The Hypoxic Microenvironment of Breast Cancer Cells Promotes Resistance in Radiation Therapy

The American Cancer Society has estimated an expected 279,100 new breast cancer cases, and an expected 42,690 breast cancer deaths in the U.S. for the year 2020. This includes an estimated 276,480 women who are expected to be diagnosed. Radiation therapy, also called ionizing radiation therapy, is o...
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Gespeichert in:

Autor*in:	Cordell Gilreath [verfasserIn] Marjan Boerma [verfasserIn] Zhiqiang Qin [verfasserIn] M. Keith Hudson [verfasserIn] Shanzhi Wang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	breast cancer radiation therapy hypoxia free radicals superoxide ions radiation resistance

Übergeordnetes Werk:	In: Frontiers in Oncology - Frontiers Media S.A., 2012, 10(2021)
Übergeordnetes Werk:	volume:10 ; year:2021

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fonc.2020.629422

Katalog-ID:	DOAJ073701734

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spelling	10.3389/fonc.2020.629422 doi (DE-627)DOAJ073701734 (DE-599)DOAJb750c3603cca42148d7ae5acf19097cf DE-627 ger DE-627 rakwb eng RC254-282 Cordell Gilreath verfasserin aut The Hypoxic Microenvironment of Breast Cancer Cells Promotes Resistance in Radiation Therapy 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The American Cancer Society has estimated an expected 279,100 new breast cancer cases, and an expected 42,690 breast cancer deaths in the U.S. for the year 2020. This includes an estimated 276,480 women who are expected to be diagnosed. Radiation therapy, also called ionizing radiation therapy, is one of the most frequently used methods in the treatment of breast cancer. While radiation therapy is used in the treatment of more than 50% of all cancer cases, tumor resistance to ionizing radiation presents a major challenge for effective cancer treatment. Most tumor cells are in a hypoxic microenvironment that promotes resistance to radiation therapy. In addition to radiation resistance, the hypoxic microenvironment also promotes cancer proliferation and metastasis. In this review, we will discuss the hypoxic microenvironment of breast cancer tumors, related signaling pathways, breast cancer stem-like cells, and the resistance to radiation therapy. Recent developments in our understanding of tumor hypoxia and hypoxic pathways may assist us in developing new strategies to increase cancer control in radiation therapy. breast cancer radiation therapy hypoxia free radicals superoxide ions radiation resistance Neoplasms. Tumors. Oncology. Including cancer and carcinogens Marjan Boerma verfasserin aut Zhiqiang Qin verfasserin aut M. Keith Hudson verfasserin aut Shanzhi Wang verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 10(2021) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:10 year:2021 https://doi.org/10.3389/fonc.2020.629422 kostenfrei https://doaj.org/article/b750c3603cca42148d7ae5acf19097cf kostenfrei https://www.frontiersin.org/articles/10.3389/fonc.2020.629422/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021
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allfieldsSound	10.3389/fonc.2020.629422 doi (DE-627)DOAJ073701734 (DE-599)DOAJb750c3603cca42148d7ae5acf19097cf DE-627 ger DE-627 rakwb eng RC254-282 Cordell Gilreath verfasserin aut The Hypoxic Microenvironment of Breast Cancer Cells Promotes Resistance in Radiation Therapy 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The American Cancer Society has estimated an expected 279,100 new breast cancer cases, and an expected 42,690 breast cancer deaths in the U.S. for the year 2020. This includes an estimated 276,480 women who are expected to be diagnosed. Radiation therapy, also called ionizing radiation therapy, is one of the most frequently used methods in the treatment of breast cancer. While radiation therapy is used in the treatment of more than 50% of all cancer cases, tumor resistance to ionizing radiation presents a major challenge for effective cancer treatment. Most tumor cells are in a hypoxic microenvironment that promotes resistance to radiation therapy. In addition to radiation resistance, the hypoxic microenvironment also promotes cancer proliferation and metastasis. In this review, we will discuss the hypoxic microenvironment of breast cancer tumors, related signaling pathways, breast cancer stem-like cells, and the resistance to radiation therapy. Recent developments in our understanding of tumor hypoxia and hypoxic pathways may assist us in developing new strategies to increase cancer control in radiation therapy. breast cancer radiation therapy hypoxia free radicals superoxide ions radiation resistance Neoplasms. Tumors. Oncology. Including cancer and carcinogens Marjan Boerma verfasserin aut Zhiqiang Qin verfasserin aut M. Keith Hudson verfasserin aut Shanzhi Wang verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 10(2021) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:10 year:2021 https://doi.org/10.3389/fonc.2020.629422 kostenfrei https://doaj.org/article/b750c3603cca42148d7ae5acf19097cf kostenfrei https://www.frontiersin.org/articles/10.3389/fonc.2020.629422/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021
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source	In Frontiers in Oncology 10(2021) volume:10 year:2021
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topic_facet	breast cancer radiation therapy hypoxia free radicals superoxide ions radiation resistance Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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container_title	Frontiers in Oncology
authorswithroles_txt_mv	Cordell Gilreath @@aut@@ Marjan Boerma @@aut@@ Zhiqiang Qin @@aut@@ M. Keith Hudson @@aut@@ Shanzhi Wang @@aut@@
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callnumber-first	R - Medicine
author	Cordell Gilreath
spellingShingle	Cordell Gilreath misc RC254-282 misc breast cancer misc radiation therapy misc hypoxia misc free radicals misc superoxide ions misc radiation resistance misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens The Hypoxic Microenvironment of Breast Cancer Cells Promotes Resistance in Radiation Therapy
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topic_title	RC254-282 The Hypoxic Microenvironment of Breast Cancer Cells Promotes Resistance in Radiation Therapy breast cancer radiation therapy hypoxia free radicals superoxide ions radiation resistance
topic	misc RC254-282 misc breast cancer misc radiation therapy misc hypoxia misc free radicals misc superoxide ions misc radiation resistance misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc breast cancer misc radiation therapy misc hypoxia misc free radicals misc superoxide ions misc radiation resistance misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	The Hypoxic Microenvironment of Breast Cancer Cells Promotes Resistance in Radiation Therapy
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title_full	The Hypoxic Microenvironment of Breast Cancer Cells Promotes Resistance in Radiation Therapy
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title_sort	hypoxic microenvironment of breast cancer cells promotes resistance in radiation therapy
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title_auth	The Hypoxic Microenvironment of Breast Cancer Cells Promotes Resistance in Radiation Therapy
abstract	The American Cancer Society has estimated an expected 279,100 new breast cancer cases, and an expected 42,690 breast cancer deaths in the U.S. for the year 2020. This includes an estimated 276,480 women who are expected to be diagnosed. Radiation therapy, also called ionizing radiation therapy, is one of the most frequently used methods in the treatment of breast cancer. While radiation therapy is used in the treatment of more than 50% of all cancer cases, tumor resistance to ionizing radiation presents a major challenge for effective cancer treatment. Most tumor cells are in a hypoxic microenvironment that promotes resistance to radiation therapy. In addition to radiation resistance, the hypoxic microenvironment also promotes cancer proliferation and metastasis. In this review, we will discuss the hypoxic microenvironment of breast cancer tumors, related signaling pathways, breast cancer stem-like cells, and the resistance to radiation therapy. Recent developments in our understanding of tumor hypoxia and hypoxic pathways may assist us in developing new strategies to increase cancer control in radiation therapy.
abstractGer	The American Cancer Society has estimated an expected 279,100 new breast cancer cases, and an expected 42,690 breast cancer deaths in the U.S. for the year 2020. This includes an estimated 276,480 women who are expected to be diagnosed. Radiation therapy, also called ionizing radiation therapy, is one of the most frequently used methods in the treatment of breast cancer. While radiation therapy is used in the treatment of more than 50% of all cancer cases, tumor resistance to ionizing radiation presents a major challenge for effective cancer treatment. Most tumor cells are in a hypoxic microenvironment that promotes resistance to radiation therapy. In addition to radiation resistance, the hypoxic microenvironment also promotes cancer proliferation and metastasis. In this review, we will discuss the hypoxic microenvironment of breast cancer tumors, related signaling pathways, breast cancer stem-like cells, and the resistance to radiation therapy. Recent developments in our understanding of tumor hypoxia and hypoxic pathways may assist us in developing new strategies to increase cancer control in radiation therapy.
abstract_unstemmed	The American Cancer Society has estimated an expected 279,100 new breast cancer cases, and an expected 42,690 breast cancer deaths in the U.S. for the year 2020. This includes an estimated 276,480 women who are expected to be diagnosed. Radiation therapy, also called ionizing radiation therapy, is one of the most frequently used methods in the treatment of breast cancer. While radiation therapy is used in the treatment of more than 50% of all cancer cases, tumor resistance to ionizing radiation presents a major challenge for effective cancer treatment. Most tumor cells are in a hypoxic microenvironment that promotes resistance to radiation therapy. In addition to radiation resistance, the hypoxic microenvironment also promotes cancer proliferation and metastasis. In this review, we will discuss the hypoxic microenvironment of breast cancer tumors, related signaling pathways, breast cancer stem-like cells, and the resistance to radiation therapy. Recent developments in our understanding of tumor hypoxia and hypoxic pathways may assist us in developing new strategies to increase cancer control in radiation therapy.
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title_short	The Hypoxic Microenvironment of Breast Cancer Cells Promotes Resistance in Radiation Therapy
url	https://doi.org/10.3389/fonc.2020.629422 https://doaj.org/article/b750c3603cca42148d7ae5acf19097cf https://www.frontiersin.org/articles/10.3389/fonc.2020.629422/full https://doaj.org/toc/2234-943X
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