Influenza vaccine effectiveness against influenza A in children based on the results of various rapid influenza tests in the 2018/19 season.
During influenza epidemics, Japanese clinicians routinely conduct rapid influenza diagnostic tests (RIDTs) in patients with influenza-like illness, and patients with positive test results are treated with anti-influenza drugs within 48 h after the onset of illness. We assessed the vaccine effectiven...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Masayoshi Shinjoh [verfasserIn] Norio Sugaya [verfasserIn] Yoshio Yamaguchi [verfasserIn] Ichiro Ookawara [verfasserIn] Yuji Nakata [verfasserIn] Atsushi Narabayashi [verfasserIn] Munehiro Furuichi [verfasserIn] Naoko Yoshida [verfasserIn] Akinobu Kamei [verfasserIn] Yuu Kuramochi [verfasserIn] Akimichi Shibata [verfasserIn] Motoko Shimoyamada [verfasserIn] Hisataka Nakazaki [verfasserIn] Naohiko Maejima [verfasserIn] Erika Yuasa [verfasserIn] Eriko Araki [verfasserIn] Naonori Maeda [verfasserIn] Takuma Ohnishi [verfasserIn] Mitsuhiro Nishida [verfasserIn] Nobuhiko Taguchi [verfasserIn] Makoto Yoshida [verfasserIn] Kenichiro Tsunematsu [verfasserIn] Meiwa Shibata [verfasserIn] Yasuhiro Hirano [verfasserIn] Shinichiro Sekiguchi [verfasserIn] Chiharu Kawakami [verfasserIn] Keiko Mitamura [verfasserIn] Takao Takahashi [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Übergeordnetes Werk: |
In: PLoS ONE - Public Library of Science (PLoS), 2007, 16(2021), 3, p e0249005 |
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| Übergeordnetes Werk: |
volume:16 ; year:2021 ; number:3, p e0249005 |
| Links: |
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| DOI / URN: |
10.1371/journal.pone.0249005 |
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| Katalog-ID: |
DOAJ074283693 |
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| 245 | 1 | 0 | |a Influenza vaccine effectiveness against influenza A in children based on the results of various rapid influenza tests in the 2018/19 season. |
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| 520 | |a During influenza epidemics, Japanese clinicians routinely conduct rapid influenza diagnostic tests (RIDTs) in patients with influenza-like illness, and patients with positive test results are treated with anti-influenza drugs within 48 h after the onset of illness. We assessed the vaccine effectiveness (VE) of inactivated influenza vaccine (IIV) in children (6 months-15 years old, N = 4243), using a test-negative case-control design based on the results of RIDTs in the 2018/19 season. The VE against influenza A(H1N1)pdm and A(H3N2) was analyzed separately using an RIDT kit specifically for detecting A(H1N1)pdm09. The adjusted VE against combined influenza A (H1N1pdm and H3N2) and against A(H1N1)pdm09 was 39% (95% confidence interval [CI], 30%-46%) and 74% (95% CI, 39%-89%), respectively. By contrast, the VE against non-A(H1N1)pdm09 influenza A (presumed to be H3N2) was very low at 7%. The adjusted VE for preventing hospitalization was 56% (95% CI, 16%-77%) against influenza A. The VE against A(H1N1)pdm09 was consistently high in our studies. By contrast, the VE against A(H3N2) was low not only in adults but also in children in the 2018/19 season. | ||
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| 700 | 0 | |a Yuji Nakata |e verfasserin |4 aut | |
| 700 | 0 | |a Atsushi Narabayashi |e verfasserin |4 aut | |
| 700 | 0 | |a Munehiro Furuichi |e verfasserin |4 aut | |
| 700 | 0 | |a Naoko Yoshida |e verfasserin |4 aut | |
| 700 | 0 | |a Akinobu Kamei |e verfasserin |4 aut | |
| 700 | 0 | |a Yuu Kuramochi |e verfasserin |4 aut | |
| 700 | 0 | |a Akimichi Shibata |e verfasserin |4 aut | |
| 700 | 0 | |a Motoko Shimoyamada |e verfasserin |4 aut | |
| 700 | 0 | |a Hisataka Nakazaki |e verfasserin |4 aut | |
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| 700 | 0 | |a Nobuhiko Taguchi |e verfasserin |4 aut | |
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| 700 | 0 | |a Takao Takahashi |e verfasserin |4 aut | |
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10.1371/journal.pone.0249005 doi (DE-627)DOAJ074283693 (DE-599)DOAJb21d1e3678ef42969561941bc3def511 DE-627 ger DE-627 rakwb eng Masayoshi Shinjoh verfasserin aut Influenza vaccine effectiveness against influenza A in children based on the results of various rapid influenza tests in the 2018/19 season. 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier During influenza epidemics, Japanese clinicians routinely conduct rapid influenza diagnostic tests (RIDTs) in patients with influenza-like illness, and patients with positive test results are treated with anti-influenza drugs within 48 h after the onset of illness. We assessed the vaccine effectiveness (VE) of inactivated influenza vaccine (IIV) in children (6 months-15 years old, N = 4243), using a test-negative case-control design based on the results of RIDTs in the 2018/19 season. The VE against influenza A(H1N1)pdm and A(H3N2) was analyzed separately using an RIDT kit specifically for detecting A(H1N1)pdm09. The adjusted VE against combined influenza A (H1N1pdm and H3N2) and against A(H1N1)pdm09 was 39% (95% confidence interval [CI], 30%-46%) and 74% (95% CI, 39%-89%), respectively. By contrast, the VE against non-A(H1N1)pdm09 influenza A (presumed to be H3N2) was very low at 7%. The adjusted VE for preventing hospitalization was 56% (95% CI, 16%-77%) against influenza A. The VE against A(H1N1)pdm09 was consistently high in our studies. By contrast, the VE against A(H3N2) was low not only in adults but also in children in the 2018/19 season. Medicine R Science Q Norio Sugaya verfasserin aut Yoshio Yamaguchi verfasserin aut Ichiro Ookawara verfasserin aut Yuji Nakata verfasserin aut Atsushi Narabayashi verfasserin aut Munehiro Furuichi verfasserin aut Naoko Yoshida verfasserin aut Akinobu Kamei verfasserin aut Yuu Kuramochi verfasserin aut Akimichi Shibata verfasserin aut Motoko Shimoyamada verfasserin aut Hisataka Nakazaki verfasserin aut Naohiko Maejima verfasserin aut Erika Yuasa verfasserin aut Eriko Araki verfasserin aut Naonori Maeda verfasserin aut Takuma Ohnishi verfasserin aut Mitsuhiro Nishida verfasserin aut Nobuhiko Taguchi verfasserin aut Makoto Yoshida verfasserin aut Kenichiro Tsunematsu verfasserin aut Meiwa Shibata verfasserin aut Yasuhiro Hirano verfasserin aut Shinichiro Sekiguchi verfasserin aut Chiharu Kawakami verfasserin aut Keiko Mitamura verfasserin aut Takao Takahashi verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 16(2021), 3, p e0249005 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:16 year:2021 number:3, p e0249005 https://doi.org/10.1371/journal.pone.0249005 kostenfrei https://doaj.org/article/b21d1e3678ef42969561941bc3def511 kostenfrei https://doi.org/10.1371/journal.pone.0249005 kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2021 3, p e0249005 |
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10.1371/journal.pone.0249005 doi (DE-627)DOAJ074283693 (DE-599)DOAJb21d1e3678ef42969561941bc3def511 DE-627 ger DE-627 rakwb eng Masayoshi Shinjoh verfasserin aut Influenza vaccine effectiveness against influenza A in children based on the results of various rapid influenza tests in the 2018/19 season. 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier During influenza epidemics, Japanese clinicians routinely conduct rapid influenza diagnostic tests (RIDTs) in patients with influenza-like illness, and patients with positive test results are treated with anti-influenza drugs within 48 h after the onset of illness. We assessed the vaccine effectiveness (VE) of inactivated influenza vaccine (IIV) in children (6 months-15 years old, N = 4243), using a test-negative case-control design based on the results of RIDTs in the 2018/19 season. The VE against influenza A(H1N1)pdm and A(H3N2) was analyzed separately using an RIDT kit specifically for detecting A(H1N1)pdm09. The adjusted VE against combined influenza A (H1N1pdm and H3N2) and against A(H1N1)pdm09 was 39% (95% confidence interval [CI], 30%-46%) and 74% (95% CI, 39%-89%), respectively. By contrast, the VE against non-A(H1N1)pdm09 influenza A (presumed to be H3N2) was very low at 7%. The adjusted VE for preventing hospitalization was 56% (95% CI, 16%-77%) against influenza A. The VE against A(H1N1)pdm09 was consistently high in our studies. By contrast, the VE against A(H3N2) was low not only in adults but also in children in the 2018/19 season. Medicine R Science Q Norio Sugaya verfasserin aut Yoshio Yamaguchi verfasserin aut Ichiro Ookawara verfasserin aut Yuji Nakata verfasserin aut Atsushi Narabayashi verfasserin aut Munehiro Furuichi verfasserin aut Naoko Yoshida verfasserin aut Akinobu Kamei verfasserin aut Yuu Kuramochi verfasserin aut Akimichi Shibata verfasserin aut Motoko Shimoyamada verfasserin aut Hisataka Nakazaki verfasserin aut Naohiko Maejima verfasserin aut Erika Yuasa verfasserin aut Eriko Araki verfasserin aut Naonori Maeda verfasserin aut Takuma Ohnishi verfasserin aut Mitsuhiro Nishida verfasserin aut Nobuhiko Taguchi verfasserin aut Makoto Yoshida verfasserin aut Kenichiro Tsunematsu verfasserin aut Meiwa Shibata verfasserin aut Yasuhiro Hirano verfasserin aut Shinichiro Sekiguchi verfasserin aut Chiharu Kawakami verfasserin aut Keiko Mitamura verfasserin aut Takao Takahashi verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 16(2021), 3, p e0249005 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:16 year:2021 number:3, p e0249005 https://doi.org/10.1371/journal.pone.0249005 kostenfrei https://doaj.org/article/b21d1e3678ef42969561941bc3def511 kostenfrei https://doi.org/10.1371/journal.pone.0249005 kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2021 3, p e0249005 |
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10.1371/journal.pone.0249005 doi (DE-627)DOAJ074283693 (DE-599)DOAJb21d1e3678ef42969561941bc3def511 DE-627 ger DE-627 rakwb eng Masayoshi Shinjoh verfasserin aut Influenza vaccine effectiveness against influenza A in children based on the results of various rapid influenza tests in the 2018/19 season. 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier During influenza epidemics, Japanese clinicians routinely conduct rapid influenza diagnostic tests (RIDTs) in patients with influenza-like illness, and patients with positive test results are treated with anti-influenza drugs within 48 h after the onset of illness. We assessed the vaccine effectiveness (VE) of inactivated influenza vaccine (IIV) in children (6 months-15 years old, N = 4243), using a test-negative case-control design based on the results of RIDTs in the 2018/19 season. The VE against influenza A(H1N1)pdm and A(H3N2) was analyzed separately using an RIDT kit specifically for detecting A(H1N1)pdm09. The adjusted VE against combined influenza A (H1N1pdm and H3N2) and against A(H1N1)pdm09 was 39% (95% confidence interval [CI], 30%-46%) and 74% (95% CI, 39%-89%), respectively. By contrast, the VE against non-A(H1N1)pdm09 influenza A (presumed to be H3N2) was very low at 7%. The adjusted VE for preventing hospitalization was 56% (95% CI, 16%-77%) against influenza A. The VE against A(H1N1)pdm09 was consistently high in our studies. By contrast, the VE against A(H3N2) was low not only in adults but also in children in the 2018/19 season. Medicine R Science Q Norio Sugaya verfasserin aut Yoshio Yamaguchi verfasserin aut Ichiro Ookawara verfasserin aut Yuji Nakata verfasserin aut Atsushi Narabayashi verfasserin aut Munehiro Furuichi verfasserin aut Naoko Yoshida verfasserin aut Akinobu Kamei verfasserin aut Yuu Kuramochi verfasserin aut Akimichi Shibata verfasserin aut Motoko Shimoyamada verfasserin aut Hisataka Nakazaki verfasserin aut Naohiko Maejima verfasserin aut Erika Yuasa verfasserin aut Eriko Araki verfasserin aut Naonori Maeda verfasserin aut Takuma Ohnishi verfasserin aut Mitsuhiro Nishida verfasserin aut Nobuhiko Taguchi verfasserin aut Makoto Yoshida verfasserin aut Kenichiro Tsunematsu verfasserin aut Meiwa Shibata verfasserin aut Yasuhiro Hirano verfasserin aut Shinichiro Sekiguchi verfasserin aut Chiharu Kawakami verfasserin aut Keiko Mitamura verfasserin aut Takao Takahashi verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 16(2021), 3, p e0249005 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:16 year:2021 number:3, p e0249005 https://doi.org/10.1371/journal.pone.0249005 kostenfrei https://doaj.org/article/b21d1e3678ef42969561941bc3def511 kostenfrei https://doi.org/10.1371/journal.pone.0249005 kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2021 3, p e0249005 |
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10.1371/journal.pone.0249005 doi (DE-627)DOAJ074283693 (DE-599)DOAJb21d1e3678ef42969561941bc3def511 DE-627 ger DE-627 rakwb eng Masayoshi Shinjoh verfasserin aut Influenza vaccine effectiveness against influenza A in children based on the results of various rapid influenza tests in the 2018/19 season. 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier During influenza epidemics, Japanese clinicians routinely conduct rapid influenza diagnostic tests (RIDTs) in patients with influenza-like illness, and patients with positive test results are treated with anti-influenza drugs within 48 h after the onset of illness. We assessed the vaccine effectiveness (VE) of inactivated influenza vaccine (IIV) in children (6 months-15 years old, N = 4243), using a test-negative case-control design based on the results of RIDTs in the 2018/19 season. The VE against influenza A(H1N1)pdm and A(H3N2) was analyzed separately using an RIDT kit specifically for detecting A(H1N1)pdm09. The adjusted VE against combined influenza A (H1N1pdm and H3N2) and against A(H1N1)pdm09 was 39% (95% confidence interval [CI], 30%-46%) and 74% (95% CI, 39%-89%), respectively. By contrast, the VE against non-A(H1N1)pdm09 influenza A (presumed to be H3N2) was very low at 7%. The adjusted VE for preventing hospitalization was 56% (95% CI, 16%-77%) against influenza A. The VE against A(H1N1)pdm09 was consistently high in our studies. By contrast, the VE against A(H3N2) was low not only in adults but also in children in the 2018/19 season. Medicine R Science Q Norio Sugaya verfasserin aut Yoshio Yamaguchi verfasserin aut Ichiro Ookawara verfasserin aut Yuji Nakata verfasserin aut Atsushi Narabayashi verfasserin aut Munehiro Furuichi verfasserin aut Naoko Yoshida verfasserin aut Akinobu Kamei verfasserin aut Yuu Kuramochi verfasserin aut Akimichi Shibata verfasserin aut Motoko Shimoyamada verfasserin aut Hisataka Nakazaki verfasserin aut Naohiko Maejima verfasserin aut Erika Yuasa verfasserin aut Eriko Araki verfasserin aut Naonori Maeda verfasserin aut Takuma Ohnishi verfasserin aut Mitsuhiro Nishida verfasserin aut Nobuhiko Taguchi verfasserin aut Makoto Yoshida verfasserin aut Kenichiro Tsunematsu verfasserin aut Meiwa Shibata verfasserin aut Yasuhiro Hirano verfasserin aut Shinichiro Sekiguchi verfasserin aut Chiharu Kawakami verfasserin aut Keiko Mitamura verfasserin aut Takao Takahashi verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 16(2021), 3, p e0249005 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:16 year:2021 number:3, p e0249005 https://doi.org/10.1371/journal.pone.0249005 kostenfrei https://doaj.org/article/b21d1e3678ef42969561941bc3def511 kostenfrei https://doi.org/10.1371/journal.pone.0249005 kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2021 3, p e0249005 |
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10.1371/journal.pone.0249005 doi (DE-627)DOAJ074283693 (DE-599)DOAJb21d1e3678ef42969561941bc3def511 DE-627 ger DE-627 rakwb eng Masayoshi Shinjoh verfasserin aut Influenza vaccine effectiveness against influenza A in children based on the results of various rapid influenza tests in the 2018/19 season. 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier During influenza epidemics, Japanese clinicians routinely conduct rapid influenza diagnostic tests (RIDTs) in patients with influenza-like illness, and patients with positive test results are treated with anti-influenza drugs within 48 h after the onset of illness. We assessed the vaccine effectiveness (VE) of inactivated influenza vaccine (IIV) in children (6 months-15 years old, N = 4243), using a test-negative case-control design based on the results of RIDTs in the 2018/19 season. The VE against influenza A(H1N1)pdm and A(H3N2) was analyzed separately using an RIDT kit specifically for detecting A(H1N1)pdm09. The adjusted VE against combined influenza A (H1N1pdm and H3N2) and against A(H1N1)pdm09 was 39% (95% confidence interval [CI], 30%-46%) and 74% (95% CI, 39%-89%), respectively. By contrast, the VE against non-A(H1N1)pdm09 influenza A (presumed to be H3N2) was very low at 7%. The adjusted VE for preventing hospitalization was 56% (95% CI, 16%-77%) against influenza A. The VE against A(H1N1)pdm09 was consistently high in our studies. By contrast, the VE against A(H3N2) was low not only in adults but also in children in the 2018/19 season. Medicine R Science Q Norio Sugaya verfasserin aut Yoshio Yamaguchi verfasserin aut Ichiro Ookawara verfasserin aut Yuji Nakata verfasserin aut Atsushi Narabayashi verfasserin aut Munehiro Furuichi verfasserin aut Naoko Yoshida verfasserin aut Akinobu Kamei verfasserin aut Yuu Kuramochi verfasserin aut Akimichi Shibata verfasserin aut Motoko Shimoyamada verfasserin aut Hisataka Nakazaki verfasserin aut Naohiko Maejima verfasserin aut Erika Yuasa verfasserin aut Eriko Araki verfasserin aut Naonori Maeda verfasserin aut Takuma Ohnishi verfasserin aut Mitsuhiro Nishida verfasserin aut Nobuhiko Taguchi verfasserin aut Makoto Yoshida verfasserin aut Kenichiro Tsunematsu verfasserin aut Meiwa Shibata verfasserin aut Yasuhiro Hirano verfasserin aut Shinichiro Sekiguchi verfasserin aut Chiharu Kawakami verfasserin aut Keiko Mitamura verfasserin aut Takao Takahashi verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 16(2021), 3, p e0249005 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:16 year:2021 number:3, p e0249005 https://doi.org/10.1371/journal.pone.0249005 kostenfrei https://doaj.org/article/b21d1e3678ef42969561941bc3def511 kostenfrei https://doi.org/10.1371/journal.pone.0249005 kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2021 3, p e0249005 |
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Masayoshi Shinjoh @@aut@@ Norio Sugaya @@aut@@ Yoshio Yamaguchi @@aut@@ Ichiro Ookawara @@aut@@ Yuji Nakata @@aut@@ Atsushi Narabayashi @@aut@@ Munehiro Furuichi @@aut@@ Naoko Yoshida @@aut@@ Akinobu Kamei @@aut@@ Yuu Kuramochi @@aut@@ Akimichi Shibata @@aut@@ Motoko Shimoyamada @@aut@@ Hisataka Nakazaki @@aut@@ Naohiko Maejima @@aut@@ Erika Yuasa @@aut@@ Eriko Araki @@aut@@ Naonori Maeda @@aut@@ Takuma Ohnishi @@aut@@ Mitsuhiro Nishida @@aut@@ Nobuhiko Taguchi @@aut@@ Makoto Yoshida @@aut@@ Kenichiro Tsunematsu @@aut@@ Meiwa Shibata @@aut@@ Yasuhiro Hirano @@aut@@ Shinichiro Sekiguchi @@aut@@ Chiharu Kawakami @@aut@@ Keiko Mitamura @@aut@@ Takao Takahashi @@aut@@ |
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Masayoshi Shinjoh |
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Masayoshi Shinjoh misc Medicine misc R misc Science misc Q Influenza vaccine effectiveness against influenza A in children based on the results of various rapid influenza tests in the 2018/19 season. |
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Influenza vaccine effectiveness against influenza A in children based on the results of various rapid influenza tests in the 2018/19 season |
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Masayoshi Shinjoh Norio Sugaya Yoshio Yamaguchi Ichiro Ookawara Yuji Nakata Atsushi Narabayashi Munehiro Furuichi Naoko Yoshida Akinobu Kamei Yuu Kuramochi Akimichi Shibata Motoko Shimoyamada Hisataka Nakazaki Naohiko Maejima Erika Yuasa Eriko Araki Naonori Maeda Takuma Ohnishi Mitsuhiro Nishida Nobuhiko Taguchi Makoto Yoshida Kenichiro Tsunematsu Meiwa Shibata Yasuhiro Hirano Shinichiro Sekiguchi Chiharu Kawakami Keiko Mitamura Takao Takahashi |
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influenza vaccine effectiveness against influenza a in children based on the results of various rapid influenza tests in the 2018/19 season |
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Influenza vaccine effectiveness against influenza A in children based on the results of various rapid influenza tests in the 2018/19 season. |
| abstract |
During influenza epidemics, Japanese clinicians routinely conduct rapid influenza diagnostic tests (RIDTs) in patients with influenza-like illness, and patients with positive test results are treated with anti-influenza drugs within 48 h after the onset of illness. We assessed the vaccine effectiveness (VE) of inactivated influenza vaccine (IIV) in children (6 months-15 years old, N = 4243), using a test-negative case-control design based on the results of RIDTs in the 2018/19 season. The VE against influenza A(H1N1)pdm and A(H3N2) was analyzed separately using an RIDT kit specifically for detecting A(H1N1)pdm09. The adjusted VE against combined influenza A (H1N1pdm and H3N2) and against A(H1N1)pdm09 was 39% (95% confidence interval [CI], 30%-46%) and 74% (95% CI, 39%-89%), respectively. By contrast, the VE against non-A(H1N1)pdm09 influenza A (presumed to be H3N2) was very low at 7%. The adjusted VE for preventing hospitalization was 56% (95% CI, 16%-77%) against influenza A. The VE against A(H1N1)pdm09 was consistently high in our studies. By contrast, the VE against A(H3N2) was low not only in adults but also in children in the 2018/19 season. |
| abstractGer |
During influenza epidemics, Japanese clinicians routinely conduct rapid influenza diagnostic tests (RIDTs) in patients with influenza-like illness, and patients with positive test results are treated with anti-influenza drugs within 48 h after the onset of illness. We assessed the vaccine effectiveness (VE) of inactivated influenza vaccine (IIV) in children (6 months-15 years old, N = 4243), using a test-negative case-control design based on the results of RIDTs in the 2018/19 season. The VE against influenza A(H1N1)pdm and A(H3N2) was analyzed separately using an RIDT kit specifically for detecting A(H1N1)pdm09. The adjusted VE against combined influenza A (H1N1pdm and H3N2) and against A(H1N1)pdm09 was 39% (95% confidence interval [CI], 30%-46%) and 74% (95% CI, 39%-89%), respectively. By contrast, the VE against non-A(H1N1)pdm09 influenza A (presumed to be H3N2) was very low at 7%. The adjusted VE for preventing hospitalization was 56% (95% CI, 16%-77%) against influenza A. The VE against A(H1N1)pdm09 was consistently high in our studies. By contrast, the VE against A(H3N2) was low not only in adults but also in children in the 2018/19 season. |
| abstract_unstemmed |
During influenza epidemics, Japanese clinicians routinely conduct rapid influenza diagnostic tests (RIDTs) in patients with influenza-like illness, and patients with positive test results are treated with anti-influenza drugs within 48 h after the onset of illness. We assessed the vaccine effectiveness (VE) of inactivated influenza vaccine (IIV) in children (6 months-15 years old, N = 4243), using a test-negative case-control design based on the results of RIDTs in the 2018/19 season. The VE against influenza A(H1N1)pdm and A(H3N2) was analyzed separately using an RIDT kit specifically for detecting A(H1N1)pdm09. The adjusted VE against combined influenza A (H1N1pdm and H3N2) and against A(H1N1)pdm09 was 39% (95% confidence interval [CI], 30%-46%) and 74% (95% CI, 39%-89%), respectively. By contrast, the VE against non-A(H1N1)pdm09 influenza A (presumed to be H3N2) was very low at 7%. The adjusted VE for preventing hospitalization was 56% (95% CI, 16%-77%) against influenza A. The VE against A(H1N1)pdm09 was consistently high in our studies. By contrast, the VE against A(H3N2) was low not only in adults but also in children in the 2018/19 season. |
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Influenza vaccine effectiveness against influenza A in children based on the results of various rapid influenza tests in the 2018/19 season. |
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https://doi.org/10.1371/journal.pone.0249005 https://doaj.org/article/b21d1e3678ef42969561941bc3def511 https://doaj.org/toc/1932-6203 |
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Norio Sugaya Yoshio Yamaguchi Ichiro Ookawara Yuji Nakata Atsushi Narabayashi Munehiro Furuichi Naoko Yoshida Akinobu Kamei Yuu Kuramochi Akimichi Shibata Motoko Shimoyamada Hisataka Nakazaki Naohiko Maejima Erika Yuasa Eriko Araki Naonori Maeda Takuma Ohnishi Mitsuhiro Nishida Nobuhiko Taguchi Makoto Yoshida Kenichiro Tsunematsu Meiwa Shibata Yasuhiro Hirano Shinichiro Sekiguchi Chiharu Kawakami Keiko Mitamura Takao Takahashi |
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Norio Sugaya Yoshio Yamaguchi Ichiro Ookawara Yuji Nakata Atsushi Narabayashi Munehiro Furuichi Naoko Yoshida Akinobu Kamei Yuu Kuramochi Akimichi Shibata Motoko Shimoyamada Hisataka Nakazaki Naohiko Maejima Erika Yuasa Eriko Araki Naonori Maeda Takuma Ohnishi Mitsuhiro Nishida Nobuhiko Taguchi Makoto Yoshida Kenichiro Tsunematsu Meiwa Shibata Yasuhiro Hirano Shinichiro Sekiguchi Chiharu Kawakami Keiko Mitamura Takao Takahashi |
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10.1371/journal.pone.0249005 |
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2024-07-03T22:19:16.720Z |
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We assessed the vaccine effectiveness (VE) of inactivated influenza vaccine (IIV) in children (6 months-15 years old, N = 4243), using a test-negative case-control design based on the results of RIDTs in the 2018/19 season. The VE against influenza A(H1N1)pdm and A(H3N2) was analyzed separately using an RIDT kit specifically for detecting A(H1N1)pdm09. The adjusted VE against combined influenza A (H1N1pdm and H3N2) and against A(H1N1)pdm09 was 39% (95% confidence interval [CI], 30%-46%) and 74% (95% CI, 39%-89%), respectively. By contrast, the VE against non-A(H1N1)pdm09 influenza A (presumed to be H3N2) was very low at 7%. The adjusted VE for preventing hospitalization was 56% (95% CI, 16%-77%) against influenza A. The VE against A(H1N1)pdm09 was consistently high in our studies. 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