Single nucleotide polymorphisms (SNPs) are inherited from parents and they measure heritable events

<p<Abstract</p< <p<Single nucleotide polymorphisms (SNPs) are extensively used in case-control studies of practically all cancer types. They are used for the identification of inherited cancer susceptibility genes and those that may interact with environmental factors. However, bei...
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Autor*in:	Hemminki Kari [verfasserIn] Försti Asta [verfasserIn] Lorenzo Bermejo Justo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2005

Schlagwörter:	genotyping interactions genomics multiple comparisons molecular epidemiology.

Übergeordnetes Werk:	In: Journal of Carcinogenesis - Wolters Kluwer Medknow Publications, 2009, 4(2005), 1, p 2
Übergeordnetes Werk:	volume:4 ; year:2005 ; number:1, p 2

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1186/1477-3163-4-2

Katalog-ID:	DOAJ073693030

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allfieldsSound	10.1186/1477-3163-4-2 doi (DE-627)DOAJ073693030 (DE-599)DOAJa77376568f9e4bc39984b8b30e9e278b DE-627 ger DE-627 rakwb eng RC254-282 Hemminki Kari verfasserin aut Single nucleotide polymorphisms (SNPs) are inherited from parents and they measure heritable events 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Single nucleotide polymorphisms (SNPs) are extensively used in case-control studies of practically all cancer types. They are used for the identification of inherited cancer susceptibility genes and those that may interact with environmental factors. However, being genetic markers, they are applicable only on heritable conditions, which is often a neglected fact. Based on the data in the nationwide Swedish Family-Cancer Database, we review familial risks for all main cancers and discuss the evidence for a heritable component in cancer. The available evidence is not conclusive but it is consistent in pointing to a minor heritable etiology in cancer, which will hamper the success of SNP-based association studies. Empirical familial risks should be used as guidance for the planning of SNP studies. We provide calculations for the assessment of familial risks for assumed allele frequencies and gene effects (odds ratios) for different modes of inheritance. Based on these data, we discuss the gene effects that could account for the unexplained proportion of familial breast and lung cancer. As a conclusion, we are concerned about the indiscriminate use of a genetic tool to cancers, which are mainly environmental in origin. We consider the likelihood of a successful application of SNPs in gene-environment studies small, unless established environmental risk factors are tested on proven candidate genes.</p< genotyping interactions genomics multiple comparisons molecular epidemiology. Neoplasms. Tumors. Oncology. Including cancer and carcinogens Försti Asta verfasserin aut Lorenzo Bermejo Justo verfasserin aut In Journal of Carcinogenesis Wolters Kluwer Medknow Publications, 2009 4(2005), 1, p 2 (DE-627)35978612X (DE-600)2098237-9 14773163 nnns volume:4 year:2005 number:1, p 2 https://doi.org/10.1186/1477-3163-4-2 kostenfrei https://doaj.org/article/a77376568f9e4bc39984b8b30e9e278b kostenfrei http://www.carcinogenesis.com/content/4/1/2 kostenfrei https://doaj.org/toc/0974-6773 Journal toc kostenfrei https://doaj.org/toc/1477-3163 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2005 1, p 2
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authorswithroles_txt_mv	Hemminki Kari @@aut@@ Försti Asta @@aut@@ Lorenzo Bermejo Justo @@aut@@
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callnumber-first	R - Medicine
author	Hemminki Kari
spellingShingle	Hemminki Kari misc RC254-282 misc genotyping misc interactions misc genomics misc multiple comparisons misc molecular epidemiology. misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Single nucleotide polymorphisms (SNPs) are inherited from parents and they measure heritable events
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topic_title	RC254-282 Single nucleotide polymorphisms (SNPs) are inherited from parents and they measure heritable events genotyping interactions genomics multiple comparisons molecular epidemiology
topic	misc RC254-282 misc genotyping misc interactions misc genomics misc multiple comparisons misc molecular epidemiology. misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc genotyping misc interactions misc genomics misc multiple comparisons misc molecular epidemiology. misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Single nucleotide polymorphisms (SNPs) are inherited from parents and they measure heritable events
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title_full	Single nucleotide polymorphisms (SNPs) are inherited from parents and they measure heritable events
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title_sort	single nucleotide polymorphisms (snps) are inherited from parents and they measure heritable events
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title_auth	Single nucleotide polymorphisms (SNPs) are inherited from parents and they measure heritable events
abstract	<p<Abstract</p< <p<Single nucleotide polymorphisms (SNPs) are extensively used in case-control studies of practically all cancer types. They are used for the identification of inherited cancer susceptibility genes and those that may interact with environmental factors. However, being genetic markers, they are applicable only on heritable conditions, which is often a neglected fact. Based on the data in the nationwide Swedish Family-Cancer Database, we review familial risks for all main cancers and discuss the evidence for a heritable component in cancer. The available evidence is not conclusive but it is consistent in pointing to a minor heritable etiology in cancer, which will hamper the success of SNP-based association studies. Empirical familial risks should be used as guidance for the planning of SNP studies. We provide calculations for the assessment of familial risks for assumed allele frequencies and gene effects (odds ratios) for different modes of inheritance. Based on these data, we discuss the gene effects that could account for the unexplained proportion of familial breast and lung cancer. As a conclusion, we are concerned about the indiscriminate use of a genetic tool to cancers, which are mainly environmental in origin. We consider the likelihood of a successful application of SNPs in gene-environment studies small, unless established environmental risk factors are tested on proven candidate genes.</p<
abstractGer	<p<Abstract</p< <p<Single nucleotide polymorphisms (SNPs) are extensively used in case-control studies of practically all cancer types. They are used for the identification of inherited cancer susceptibility genes and those that may interact with environmental factors. However, being genetic markers, they are applicable only on heritable conditions, which is often a neglected fact. Based on the data in the nationwide Swedish Family-Cancer Database, we review familial risks for all main cancers and discuss the evidence for a heritable component in cancer. The available evidence is not conclusive but it is consistent in pointing to a minor heritable etiology in cancer, which will hamper the success of SNP-based association studies. Empirical familial risks should be used as guidance for the planning of SNP studies. We provide calculations for the assessment of familial risks for assumed allele frequencies and gene effects (odds ratios) for different modes of inheritance. Based on these data, we discuss the gene effects that could account for the unexplained proportion of familial breast and lung cancer. As a conclusion, we are concerned about the indiscriminate use of a genetic tool to cancers, which are mainly environmental in origin. We consider the likelihood of a successful application of SNPs in gene-environment studies small, unless established environmental risk factors are tested on proven candidate genes.</p<
abstract_unstemmed	<p<Abstract</p< <p<Single nucleotide polymorphisms (SNPs) are extensively used in case-control studies of practically all cancer types. They are used for the identification of inherited cancer susceptibility genes and those that may interact with environmental factors. However, being genetic markers, they are applicable only on heritable conditions, which is often a neglected fact. Based on the data in the nationwide Swedish Family-Cancer Database, we review familial risks for all main cancers and discuss the evidence for a heritable component in cancer. The available evidence is not conclusive but it is consistent in pointing to a minor heritable etiology in cancer, which will hamper the success of SNP-based association studies. Empirical familial risks should be used as guidance for the planning of SNP studies. We provide calculations for the assessment of familial risks for assumed allele frequencies and gene effects (odds ratios) for different modes of inheritance. Based on these data, we discuss the gene effects that could account for the unexplained proportion of familial breast and lung cancer. As a conclusion, we are concerned about the indiscriminate use of a genetic tool to cancers, which are mainly environmental in origin. We consider the likelihood of a successful application of SNPs in gene-environment studies small, unless established environmental risk factors are tested on proven candidate genes.</p<
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Single nucleotide polymorphisms (SNPs) are inherited from parents and they measure heritable events

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