Psychotria viridis: Chemical constituents from leaves and biological properties
ABSTRACT The phytochemical study of hexane, chloroform and methanol extracts from leaves of Psychotria viridis resulted in the identification of: the pentacyclic triterpenes, ursolic and oleanolic acid; the steroids, 24-methylene-cycloartanol, stigmasterol and β-sitosterol; the glycosylated steroids...
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DÉBORA B.S. SOARES [verfasserIn] LUCIENIR P. DUARTE [verfasserIn] ANDRÉ D. CAVALCANTI [verfasserIn] FERNANDO C. SILVA [verfasserIn] ARIADNE D. BRAGA [verfasserIn] MIRIAM T.P. LOPES [verfasserIn] JACQUELINE A. TAKAHASHI [verfasserIn] SIDNEY A. VIEIRA-FILHO [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
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In: Anais da Academia Brasileira de Ciências - Academia Brasileira de Ciências, 2004 |
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| Links: |
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| DOI / URN: |
10.1590/0001-3765201720160411 |
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| Katalog-ID: |
DOAJ074325965 |
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| 520 | |a ABSTRACT The phytochemical study of hexane, chloroform and methanol extracts from leaves of Psychotria viridis resulted in the identification of: the pentacyclic triterpenes, ursolic and oleanolic acid; the steroids, 24-methylene-cycloartanol, stigmasterol and β-sitosterol; the glycosylated steroids 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol; a polyunsaturated triterpene, squalene; the esters of glycerol, 1-palmitoylglycerol and triacylglycerol; a mixture of long chain hydrocarbons; the aldehyde nonacosanal; the long chain fat acids hentriacontanoic, hexadecanoic and heptadenoic acid; the ester methyl heptadecanoate; the 4-methyl-epi-quinate and two indole alkaloids, N,N-dimethyltryptamine (DMT) and N-methyltryptamine. The chemical structures were determined by means of spectroscopic (IR, 1H and 13C NMR, HSQC, HMBC and NOESY) and spectrometric (CG-MS and LCMS-ESI-ITTOF) methods. The study of biologic properties of P. viridis consisted in the evaluation of the acetylcholinesterase inhibition and cytotoxic activities. The hexane, chloroform, ethyl acetate and methanol extracts, the substances 24-methylene-cycloartanol, DMT and a mixture of 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol showed cholinesterase inhibiting activity. This activity induced by chloroform and ethyl acetate extracts was higher than 90%. The methanol and ethyl acetate extracts inhibit the growth and/or induce the death of the tumor cells strains B16F10 and 4T1, without damaging the integrity of the normal cells BHK and CHO. DMT also demonstrated a marked activity against tumor cell strains B16F10 and 4T1. | ||
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10.1590/0001-3765201720160411 doi (DE-627)DOAJ074325965 (DE-599)DOAJd7d34a1a2b814df6bb5cfa17cf132f0b DE-627 ger DE-627 rakwb eng DÉBORA B.S. SOARES verfasserin aut Psychotria viridis: Chemical constituents from leaves and biological properties Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT The phytochemical study of hexane, chloroform and methanol extracts from leaves of Psychotria viridis resulted in the identification of: the pentacyclic triterpenes, ursolic and oleanolic acid; the steroids, 24-methylene-cycloartanol, stigmasterol and β-sitosterol; the glycosylated steroids 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol; a polyunsaturated triterpene, squalene; the esters of glycerol, 1-palmitoylglycerol and triacylglycerol; a mixture of long chain hydrocarbons; the aldehyde nonacosanal; the long chain fat acids hentriacontanoic, hexadecanoic and heptadenoic acid; the ester methyl heptadecanoate; the 4-methyl-epi-quinate and two indole alkaloids, N,N-dimethyltryptamine (DMT) and N-methyltryptamine. The chemical structures were determined by means of spectroscopic (IR, 1H and 13C NMR, HSQC, HMBC and NOESY) and spectrometric (CG-MS and LCMS-ESI-ITTOF) methods. The study of biologic properties of P. viridis consisted in the evaluation of the acetylcholinesterase inhibition and cytotoxic activities. The hexane, chloroform, ethyl acetate and methanol extracts, the substances 24-methylene-cycloartanol, DMT and a mixture of 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol showed cholinesterase inhibiting activity. This activity induced by chloroform and ethyl acetate extracts was higher than 90%. The methanol and ethyl acetate extracts inhibit the growth and/or induce the death of the tumor cells strains B16F10 and 4T1, without damaging the integrity of the normal cells BHK and CHO. DMT also demonstrated a marked activity against tumor cell strains B16F10 and 4T1. Psychotria viridis Rubiaceae N,N-dimethyltryptamine B16F10 4T1 tumor cells Science Q LUCIENIR P. DUARTE verfasserin aut ANDRÉ D. CAVALCANTI verfasserin aut FERNANDO C. SILVA verfasserin aut ARIADNE D. BRAGA verfasserin aut MIRIAM T.P. LOPES verfasserin aut JACQUELINE A. TAKAHASHI verfasserin aut SIDNEY A. VIEIRA-FILHO verfasserin aut In Anais da Academia Brasileira de Ciências Academia Brasileira de Ciências, 2004 (DE-627)329269984 (DE-600)2046885-4 16782690 nnns https://doi.org/10.1590/0001-3765201720160411 kostenfrei https://doaj.org/article/d7d34a1a2b814df6bb5cfa17cf132f0b kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000300927&lng=en&tlng=en kostenfrei https://doaj.org/toc/1678-2690 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR |
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10.1590/0001-3765201720160411 doi (DE-627)DOAJ074325965 (DE-599)DOAJd7d34a1a2b814df6bb5cfa17cf132f0b DE-627 ger DE-627 rakwb eng DÉBORA B.S. SOARES verfasserin aut Psychotria viridis: Chemical constituents from leaves and biological properties Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT The phytochemical study of hexane, chloroform and methanol extracts from leaves of Psychotria viridis resulted in the identification of: the pentacyclic triterpenes, ursolic and oleanolic acid; the steroids, 24-methylene-cycloartanol, stigmasterol and β-sitosterol; the glycosylated steroids 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol; a polyunsaturated triterpene, squalene; the esters of glycerol, 1-palmitoylglycerol and triacylglycerol; a mixture of long chain hydrocarbons; the aldehyde nonacosanal; the long chain fat acids hentriacontanoic, hexadecanoic and heptadenoic acid; the ester methyl heptadecanoate; the 4-methyl-epi-quinate and two indole alkaloids, N,N-dimethyltryptamine (DMT) and N-methyltryptamine. The chemical structures were determined by means of spectroscopic (IR, 1H and 13C NMR, HSQC, HMBC and NOESY) and spectrometric (CG-MS and LCMS-ESI-ITTOF) methods. The study of biologic properties of P. viridis consisted in the evaluation of the acetylcholinesterase inhibition and cytotoxic activities. The hexane, chloroform, ethyl acetate and methanol extracts, the substances 24-methylene-cycloartanol, DMT and a mixture of 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol showed cholinesterase inhibiting activity. This activity induced by chloroform and ethyl acetate extracts was higher than 90%. The methanol and ethyl acetate extracts inhibit the growth and/or induce the death of the tumor cells strains B16F10 and 4T1, without damaging the integrity of the normal cells BHK and CHO. DMT also demonstrated a marked activity against tumor cell strains B16F10 and 4T1. Psychotria viridis Rubiaceae N,N-dimethyltryptamine B16F10 4T1 tumor cells Science Q LUCIENIR P. DUARTE verfasserin aut ANDRÉ D. CAVALCANTI verfasserin aut FERNANDO C. SILVA verfasserin aut ARIADNE D. BRAGA verfasserin aut MIRIAM T.P. LOPES verfasserin aut JACQUELINE A. TAKAHASHI verfasserin aut SIDNEY A. VIEIRA-FILHO verfasserin aut In Anais da Academia Brasileira de Ciências Academia Brasileira de Ciências, 2004 (DE-627)329269984 (DE-600)2046885-4 16782690 nnns https://doi.org/10.1590/0001-3765201720160411 kostenfrei https://doaj.org/article/d7d34a1a2b814df6bb5cfa17cf132f0b kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000300927&lng=en&tlng=en kostenfrei https://doaj.org/toc/1678-2690 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR |
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10.1590/0001-3765201720160411 doi (DE-627)DOAJ074325965 (DE-599)DOAJd7d34a1a2b814df6bb5cfa17cf132f0b DE-627 ger DE-627 rakwb eng DÉBORA B.S. SOARES verfasserin aut Psychotria viridis: Chemical constituents from leaves and biological properties Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT The phytochemical study of hexane, chloroform and methanol extracts from leaves of Psychotria viridis resulted in the identification of: the pentacyclic triterpenes, ursolic and oleanolic acid; the steroids, 24-methylene-cycloartanol, stigmasterol and β-sitosterol; the glycosylated steroids 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol; a polyunsaturated triterpene, squalene; the esters of glycerol, 1-palmitoylglycerol and triacylglycerol; a mixture of long chain hydrocarbons; the aldehyde nonacosanal; the long chain fat acids hentriacontanoic, hexadecanoic and heptadenoic acid; the ester methyl heptadecanoate; the 4-methyl-epi-quinate and two indole alkaloids, N,N-dimethyltryptamine (DMT) and N-methyltryptamine. The chemical structures were determined by means of spectroscopic (IR, 1H and 13C NMR, HSQC, HMBC and NOESY) and spectrometric (CG-MS and LCMS-ESI-ITTOF) methods. The study of biologic properties of P. viridis consisted in the evaluation of the acetylcholinesterase inhibition and cytotoxic activities. The hexane, chloroform, ethyl acetate and methanol extracts, the substances 24-methylene-cycloartanol, DMT and a mixture of 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol showed cholinesterase inhibiting activity. This activity induced by chloroform and ethyl acetate extracts was higher than 90%. The methanol and ethyl acetate extracts inhibit the growth and/or induce the death of the tumor cells strains B16F10 and 4T1, without damaging the integrity of the normal cells BHK and CHO. DMT also demonstrated a marked activity against tumor cell strains B16F10 and 4T1. Psychotria viridis Rubiaceae N,N-dimethyltryptamine B16F10 4T1 tumor cells Science Q LUCIENIR P. DUARTE verfasserin aut ANDRÉ D. CAVALCANTI verfasserin aut FERNANDO C. SILVA verfasserin aut ARIADNE D. BRAGA verfasserin aut MIRIAM T.P. LOPES verfasserin aut JACQUELINE A. TAKAHASHI verfasserin aut SIDNEY A. VIEIRA-FILHO verfasserin aut In Anais da Academia Brasileira de Ciências Academia Brasileira de Ciências, 2004 (DE-627)329269984 (DE-600)2046885-4 16782690 nnns https://doi.org/10.1590/0001-3765201720160411 kostenfrei https://doaj.org/article/d7d34a1a2b814df6bb5cfa17cf132f0b kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000300927&lng=en&tlng=en kostenfrei https://doaj.org/toc/1678-2690 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR |
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10.1590/0001-3765201720160411 doi (DE-627)DOAJ074325965 (DE-599)DOAJd7d34a1a2b814df6bb5cfa17cf132f0b DE-627 ger DE-627 rakwb eng DÉBORA B.S. SOARES verfasserin aut Psychotria viridis: Chemical constituents from leaves and biological properties Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT The phytochemical study of hexane, chloroform and methanol extracts from leaves of Psychotria viridis resulted in the identification of: the pentacyclic triterpenes, ursolic and oleanolic acid; the steroids, 24-methylene-cycloartanol, stigmasterol and β-sitosterol; the glycosylated steroids 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol; a polyunsaturated triterpene, squalene; the esters of glycerol, 1-palmitoylglycerol and triacylglycerol; a mixture of long chain hydrocarbons; the aldehyde nonacosanal; the long chain fat acids hentriacontanoic, hexadecanoic and heptadenoic acid; the ester methyl heptadecanoate; the 4-methyl-epi-quinate and two indole alkaloids, N,N-dimethyltryptamine (DMT) and N-methyltryptamine. The chemical structures were determined by means of spectroscopic (IR, 1H and 13C NMR, HSQC, HMBC and NOESY) and spectrometric (CG-MS and LCMS-ESI-ITTOF) methods. The study of biologic properties of P. viridis consisted in the evaluation of the acetylcholinesterase inhibition and cytotoxic activities. The hexane, chloroform, ethyl acetate and methanol extracts, the substances 24-methylene-cycloartanol, DMT and a mixture of 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol showed cholinesterase inhibiting activity. This activity induced by chloroform and ethyl acetate extracts was higher than 90%. The methanol and ethyl acetate extracts inhibit the growth and/or induce the death of the tumor cells strains B16F10 and 4T1, without damaging the integrity of the normal cells BHK and CHO. DMT also demonstrated a marked activity against tumor cell strains B16F10 and 4T1. Psychotria viridis Rubiaceae N,N-dimethyltryptamine B16F10 4T1 tumor cells Science Q LUCIENIR P. DUARTE verfasserin aut ANDRÉ D. CAVALCANTI verfasserin aut FERNANDO C. SILVA verfasserin aut ARIADNE D. BRAGA verfasserin aut MIRIAM T.P. LOPES verfasserin aut JACQUELINE A. TAKAHASHI verfasserin aut SIDNEY A. VIEIRA-FILHO verfasserin aut In Anais da Academia Brasileira de Ciências Academia Brasileira de Ciências, 2004 (DE-627)329269984 (DE-600)2046885-4 16782690 nnns https://doi.org/10.1590/0001-3765201720160411 kostenfrei https://doaj.org/article/d7d34a1a2b814df6bb5cfa17cf132f0b kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000300927&lng=en&tlng=en kostenfrei https://doaj.org/toc/1678-2690 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR |
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10.1590/0001-3765201720160411 doi (DE-627)DOAJ074325965 (DE-599)DOAJd7d34a1a2b814df6bb5cfa17cf132f0b DE-627 ger DE-627 rakwb eng DÉBORA B.S. SOARES verfasserin aut Psychotria viridis: Chemical constituents from leaves and biological properties Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT The phytochemical study of hexane, chloroform and methanol extracts from leaves of Psychotria viridis resulted in the identification of: the pentacyclic triterpenes, ursolic and oleanolic acid; the steroids, 24-methylene-cycloartanol, stigmasterol and β-sitosterol; the glycosylated steroids 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol; a polyunsaturated triterpene, squalene; the esters of glycerol, 1-palmitoylglycerol and triacylglycerol; a mixture of long chain hydrocarbons; the aldehyde nonacosanal; the long chain fat acids hentriacontanoic, hexadecanoic and heptadenoic acid; the ester methyl heptadecanoate; the 4-methyl-epi-quinate and two indole alkaloids, N,N-dimethyltryptamine (DMT) and N-methyltryptamine. The chemical structures were determined by means of spectroscopic (IR, 1H and 13C NMR, HSQC, HMBC and NOESY) and spectrometric (CG-MS and LCMS-ESI-ITTOF) methods. The study of biologic properties of P. viridis consisted in the evaluation of the acetylcholinesterase inhibition and cytotoxic activities. The hexane, chloroform, ethyl acetate and methanol extracts, the substances 24-methylene-cycloartanol, DMT and a mixture of 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol showed cholinesterase inhibiting activity. This activity induced by chloroform and ethyl acetate extracts was higher than 90%. The methanol and ethyl acetate extracts inhibit the growth and/or induce the death of the tumor cells strains B16F10 and 4T1, without damaging the integrity of the normal cells BHK and CHO. DMT also demonstrated a marked activity against tumor cell strains B16F10 and 4T1. Psychotria viridis Rubiaceae N,N-dimethyltryptamine B16F10 4T1 tumor cells Science Q LUCIENIR P. DUARTE verfasserin aut ANDRÉ D. CAVALCANTI verfasserin aut FERNANDO C. SILVA verfasserin aut ARIADNE D. BRAGA verfasserin aut MIRIAM T.P. LOPES verfasserin aut JACQUELINE A. TAKAHASHI verfasserin aut SIDNEY A. VIEIRA-FILHO verfasserin aut In Anais da Academia Brasileira de Ciências Academia Brasileira de Ciências, 2004 (DE-627)329269984 (DE-600)2046885-4 16782690 nnns https://doi.org/10.1590/0001-3765201720160411 kostenfrei https://doaj.org/article/d7d34a1a2b814df6bb5cfa17cf132f0b kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000300927&lng=en&tlng=en kostenfrei https://doaj.org/toc/1678-2690 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR |
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SOARES</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Psychotria viridis: Chemical constituents from leaves and biological properties</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">ABSTRACT The phytochemical study of hexane, chloroform and methanol extracts from leaves of Psychotria viridis resulted in the identification of: the pentacyclic triterpenes, ursolic and oleanolic acid; the steroids, 24-methylene-cycloartanol, stigmasterol and β-sitosterol; the glycosylated steroids 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol; a polyunsaturated triterpene, squalene; the esters of glycerol, 1-palmitoylglycerol and triacylglycerol; a mixture of long chain hydrocarbons; the aldehyde nonacosanal; the long chain fat acids hentriacontanoic, hexadecanoic and heptadenoic acid; the ester methyl heptadecanoate; the 4-methyl-epi-quinate and two indole alkaloids, N,N-dimethyltryptamine (DMT) and N-methyltryptamine. The chemical structures were determined by means of spectroscopic (IR, 1H and 13C NMR, HSQC, HMBC and NOESY) and spectrometric (CG-MS and LCMS-ESI-ITTOF) methods. The study of biologic properties of P. viridis consisted in the evaluation of the acetylcholinesterase inhibition and cytotoxic activities. The hexane, chloroform, ethyl acetate and methanol extracts, the substances 24-methylene-cycloartanol, DMT and a mixture of 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol showed cholinesterase inhibiting activity. This activity induced by chloroform and ethyl acetate extracts was higher than 90%. The methanol and ethyl acetate extracts inhibit the growth and/or induce the death of the tumor cells strains B16F10 and 4T1, without damaging the integrity of the normal cells BHK and CHO. 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DÉBORA B.S. SOARES LUCIENIR P. DUARTE ANDRÉ D. CAVALCANTI FERNANDO C. SILVA ARIADNE D. BRAGA MIRIAM T.P. LOPES JACQUELINE A. TAKAHASHI SIDNEY A. VIEIRA-FILHO |
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Psychotria viridis: Chemical constituents from leaves and biological properties |
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ABSTRACT The phytochemical study of hexane, chloroform and methanol extracts from leaves of Psychotria viridis resulted in the identification of: the pentacyclic triterpenes, ursolic and oleanolic acid; the steroids, 24-methylene-cycloartanol, stigmasterol and β-sitosterol; the glycosylated steroids 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol; a polyunsaturated triterpene, squalene; the esters of glycerol, 1-palmitoylglycerol and triacylglycerol; a mixture of long chain hydrocarbons; the aldehyde nonacosanal; the long chain fat acids hentriacontanoic, hexadecanoic and heptadenoic acid; the ester methyl heptadecanoate; the 4-methyl-epi-quinate and two indole alkaloids, N,N-dimethyltryptamine (DMT) and N-methyltryptamine. The chemical structures were determined by means of spectroscopic (IR, 1H and 13C NMR, HSQC, HMBC and NOESY) and spectrometric (CG-MS and LCMS-ESI-ITTOF) methods. The study of biologic properties of P. viridis consisted in the evaluation of the acetylcholinesterase inhibition and cytotoxic activities. The hexane, chloroform, ethyl acetate and methanol extracts, the substances 24-methylene-cycloartanol, DMT and a mixture of 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol showed cholinesterase inhibiting activity. This activity induced by chloroform and ethyl acetate extracts was higher than 90%. The methanol and ethyl acetate extracts inhibit the growth and/or induce the death of the tumor cells strains B16F10 and 4T1, without damaging the integrity of the normal cells BHK and CHO. DMT also demonstrated a marked activity against tumor cell strains B16F10 and 4T1. |
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ABSTRACT The phytochemical study of hexane, chloroform and methanol extracts from leaves of Psychotria viridis resulted in the identification of: the pentacyclic triterpenes, ursolic and oleanolic acid; the steroids, 24-methylene-cycloartanol, stigmasterol and β-sitosterol; the glycosylated steroids 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol; a polyunsaturated triterpene, squalene; the esters of glycerol, 1-palmitoylglycerol and triacylglycerol; a mixture of long chain hydrocarbons; the aldehyde nonacosanal; the long chain fat acids hentriacontanoic, hexadecanoic and heptadenoic acid; the ester methyl heptadecanoate; the 4-methyl-epi-quinate and two indole alkaloids, N,N-dimethyltryptamine (DMT) and N-methyltryptamine. The chemical structures were determined by means of spectroscopic (IR, 1H and 13C NMR, HSQC, HMBC and NOESY) and spectrometric (CG-MS and LCMS-ESI-ITTOF) methods. The study of biologic properties of P. viridis consisted in the evaluation of the acetylcholinesterase inhibition and cytotoxic activities. The hexane, chloroform, ethyl acetate and methanol extracts, the substances 24-methylene-cycloartanol, DMT and a mixture of 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol showed cholinesterase inhibiting activity. This activity induced by chloroform and ethyl acetate extracts was higher than 90%. The methanol and ethyl acetate extracts inhibit the growth and/or induce the death of the tumor cells strains B16F10 and 4T1, without damaging the integrity of the normal cells BHK and CHO. DMT also demonstrated a marked activity against tumor cell strains B16F10 and 4T1. |
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ABSTRACT The phytochemical study of hexane, chloroform and methanol extracts from leaves of Psychotria viridis resulted in the identification of: the pentacyclic triterpenes, ursolic and oleanolic acid; the steroids, 24-methylene-cycloartanol, stigmasterol and β-sitosterol; the glycosylated steroids 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol; a polyunsaturated triterpene, squalene; the esters of glycerol, 1-palmitoylglycerol and triacylglycerol; a mixture of long chain hydrocarbons; the aldehyde nonacosanal; the long chain fat acids hentriacontanoic, hexadecanoic and heptadenoic acid; the ester methyl heptadecanoate; the 4-methyl-epi-quinate and two indole alkaloids, N,N-dimethyltryptamine (DMT) and N-methyltryptamine. The chemical structures were determined by means of spectroscopic (IR, 1H and 13C NMR, HSQC, HMBC and NOESY) and spectrometric (CG-MS and LCMS-ESI-ITTOF) methods. The study of biologic properties of P. viridis consisted in the evaluation of the acetylcholinesterase inhibition and cytotoxic activities. The hexane, chloroform, ethyl acetate and methanol extracts, the substances 24-methylene-cycloartanol, DMT and a mixture of 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol showed cholinesterase inhibiting activity. This activity induced by chloroform and ethyl acetate extracts was higher than 90%. The methanol and ethyl acetate extracts inhibit the growth and/or induce the death of the tumor cells strains B16F10 and 4T1, without damaging the integrity of the normal cells BHK and CHO. DMT also demonstrated a marked activity against tumor cell strains B16F10 and 4T1. |
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