Marrow signal mimicking tumor on MRI T1-weighted imaging after neoadjuvant chemotherapy in extremity osteosarcomas
Purpose: Many studies had demonstrated that MRI T1-weighted imaging was the most accurate method to evaluate the intramedullary extent of extremity osteosarcoma. However, we found that after neoadjuvant chemotherapy new low signal of MRI T1 imaging was detected near tumor, which mimicked the tumor p...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Zhiping Deng [verfasserIn] Yi Ding [verfasserIn] Lin Hao [verfasserIn] Qing Zhang [verfasserIn] Yongbin Su [verfasserIn] Xiaohui Niu [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Journal of Bone Oncology - Elsevier, 2016, 6(2017), C, Seite 22-26 |
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| Übergeordnetes Werk: |
volume:6 ; year:2017 ; number:C ; pages:22-26 |
| Links: |
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| DOI / URN: |
10.1016/j.jbo.2016.09.001 |
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| Katalog-ID: |
DOAJ074261460 |
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| 245 | 1 | 0 | |a Marrow signal mimicking tumor on MRI T1-weighted imaging after neoadjuvant chemotherapy in extremity osteosarcomas |
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| 520 | |a Purpose: Many studies had demonstrated that MRI T1-weighted imaging was the most accurate method to evaluate the intramedullary extent of extremity osteosarcoma. However, we found that after neoadjuvant chemotherapy new low signal of MRI T1 imaging was detected near tumor, which mimicked the tumor progression. The aim of this study was to describe the incidence and type of this new signal, to reveal the pathological correlation with this imaging change. Methods: We included 74 extremity osteosarcomas managed between June 2011 and November 2012 in this retrospective study. The T1-weighted MRI images of the affected extremity before and after neoadjuvant chemotherapy were reviewed and compared. The subjects were then classified according to the appearance of the border between the area involved by osteosarcoma and the normal marrow with attention paid to whether the border was continuous and the width of the zone of transition. The study population was classified into one of four classifications: ‘clear’, ‘continuous diffuse’, ‘discontinuous island-like’ and ‘discontinuous diffuse’. 11 patients underwent MRI of bilateral extremities, and for these patients we assessed the appearance of the uninvolved extremity with that with osteosarcoma. Following surgical resection of the tumor, the pathologic appearance was compared with the pre-operative MRI findings. Results: According to our classification system, all 74 subjects were ‘clear’ before neoadjuvant chemotherapy. After neoadjuvant chemotherapy, 30 subjects (40.5%) were still clear. Of the 44 subjects (59.5%) not classified as ‘clear’, 22 (29.7%) were classified as ‘continuous diffuse’, 4 (5.4%) as ‘discontinuous island-like’, and 18 (24.3%) as ‘discontinuous diffuse’. Of the subjects with MRI of bilateral femurs, no radiologic difference was noted in the normal marrow bilaterally. No significant difference in overall survival and relapse free survival was noted between patients grouped according to the subtypes of MRI noted. Conclusions: Neoadjuvant chemotherapy for extremity osteosarcoma can result in a variety of changes of the MRI appearance of tumor and adjacent bone and marrow. Areas of signal change beyond the tumor that represent marrow conversion and not tumor progression appear on T1 weighted imaging to be lower in signal than subcutaneous fat and higher in signal than muscle. Recognizing the existence of the effect of neoadjuvant chemotherapy on the MR appearance of the tumor and surrounding bone and myeloid elements is important so as to plan for oncological sound tumor resections while avoiding resecting more normal bone than necessary. | ||
| 650 | 4 | |a Osteosarcoma | |
| 650 | 4 | |a MRI | |
| 650 | 4 | |a Limb salvage surgery | |
| 650 | 4 | |a Neoadjuvant chemotherapy | |
| 650 | 4 | |a Tumor | |
| 653 | 0 | |a Diseases of the musculoskeletal system | |
| 653 | 0 | |a Neoplasms. Tumors. Oncology. Including cancer and carcinogens | |
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| 700 | 0 | |a Lin Hao |e verfasserin |4 aut | |
| 700 | 0 | |a Qing Zhang |e verfasserin |4 aut | |
| 700 | 0 | |a Yongbin Su |e verfasserin |4 aut | |
| 700 | 0 | |a Xiaohui Niu |e verfasserin |4 aut | |
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10.1016/j.jbo.2016.09.001 doi (DE-627)DOAJ074261460 (DE-599)DOAJd1e8e8e99ce049f09e9ea1145e4439da DE-627 ger DE-627 rakwb eng RC925-935 RC254-282 Zhiping Deng verfasserin aut Marrow signal mimicking tumor on MRI T1-weighted imaging after neoadjuvant chemotherapy in extremity osteosarcomas 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose: Many studies had demonstrated that MRI T1-weighted imaging was the most accurate method to evaluate the intramedullary extent of extremity osteosarcoma. However, we found that after neoadjuvant chemotherapy new low signal of MRI T1 imaging was detected near tumor, which mimicked the tumor progression. The aim of this study was to describe the incidence and type of this new signal, to reveal the pathological correlation with this imaging change. Methods: We included 74 extremity osteosarcomas managed between June 2011 and November 2012 in this retrospective study. The T1-weighted MRI images of the affected extremity before and after neoadjuvant chemotherapy were reviewed and compared. The subjects were then classified according to the appearance of the border between the area involved by osteosarcoma and the normal marrow with attention paid to whether the border was continuous and the width of the zone of transition. The study population was classified into one of four classifications: ‘clear’, ‘continuous diffuse’, ‘discontinuous island-like’ and ‘discontinuous diffuse’. 11 patients underwent MRI of bilateral extremities, and for these patients we assessed the appearance of the uninvolved extremity with that with osteosarcoma. Following surgical resection of the tumor, the pathologic appearance was compared with the pre-operative MRI findings. Results: According to our classification system, all 74 subjects were ‘clear’ before neoadjuvant chemotherapy. After neoadjuvant chemotherapy, 30 subjects (40.5%) were still clear. Of the 44 subjects (59.5%) not classified as ‘clear’, 22 (29.7%) were classified as ‘continuous diffuse’, 4 (5.4%) as ‘discontinuous island-like’, and 18 (24.3%) as ‘discontinuous diffuse’. Of the subjects with MRI of bilateral femurs, no radiologic difference was noted in the normal marrow bilaterally. No significant difference in overall survival and relapse free survival was noted between patients grouped according to the subtypes of MRI noted. Conclusions: Neoadjuvant chemotherapy for extremity osteosarcoma can result in a variety of changes of the MRI appearance of tumor and adjacent bone and marrow. Areas of signal change beyond the tumor that represent marrow conversion and not tumor progression appear on T1 weighted imaging to be lower in signal than subcutaneous fat and higher in signal than muscle. Recognizing the existence of the effect of neoadjuvant chemotherapy on the MR appearance of the tumor and surrounding bone and myeloid elements is important so as to plan for oncological sound tumor resections while avoiding resecting more normal bone than necessary. Osteosarcoma MRI Limb salvage surgery Neoadjuvant chemotherapy Tumor Diseases of the musculoskeletal system Neoplasms. Tumors. Oncology. Including cancer and carcinogens Yi Ding verfasserin aut Lin Hao verfasserin aut Qing Zhang verfasserin aut Yongbin Su verfasserin aut Xiaohui Niu verfasserin aut In Journal of Bone Oncology Elsevier, 2016 6(2017), C, Seite 22-26 (DE-627)733358004 (DE-600)2695887-9 22121374 nnns volume:6 year:2017 number:C pages:22-26 https://doi.org/10.1016/j.jbo.2016.09.001 kostenfrei https://doaj.org/article/d1e8e8e99ce049f09e9ea1145e4439da kostenfrei http://www.sciencedirect.com/science/article/pii/S2212137416300471 kostenfrei https://doaj.org/toc/2212-1374 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 6 2017 C 22-26 |
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10.1016/j.jbo.2016.09.001 doi (DE-627)DOAJ074261460 (DE-599)DOAJd1e8e8e99ce049f09e9ea1145e4439da DE-627 ger DE-627 rakwb eng RC925-935 RC254-282 Zhiping Deng verfasserin aut Marrow signal mimicking tumor on MRI T1-weighted imaging after neoadjuvant chemotherapy in extremity osteosarcomas 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose: Many studies had demonstrated that MRI T1-weighted imaging was the most accurate method to evaluate the intramedullary extent of extremity osteosarcoma. However, we found that after neoadjuvant chemotherapy new low signal of MRI T1 imaging was detected near tumor, which mimicked the tumor progression. The aim of this study was to describe the incidence and type of this new signal, to reveal the pathological correlation with this imaging change. Methods: We included 74 extremity osteosarcomas managed between June 2011 and November 2012 in this retrospective study. The T1-weighted MRI images of the affected extremity before and after neoadjuvant chemotherapy were reviewed and compared. The subjects were then classified according to the appearance of the border between the area involved by osteosarcoma and the normal marrow with attention paid to whether the border was continuous and the width of the zone of transition. The study population was classified into one of four classifications: ‘clear’, ‘continuous diffuse’, ‘discontinuous island-like’ and ‘discontinuous diffuse’. 11 patients underwent MRI of bilateral extremities, and for these patients we assessed the appearance of the uninvolved extremity with that with osteosarcoma. Following surgical resection of the tumor, the pathologic appearance was compared with the pre-operative MRI findings. Results: According to our classification system, all 74 subjects were ‘clear’ before neoadjuvant chemotherapy. After neoadjuvant chemotherapy, 30 subjects (40.5%) were still clear. Of the 44 subjects (59.5%) not classified as ‘clear’, 22 (29.7%) were classified as ‘continuous diffuse’, 4 (5.4%) as ‘discontinuous island-like’, and 18 (24.3%) as ‘discontinuous diffuse’. Of the subjects with MRI of bilateral femurs, no radiologic difference was noted in the normal marrow bilaterally. No significant difference in overall survival and relapse free survival was noted between patients grouped according to the subtypes of MRI noted. Conclusions: Neoadjuvant chemotherapy for extremity osteosarcoma can result in a variety of changes of the MRI appearance of tumor and adjacent bone and marrow. Areas of signal change beyond the tumor that represent marrow conversion and not tumor progression appear on T1 weighted imaging to be lower in signal than subcutaneous fat and higher in signal than muscle. Recognizing the existence of the effect of neoadjuvant chemotherapy on the MR appearance of the tumor and surrounding bone and myeloid elements is important so as to plan for oncological sound tumor resections while avoiding resecting more normal bone than necessary. Osteosarcoma MRI Limb salvage surgery Neoadjuvant chemotherapy Tumor Diseases of the musculoskeletal system Neoplasms. Tumors. Oncology. Including cancer and carcinogens Yi Ding verfasserin aut Lin Hao verfasserin aut Qing Zhang verfasserin aut Yongbin Su verfasserin aut Xiaohui Niu verfasserin aut In Journal of Bone Oncology Elsevier, 2016 6(2017), C, Seite 22-26 (DE-627)733358004 (DE-600)2695887-9 22121374 nnns volume:6 year:2017 number:C pages:22-26 https://doi.org/10.1016/j.jbo.2016.09.001 kostenfrei https://doaj.org/article/d1e8e8e99ce049f09e9ea1145e4439da kostenfrei http://www.sciencedirect.com/science/article/pii/S2212137416300471 kostenfrei https://doaj.org/toc/2212-1374 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 6 2017 C 22-26 |
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10.1016/j.jbo.2016.09.001 doi (DE-627)DOAJ074261460 (DE-599)DOAJd1e8e8e99ce049f09e9ea1145e4439da DE-627 ger DE-627 rakwb eng RC925-935 RC254-282 Zhiping Deng verfasserin aut Marrow signal mimicking tumor on MRI T1-weighted imaging after neoadjuvant chemotherapy in extremity osteosarcomas 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose: Many studies had demonstrated that MRI T1-weighted imaging was the most accurate method to evaluate the intramedullary extent of extremity osteosarcoma. However, we found that after neoadjuvant chemotherapy new low signal of MRI T1 imaging was detected near tumor, which mimicked the tumor progression. The aim of this study was to describe the incidence and type of this new signal, to reveal the pathological correlation with this imaging change. Methods: We included 74 extremity osteosarcomas managed between June 2011 and November 2012 in this retrospective study. The T1-weighted MRI images of the affected extremity before and after neoadjuvant chemotherapy were reviewed and compared. The subjects were then classified according to the appearance of the border between the area involved by osteosarcoma and the normal marrow with attention paid to whether the border was continuous and the width of the zone of transition. The study population was classified into one of four classifications: ‘clear’, ‘continuous diffuse’, ‘discontinuous island-like’ and ‘discontinuous diffuse’. 11 patients underwent MRI of bilateral extremities, and for these patients we assessed the appearance of the uninvolved extremity with that with osteosarcoma. Following surgical resection of the tumor, the pathologic appearance was compared with the pre-operative MRI findings. Results: According to our classification system, all 74 subjects were ‘clear’ before neoadjuvant chemotherapy. After neoadjuvant chemotherapy, 30 subjects (40.5%) were still clear. Of the 44 subjects (59.5%) not classified as ‘clear’, 22 (29.7%) were classified as ‘continuous diffuse’, 4 (5.4%) as ‘discontinuous island-like’, and 18 (24.3%) as ‘discontinuous diffuse’. Of the subjects with MRI of bilateral femurs, no radiologic difference was noted in the normal marrow bilaterally. No significant difference in overall survival and relapse free survival was noted between patients grouped according to the subtypes of MRI noted. Conclusions: Neoadjuvant chemotherapy for extremity osteosarcoma can result in a variety of changes of the MRI appearance of tumor and adjacent bone and marrow. Areas of signal change beyond the tumor that represent marrow conversion and not tumor progression appear on T1 weighted imaging to be lower in signal than subcutaneous fat and higher in signal than muscle. Recognizing the existence of the effect of neoadjuvant chemotherapy on the MR appearance of the tumor and surrounding bone and myeloid elements is important so as to plan for oncological sound tumor resections while avoiding resecting more normal bone than necessary. Osteosarcoma MRI Limb salvage surgery Neoadjuvant chemotherapy Tumor Diseases of the musculoskeletal system Neoplasms. Tumors. Oncology. Including cancer and carcinogens Yi Ding verfasserin aut Lin Hao verfasserin aut Qing Zhang verfasserin aut Yongbin Su verfasserin aut Xiaohui Niu verfasserin aut In Journal of Bone Oncology Elsevier, 2016 6(2017), C, Seite 22-26 (DE-627)733358004 (DE-600)2695887-9 22121374 nnns volume:6 year:2017 number:C pages:22-26 https://doi.org/10.1016/j.jbo.2016.09.001 kostenfrei https://doaj.org/article/d1e8e8e99ce049f09e9ea1145e4439da kostenfrei http://www.sciencedirect.com/science/article/pii/S2212137416300471 kostenfrei https://doaj.org/toc/2212-1374 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 6 2017 C 22-26 |
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10.1016/j.jbo.2016.09.001 doi (DE-627)DOAJ074261460 (DE-599)DOAJd1e8e8e99ce049f09e9ea1145e4439da DE-627 ger DE-627 rakwb eng RC925-935 RC254-282 Zhiping Deng verfasserin aut Marrow signal mimicking tumor on MRI T1-weighted imaging after neoadjuvant chemotherapy in extremity osteosarcomas 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose: Many studies had demonstrated that MRI T1-weighted imaging was the most accurate method to evaluate the intramedullary extent of extremity osteosarcoma. However, we found that after neoadjuvant chemotherapy new low signal of MRI T1 imaging was detected near tumor, which mimicked the tumor progression. The aim of this study was to describe the incidence and type of this new signal, to reveal the pathological correlation with this imaging change. Methods: We included 74 extremity osteosarcomas managed between June 2011 and November 2012 in this retrospective study. The T1-weighted MRI images of the affected extremity before and after neoadjuvant chemotherapy were reviewed and compared. The subjects were then classified according to the appearance of the border between the area involved by osteosarcoma and the normal marrow with attention paid to whether the border was continuous and the width of the zone of transition. The study population was classified into one of four classifications: ‘clear’, ‘continuous diffuse’, ‘discontinuous island-like’ and ‘discontinuous diffuse’. 11 patients underwent MRI of bilateral extremities, and for these patients we assessed the appearance of the uninvolved extremity with that with osteosarcoma. Following surgical resection of the tumor, the pathologic appearance was compared with the pre-operative MRI findings. Results: According to our classification system, all 74 subjects were ‘clear’ before neoadjuvant chemotherapy. After neoadjuvant chemotherapy, 30 subjects (40.5%) were still clear. Of the 44 subjects (59.5%) not classified as ‘clear’, 22 (29.7%) were classified as ‘continuous diffuse’, 4 (5.4%) as ‘discontinuous island-like’, and 18 (24.3%) as ‘discontinuous diffuse’. Of the subjects with MRI of bilateral femurs, no radiologic difference was noted in the normal marrow bilaterally. No significant difference in overall survival and relapse free survival was noted between patients grouped according to the subtypes of MRI noted. Conclusions: Neoadjuvant chemotherapy for extremity osteosarcoma can result in a variety of changes of the MRI appearance of tumor and adjacent bone and marrow. Areas of signal change beyond the tumor that represent marrow conversion and not tumor progression appear on T1 weighted imaging to be lower in signal than subcutaneous fat and higher in signal than muscle. Recognizing the existence of the effect of neoadjuvant chemotherapy on the MR appearance of the tumor and surrounding bone and myeloid elements is important so as to plan for oncological sound tumor resections while avoiding resecting more normal bone than necessary. Osteosarcoma MRI Limb salvage surgery Neoadjuvant chemotherapy Tumor Diseases of the musculoskeletal system Neoplasms. Tumors. Oncology. Including cancer and carcinogens Yi Ding verfasserin aut Lin Hao verfasserin aut Qing Zhang verfasserin aut Yongbin Su verfasserin aut Xiaohui Niu verfasserin aut In Journal of Bone Oncology Elsevier, 2016 6(2017), C, Seite 22-26 (DE-627)733358004 (DE-600)2695887-9 22121374 nnns volume:6 year:2017 number:C pages:22-26 https://doi.org/10.1016/j.jbo.2016.09.001 kostenfrei https://doaj.org/article/d1e8e8e99ce049f09e9ea1145e4439da kostenfrei http://www.sciencedirect.com/science/article/pii/S2212137416300471 kostenfrei https://doaj.org/toc/2212-1374 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 6 2017 C 22-26 |
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10.1016/j.jbo.2016.09.001 doi (DE-627)DOAJ074261460 (DE-599)DOAJd1e8e8e99ce049f09e9ea1145e4439da DE-627 ger DE-627 rakwb eng RC925-935 RC254-282 Zhiping Deng verfasserin aut Marrow signal mimicking tumor on MRI T1-weighted imaging after neoadjuvant chemotherapy in extremity osteosarcomas 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose: Many studies had demonstrated that MRI T1-weighted imaging was the most accurate method to evaluate the intramedullary extent of extremity osteosarcoma. However, we found that after neoadjuvant chemotherapy new low signal of MRI T1 imaging was detected near tumor, which mimicked the tumor progression. The aim of this study was to describe the incidence and type of this new signal, to reveal the pathological correlation with this imaging change. Methods: We included 74 extremity osteosarcomas managed between June 2011 and November 2012 in this retrospective study. The T1-weighted MRI images of the affected extremity before and after neoadjuvant chemotherapy were reviewed and compared. The subjects were then classified according to the appearance of the border between the area involved by osteosarcoma and the normal marrow with attention paid to whether the border was continuous and the width of the zone of transition. The study population was classified into one of four classifications: ‘clear’, ‘continuous diffuse’, ‘discontinuous island-like’ and ‘discontinuous diffuse’. 11 patients underwent MRI of bilateral extremities, and for these patients we assessed the appearance of the uninvolved extremity with that with osteosarcoma. Following surgical resection of the tumor, the pathologic appearance was compared with the pre-operative MRI findings. Results: According to our classification system, all 74 subjects were ‘clear’ before neoadjuvant chemotherapy. After neoadjuvant chemotherapy, 30 subjects (40.5%) were still clear. Of the 44 subjects (59.5%) not classified as ‘clear’, 22 (29.7%) were classified as ‘continuous diffuse’, 4 (5.4%) as ‘discontinuous island-like’, and 18 (24.3%) as ‘discontinuous diffuse’. Of the subjects with MRI of bilateral femurs, no radiologic difference was noted in the normal marrow bilaterally. No significant difference in overall survival and relapse free survival was noted between patients grouped according to the subtypes of MRI noted. Conclusions: Neoadjuvant chemotherapy for extremity osteosarcoma can result in a variety of changes of the MRI appearance of tumor and adjacent bone and marrow. Areas of signal change beyond the tumor that represent marrow conversion and not tumor progression appear on T1 weighted imaging to be lower in signal than subcutaneous fat and higher in signal than muscle. Recognizing the existence of the effect of neoadjuvant chemotherapy on the MR appearance of the tumor and surrounding bone and myeloid elements is important so as to plan for oncological sound tumor resections while avoiding resecting more normal bone than necessary. Osteosarcoma MRI Limb salvage surgery Neoadjuvant chemotherapy Tumor Diseases of the musculoskeletal system Neoplasms. Tumors. Oncology. Including cancer and carcinogens Yi Ding verfasserin aut Lin Hao verfasserin aut Qing Zhang verfasserin aut Yongbin Su verfasserin aut Xiaohui Niu verfasserin aut In Journal of Bone Oncology Elsevier, 2016 6(2017), C, Seite 22-26 (DE-627)733358004 (DE-600)2695887-9 22121374 nnns volume:6 year:2017 number:C pages:22-26 https://doi.org/10.1016/j.jbo.2016.09.001 kostenfrei https://doaj.org/article/d1e8e8e99ce049f09e9ea1145e4439da kostenfrei http://www.sciencedirect.com/science/article/pii/S2212137416300471 kostenfrei https://doaj.org/toc/2212-1374 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 6 2017 C 22-26 |
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Zhiping Deng @@aut@@ Yi Ding @@aut@@ Lin Hao @@aut@@ Qing Zhang @@aut@@ Yongbin Su @@aut@@ Xiaohui Niu @@aut@@ |
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However, we found that after neoadjuvant chemotherapy new low signal of MRI T1 imaging was detected near tumor, which mimicked the tumor progression. The aim of this study was to describe the incidence and type of this new signal, to reveal the pathological correlation with this imaging change. Methods: We included 74 extremity osteosarcomas managed between June 2011 and November 2012 in this retrospective study. The T1-weighted MRI images of the affected extremity before and after neoadjuvant chemotherapy were reviewed and compared. The subjects were then classified according to the appearance of the border between the area involved by osteosarcoma and the normal marrow with attention paid to whether the border was continuous and the width of the zone of transition. The study population was classified into one of four classifications: ‘clear’, ‘continuous diffuse’, ‘discontinuous island-like’ and ‘discontinuous diffuse’. 11 patients underwent MRI of bilateral extremities, and for these patients we assessed the appearance of the uninvolved extremity with that with osteosarcoma. Following surgical resection of the tumor, the pathologic appearance was compared with the pre-operative MRI findings. Results: According to our classification system, all 74 subjects were ‘clear’ before neoadjuvant chemotherapy. After neoadjuvant chemotherapy, 30 subjects (40.5%) were still clear. Of the 44 subjects (59.5%) not classified as ‘clear’, 22 (29.7%) were classified as ‘continuous diffuse’, 4 (5.4%) as ‘discontinuous island-like’, and 18 (24.3%) as ‘discontinuous diffuse’. Of the subjects with MRI of bilateral femurs, no radiologic difference was noted in the normal marrow bilaterally. No significant difference in overall survival and relapse free survival was noted between patients grouped according to the subtypes of MRI noted. Conclusions: Neoadjuvant chemotherapy for extremity osteosarcoma can result in a variety of changes of the MRI appearance of tumor and adjacent bone and marrow. Areas of signal change beyond the tumor that represent marrow conversion and not tumor progression appear on T1 weighted imaging to be lower in signal than subcutaneous fat and higher in signal than muscle. 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Zhiping Deng misc RC925-935 misc RC254-282 misc Osteosarcoma misc MRI misc Limb salvage surgery misc Neoadjuvant chemotherapy misc Tumor misc Diseases of the musculoskeletal system misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Marrow signal mimicking tumor on MRI T1-weighted imaging after neoadjuvant chemotherapy in extremity osteosarcomas |
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RC925-935 RC254-282 Marrow signal mimicking tumor on MRI T1-weighted imaging after neoadjuvant chemotherapy in extremity osteosarcomas Osteosarcoma MRI Limb salvage surgery Neoadjuvant chemotherapy Tumor |
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Zhiping Deng Yi Ding Lin Hao Qing Zhang Yongbin Su Xiaohui Niu |
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marrow signal mimicking tumor on mri t1-weighted imaging after neoadjuvant chemotherapy in extremity osteosarcomas |
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Marrow signal mimicking tumor on MRI T1-weighted imaging after neoadjuvant chemotherapy in extremity osteosarcomas |
| abstract |
Purpose: Many studies had demonstrated that MRI T1-weighted imaging was the most accurate method to evaluate the intramedullary extent of extremity osteosarcoma. However, we found that after neoadjuvant chemotherapy new low signal of MRI T1 imaging was detected near tumor, which mimicked the tumor progression. The aim of this study was to describe the incidence and type of this new signal, to reveal the pathological correlation with this imaging change. Methods: We included 74 extremity osteosarcomas managed between June 2011 and November 2012 in this retrospective study. The T1-weighted MRI images of the affected extremity before and after neoadjuvant chemotherapy were reviewed and compared. The subjects were then classified according to the appearance of the border between the area involved by osteosarcoma and the normal marrow with attention paid to whether the border was continuous and the width of the zone of transition. The study population was classified into one of four classifications: ‘clear’, ‘continuous diffuse’, ‘discontinuous island-like’ and ‘discontinuous diffuse’. 11 patients underwent MRI of bilateral extremities, and for these patients we assessed the appearance of the uninvolved extremity with that with osteosarcoma. Following surgical resection of the tumor, the pathologic appearance was compared with the pre-operative MRI findings. Results: According to our classification system, all 74 subjects were ‘clear’ before neoadjuvant chemotherapy. After neoadjuvant chemotherapy, 30 subjects (40.5%) were still clear. Of the 44 subjects (59.5%) not classified as ‘clear’, 22 (29.7%) were classified as ‘continuous diffuse’, 4 (5.4%) as ‘discontinuous island-like’, and 18 (24.3%) as ‘discontinuous diffuse’. Of the subjects with MRI of bilateral femurs, no radiologic difference was noted in the normal marrow bilaterally. No significant difference in overall survival and relapse free survival was noted between patients grouped according to the subtypes of MRI noted. Conclusions: Neoadjuvant chemotherapy for extremity osteosarcoma can result in a variety of changes of the MRI appearance of tumor and adjacent bone and marrow. Areas of signal change beyond the tumor that represent marrow conversion and not tumor progression appear on T1 weighted imaging to be lower in signal than subcutaneous fat and higher in signal than muscle. Recognizing the existence of the effect of neoadjuvant chemotherapy on the MR appearance of the tumor and surrounding bone and myeloid elements is important so as to plan for oncological sound tumor resections while avoiding resecting more normal bone than necessary. |
| abstractGer |
Purpose: Many studies had demonstrated that MRI T1-weighted imaging was the most accurate method to evaluate the intramedullary extent of extremity osteosarcoma. However, we found that after neoadjuvant chemotherapy new low signal of MRI T1 imaging was detected near tumor, which mimicked the tumor progression. The aim of this study was to describe the incidence and type of this new signal, to reveal the pathological correlation with this imaging change. Methods: We included 74 extremity osteosarcomas managed between June 2011 and November 2012 in this retrospective study. The T1-weighted MRI images of the affected extremity before and after neoadjuvant chemotherapy were reviewed and compared. The subjects were then classified according to the appearance of the border between the area involved by osteosarcoma and the normal marrow with attention paid to whether the border was continuous and the width of the zone of transition. The study population was classified into one of four classifications: ‘clear’, ‘continuous diffuse’, ‘discontinuous island-like’ and ‘discontinuous diffuse’. 11 patients underwent MRI of bilateral extremities, and for these patients we assessed the appearance of the uninvolved extremity with that with osteosarcoma. Following surgical resection of the tumor, the pathologic appearance was compared with the pre-operative MRI findings. Results: According to our classification system, all 74 subjects were ‘clear’ before neoadjuvant chemotherapy. After neoadjuvant chemotherapy, 30 subjects (40.5%) were still clear. Of the 44 subjects (59.5%) not classified as ‘clear’, 22 (29.7%) were classified as ‘continuous diffuse’, 4 (5.4%) as ‘discontinuous island-like’, and 18 (24.3%) as ‘discontinuous diffuse’. Of the subjects with MRI of bilateral femurs, no radiologic difference was noted in the normal marrow bilaterally. No significant difference in overall survival and relapse free survival was noted between patients grouped according to the subtypes of MRI noted. Conclusions: Neoadjuvant chemotherapy for extremity osteosarcoma can result in a variety of changes of the MRI appearance of tumor and adjacent bone and marrow. Areas of signal change beyond the tumor that represent marrow conversion and not tumor progression appear on T1 weighted imaging to be lower in signal than subcutaneous fat and higher in signal than muscle. Recognizing the existence of the effect of neoadjuvant chemotherapy on the MR appearance of the tumor and surrounding bone and myeloid elements is important so as to plan for oncological sound tumor resections while avoiding resecting more normal bone than necessary. |
| abstract_unstemmed |
Purpose: Many studies had demonstrated that MRI T1-weighted imaging was the most accurate method to evaluate the intramedullary extent of extremity osteosarcoma. However, we found that after neoadjuvant chemotherapy new low signal of MRI T1 imaging was detected near tumor, which mimicked the tumor progression. The aim of this study was to describe the incidence and type of this new signal, to reveal the pathological correlation with this imaging change. Methods: We included 74 extremity osteosarcomas managed between June 2011 and November 2012 in this retrospective study. The T1-weighted MRI images of the affected extremity before and after neoadjuvant chemotherapy were reviewed and compared. The subjects were then classified according to the appearance of the border between the area involved by osteosarcoma and the normal marrow with attention paid to whether the border was continuous and the width of the zone of transition. The study population was classified into one of four classifications: ‘clear’, ‘continuous diffuse’, ‘discontinuous island-like’ and ‘discontinuous diffuse’. 11 patients underwent MRI of bilateral extremities, and for these patients we assessed the appearance of the uninvolved extremity with that with osteosarcoma. Following surgical resection of the tumor, the pathologic appearance was compared with the pre-operative MRI findings. Results: According to our classification system, all 74 subjects were ‘clear’ before neoadjuvant chemotherapy. After neoadjuvant chemotherapy, 30 subjects (40.5%) were still clear. Of the 44 subjects (59.5%) not classified as ‘clear’, 22 (29.7%) were classified as ‘continuous diffuse’, 4 (5.4%) as ‘discontinuous island-like’, and 18 (24.3%) as ‘discontinuous diffuse’. Of the subjects with MRI of bilateral femurs, no radiologic difference was noted in the normal marrow bilaterally. No significant difference in overall survival and relapse free survival was noted between patients grouped according to the subtypes of MRI noted. Conclusions: Neoadjuvant chemotherapy for extremity osteosarcoma can result in a variety of changes of the MRI appearance of tumor and adjacent bone and marrow. Areas of signal change beyond the tumor that represent marrow conversion and not tumor progression appear on T1 weighted imaging to be lower in signal than subcutaneous fat and higher in signal than muscle. Recognizing the existence of the effect of neoadjuvant chemotherapy on the MR appearance of the tumor and surrounding bone and myeloid elements is important so as to plan for oncological sound tumor resections while avoiding resecting more normal bone than necessary. |
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Marrow signal mimicking tumor on MRI T1-weighted imaging after neoadjuvant chemotherapy in extremity osteosarcomas |
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https://doi.org/10.1016/j.jbo.2016.09.001 https://doaj.org/article/d1e8e8e99ce049f09e9ea1145e4439da http://www.sciencedirect.com/science/article/pii/S2212137416300471 https://doaj.org/toc/2212-1374 |
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Yi Ding Lin Hao Qing Zhang Yongbin Su Xiaohui Niu |
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2024-07-03T22:12:20.766Z |
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