Neurology. Diseases of the nervous system Moxley K verfasserin aut Womersley JS verfasserin aut Spies G verfasserin aut Hemmings SMJ verfasserin aut Seedat S verfasserin aut In Neuropsychiatric Disease and Treatment Dove Medical Press, 2009 (2018), Seite 2497-2504 (DE-627)481905693 (DE-600)2180554-4 11782021 nnns year:2018 pages:2497-2504 https://doaj.org/article/8758c02d65364df3b650f39148d9e45d kostenfrei https://www.dovepress.com/hpa-axis-genes-as-potential-risk-variants-for-neurocognitive-decline-i-peer-reviewed-article-NDT kostenfrei https://doaj.org/toc/1178-2021 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2018 2497-2504
language	English
source	In Neuropsychiatric Disease and Treatment (2018), Seite 2497-2504 year:2018 pages:2497-2504
sourceStr	In Neuropsychiatric Disease and Treatment (2018), Seite 2497-2504 year:2018 pages:2497-2504
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Neurocognitive impairment HIV Childhood trauma HPA-axis CRHBP CRHR1 Neurosciences. Biological psychiatry. Neuropsychiatry Neurology. Diseases of the nervous system
isfreeaccess_bool	true
container_title	Neuropsychiatric Disease and Treatment
authorswithroles_txt_mv	Jacobs S @@aut@@ Moxley K @@aut@@ Womersley JS @@aut@@ Spies G @@aut@@ Hemmings SMJ @@aut@@ Seedat S @@aut@@
publishDateDaySort_date	2018-01-01T00:00:00Z
hierarchy_top_id	481905693
id	DOAJ073680591
language_de	englisch
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callnumber-first	R - Medicine
author	Jacobs S
spellingShingle	Jacobs S misc RC321-571 misc RC346-429 misc Neurocognitive impairment misc HIV misc Childhood trauma misc HPA-axis misc CRHBP misc CRHR1 misc Neurosciences. Biological psychiatry. Neuropsychiatry misc Neurology. Diseases of the nervous system HPA-axis genes as potential risk variants for neurocognitive decline in trauma-exposed, HIV-positive females
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topic_title	RC321-571 RC346-429 HPA-axis genes as potential risk variants for neurocognitive decline in trauma-exposed, HIV-positive females Neurocognitive impairment HIV Childhood trauma HPA-axis CRHBP CRHR1
topic	misc RC321-571 misc RC346-429 misc Neurocognitive impairment misc HIV misc Childhood trauma misc HPA-axis misc CRHBP misc CRHR1 misc Neurosciences. Biological psychiatry. Neuropsychiatry misc Neurology. Diseases of the nervous system
topic_unstemmed	misc RC321-571 misc RC346-429 misc Neurocognitive impairment misc HIV misc Childhood trauma misc HPA-axis misc CRHBP misc CRHR1 misc Neurosciences. Biological psychiatry. Neuropsychiatry misc Neurology. Diseases of the nervous system
topic_browse	misc RC321-571 misc RC346-429 misc Neurocognitive impairment misc HIV misc Childhood trauma misc HPA-axis misc CRHBP misc CRHR1 misc Neurosciences. Biological psychiatry. Neuropsychiatry misc Neurology. Diseases of the nervous system
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title	HPA-axis genes as potential risk variants for neurocognitive decline in trauma-exposed, HIV-positive females
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title_full	HPA-axis genes as potential risk variants for neurocognitive decline in trauma-exposed, HIV-positive females
author_sort	Jacobs S
journal	Neuropsychiatric Disease and Treatment
journalStr	Neuropsychiatric Disease and Treatment
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author_browse	Jacobs S Moxley K Womersley JS Spies G Hemmings SMJ Seedat S
class	RC321-571 RC346-429
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author-letter	Jacobs S
author2-role	verfasserin
title_sort	hpa-axis genes as potential risk variants for neurocognitive decline in trauma-exposed, hiv-positive females
callnumber	RC321-571
title_auth	HPA-axis genes as potential risk variants for neurocognitive decline in trauma-exposed, HIV-positive females
abstract	Sean Jacobs, Karis Moxley, Jacqueline S Womersley, Georgina Spies, Sian MJ Hemmings, Soraya Seedat Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa Purpose: Previous studies have independently provided evidence for the effects of HIV infection, hypothalamic–pituitary–adrenal (HPA) axis dysfunction and early life trauma on neurocognitive impairment (NCI). This study examined the interaction between single-nucleotide polymorphisms (SNPs) of two HPA axis genes, corticotrophin-releasing hormone receptor 1 (CRHR1; rs110402, rs242924, rs7209436, and rs4792888) and corticotrophin-releasing hormone-binding protein (CRHBP; rs32897, rs10062367, and rs1053989), childhood trauma, and HIV-associated NCI. Patients and methods: The sample comprised 128 HIV-positive Xhosa females of whom 88 (69%) had a history of childhood trauma. NCI was assessed using a battery of 17 measures sensitive to the effects of HIV, and the history of childhood trauma was assessed using the validated retrospective Childhood Trauma Questionnaire-Short Form. Generalized linear regression models were used to compare allelic distribution by trauma status and global NCI. The association between genotype, childhood trauma, and cognitive scores was also evaluated using generalized linear regression models, assuming additive models for the SNPs, and ANOVA. Results: Of the seven polymorphisms assessed, only the rs10062367 variant of CRHBP was significantly associated with global NCI (P=0.034), independent of childhood trauma. This polymorphism was not significantly associated with z-scores on any specific cognitive domain. The interaction of childhood trauma and variants of CRHR1 was associated with poorer learning (rs110402) and/or recall (rs110402 and rs4792888). Conclusion: These findings suggest that CRHBP rs10062367 A allele is a possible risk variant for NCI in HIV, independent of childhood trauma. Furthermore, results show that the interaction of childhood trauma with variants of CRHR1, rs110402 and rs4792888, confer added vulnerability to NCI in HIV-infected individuals in cognitive domains that are known to be impacted by HIV. While these findings need independent replication in larger samples, it adds CRHBP and CRHR1 to the list of known genes linked to HIV- and childhood trauma-associated neurocognitive phenotypes. Keywords: neurocognitive impairment, HIV, childhood trauma, HPA-axis, CRHBP, CRHR1
abstractGer	Sean Jacobs, Karis Moxley, Jacqueline S Womersley, Georgina Spies, Sian MJ Hemmings, Soraya Seedat Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa Purpose: Previous studies have independently provided evidence for the effects of HIV infection, hypothalamic–pituitary–adrenal (HPA) axis dysfunction and early life trauma on neurocognitive impairment (NCI). This study examined the interaction between single-nucleotide polymorphisms (SNPs) of two HPA axis genes, corticotrophin-releasing hormone receptor 1 (CRHR1; rs110402, rs242924, rs7209436, and rs4792888) and corticotrophin-releasing hormone-binding protein (CRHBP; rs32897, rs10062367, and rs1053989), childhood trauma, and HIV-associated NCI. Patients and methods: The sample comprised 128 HIV-positive Xhosa females of whom 88 (69%) had a history of childhood trauma. NCI was assessed using a battery of 17 measures sensitive to the effects of HIV, and the history of childhood trauma was assessed using the validated retrospective Childhood Trauma Questionnaire-Short Form. Generalized linear regression models were used to compare allelic distribution by trauma status and global NCI. The association between genotype, childhood trauma, and cognitive scores was also evaluated using generalized linear regression models, assuming additive models for the SNPs, and ANOVA. Results: Of the seven polymorphisms assessed, only the rs10062367 variant of CRHBP was significantly associated with global NCI (P=0.034), independent of childhood trauma. This polymorphism was not significantly associated with z-scores on any specific cognitive domain. The interaction of childhood trauma and variants of CRHR1 was associated with poorer learning (rs110402) and/or recall (rs110402 and rs4792888). Conclusion: These findings suggest that CRHBP rs10062367 A allele is a possible risk variant for NCI in HIV, independent of childhood trauma. Furthermore, results show that the interaction of childhood trauma with variants of CRHR1, rs110402 and rs4792888, confer added vulnerability to NCI in HIV-infected individuals in cognitive domains that are known to be impacted by HIV. While these findings need independent replication in larger samples, it adds CRHBP and CRHR1 to the list of known genes linked to HIV- and childhood trauma-associated neurocognitive phenotypes. Keywords: neurocognitive impairment, HIV, childhood trauma, HPA-axis, CRHBP, CRHR1
abstract_unstemmed	Sean Jacobs, Karis Moxley, Jacqueline S Womersley, Georgina Spies, Sian MJ Hemmings, Soraya Seedat Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa Purpose: Previous studies have independently provided evidence for the effects of HIV infection, hypothalamic–pituitary–adrenal (HPA) axis dysfunction and early life trauma on neurocognitive impairment (NCI). This study examined the interaction between single-nucleotide polymorphisms (SNPs) of two HPA axis genes, corticotrophin-releasing hormone receptor 1 (CRHR1; rs110402, rs242924, rs7209436, and rs4792888) and corticotrophin-releasing hormone-binding protein (CRHBP; rs32897, rs10062367, and rs1053989), childhood trauma, and HIV-associated NCI. Patients and methods: The sample comprised 128 HIV-positive Xhosa females of whom 88 (69%) had a history of childhood trauma. NCI was assessed using a battery of 17 measures sensitive to the effects of HIV, and the history of childhood trauma was assessed using the validated retrospective Childhood Trauma Questionnaire-Short Form. Generalized linear regression models were used to compare allelic distribution by trauma status and global NCI. The association between genotype, childhood trauma, and cognitive scores was also evaluated using generalized linear regression models, assuming additive models for the SNPs, and ANOVA. Results: Of the seven polymorphisms assessed, only the rs10062367 variant of CRHBP was significantly associated with global NCI (P=0.034), independent of childhood trauma. This polymorphism was not significantly associated with z-scores on any specific cognitive domain. The interaction of childhood trauma and variants of CRHR1 was associated with poorer learning (rs110402) and/or recall (rs110402 and rs4792888). Conclusion: These findings suggest that CRHBP rs10062367 A allele is a possible risk variant for NCI in HIV, independent of childhood trauma. Furthermore, results show that the interaction of childhood trauma with variants of CRHR1, rs110402 and rs4792888, confer added vulnerability to NCI in HIV-infected individuals in cognitive domains that are known to be impacted by HIV. While these findings need independent replication in larger samples, it adds CRHBP and CRHR1 to the list of known genes linked to HIV- and childhood trauma-associated neurocognitive phenotypes. Keywords: neurocognitive impairment, HIV, childhood trauma, HPA-axis, CRHBP, CRHR1
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title_short	HPA-axis genes as potential risk variants for neurocognitive decline in trauma-exposed, HIV-positive females
url	https://doaj.org/article/8758c02d65364df3b650f39148d9e45d https://www.dovepress.com/hpa-axis-genes-as-potential-risk-variants-for-neurocognitive-decline-i-peer-reviewed-article-NDT https://doaj.org/toc/1178-2021
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author2	Moxley K Womersley JS Spies G Hemmings SMJ Seedat S
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up_date	2024-07-03T19:02:07.069Z
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