Electrochemical Sensing of Interactions between DNA and Charged Macrocycles

In this work, we investigated aggregation of native DNA and thiacalix[4]arene derivative bearing eight terminal amino groups in <i<cone</i< configuration using various redox probes on the glassy carbon electrode. It was shown that sorption transfer of the aggregates on the surface of the...
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Autor*in:	Tatjana Kulikova [verfasserIn] Pavel Padnya [verfasserIn] Igor Shiabiev [verfasserIn] Alexey Rogov [verfasserIn] Ivan Stoikov [verfasserIn] Gennady Evtugyn [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	thiacalix[4]arene DNA sensing methylene green cyclic voltammetry electrochemical impedance spectroscopy

Übergeordnetes Werk:	In: Chemosensors - MDPI AG, 2013, 9(2021), 12, p 347
Übergeordnetes Werk:	volume:9 ; year:2021 ; number:12, p 347

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/chemosensors9120347

Katalog-ID:	DOAJ07430903X

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allfields	10.3390/chemosensors9120347 doi (DE-627)DOAJ07430903X (DE-599)DOAJcbead3e585c549e9ae2ddc552bfc9b72 DE-627 ger DE-627 rakwb eng QD415-436 Tatjana Kulikova verfasserin aut Electrochemical Sensing of Interactions between DNA and Charged Macrocycles 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this work, we investigated aggregation of native DNA and thiacalix[4]arene derivative bearing eight terminal amino groups in <i<cone</i< configuration using various redox probes on the glassy carbon electrode. It was shown that sorption transfer of the aggregates on the surface of the electrode covered with carbon black resulted in changes in electrostatic interactions and diffusional permeability of the surface layer. Such changes alter the signals of ferricyanide ion, methylene green and hydroquinone as redox probes to a degree depending on their specific interactions with DNA and own charge. Inclusion of DNA in the surface layer was independently confirmed by scanning electron microscopy, electrochemical impedance spectroscopy and experiments with doxorubicin as a model intercalator. Thermal denaturing of DNA affected the charge separation on the electrode interface and the signals of redox probes. Using hydroquinone, less sensitive to electrostatic interactions, made it possible to determine from 10 pM to 1.0 nM doxorubicin (limit of detection 3 pM) after 10 min incubation. Stabilizers present in the commercial medications did not alter the signal. The DNA sensors developed can find future application in the assessment of the complexes formed by DNA and macrocycles as delivery agents for small chemical species. thiacalix[4]arene DNA sensing methylene green cyclic voltammetry electrochemical impedance spectroscopy Biochemistry Pavel Padnya verfasserin aut Igor Shiabiev verfasserin aut Alexey Rogov verfasserin aut Ivan Stoikov verfasserin aut Gennady Evtugyn verfasserin aut In Chemosensors MDPI AG, 2013 9(2021), 12, p 347 (DE-627)737287594 (DE-600)2704218-2 22279040 nnns volume:9 year:2021 number:12, p 347 https://doi.org/10.3390/chemosensors9120347 kostenfrei https://doaj.org/article/cbead3e585c549e9ae2ddc552bfc9b72 kostenfrei https://www.mdpi.com/2227-9040/9/12/347 kostenfrei https://doaj.org/toc/2227-9040 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 12, p 347
spelling	10.3390/chemosensors9120347 doi (DE-627)DOAJ07430903X (DE-599)DOAJcbead3e585c549e9ae2ddc552bfc9b72 DE-627 ger DE-627 rakwb eng QD415-436 Tatjana Kulikova verfasserin aut Electrochemical Sensing of Interactions between DNA and Charged Macrocycles 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this work, we investigated aggregation of native DNA and thiacalix[4]arene derivative bearing eight terminal amino groups in <i<cone</i< configuration using various redox probes on the glassy carbon electrode. It was shown that sorption transfer of the aggregates on the surface of the electrode covered with carbon black resulted in changes in electrostatic interactions and diffusional permeability of the surface layer. Such changes alter the signals of ferricyanide ion, methylene green and hydroquinone as redox probes to a degree depending on their specific interactions with DNA and own charge. Inclusion of DNA in the surface layer was independently confirmed by scanning electron microscopy, electrochemical impedance spectroscopy and experiments with doxorubicin as a model intercalator. Thermal denaturing of DNA affected the charge separation on the electrode interface and the signals of redox probes. Using hydroquinone, less sensitive to electrostatic interactions, made it possible to determine from 10 pM to 1.0 nM doxorubicin (limit of detection 3 pM) after 10 min incubation. Stabilizers present in the commercial medications did not alter the signal. The DNA sensors developed can find future application in the assessment of the complexes formed by DNA and macrocycles as delivery agents for small chemical species. thiacalix[4]arene DNA sensing methylene green cyclic voltammetry electrochemical impedance spectroscopy Biochemistry Pavel Padnya verfasserin aut Igor Shiabiev verfasserin aut Alexey Rogov verfasserin aut Ivan Stoikov verfasserin aut Gennady Evtugyn verfasserin aut In Chemosensors MDPI AG, 2013 9(2021), 12, p 347 (DE-627)737287594 (DE-600)2704218-2 22279040 nnns volume:9 year:2021 number:12, p 347 https://doi.org/10.3390/chemosensors9120347 kostenfrei https://doaj.org/article/cbead3e585c549e9ae2ddc552bfc9b72 kostenfrei https://www.mdpi.com/2227-9040/9/12/347 kostenfrei https://doaj.org/toc/2227-9040 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 12, p 347
allfields_unstemmed	10.3390/chemosensors9120347 doi (DE-627)DOAJ07430903X (DE-599)DOAJcbead3e585c549e9ae2ddc552bfc9b72 DE-627 ger DE-627 rakwb eng QD415-436 Tatjana Kulikova verfasserin aut Electrochemical Sensing of Interactions between DNA and Charged Macrocycles 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this work, we investigated aggregation of native DNA and thiacalix[4]arene derivative bearing eight terminal amino groups in <i<cone</i< configuration using various redox probes on the glassy carbon electrode. It was shown that sorption transfer of the aggregates on the surface of the electrode covered with carbon black resulted in changes in electrostatic interactions and diffusional permeability of the surface layer. Such changes alter the signals of ferricyanide ion, methylene green and hydroquinone as redox probes to a degree depending on their specific interactions with DNA and own charge. Inclusion of DNA in the surface layer was independently confirmed by scanning electron microscopy, electrochemical impedance spectroscopy and experiments with doxorubicin as a model intercalator. Thermal denaturing of DNA affected the charge separation on the electrode interface and the signals of redox probes. Using hydroquinone, less sensitive to electrostatic interactions, made it possible to determine from 10 pM to 1.0 nM doxorubicin (limit of detection 3 pM) after 10 min incubation. Stabilizers present in the commercial medications did not alter the signal. The DNA sensors developed can find future application in the assessment of the complexes formed by DNA and macrocycles as delivery agents for small chemical species. thiacalix[4]arene DNA sensing methylene green cyclic voltammetry electrochemical impedance spectroscopy Biochemistry Pavel Padnya verfasserin aut Igor Shiabiev verfasserin aut Alexey Rogov verfasserin aut Ivan Stoikov verfasserin aut Gennady Evtugyn verfasserin aut In Chemosensors MDPI AG, 2013 9(2021), 12, p 347 (DE-627)737287594 (DE-600)2704218-2 22279040 nnns volume:9 year:2021 number:12, p 347 https://doi.org/10.3390/chemosensors9120347 kostenfrei https://doaj.org/article/cbead3e585c549e9ae2ddc552bfc9b72 kostenfrei https://www.mdpi.com/2227-9040/9/12/347 kostenfrei https://doaj.org/toc/2227-9040 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 12, p 347
allfieldsGer	10.3390/chemosensors9120347 doi (DE-627)DOAJ07430903X (DE-599)DOAJcbead3e585c549e9ae2ddc552bfc9b72 DE-627 ger DE-627 rakwb eng QD415-436 Tatjana Kulikova verfasserin aut Electrochemical Sensing of Interactions between DNA and Charged Macrocycles 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this work, we investigated aggregation of native DNA and thiacalix[4]arene derivative bearing eight terminal amino groups in <i<cone</i< configuration using various redox probes on the glassy carbon electrode. It was shown that sorption transfer of the aggregates on the surface of the electrode covered with carbon black resulted in changes in electrostatic interactions and diffusional permeability of the surface layer. Such changes alter the signals of ferricyanide ion, methylene green and hydroquinone as redox probes to a degree depending on their specific interactions with DNA and own charge. Inclusion of DNA in the surface layer was independently confirmed by scanning electron microscopy, electrochemical impedance spectroscopy and experiments with doxorubicin as a model intercalator. Thermal denaturing of DNA affected the charge separation on the electrode interface and the signals of redox probes. Using hydroquinone, less sensitive to electrostatic interactions, made it possible to determine from 10 pM to 1.0 nM doxorubicin (limit of detection 3 pM) after 10 min incubation. Stabilizers present in the commercial medications did not alter the signal. The DNA sensors developed can find future application in the assessment of the complexes formed by DNA and macrocycles as delivery agents for small chemical species. thiacalix[4]arene DNA sensing methylene green cyclic voltammetry electrochemical impedance spectroscopy Biochemistry Pavel Padnya verfasserin aut Igor Shiabiev verfasserin aut Alexey Rogov verfasserin aut Ivan Stoikov verfasserin aut Gennady Evtugyn verfasserin aut In Chemosensors MDPI AG, 2013 9(2021), 12, p 347 (DE-627)737287594 (DE-600)2704218-2 22279040 nnns volume:9 year:2021 number:12, p 347 https://doi.org/10.3390/chemosensors9120347 kostenfrei https://doaj.org/article/cbead3e585c549e9ae2ddc552bfc9b72 kostenfrei https://www.mdpi.com/2227-9040/9/12/347 kostenfrei https://doaj.org/toc/2227-9040 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 12, p 347
allfieldsSound	10.3390/chemosensors9120347 doi (DE-627)DOAJ07430903X (DE-599)DOAJcbead3e585c549e9ae2ddc552bfc9b72 DE-627 ger DE-627 rakwb eng QD415-436 Tatjana Kulikova verfasserin aut Electrochemical Sensing of Interactions between DNA and Charged Macrocycles 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this work, we investigated aggregation of native DNA and thiacalix[4]arene derivative bearing eight terminal amino groups in <i<cone</i< configuration using various redox probes on the glassy carbon electrode. It was shown that sorption transfer of the aggregates on the surface of the electrode covered with carbon black resulted in changes in electrostatic interactions and diffusional permeability of the surface layer. Such changes alter the signals of ferricyanide ion, methylene green and hydroquinone as redox probes to a degree depending on their specific interactions with DNA and own charge. Inclusion of DNA in the surface layer was independently confirmed by scanning electron microscopy, electrochemical impedance spectroscopy and experiments with doxorubicin as a model intercalator. Thermal denaturing of DNA affected the charge separation on the electrode interface and the signals of redox probes. Using hydroquinone, less sensitive to electrostatic interactions, made it possible to determine from 10 pM to 1.0 nM doxorubicin (limit of detection 3 pM) after 10 min incubation. Stabilizers present in the commercial medications did not alter the signal. The DNA sensors developed can find future application in the assessment of the complexes formed by DNA and macrocycles as delivery agents for small chemical species. thiacalix[4]arene DNA sensing methylene green cyclic voltammetry electrochemical impedance spectroscopy Biochemistry Pavel Padnya verfasserin aut Igor Shiabiev verfasserin aut Alexey Rogov verfasserin aut Ivan Stoikov verfasserin aut Gennady Evtugyn verfasserin aut In Chemosensors MDPI AG, 2013 9(2021), 12, p 347 (DE-627)737287594 (DE-600)2704218-2 22279040 nnns volume:9 year:2021 number:12, p 347 https://doi.org/10.3390/chemosensors9120347 kostenfrei https://doaj.org/article/cbead3e585c549e9ae2ddc552bfc9b72 kostenfrei https://www.mdpi.com/2227-9040/9/12/347 kostenfrei https://doaj.org/toc/2227-9040 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 12, p 347
language	English
source	In Chemosensors 9(2021), 12, p 347 volume:9 year:2021 number:12, p 347
sourceStr	In Chemosensors 9(2021), 12, p 347 volume:9 year:2021 number:12, p 347
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	thiacalix[4]arene DNA sensing methylene green cyclic voltammetry electrochemical impedance spectroscopy Biochemistry
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container_title	Chemosensors
authorswithroles_txt_mv	Tatjana Kulikova @@aut@@ Pavel Padnya @@aut@@ Igor Shiabiev @@aut@@ Alexey Rogov @@aut@@ Ivan Stoikov @@aut@@ Gennady Evtugyn @@aut@@
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callnumber-first	Q - Science
author	Tatjana Kulikova
spellingShingle	Tatjana Kulikova misc QD415-436 misc thiacalix[4]arene misc DNA sensing misc methylene green misc cyclic voltammetry misc electrochemical impedance spectroscopy misc Biochemistry Electrochemical Sensing of Interactions between DNA and Charged Macrocycles
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topic_title	QD415-436 Electrochemical Sensing of Interactions between DNA and Charged Macrocycles thiacalix[4]arene DNA sensing methylene green cyclic voltammetry electrochemical impedance spectroscopy
topic	misc QD415-436 misc thiacalix[4]arene misc DNA sensing misc methylene green misc cyclic voltammetry misc electrochemical impedance spectroscopy misc Biochemistry
topic_unstemmed	misc QD415-436 misc thiacalix[4]arene misc DNA sensing misc methylene green misc cyclic voltammetry misc electrochemical impedance spectroscopy misc Biochemistry
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title	Electrochemical Sensing of Interactions between DNA and Charged Macrocycles
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title_full	Electrochemical Sensing of Interactions between DNA and Charged Macrocycles
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author_browse	Tatjana Kulikova Pavel Padnya Igor Shiabiev Alexey Rogov Ivan Stoikov Gennady Evtugyn
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title_sort	electrochemical sensing of interactions between dna and charged macrocycles
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title_auth	Electrochemical Sensing of Interactions between DNA and Charged Macrocycles
abstract	In this work, we investigated aggregation of native DNA and thiacalix[4]arene derivative bearing eight terminal amino groups in <i<cone</i< configuration using various redox probes on the glassy carbon electrode. It was shown that sorption transfer of the aggregates on the surface of the electrode covered with carbon black resulted in changes in electrostatic interactions and diffusional permeability of the surface layer. Such changes alter the signals of ferricyanide ion, methylene green and hydroquinone as redox probes to a degree depending on their specific interactions with DNA and own charge. Inclusion of DNA in the surface layer was independently confirmed by scanning electron microscopy, electrochemical impedance spectroscopy and experiments with doxorubicin as a model intercalator. Thermal denaturing of DNA affected the charge separation on the electrode interface and the signals of redox probes. Using hydroquinone, less sensitive to electrostatic interactions, made it possible to determine from 10 pM to 1.0 nM doxorubicin (limit of detection 3 pM) after 10 min incubation. Stabilizers present in the commercial medications did not alter the signal. The DNA sensors developed can find future application in the assessment of the complexes formed by DNA and macrocycles as delivery agents for small chemical species.
abstractGer	In this work, we investigated aggregation of native DNA and thiacalix[4]arene derivative bearing eight terminal amino groups in <i<cone</i< configuration using various redox probes on the glassy carbon electrode. It was shown that sorption transfer of the aggregates on the surface of the electrode covered with carbon black resulted in changes in electrostatic interactions and diffusional permeability of the surface layer. Such changes alter the signals of ferricyanide ion, methylene green and hydroquinone as redox probes to a degree depending on their specific interactions with DNA and own charge. Inclusion of DNA in the surface layer was independently confirmed by scanning electron microscopy, electrochemical impedance spectroscopy and experiments with doxorubicin as a model intercalator. Thermal denaturing of DNA affected the charge separation on the electrode interface and the signals of redox probes. Using hydroquinone, less sensitive to electrostatic interactions, made it possible to determine from 10 pM to 1.0 nM doxorubicin (limit of detection 3 pM) after 10 min incubation. Stabilizers present in the commercial medications did not alter the signal. The DNA sensors developed can find future application in the assessment of the complexes formed by DNA and macrocycles as delivery agents for small chemical species.
abstract_unstemmed	In this work, we investigated aggregation of native DNA and thiacalix[4]arene derivative bearing eight terminal amino groups in <i<cone</i< configuration using various redox probes on the glassy carbon electrode. It was shown that sorption transfer of the aggregates on the surface of the electrode covered with carbon black resulted in changes in electrostatic interactions and diffusional permeability of the surface layer. Such changes alter the signals of ferricyanide ion, methylene green and hydroquinone as redox probes to a degree depending on their specific interactions with DNA and own charge. Inclusion of DNA in the surface layer was independently confirmed by scanning electron microscopy, electrochemical impedance spectroscopy and experiments with doxorubicin as a model intercalator. Thermal denaturing of DNA affected the charge separation on the electrode interface and the signals of redox probes. Using hydroquinone, less sensitive to electrostatic interactions, made it possible to determine from 10 pM to 1.0 nM doxorubicin (limit of detection 3 pM) after 10 min incubation. Stabilizers present in the commercial medications did not alter the signal. The DNA sensors developed can find future application in the assessment of the complexes formed by DNA and macrocycles as delivery agents for small chemical species.
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container_issue	12, p 347
title_short	Electrochemical Sensing of Interactions between DNA and Charged Macrocycles
url	https://doi.org/10.3390/chemosensors9120347 https://doaj.org/article/cbead3e585c549e9ae2ddc552bfc9b72 https://www.mdpi.com/2227-9040/9/12/347 https://doaj.org/toc/2227-9040
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author2	Pavel Padnya Igor Shiabiev Alexey Rogov Ivan Stoikov Gennady Evtugyn
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up_date	2024-07-03T22:27:11.106Z
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